Clinical trials: Retina
Diabetic Retinopathy, Macular Edema
PPV With Internal Limiting Membrane Peeling for Treatment-Naïve DME
Treatment-naïve subjects with center-involved diabetic macular edema undergoing pars plana vitrectomy with internal limiting membrane peeling will have similar visual outcomes but better anatomical outcomes compared to subjects…
- Trial name
- NCT03660345
- Testing
- PPV/MP, Intravitreal injection
- Where
- Mexico
- Volunteers
- 11 people
- Sponsor
- Rush Eye Associates
Vitreous Hemorrhage, Macula Hole
Performance, Safety and Efficiency Comparison Between 10,000 and 5,000 Cuts Per Minute Vitrectomy Using a 25G Cutter - A Prospective Randomized Controlled Study
As technology advances, vitrectomy cutters are smaller and cut rates have become faster. In this prospective study, the vitrectomy efficiency and safety between 5,000 cuts per minute with 10,000 cuts per minute are compared
- Conditions
- Vitreous Hemorrhage, Macula Hole, Epiretinal Membrane, Retinal Detachment
- Trial name
- NCT04859556
- Testing
- Alcon 25Gauge, 10,000 cuts per minute Ultravit cutter, Alcon 25Gauge, 5,000 cuts per minute Ultravit cutter
- Where
- Hong Kong
- Volunteers
- 52 people
- Sponsor
- The University of Hong Kong
Amyotrophic Lateral Sclerosis (ALS), Angina, Stable
Quest to Analyze One Thousand Humans Meditating
This study will be focused on assessing the molecular, physiological, and emotional correlates of an intensive meditation experience in the context of a retreat setting in a large 2000 plus-person cohort comprised of healthy and…
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Angina, Stable, Anxiety, Asthma
- Trial name
- QUANTUM (NCT06583395)
- Testing
- Advanced multi-component meditation practice
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Tobias Moeller-Bertram
Diabetic Retinopathy
Diabetic Retinopathy Sulodexide Study
The aim of this phase 2 controlled placebo study is to assess the effectiveness of Sulodexide in the treatment of non proliferative (background) retinopathy in patients with Type 1 and Type 2 Diabetes Mellitus.
- Trial name
- DRESS (NCT01295775)
- Testing
- sulodexide
- Where
- South Korea
- Volunteers
- 127 people
- Sponsor
- Ajou University School of Medicine
Diabetes, Retinopathy
Microvascular Reactivity.
This study attempts to test capillary responses to various challenges without the need for iontophoresis (electrical current).
- Conditions
- Diabetes, Retinopathy, Vascular Pathology
- Trial name
- NCT00259701
- Testing
- Laser Doppler Flowmetry with topical acetylcholine and nitroglycerin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Yale University
Retinal Detachment
23-gauge Pars Plana Vitrectomy With Silicone Oil Injectionsilicone Oil Injection With Surgical
Objective: to evaluate anatomical and visual outcomes of 23-gauge vitrectomy for retinal detachment with silicone oil injection in fifty cases.
- Trial name
- NCT04280770
- Testing
- 23 PARS PLANA VITRECTOMY
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Diabetic Retinopathy, Artificial Intelligence
Implementation of an Integrated System of Artificial Intelligence and Referral Tracking for Real-time Diabetic Retinopathy Screening
This research study aims to bring an artificial intelligence system to screen for diabetic retinopathy (DR) along with referral tracking systems to the screening unit in Uthai Hospital in Phra Nakhon Sri Ayutthaya to assess the…
- Conditions
- Diabetic Retinopathy, Artificial Intelligence, Screening
- Trial name
- NCT05166122
- Testing
- Artificial Intelligence
- Where
- Thailand
- Volunteers
- 1,600 people
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Age-Related Macular Degeneration, Retinal Vein Occlusion
Extension Study to Gather Data on Effect of Macugen on the Corneal Endothelium
This study was conducted because the FDA requested clinical information on potential effects of intravitreal injections of Macugen (pegaptanib sodium injection) on the corneal endothelium from a 1-year (minimum) post-approval…
- Conditions
- Age-Related Macular Degeneration, Retinal Vein Occlusion, Diabetic Macular Edema
- Trial name
- NCT01573572
- Testing
- pegaptanib sodium injection
- Where
- 4 sites in United States
- Volunteers
- 131 people
- Sponsor
- Bausch & Lomb Incorporated
Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor
High-Dose Thiotepa Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Conditions
- Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Ovarian Cancer
- Trial name
- NCT00003173
- Testing
- filgrastim, thiotepa, autologous bone marrow transplantation
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Age-Related Macular Degeneration
Dark Adaptation in Participants With Age-Related Macular Degeneration
Background: Macular degeneration can cause permanent loss of central vision. This vision is important for seeing details. Age-related macular degeneration (AMD) is the leading cause of vision loss in people over 55 in the United…
- Trial name
- NCT03225131
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- National Eye Institute (NEI)
Age Related Macular Degeneration, Glaucoma
Prospective Study Phase: Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human Eye
Canadians fear loss of vision more than any other disability. Vision loss has an enormous impact on quality-of-life and is extremely costly from a societal and economic perspective.
- Conditions
- Age Related Macular Degeneration, Glaucoma, Diabetic Retinopathy.
- Trial name
- NCT01348672
- Where
- Canada
- Volunteers
- 381 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Age Related Macular Degeneration
Superoxide Dismutase (SOD) as Antioxidant Treatment OF Age Related Macular Degeneration (ARMD)
INTRODUCTION: Acting directly on the anti-radical enzyme chain, the superoxide dismutase (SOD), a major enzyme of the anti-oxidant system, provides an alternative of the antioxidants treatment in ARMD.
- Trial name
- NCT00800995
- Testing
- SOD
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Centre de Recherche en Nutrition Humaine Rhone-Alpe
Macular Edema
Japanese Safety Study of VEGF Trap-Eye in DME (Diabetic Macular Edema)
This study will assess the safety and tolerability of intravitreally (IVT) administered VEGF Trap-Eye in Japanese subjects with diabetic macular edema (DME) over the period of one year.
- Trial name
- VIVID-Japan (NCT01512966)
- Testing
- VEGF Trap-Eye (BAY86-5321)
- Where
- 18 sites in Japan
- Volunteers
- 73 people
- Sponsor
- Bayer
Diabetic Retinopathy, Macular Edema
Bevacizumab Versus Ranibizumab for the Treatment of Diabetic Macular Edema
The purpose of this study is to compare the morphological and visual acuity outcomes associated with 1.5 mg bevacizumab versus 0.5 ranibizumab intravitreal injections for treatment of diabetic macular edema.
- Trial name
- IBERA-DME (NCT01487629)
- Testing
- Bevacizumab, Ranibizumab
- Where
- Brazil
- Volunteers
- 53 people
- Sponsor
- University of Sao Paulo
Macular Edema
Simultaneous Therapy With Intravitreal Dexamethasone Implant and Bevacizumab for the Treatment of Macular Edema
Retrospective cases series is a non-randomized, open-label, single-center investigation (Retina Clinic, São Paulo, Brazil) of patients diagnosed with macular edema secondary to diabetic retinopathy (DME) and retinal vein…
- Trial name
- NCT02623673
- Testing
- simultaneous treatment with intravitreal injection of bevacizumab 1.25mg and intravitreal implant of dexamethasone 0.7mg.
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Retina Clinic, Sao Paulo, Brazil
Macular Edema, Diabetic Retinopathy
Combined Triple Therapy in Diabetic Retinopathy (DRP)
The aim of this pilot study was to investigate the effects of an intravitreal combination therapy using triamcinolone and bevacizumab in patients with macular edema due to diabetic retinopathy.
- Trial name
- NCT00806169
- Testing
- triamcinolone and bevacizumab
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Macular Hole
Visual Acuity and Optical Coherence Tomography One Year After ILM-flap Transposition
ILM-flap (internal limiting Membrane-flap) transposition is a new surgical option in repair of macular holes, therefore one year outcomes are needed to better evaluate that method.
- Trial name
- NCT03465865
- Testing
- optical coherence tomography
- Where
- Austria
- Volunteers
- 41 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Age-Related Macular Degeneration, Nonexudative Age-related Macular Degeneration
Transpalpebral Microcurrent Stimulation for the Improvement of Visual Acuity in Patients With Macular Degeneration
The goal of this clinical trial is to evaluate the effectiveness of transpalpebral microcurrent stimulation as a therapy for dry age-related macular degeneration.
- Trial name
- NCT05703867
- Testing
- Active microcurrent therapy
- Volunteers
- 404 people
- Sponsor
- Jarding, John, OD
NPDR - Non Proliferative Diabetic Retinopathy, Diabetes Mellitus, Type 2
Characterization of Retinal Disease Progression in Eyes With Non Proliferative Diabetic Retinopathy in Diabetes Type 2 Using Non-invasive Procedures (CHART)
To identify biomarkers, obtained using non-invasive procedures, that can predict disease progression and progression to sight-threatening stages of the disease and to characterize the retinal changes that occur in Non…
- Conditions
- NPDR - Non Proliferative Diabetic Retinopathy, Diabetes Mellitus, Type 2, Retinal Disease
- Trial name
- CHART (NCT04636307)
- Testing
- Biomarkers
- Where
- 5 sites in France, Italy and 1 more
- Volunteers
- 202 people
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Diabetic Macular Edema
A Study of the Safety and Tolerability of Intravitreal LKA651 in Patients With Diabetic Macular Edema
The purpose of this study is to evaluate the initial safety of intravitreal (IVT) LKA651 and potential for use alone or in combination with Ranibizumab ophthalmic solution (Lucentis®) for the treatment of Diabetic Macular Edema…
- Trial name
- NCT02281292
- Testing
- LKA651 ophthalmic solution, Ranibizumab ophthalmic solution
- Sponsor
- Alcon Research
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