Clinical trials: Retina
Retinal Vein Occlusion, Obstructive Sleep Apnea
Retinal Vein Occlusion and Obstructive Sleep Apnea: A Case Control Study
This study purpose is to evaluate the association between Retinal Vein Occlusion and Obstructive Sleep Apnea.
- Trial name
- SASOVR (NCT04011358)
- Testing
- Sleeping Monitor
- Where
- France
- Sponsor
- Centre Hospitalier Régional d'Orléans
Retinitis Pigmentosa
Safety and Tolerability of Intravitreal Administration of VG901 in Patients With Retinitis Pigmentosa Due to Mutations in the CNGA1 Gene
The goal of this phase 1 clinical trial is to learn about the safety and efficacy of a gene therapy, VG901, in patients with a rare disorder of the eye called Retinitis Pigmentosa.
- Trial name
- NCT06291935
- Testing
- VG901
- Where
- Germany
- Volunteers
- 6 people
- Sponsor
- VeonGen Therapeutics GmbH
Diffuse Diabetic Macular Edema
Safety Study of iCo-007 Intravitreal Injection to Treat Diabetic Macular Edema
The goal of the study is to evaluate the safety and tolerability of 4 different doses of iCo-007 Intravitreal Injection in patients with diffuse diabetic macular edema.
- Trial name
- NCT00886808
- Testing
- iCo-007 Intravitreal Injection
- Where
- 4 sites in United States
- Volunteers
- 15 people
- Sponsor
- iCo Therapeutics Inc.
Visual Acuity Reduced Transiently, Macular Edema, Cystoid
Influence of Diabetes Control on Treatment of Diabetic Macular Edema With Ranibizumab
The aim of the prospective randomized study is to investigate whether a intensified diabetic control program leads to better final visual acuity and less frequent diabetic ocular complications in patients with diabetic…
- Trial name
- DORO (NCT02665689)
- Testing
- ranibizumab
- Where
- Germany
- Volunteers
- 4 people
- Sponsor
- Prof. Dr. Antonia M. Joussen
Age-Related Macular Degeneration
A Pilot Study of the Safety of MC-1101 in Both Normal Volunteers and Patients With Early Dry AMD
The safety and comfort of repeated administrations of a topically-administered ophthalmic formulation of MC-1101 will be established through investigator assessments and subject reporting over a 3 day period.
- Trial name
- NCT01013376
- Testing
- MC-1101, Vehicle
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- MacuCLEAR, Inc.
Central Serous Choroidopathy
Micropulse 577nm Laser vs Traditional Laser Treatment in Central Serous Chorioretinopathy
The purpose of this study is to observe whether micropulse laser (MPL) is noninferiority to traditional laser therapy in central serous chorioretinopathy.
- Trial name
- NCT02735213
- Testing
- 577-MPL, TLT
- Where
- China
- Volunteers
- 88 people
- Sponsor
- The Eye Hospital of Wenzhou Medical University
Central Retinal Vein Occlusion
Study of Comparative Treatments for Retinal Vein Occlusion 2 (SCORE2)
SCORE2 is a multicenter, prospective, randomized, phase III clinical trial in which all participants enrolled will be followed for up to 2.5 years.
- Trial name
- SCORE2 (NCT01969708)
- Testing
- aflibercept, bevacizumab
- Where
- 72 sites in United States
- Volunteers
- 362 people
- Sponsor
- The Emmes Company, LLC
Central Retinal Vein Occlusion
Predictive Factors of Ranibizumab Treatment in Macular Edema With CRVO
Recent studies have shown that intravitreal injection of anti-VEGF agent, Lucentis (Ranibizumab) is effective for macular edema associated with central retinal vein occlusion (CRVO).
- Trial name
- CRVO (NCT02091505)
- Testing
- Ranibizumab
- Where
- Japan
- Volunteers
- 30 people
- Sponsor
- Mie University
Neovascular Age-related Macular Degeneration
Development of an Optimal Algorithm for the Management of Patients With Retinal Pigment Epithelium Detachment in Neovascular Age-related Macular Degeneration Using Artificial Intelligence
The study involves the development of an algorithm for predicting anatomical and functional results of therapy with angiogenesis inhibitors in patients with retinal pigment epithelium detachments in neovascular age-related…
- Trial name
- NCT05208931
- Testing
- Anti-vascular endothelial growth factor therapy
- Where
- Russia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The S.N. Fyodorov Eye Microsurgery State Institution
Retinal Disease, Macular Disease
Topical Interferon Gamma-1b for Central Serous Chorioretinopathy
Background: In the eye disease central serous chorioretinopathy (CSC), fluid collects under the retina at the back of the eye. CSC can resolve on its own, but in some people it lasts for several months or can come back.
- Trial name
- NCT01468337
- Testing
- Interferon gamma-1b
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Eye Institute (NEI)
Diabetic Retinopathy
Anti-inflammatory Effect of Curcumin, Homotaurine, Vitamin D3 on Human Vitreous in Patients With Diabetic Retinopathy
Dosage of pro-inflammatory cytokines and soluble mediators (TNFα, IL6, IL2 and PDGF-AB) performed on 25 vitreous biopsies taken from patients with diabetic retinopathy and treated with increasing doses of curcumin (0.5uM and…
- Trial name
- NCT04378972
- Testing
- curcumin, homotaurine, vitamin D3, control
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- University of Molise
Diabetic Retinopathy, Diabetic Macular Edema (DME)
AI Prediction of Treatment Response in DME
Diabetic macular edema (DME) is a leading cause of vision loss among individuals with diabetes mellitus. Although intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy is the standard treatment for…
- Trial name
- NCT07707856
- Testing
- Artificial Intelligence-Based Imaging Analysis
- Where
- Egypt
- Volunteers
- 1,284 people
- Sponsor
- Benha University
Depression, Age-related Macular Degeneration
Effect of a Self-care Intervention on Depression in People With Age-related Macular Degeneration or Diabetic Retinopathy
The purpose of this trial is to determine the short-term effect of a self-care intervention on depression in patients with age-related macular degeneration or diabetic retinopathy.
- Trial name
- NCT02261194
- Testing
- Self-Care Tools
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Diabetic Neuropathies, Diabetic Foot
Thermal Screening for Early Diabetic Peripheral Neuropathy (DPN)
The goal of this research is to develop better tools for diagnosing illness of the feet and legs of people who have diabetes. Investigators will use thermal videos of the foot to aid in the refinement of a system designed to…
- Conditions
- Diabetic Neuropathies, Diabetic Foot, Diabetic Retinopathy
- Trial name
- NCT03069729
- Testing
- no intervention
- Where
- United States
- Volunteers
- 331 people, healthy volunteers welcome
- Sponsor
- VisionQuest Biomedical LLC
Branch Retinal Vein Occlusion with Macular Edema
Eylea and Lucentis for Macular Edema in Branch Retinal Vein Occlusion
Comparing time to recurrence of macular edema after an initial loading dose of at least three monthly anti VEGF injections (aflibercept or ranibizumab) for macular edema in BRVO.
- Trial name
- NCT03709745
- Testing
- Aflibercept Injection [Eylea], Ranibizumab Injection [Lucentis]
- Where
- Sweden
- Volunteers
- 110 people
- Sponsor
- St. Erik Eye Hospital
Age-Related Macular Degeneration, Wet Age-related Macular Degeneration
Automated Vision Assessment and Impairment Detection Through Gaze Analysis in Wet AMD Patients
The study aims to evaluate the Automated Vision Assessment and Impairment Detection through Gaze Analysis (AVIGA) system in the ability to detect and assess central vision dysfunction in a personalized, adaptive, objective, and…
- Trial name
- AVIGA2 (NCT06518512)
- Testing
- Automated Vision Assessment and Impairment Detection through Gaze Analysis (AVIGA) system
- Where
- Singapore
- Volunteers
- 128 people
- Sponsor
- Tan Tock Seng Hospital
Wet Age Related Macular Degeneration, Neovascular (Wet) Age-Related Macular Degeneration
Evaluation of PAN-90806 Eye Drops in Healthy Subjects
The goal of this clinical trial is to learn about the safety, tolerability, and systemic pharmacokinetics of PAN-90806 eye drops in healthy adults.
- Trial name
- NCT07764965
- Testing
- PAN-90806 Ophthalmic Solution, Vehicle Ophthalmic Solution
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.
Neovascular Age-related Macular Degeneration
Retinal Pigment Epithelial Characteristics in Eyes With Neovascular Age-related Macular Degeneration Following Long-term Treatment With Anti Neovascular Endothelial Growth Factor
Purpose: To assess retinal pigment epithelial (RPE) and retinal structural changes in eyes with neovascular age-related macular degeneration (AMD) treated with anti-vascular endothelial growth factor (anti-VEGF) during long-term…
- Trial name
- NCT03679156
- Testing
- OCT
- Volunteers
- 18 people
- Sponsor
- Hospital Hietzing
Ocular Toxoplasmosis
Influence of Trimethoprim-Sulfamethoxazole for the Recurrence of Ocular Toxoplasmosis
The investigators study aims to determine the effect of prophylactic therapy with Trimethoprim-sulfamethoxazole on the recurrences of toxoplasma retinochoroiditis gondii.
- Trial name
- ISROT (NCT01449877)
- Testing
- Trimethoprim-Sulfamethoxazole
- Where
- Brazil
- Volunteers
- 141 people
- Sponsor
- University of Campinas, Brazil
Diabetic Retinopathy
Reduction in the Occurrence of Center-Involved Diabetic Macular Edema
The purpose of this study is to determine if ruboxistaurin can help slow the worsening of an eye disease called macular edema in patients with diabetes.
- Trial name
- NCT00090519
- Testing
- ruboxistaurin
- Where
- 84 sites in United States, Australia and 15 more
- Volunteers
- 731 people
- Sponsor
- Chromaderm, Inc.
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