Clinical trials: Retina Disease
Diabetic Retinopathy, Macular Oedema
Ranibizumab Treatment of Diabetic Macular Oedema With Bimonthly Monitoring After a Phase of Initial Treatment
This study evaluates a new investigational treatment regimen of three consecutive monthly doses of ranibizumab followed by an as-needed treatment regimen, with monthly follow-up for the first three months then two-monthly…
- Trial name
- RELIGHT (NCT01257815)
- Testing
- Ranibizumab
- Where
- 15 sites in United Kingdom
- Volunteers
- 111 people
- Sponsor
- Novartis Pharmaceuticals
Macular Edema, Diabetic Macular Edema
A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamic Activity of Intravitreal LKA651 in Patients With Macular Edema
To evaluate the safety and tolerability of LKA651 in patients with macular edema from diabetic macular edema (DME), neovascular age-related macular degeneration (AMD), or retinal vein occlusions (RVO)
- Conditions
- Macular Edema, Diabetic Macular Edema, Neovascular Age-related Macular Degeneration, Retinal Vein Occlusions
- Trial name
- NCT02867735
- Testing
- LKA651
- Where
- 6 sites in United States, Puerto Rico
- Volunteers
- 28 people
- Sponsor
- Novartis Pharmaceuticals
Carcinoid, Neuroendocrine
Safety Study of Seneca Valley Virus in Patients With Solid Tumors With Neuroendocrine Features
The primary purpose of the study is to determine if Seneca Valley Virus may be administered safely to patients with certain types of advanced cancer.
- Trial name
- NCT00314925
- Testing
- Seneca Valley Virus (biological agent)
- Where
- 10 sites in United States
- Volunteers
- 60 people
- Sponsor
- Neotropix
Retinopathy of Prematurity (ROP)
Efficacy and Safety of Low-dose Conbercept for Retinopathy of Prematurity Therapy
Evaluating the Optimal Effective Dose and Safety of Conbercept in Treating Retinopathy of Prematurity (ROP)
- Trial name
- NCT06717412
- Testing
- Conbercept
- Where
- 3 sites in China
- Volunteers
- 146 people
- Sponsor
- Wang Yusheng
Type 2 Diabetes Mellitus, Obesity
Macrovascular and Microvascular Morbidity and Mortality After Metabolic Surgery Versus Medicines
The goal of this study is to compare the impact of metabolic surgery and a class of anti-diabetes medications (Glucagon-like peptide-1 receptor agonists,GLP-1 RAs) on occurrence of diseases involving small and large vessels such…
- Conditions
- Type 2 Diabetes Mellitus, Obesity, Microvascular Disease, Macrovascular Disease
- Trial name
- M6 (NCT06355219)
- Volunteers
- 3,932 people
- Sponsor
- Ali Aminian
Diabetic Retinopathy, Artificial Intelligence
Implementation of an Integrated System of Artificial Intelligence and Referral Tracking for Real-time Diabetic Retinopathy Screening
This research study aims to bring an artificial intelligence system to screen for diabetic retinopathy (DR) along with referral tracking systems to the screening unit in Uthai Hospital in Phra Nakhon Sri Ayutthaya to assess the…
- Conditions
- Diabetic Retinopathy, Artificial Intelligence, Screening
- Trial name
- NCT05166122
- Testing
- Artificial Intelligence
- Where
- Thailand
- Volunteers
- 1,600 people
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Central Serous Chorioretinopathy, Melatonin
Evaluating Efficacy and Safety of Oral Melatonin in Acute Central Serous Chorioretinopathy
The goal of this clinical trial is to learn if oral melatonin can enhance visual acuity and central macular thickness in central serous chorioretinopathy (CSCR) in adults. The main questions it aims to answer are: 1.
- Conditions
- Central Serous Chorioretinopathy, Melatonin, Ocular Diseases, Visual Acuity
- Trial name
- NCT06809751
- Testing
- melatonin 3mg
- Volunteers
- 48 people
- Sponsor
- Mohsen Pourazizi
Age Related Macular Degeneration
Functional and Anatomical Visual Investigations in Patients With Early Forms of Age-related Macular Degeneration
Age-related macular degeneration (AMD) is the leading cause of visual impairment in industrialized countries. Anatomical examination findings at the early and intermediate stages of AMD are not sufficient to determine any…
- Trial name
- NOGA1 (NCT06694272)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Diabetic Retinopathy
Assessment of EyeArt Performance With Retinal Imaging Devices
The study evaluates the performance of the EyeArt system for detecting diabetic retinopathy from images captured using multiple retinal imaging devices and operators.
- Trial name
- NCT04302012
- Testing
- Color fundus photography, Mydriatic Agent
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Eyenuk, Inc.
Retinal Detachment
Dexmedetomidine Versus Propofol in Vitreoretinal Surgery
The investigators would like to determine if using Dexmedetomidine alone or in a reduced dose can prevent or reduce the incidence of adverse effects, while providing adequate sedation, and respiratory stability as compared to…
- Trial name
- NCT01001429
- Testing
- Dexmedetomidine infusion, propofol
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- Rutgers, The State University of New Jersey
Non-Proliferative Diabetic Retinopathy, Cataract
Nepafenac Once Daily for Macular Edema - Study 1
The purpose of this study is to demonstrate superiority of Nepafenac Ophthalmic Suspension, 0.3% dosed once daily relative to Nepafenac Vehicle based upon clinical outcomes among diabetic subjects following cataract surgery.
- Trial name
- NCT01853072
- Testing
- Nepafenac Ophthalmic Suspension, 0.3%, Nepafenac vehicle, Prednisolone acetate
- Volunteers
- 881 people
- Sponsor
- Alcon Research
Chronic Low Back and Leg Pain
Spinal Cord Stimulation Research Study
The purpose of this study is to characterize subjects' response to spinal cord stimulation with postural changes.
- Trial name
- NCT00737581
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- MedtronicNeuro
Glaucoma
Comparing SD-tVEP and PERG Tests Between Patients With Glaucoma, Patients With High Eye Pressure and "Normal" Patients
Wills Eye Hospital Glaucoma Research Center will conduct a 1-year prospective study to assess the ability of a Short Duration Transient Visual Evoked Potential (SD- tVEP) and a Steady-State Pattern electro-retinogram (PERG)…
- Trial name
- NCT02604953
- Testing
- Short Duration Transient Visual Evoked Potential (SDtVEP), Pattern electroretinogram (PERG)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Wills Eye
Rhegmatogenous Retinal Detachment
Efficacy of Oral Colchicine in Prevention of Proliferative Vitreoretinopathy in Rhegmatogenous Retinal Detachment
This clinical trial will test the efficacy and safety of oral colchicine in prevention of proliferative vitreoretinopathy (PVR) in cases of rhegmatogenous retinal detachment
- Trial name
- NCT00370201
- Testing
- colchicine
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Glaucoma
Partial Least Squares Regression Modelling for Glaucoma Detection
A partial least squares regression model for visual field testing among glaucoma patients will be developed. In addition, microperimetry will be compared to conventional perimetry and reproducibility will be assessed.
- Trial name
- NCT03365245
- Testing
- Microperimetry, automated visual field
- Where
- Austria
- Volunteers
- 19 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Macular Edema
Mechanical Properties of the Internal Limiting Membrane and Intraoperative Utility of Brilliant Blue g (Bbg) and Indocyanine Green (Icg) Assisted Chromovitrectomy
Intravitreal dyes are intended to make the surgical extraction of the Internal limiting membrane (ILM) safer and more complete. However, the search for an adequate vitaly dye is ongoing.
- Trial name
- NCT01485575
- Testing
- Use of intraoperative filters in vitrectomy
- Where
- 3 sites in Austria, Switzerland
- Volunteers
- 50 people
- Sponsor
- University Hospital, Basel, Switzerland
Retinal Disease
Finasteride for Chronic Central Serous Chorioretinopathy
Background: Central serous chorioretinopathy (CSC) is a disease that causes fluid to collect under the retina. It affects the macula, which is in the center of the retina and is needed for sharp, clear vision.
- Trial name
- NCT01585441
- Testing
- Finasteride
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Eye Institute (NEI)
Age-Related Macular Degeneration
Assessing the Quality of Life and Social Support in Age-Related Macular Degeneration Patients
The aim of this study is to evaluate the quality of life of AMD patients related to vision using the short version of the National Eye Institute Visual Function Questionnaire (NEI-VFQ-25), patients' social support, and their…
- Trial name
- NCT05427994
- Testing
- National Eye Institute Visual Function Questionnaire
- Where
- 2 sites in Kazakhstan
- Volunteers
- 458 people
- Sponsor
- Asfendiyarov Kazakh National Medical University
Age-Related Macular Degeneration
A Phase I/II Safety Study of DE-120 Injectable Solution for Age-related Macular Degeneration
The purpose of this study is to assess the safety, tolerability, bioactivity and pharmacokinetics of three concentrations of DE-120 after a single intravitreal injection in subjects with late stage exudative age-related macular…
- Trial name
- NCT02022501
- Testing
- DE-120
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- Santen Inc.
Diabetes Mellitus
Retinal Function in Relation to Long Term Changes in the Glucose Level
The purpose of this study is to measure the amplitude and implicit time of electroretinogram (ERG), darkadaptation and the calibre of retinal vessels before and after optimized medical treatment of diabetic individuals (a lower…
- Trial name
- NCT00973401
- Testing
- Insulin pump
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Glostrup University Hospital, Copenhagen