Clinical trials: Retinal Blood Vessels
Diabetes Complications, Diabetic Retinopathy
Human iPSC for Repair of Vasodegenerative Vessels in Diabetic Retinopathy
This study proposes to carefully examine the hypothesis that human inducible pluripotent stem cells (iPSCs) can be effectively employed as a future therapeutic option for individuals with diabetic retinopathy and macular…
- Trial name
- iPSC (NCT03403699)
- Testing
- Generation of inducible pluripotent stem cells
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Retinal Hypoxia
The Mechanisms of Diameter Changes in Retinal Vessels During Hypoxia
The primary objective is to study if a stimulation of nitric oxide and/or prostaglandin affect the diameter changes of retinal vessels during hypoxia. Diameter changes are studied using the Dynamic Vessel Analyzer.
- Trial name
- NCT02059018
- Testing
- COX-inhibitor, Nitroglycerin, COX-inhibitor + Nitroglycerin
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Hypertension, Blood Pressure
REtinaL Imaging & Ambulatory BLood PrEssure
High blood pressure is a common condition which generally does not have any symptoms. Its estimated that around one third of people with high blood pressure do not know they have it.
- Trial name
- RELIABLE (NCT04118205)
- Where
- United Kingdom
- Volunteers
- 591 people
- Sponsor
- University of Edinburgh
Cerebral Small Vessel Diseases, Lacunar Stroke
Retinal Vessel Leakage in Cerebral Small Vessel Disease
The goal of this observational study is to learn about leakage from retinal vessels in cerebral small vessel disease. The main questions it aims to answer are: Does retinal vessel leakage occur in cerebral small vessel disease?…
- Conditions
- Cerebral Small Vessel Diseases, Lacunar Stroke, Vascular Dementia
- Trial name
- NCT06416371
- Testing
- Fundus fluorescein angiography, with ultrawide field retinal imaging
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Edinburgh
Hypertensive Retinopathy
Non-invasive Measurement of Retinal Blood Flow Based on Vessel Analysis and Fourier Domain Optical Coherence Tomography in Patients With Hypertensive Retinopathy
Recently, a new and sophisticated method for assessment of retinal blood flow and retinal blood flow velocity profiles has become available.
- Trial name
- NCT01753648
- Testing
- Dynamic Vessel Analyzer, FDOCT, Ocular perfusion pressure
- Where
- Austria
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Healthy
Measurement of the Eye's Blood Vessels Using the Dynamic Vessel Analyzer (DVA)
The purpose of this research study is examine the response of the blood vessels in the eye to a light flicker stimulus using the Dynamic Vessel Analyzer (DVA) on two separate days in healthy individuals.
- Trial name
- NCT00783029
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Penn State University
Hiv, Coronary Artery Disease
ARIA to Predict Coronary Artery Disease in HIV-infected Individuals
With effective anti-retroviral therapy, non-communicable diseases, such as cardiovascular diseases, have become the major cause of morbidity and mortality for people living with HIV.
- Trial name
- NCT03874221
- Where
- Hong Kong
- Volunteers
- 120 people
- Sponsor
- Chinese University of Hong Kong
Chorioretinal Disorders in Diseases Classified Elsewhere
Measurement of the Oxygen Saturation in the Retinal Vessels With Oxymap
Retinal oximetry can be measured with newly developed Oxymap (Oxymap ehf, Reykjavik, Iceland). Briefly, the device simultaneously acquires digital images at two wavelengths and automatically tracks retinal vessels on both images.
- Trial name
- NCT02318641
- Testing
- oximetry
- Where
- Japan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Kagawa University
Sexual Desire
Effects of Glucagon-like-Peptide-1 Analogues on Sexuality
This study is to investigate the effects of GLP-1 analogues (combined with lifestyle interventions in comparison to lifestyle interventions only) on sexual desire, mood, quality of life, the reproductive axis, retinal vessel…
- Trial name
- Desire PLUS (NCT05598008)
- Where
- Switzerland
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Diabetes Mellitus
Measuring Retinal Vessel Caliber in Relation to Dark Adaptation and Blood Glucose Level
The overall objective is to investigate, whether retinal blood vessel diameter change during the energy consuming dark adaptation process and if responses vary between low and high blood glucose.
- Trial name
- NCT01136902
- Testing
- Oral Glucose Tolerance Test (OGTT)
- Where
- Denmark
- Volunteers
- 14 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Cadasil
AusCADASIL: An Australian Cohort of CADASIL
The aim of this project is to establish an Australian cohort of patients diagnosed with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL).
- Trial name
- NCT06148051
- Where
- 5 sites in Australia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Perminder Sachdev
Diabetic Retinopathy
The Sensitivity of Traditional Chinese Medical Diagnostic Tools for Diabetic Retinopathy Diabetic retinopathy-a Pilot Study
Diabetic retinopathy (DR) is the leading cause of impaired visual function and blindness in adults. The fundus photographs were examined to detect DR.
- Trial name
- NCT04030611
- Testing
- tongue diagnosis system
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- China Medical University Hospital
Diabetic Retinopathy, Diabetic Eye Problems
Multicentre, Randomized, Controlled Trial of Qideng Mingmu Capsule in The Treatment of Diabetic Retinopathy
Objectives of study: To preliminarily evaluate the efficacy and safety of Qideng Mingmu Capsule in the treatment of patients with diabetic retinopathy (deficiency of Qi-Yin syndrome, blood stasis syndrome), to discuss the…
- Conditions
- Diabetic Retinopathy, Diabetic Eye Problems, Retinal Disorders
- Trial name
- NCT01373476
- Testing
- Qideng Mingmu capsule
- Where
- 8 sites in China
- Volunteers
- 240 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Diabetic Retinopathy
High Blood Pressure and Sleep Apnea in Diabetic Macular Edema
Macular edema remains a major cause of vision impairment in diabetic patients. Its pathogenesis is multifactorial and incompletely understood.
- Trial name
- OMHADIA (NCT00970723)
- Testing
- high blood pressure treatment, sleep apnea treatment, diabetic macular edema treatment
- Where
- 5 sites in France
- Volunteers
- 86 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetic Retinopathy
Evaluation of Blood-retinal Barrier Functional Alterations by Optical Coherence Tomography
The purpose of this study is to identify alterations of the blood-retinal barrier (BRB) in diabetic retinas using a novel non-invasive approach based on the Fourier domain high-definition optical coherence tomograph (OCT).
- Trial name
- CNTM025A OCT (NCT01220804)
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Retinal Displacement After Retinal Detachment Surgery
Influence of Perfluorocarbon Liquid (LIQUID) During Pars Plana Vitrectomy on Retinal Vessel Displacement in Primary Macula-involving Rhegmatogenous Retinal Detachment
Rhegmatogenous retinal detachment (RRD) is an acute, sight threatening condition, with an incidence of approximately 10 per 100,000 people.
- Trial name
- LIQUID (NCT07027098)
- Testing
- Perflurocarbon liquid, Without Perflurocarbon liquid
- Where
- United Kingdom
- Volunteers
- 292 people
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
Cerebral Stroke
Conjunctival and Retinal Vascularization and Small Vessel Disease
The purpose of the study is to use a simple photography of conjunctival vessels to search for an association between conjunctival vessels abnormalities and the load of small vessel disease as quantified by MRI in patients with…
- Trial name
- EVACORMA (NCT04447599)
- Testing
- photography of conjunctival vessels
- Where
- France
- Volunteers
- 850 people
- Sponsor
- University Hospital, Toulouse
Neovascular Glaucoma, Type 2 Diabetes
Observation of Iris Blood Flow Via OCTA in Diabetic Neovascular Glaucoma
The goal of this observational study is to quantify iris blood flow via non-invasive eye scanning for evaluating ocular lesions in adults aged 18 years and older, including healthy volunteers, patients with type 2 diabetes…
- Trial name
- NCT07722910
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Qilu Hospital of Shandong University
Retinal Ischemia
Spectral-domain Optical Coherence Tomography Findings in Retinal Vessel Occlusion
Retinal vessel occlusions might lead to ischemia of the inner retina, more severe so in artery occlusions. Intracellular edema may develop and decrease transparency of those layers, showing retinal edema.
- Trial name
- NCT03061526
- Testing
- optical coherence tomography
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Technische Universität Dresden
Branch Retinal Vein Occlusion
Retinal Vessel Diameter in Branch Retinal Vein Occlusion
The authors investigated the consecutive change of retinal vessel's diameter in affected eye and fellow eye of Branch Retinal Vein Occlusion.
- Trial name
- NCT02215109
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Kyungpook National University Hospital