Clinical trials: Retinal Break
Rhegmatogenous Retinal Detachment
Healaflow Patch for the Treatment of Rhegmatogenous Retinal Detachment
To report the surgical results of primary rhegmatogenous retinal detachment (RRD) repaired by 27G pars plana vitrectomy (PPV) combined with Healaflow patch and air tamponade, and do not need prone position postoperation.
- Trial name
- NCT03542162
- Testing
- Healaflow
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University Eye Hospital
Macular Hole
Optical Coherence Tomography in Gas-filled Eyes
The aim of this study is to determine the condition to detect the status of a macular hole by spectral domain optical coherence tomography (SD-OCT) in gas-filled eyes.
- Trial name
- NCT01266746
- Testing
- Vitreous surgery
- Where
- Japan
- Volunteers
- 37 people
- Sponsor
- Kyorin University
Macular Hole, Proliferative Diabetic Retinopathy
Macular Hole in Diabetic Retinopathy
Macular hole in proliferative diabetic retinopathy with fibrovascular proliferation may have unique features. Internal limiting membrane peeling facilitates hole closure only in cases with shallow macular detachment.
- Trial name
- NCT00737074
- Where
- Taiwan
- Volunteers
- 23 people
- Sponsor
- National Taiwan University Hospital
Retinal Detachment, Full Thickness Macular Hole
Inflammasomes in Cell Death in FTMH, ERM, and RRD
Prospective study evaluating the role of inflammasomes in cell death in retinal detachment, full thickness macular hole, and epiretinal membrane.
- Conditions
- Retinal Detachment, Full Thickness Macular Hole, Epiretinal Membrane
- Trial name
- NCT03332758
- Testing
- Pars plana vitrectomy, External drainage
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Allen C. Ho, MD
Retinal Perforation
Early Vitrectomy for Impending Macular Hole
This study is designed to verify hypothesis that early vitrectomy may prevent impending macular hole from progression to full-thickness macular hole.
- Trial name
- NCT01121965
- Testing
- Pars plana vitrectomy with ILM peeling
- Where
- 10 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul Retina Investigator Group
Macular Holes
Full-Thickness Macular Hole Surgery: A Comparison of Ten Techniques
This study compares ten modern vitreoretinal surgical techniques for full-thickness macular hole repair. Participants will be randomly assigned to one of the surgical approaches during pars plana vitrectomy, using stratified…
- Trial name
- FTMH-10 (NCT07606404)
- Testing
- Pars Plana Vitrectomy (PPV)-Based Macular Hole Surgery, Autologous Platelet-Rich Plasma (PRP), Human Amniotic Membrane (hAM) Graft
- Where
- Kazakhstan
- Volunteers
- 120 people
- Sponsor
- Kazakh Eye Research Institute
Epiretinal Membrane, Macular Hole
UNITY VCS Vitreoretinal Surgery
This purpose of this study is to compare the safety and effectiveness of two eye surgery systems-UNITY VCS and CONSTELLATION-in treating adults with vitreoretinal diseases or disorders.
- Conditions
- Epiretinal Membrane, Macular Hole, Visually Significant Vitreous Floater, Vitreomacular Traction
- Trial name
- NCT07054281
- Testing
- UNITY Vitreoretinal Cataract System (VCS), CONSTELLATION Vision System, Vitreoretinal ophthalmic surgery
- Where
- 8 sites in United States
- Sponsor
- Alcon Research
Macular Holes
The Correlation of Preoperative Measurement Parameter on the Predicting of Visual Outcomes Among Patients With Idiopathic Macular Holes
This study retrospectively analyzed the relationship between the preoperative optical coherence tomography(OCT) and optical coherence tomography angiography(OCTA) software related parameters of patients with idiopathic macular…
- Trial name
- NCT04957459
- Testing
- No intervention
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Macular Hole
Air Tamponade in Macular Hole Surgery
Macular hole is a hole formation which takes place in the center of the retina. Such a hole needs surgical steps in order to close. Closure of the macular hole will lead to a substantially improvement of vision in most cases.
- Trial name
- NCT01680068
- Testing
- Pars plana vitrectomy and postoperative air tamponade
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Helse Stavanger HF
Macular Holes
Macular Hole Surgery With and Without Internal Limiting Membrane Peeling：A Systematic Review and Meta-analysis
Since Kelly and Wendel first reported successful closure of idiopathic macular holes (MH) by vitrectomy in 1991, many surgical modifications have been made to improve the anatomical and visual outcomes of this surgery.
- Trial name
- NCT01687829
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Yifan Feng
Retinal Detachment With Break
Suprachoroidal Visco-buckling for the Treatment of Rhegmatogenous Retinal Detachment
The study compares standard surgery for retinal detachment (RD) (vitrectomy, cryotherapy and gas) with a surgical variation that replaces the intraocular gas tamponade with suprachoroidal injection of viscoelastic underneath the…
- Trial name
- VIKING (NCT04557527)
- Testing
- Pars plana vitrectomy, laser or cryo retinopexy and intraocular gas tamponade, Suprachoroidal viscobuckle with 2.3% Sodium hyaluronate (Healon 5 Ophthalmic viscoelastic device)
- Where
- 6 sites in United Kingdom
- Volunteers
- 36 people
- Sponsor
- King's College Hospital NHS Trust
Macular Hole
Alleviated Positioning for Small Macular Holes
Rational of the study: There are arguments to think that the closure of macular holes can be obtained without a strict positioning under certain conditions, i.e.
- Trial name
- NCT00190164
- Testing
- Macular hole surgery with alleviated positioning, Macular hole surgery with no alleviated positioning
- Where
- France
- Volunteers
- 69 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Macular Holes
Infracyanine Green vs Brilliant Blue G in Macular Hole Inverted Flap Surgery: A Swept Source OCT Analysis.
This study will compare by swept-source optical coherence tomography (SS-OCT) the retinal morphology after inverted internal limiting membrane (I-ILM) flap vitreoretinal surgery for medium-to-large macular holes using…
- Trial name
- NCT03946267
- Testing
- Inverted inner limiting membrane flap technique for large full thickness macular holes
- Where
- Italy
- Volunteers
- 43 people
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo
Epiretinal Membrane, Macular Hole
Association of Lutein, Zeaxanthin and Brilliant Blue in Chromovitrectomy
The aim of this study is to test the efficacy of the combination of dye Lutein, Zeaxanthin and brilliant blue to stain the internal limiting membrane as well as the epiretinal membranes during the Vitrectomy surgery.
- Conditions
- Epiretinal Membrane, Macular Hole, Proliferative Diabetic Retinopathy
- Trial name
- NCT01627977
- Testing
- Dye of Lutein, Zeaxanthin and Brilliant Blue
- Where
- Brazil
- Volunteers
- 18 people
- Sponsor
- Federal University of São Paulo
no Obvious Abnormalities, Diabetic Retinopathy (DR)
Retinal Clinical Assessment With AI-derived Quantitative Information
This randomized controlled trial evaluates whether providing clinicians with AI-derived quantitative retinal information improves the quality and efficiency of retinal clinical assessment.
- Conditions
- no Obvious Abnormalities, Diabetic Retinopathy (DR), AMD, Cup-to-disc Ratio Bigger Than 0.5
- Trial name
- NCT07291960
- Testing
- AI-derived retinal quantitative information-assisted reporting
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Proliferative Diabetic Retinopathy, Macular Holes
Macular Hole After Diabetic Vitrectomy
To present the clinical characteristics and rational treatment of macular hole (MH) after the diabetic vitrectomy (DV) in patients with proliferative diabetic retinopathy (PDR).
- Trial name
- NCT03525899
- Testing
- Pars plana vitrectomy
- Where
- Taiwan
- Volunteers
- 7 people
- Sponsor
- National Taiwan University Hospital
Macular Hole Retinal Detachment
Inverted Internal Limiting Membrane Flap Technique for Macular Hole Retinal Detachment in Highly Myopic Eyes
To evaluate efficacy of vitrectomy with inverted internal limiting membrane (ILM) flap technique for macular hole retinal detachment (MHRD) in highly myopic eyes, and to demonstrate postoperative clinical course of MHRD after…
- Trial name
- NCT02896972
- Testing
- Vitrectomy
- Volunteers
- 32 people
- Sponsor
- Kyorin University
Rhegmatogenous Retinal Detachment - Macula Off
Acute Retinal Detachment Repair With the iSeelr™ Retinal Detachment Repair System
This study is a first-in-human clinical trial testing a new treatment for rhegmatogenous retinal detachments. The new treatment called retinal thermofusion uses a special laser device called iSeelr™ during surgery.
- Trial name
- NCT06468397
- Testing
- iSeelr™
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- Photofuse Pty Ltd
Macular Holes
Inverted ILM-flap Techniques Variants for Macular Hole Surgery: Outcomes Comparison
To report closure rate, Best Corrected Visual Acuity (BCVA), Retinal Sensitivity (RS) and Fixation Stability (FS) of idiopathic Macular Holes (MH) randomized to Cover Group (CG) or Fill Group (FG) of the Inverted Internal…
- Trial name
- NCT04135638
- Testing
- Cover Group, Fill Group
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- University of Molise
High Myopia, Macular Holes
High Myopia Macular Hole and Retinal Detachment Treated With Double ILM Flaps
From July 2015 to December 2015, clinical record of 8 consecutive cases of macular hole with retinal detachment in high myopia treated with combined inverted and free ILM flap insertion into the hole were retrospectively…
- Conditions
- High Myopia, Macular Holes, Retinal Detachment
- Trial name
- NCT03174639
- Testing
- Inverted and free ILM insertion
- Volunteers
- 8 people
- Sponsor
- National Taiwan University Hospital