Clinical trials: Retinal Detachment, active
Retinal Detachment, Macular Edema
OCT Macula Biomarkers Before Silicone Oil Removal and Visual Outcome After Silicone Oil Removal
Silicone oil is commonly used as a temporary intraocular tamponade to support the retina during vitreoretinal surgery for complex retinal detachment and other severe retinal conditions.
- Conditions
- Retinal Detachment, Macular Edema, Silicone Oil Tamponade, Epiretinal Membrane
- Trial name
- NCT07865468
- Volunteers
- 30 people
- Sponsor
- Assiut University
Retinal Displacement After Retinal Detachment Surgery
Influence of Perfluorocarbon Liquid (LIQUID) During Pars Plana Vitrectomy on Retinal Vessel Displacement in Primary Macula-involving Rhegmatogenous Retinal Detachment
Rhegmatogenous retinal detachment (RRD) is an acute, sight threatening condition, with an incidence of approximately 10 per 100,000 people.
- Trial name
- LIQUID (NCT07027098)
- Testing
- Perflurocarbon liquid, Without Perflurocarbon liquid
- Where
- United Kingdom
- Volunteers
- 292 people
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
Retinal Detachment
Nicotinamide Riboside Oral Supplementation in Macula Off Retinal Detachment
Retinal detachment occurs when fluid separates the retina (a thin, light sensing tissue) from its usual attachment at the back of the eye.
- Trial name
- NOMAD (NCT06587945)
- Testing
- Nicotinamide Riboside, Vitrectomy and Gas tamponade
- Where
- 5 sites in Australia
- Volunteers
- 144 people
- Sponsor
- Center for Eye Research Australia
Rhegmatogenous Retinal Detachment, Hypotony Ocular
Ocular Hypotony and Refractive Predictability in RRD Surgery
This study evaluates how preoperative ocular hypotony (Goldmann IOP ≤ 7 mmHg) affects refractive predictability, axial length measurements, and visual outcomes in patients undergoing combined phacovitrectomy with silicone oil for…
- Trial name
- HYP-RRD (NCT07283614)
- Testing
- Combined Phacovitrectomy with Intraocular Lens Implantation and Silicone Oil Tamponade, Silicone Oil Removal
- Where
- Kazakhstan
- Volunteers
- 45 people
- Sponsor
- Kazakh Eye Research Institute
Rhegmatogenous Retinal Detachment
Foldable Capsular Scleral Buckling Versus Vitrectomy in Medium-complex Rhegmatogenous Retinal Detachment Treatment
The objective of the study is to evaluate: 1. Safety and efficacy of a novel foldable capsular scleral buckle (FCSB) in scleral buckling for primary rhegmatogenous retinal detachment (RRD) of medium complexity. 2.
- Trial name
- FCSB (NCT06610786)
- Testing
- foldable capsular scleral buckling, vitrectomy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Proliferative Vitreoretinopathy in Rhegmatogenous Retinal Detachment
Intravitreal Topotecan in the Repair of Rhegmatogenous Retinal Detachment with Proliferative Vitreoretinopathy
Intravitreal topotecan has anti-inflammatory, anti-proliferative and anti-fibrotic activity that we hypothesize may exhibit high efficacy for the treatment of proliferative vitreoretinopathy (PVR) in patients with rhegmatogenous…
- Trial name
- TOPO-RD (NCT05523869)
- Testing
- Intravitreal topotecan, Pars plana vitrectomy with or without scleral buckle
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Unity Health Toronto
Rhegmatogenous Retinal Detachment With Grade C Proliferative Vitreoretinopathy
Comparison of Visual Outcomes of Pars Plana Vitrectomy With and Without Injection Clexane for Rhegmatogenous Retinal Detachment Proliferative Vitreoretinopathy
This interventional prospective study was conducted in the Department of Ophthalmology at Lahore General Hospital, Lahore. The study included 60 male and female patients aged 18-65 years who had rhegmatogenous retinal detachment…
- Trial name
- NCT07787377
- Testing
- Enoxaparin Sodium, Pars Plana Vitrectomy
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Lahore General Hospital
Proliferative Vitreoretinopathy, Proliferative Vitreo-Retinopathy
The Safety and Efficacy of Intravitreal Topotecan for the Treatment of Proliferative Vitreoretinopathy
The goal of this clinical trial is to evaluate the safety and efficacy of intravitreal topotecan for the treatment of patients with rhegmatogenous retinal detachment due to proliferative vitreoretinopathy (PVR) or resulting from…
- Conditions
- Proliferative Vitreoretinopathy, Proliferative Vitreo-Retinopathy, Rhegmatogenous Retinal Detachment
- Trial name
- NCT06425419
- Testing
- Topotecan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Retina; Detachment, Rhegmatogenous
Head Positioning After Retina Detachment Repair
This study aims to determine if one day post-operative prone head positioning can be as good as seven days post-operative prone head positioning in patients with retinal detachments with inferior retinal breaks after pars that…
- Trial name
- NCT03714503
- Testing
- Retina re-attachment repair using C3F8 gas tamponade
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Kansas Medical Center
Epiretinal Membranes, Retinal Detachment
Subjective Pain Scoring for Subtenonal Anesthesia During Vitrectomy
Subtenonal anesthesia is a well-known technique of local anesthesia for patients undergoing pars plana vitrectomies. It was described to be efficient with respect to anesthesia of the eye and it showed less risks compared to…
- Conditions
- Epiretinal Membranes, Retinal Detachment, Full Thickness Macular Hole
- Trial name
- NCT06830070
- Testing
- subjective pain score assessment
- Where
- Austria
- Volunteers
- 70 people
- Sponsor
- Prim. Prof. Dr. Oliver Findl, MBA
Rhegmatogenous Retinal Detachment
Comparison of Anatomical and Functional Outcomes of Laser Photocoagulation and Cryopexy in Patients with Rhegmatogenous Retinal Detachment Treated with Pneumatic Retinopexy
Rhegmatogenous Retinal Detachment is a pathological condition in which the inner layers of the retina separate from its outermost layer due to fluid entering between these layers through a retinal tear.
- Trial name
- NCT06694259
- Testing
- Pneumatic retinopexy with transscleral cryopexy, Pneumatic retinopexy with laser photocoagulation
- Where
- Croatia
- Volunteers
- 40 people
- Sponsor
- Clinical Hospital Center, Split
Rhegmatogenous Retinal Detachment, Proliferative Vitreoretinopathy
Topical Netarsudil for the Prevention of Proliferative Vitreoretinopathy in Patients With Retinal Detachment
This study has two main objectives. The first objective is to study the pharmacokinetics of topical netarsudil administration in the posterior segment of the eye, where netarsudil must exert its effect in order to prevent…
- Trial name
- NCT06033703
- Testing
- Netarsudil Ophthalmic
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Retinal Detachment, Macular Hole
Head Position Monitoring After Pars Planar Vitrectomy
In ophthalmic surgical practice, particularly for treating retinal detachment and macular hole disorders, vitrectomy procedures are routinely performed to remove the vitreous body followed by the injection of tamponade agents…
- Trial name
- HPMPPV (NCT06985030)
- Testing
- gyroscope embedded eye-sheild
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital
Retinal Detachment Rhegmatogenous
Use of Preoperative Gas in Eyes With Macula-off Rhegmatogenous Retinal Detachment (RRD)
The purpose of this study is to evaluate whether a preoperative intraocular gas injection improves visual outcomes in patients with a macula-off rhegmatogenous retinal detachment (RRD).
- Trial name
- NCT07855770
- Testing
- Intravitreal 100% C3F8 Injection, Pars plana vitrectomy or pars plana vitrectomy with scleral buckle
- Where
- 2 sites in United States
- Volunteers
- 190 people
- Sponsor
- Wills Eye
Proliferative Vitreoretinopathy, Rhegmatogenous Retinal Detachment
Prevention of ProliFerative Vitreoretinopathy With Intravitreal MethotreXate in Primary Retinal DEtachment Repair (FIXER) Trial
I. Title Prevention of ProliFerative Vitreoretinopathy with Intravitreal MethotreXate in Primary Retinal DEtachment Repair (FIXER) Trial Today's Date: September 18, 2023 II.
- Trial name
- FIXER (NCT06541574)
- Testing
- Methotrexate Injection, Methotrexate Infusion
- Where
- United States
- Volunteers
- 860 people
- Sponsor
- Cincinnati Eye Institute, Southwest Ohio
Rhegmatogenous Macula-off Retinal Detachment
Corneal Endothelial Cell Changes In Silicon Filled Eye
The aim of this study is to evaluate corneal endothelial cell changes after pars plana vitrectomy in Rhegmatogenous Retinal detachment , compare the results using different silicon oil viscositites , and assess whether these…
- Trial name
- Endothelium (NCT07418606)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Minia University
Retinal Detachment
REtinal Detachment Outcomes Study
Background: Few large randomized controlled trials provide strong evidence to guide surgical repair of primary rhegmatogenous retinal detachment (RRD) repair.
- Trial name
- REDOS (NCT05863312)
- Testing
- Pars plana vitrectomy, Pars plana vitrectomy with scleral buckle, Sulfur hexafluoride gas tamponade
- Where
- Canada
- Volunteers
- 560 people
- Sponsor
- CHU de Quebec-Universite Laval
Retinal Detachment
Ursodeoxycholic Acid (UDCA) as a Neuroprotective Adjuvant Treatment to Rhegmatogenous Retinal Detachment Surgery
This study is indicated for patients with extended rhegmatogenous retinal detachment (RRD) (≥ 2 quadrants) with macula OFF lasting 7 days or less, pseudophakic or aphakic, and scheduled to undergo surgical intervention with…
- Trial name
- UDCA (NCT06294847)
- Testing
- Ursolvan
- Where
- 2 sites in France
- Volunteers
- 120 people
- Sponsor
- Hopital Foch
Retinal Detachment Rhegmatogenous, Proliferative Vitreoretinopathy
Intravitreal Topotecan for Prevention or Treatment of Proliferative Vitreoretinopathy in Retinal Detachment
Intravitreal topotecan exhibits strong anti-inflammatory, anti-proliferative, and anti-fibrotic properties, making it a promising option for preventing and treating proliferative vitreoretinopathy in rhegmatogenous retinal…
- Trial name
- TOPO-PT (NCT06818721)
- Testing
- Intravitreal topotecan, Retinal detachment surgery
- Where
- 2 sites in Canada
- Volunteers
- 394 people
- Sponsor
- Unity Health Toronto
Retinal Detachment Rhegmatogenous
Air Tamponade Versus Fluorinated Gas Tamponade for Rhegmatogenous Retinal Detachment
TITLE: RCT of air tamponade versus fluorinated gas tamponade for rhegmatogenous retinal detachment DESIGN: Non-inferiority RCT of 150 patients from 10 UK centres AIMS: To assess whether air tamponade is non inferior to gas…
- Trial name
- GREEN (NCT07034469)
- Testing
- air, Gas SF6 (Sulfur Hexafluoride) and others
- Volunteers
- 150 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust