Clinical trials: Retinal Disease
Diabetic Retinopathy Visually Threatening
Internal Limiting Membrane Peeling in Proliferative Diabetic Retinopathy
Subject/Participant Groups: Study Group: Subjects undergo internal limiting membrane (ILM) peeling during vitrectomy for the indication of tractional retinal detachment Control Group: Subjects do not undergo ILM peeling during…
- Trial name
- NCT04380064
- Testing
- ILM Peeling, No ILM Peeling
- Where
- Mexico
- Volunteers
- 200 people
- Sponsor
- Rush Eye Associates
Age-related Macular Degeneration
Dark Adaptation as an Early Indicator of Response to Statin Therapy for Intermediate AMD
interventional trial for off label use of high dose atorvastatin 80 mg in intermediate AMD patients and correlate recovery response measured by dark adaptation recovery time with drusen volume reduction measured by SD-OCT
- Trial name
- DELPHI (NCT04735263)
- Testing
- Atorvastatin 80mg
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Proliferative Diabetic Retinopathy (PDR)
Early Vitrectomy vs PRP in Early Proliferative Diabetic Retinopathy
The goal of this clinical trial is to learn whether early microincision vitrectomy surgery (MIVS) can improve retinal neovascularization outcomes compared to standard pan-retinal photocoagulation (PRP) in patients with early…
- Trial name
- NCT07586787
- Testing
- Microincision Vitrectomy Surgery, Panretinal Photocoagulation
- Where
- 6 sites in China
- Volunteers
- 100 people
- Sponsor
- Xiamen Ophthalmology Center Affiliated to Xiamen University
Age-related Macular Degeneration
RBM-007 in Subjects witH ExudatIve Age-related Macular Degeneration
This is an open label, non-controlled, dose-escalating study assessing the safety, tolerability, and bioactivity of a single intravitreal (i.vt.) injection of RBM-007 in approximately nine subjects with exudative age-related…
- Trial name
- SUSHI (NCT03633084)
- Testing
- RBM-007 Injectable Solution
- Where
- 4 sites in United States
- Volunteers
- 9 people
- Sponsor
- Ribomic USA Inc
Geographic Atrophy of the Macula
A Phase 2 Efficacy and Safety Study of GAL-101, 2% Ophthalmic Solution in Non-foveal Geographic Atrophy Secondary to Non-neovascular AMD
Age-related macular degeneration (AMD) affects millions of elderly patients. When advanced, there is Geographic Atrophy (GA) in the retina.
- Trial name
- eDREAM (NCT06659549)
- Testing
- GAL-101
- Where
- 24 sites in United States, Armenia and 6 more
- Volunteers
- 110 people
- Sponsor
- Galimedix Therapeutics Inc
Stargardt's Macular Dystrophy
Sub-retinal Transplantation of hESC Derived RPE(MA09-hRPE)Cells in Patients With Stargardt's Macular Dystrophy
This is a safety and tolerability trial to evaluate the effect of subretinal injection of human embryonic stem cell derived retinal pigment epithelium cells in patients with Stargardt's Macular Dystrophy (SMD).
- Trial name
- NCT01345006
- Testing
- MA09-hRPE
- Where
- 3 sites in United States
- Volunteers
- 13 people
- Sponsor
- Astellas Institute for Regenerative Medicine
Epiretinal Membranectomy
Change of Retinally-Induced Aniseikonia in Patients With Epiretinal Membrane After Vitrectomy
Epiretinal membrane is common disease, affecting 5~10 % incidence over 60 years old population. It reduce visual acuity, cause metamorphopsia.
- Trial name
- NCT01901406
- Where
- South Korea
- Volunteers
- 24 people
- Sponsor
- Yonsei University
Diabetic Retinal Disease
Longitudinal Study of Retinal Function in Eyes Treated for Diabetic Macular Edema With Anti-VEGF Agents
A considerable hurdle to the development of novel, more effective therapies for diabetic retinal disease is the limited number of primary endpoints available for use in regulatory trials.
- Trial name
- AS (NCT07567833)
- Testing
- Anti-Vascular Endothelial Growth Factor
- Where
- 8 sites in United States
- Volunteers
- 100 people
- Sponsor
- Jaeb Center for Health Research
Atrophy, Geographic Atrophy
Sparing of the Fovea in Geographic Atrophy Progression
Dry age-related macular degeneration (AMD) is a common cause for severe visual loss in the elderly and represents an unmet need.
- Conditions
- Atrophy, Geographic Atrophy, Age-related Macular Degeneration, Eye Diseases
- Trial name
- SIGHT (NCT02332343)
- Testing
- No intervention - Natural history study
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- University Hospital, Bonn
Diabetic Macular Edema, Diabetic Retinopathy
Intravitreal Ranibizumab or Aflibercept After Bevacizumab in Diabetic Macular Edema
PURPOSE: To evaluate the efficacy of switching from bevacizumab to ranibizumab (Lucentis; Genentech, South San Francisco, CA) or aflibercept (Eylea; Regeneron, Tarrytown, NY) in eyes with diabetic macular edema (DME) nonresponders…
- Trial name
- SWITCH (NCT04018833)
- Testing
- Ranibizumab 0.5 MG/0.05 ML Intraocular Solution [LUCENTIS], Aflibercept 40 MG/ML Intraocular Solution [EYLEA]
- Volunteers
- 40 people
- Sponsor
- Bernardete Pessoa MD
Epiretinal Membrane
Choroidal Thickness Vitrectomy
The purpose of this study is to assess the influence of vitrectomy on changes in central choroidea and comparing the results in imaging of the choroidea with two different OCT devices.
- Trial name
- NCT02617147
- Where
- Austria
- Volunteers
- 76 people
- Sponsor
- Medical University of Vienna
Advanced Dry Macular Degeneration
Alpha MSH in Ocular Disease
The purpose of this study is gain a better understanding of a molecule called alpha melanocyte stimulating hormone (alpha MSH) and its potential role in your retinal disease.
- Trial name
- NCT03451578
- Testing
- Alpha MSH assay
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Duke University
Cystoid Macular Edema
Pilot Study of the Effect of Topical Bromfenac Ophthalmic Solution 0.09%in Patients With Acute Post-operative Cystoid Macular Edema.
This research is being done to look at the effects of Bromfenac, also called Xibrom for the treatment of swelling in the retina (the light sensitive tissue in the back of the eye) called "macular edema" that occurs after cataract…
- Trial name
- NCT00438243
- Testing
- Bromfenac (Xibrom), Refresh Plus
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Retinopathy of Prematurity, Neurodevelopmental Abnormality
Analysis of Ocular and Neurodevelopmental Function for Retinopathy of Prematurity
The goal of this research project is to identify the long-term outcome of neurodevelopment in patients with retinopathy of prematurity(ROP) and the treatment of anti-vascular endothelial growth factor (VEGF) such as intravitreal…
- Trial name
- NCT05186155
- Testing
- Severe ROP
- Where
- Taiwan
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Eye Cancer, Retinoblastoma
A Prospective International Multicenter Clinical Trial for Eyes With Relapsed Retinoblastoma
While 95% of patients with retinoblastoma can be cured nowadays, treatment of relapse remains challenging, ending often in enucleation and/or radiotherapy.
- Trial name
- EuRbG2018 (NCT04455139)
- Testing
- Topotecan, Melphalan
- Where
- Switzerland
- Volunteers
- 2 people
- Sponsor
- Prof. Beck Popovic Maja
Inflammation
Intravitreal Celecoxib for Chronic Uveitis
Intraocular delivery of celecoxib will be an effective means to treat inflammation and macular edema and prevent structural complications and vision loss in patients with chronic inflammation or macular edema who are unable to…
- Trial name
- Celecoxib (NCT02131012)
- Testing
- Intravitreal Celecoxib
- Volunteers
- 4 people
- Sponsor
- Vanderbilt University
Vitrectomy
Macular Hole Reopening
The purpose of this investigation was to determine the incidence and the factors that cause a reopening of a macular hole (MH) after a surgical closure.
- Trial name
- NCT00927628
- Testing
- Vitrectomy
- Where
- Japan
- Volunteers
- 831 people
- Sponsor
- Shinjo Ophthalmologic Institute
Macular Edema, Retinal Artery Macroaneurysm
Intravitreal Aflibercept Injection for Symptomatic Macular Edema From Retinal Artery Macroaneurysms
Phase 1, non-randomized, open label, noncomparative trial to study the effect of intravitreal injection of aflibercept on eyes with symptomatic macular edema from retinal artery macroaneurysms.
- Trial name
- NCT02403128
- Testing
- aflibercept
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Kamal Kishore, MD
Dehydration, Retinal Vascular Occlusion
Body-fluid Balance and Drinking Habits in Patients With Retinal Vascular Occlusion
The purpose of this study is to examine the body-fluid balance in patients with retinal vascular occlusion and the influence of drinking habits and hemodilution on the degree of body hydration.
- Trial name
- NCT01939119
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Technische Universität Dresden
Age-related Macular Degeneration
Rheohemapheresis and Lutein Supplementation in the Non-Exsudative Form of Age-Related Macular Degeneration
Age-related macular degeneration is one of the major causes of blindness in the western world. There is an exsudative and a non-exsudative form of age-related macular degeneration.Most studies concentrate on the exsudative form.
- Trial name
- ReLux-AMD (NCT00443911)
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery