Clinical trials: Retinal Disorder
Cytomegalovirus Retinitis, Acquired Immunodeficiency Syndrome
Phase II Randomized Study of Cidofovir for Peripheral Cytomegalovirus Retinitis
OBJECTIVES: I. Evaluate the safety and efficacy of intravenous cidofovir in patients with small peripheral cytomegalovirus retinitis. II. Obtain safety and efficacy data related to different dosages of cidofovir.
- Trial name
- NCT00004794
- Testing
- cidofovir
- Volunteers
- 90 people
- Sponsor
- National Center for Research Resources (NCRR)
Retinal Disease
P200TxE Diseased Eye Image Collection
The primary objective is to collect images on the P200TxE device in diseased eyes.
- Trial name
- NCT06269666
- Testing
- P200TxE
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Optos, PLC
Diabetes Mellitus, Diabetic Retinopathy
A Study to Evaluate THR-317 and Ranibizumab Combination Treatment for Diabetic Macular Oedema (DME)
This study is conducted to evaluate the safety of intravitreal THR-317 administered in combination with ranibizumab, and to assess the efficacy of the combination treatment in improving best-corrected visual acuity (BCVA) and…
- Conditions
- Diabetes Mellitus, Diabetic Retinopathy, Macular Edema
- Trial name
- NCT03499223
- Testing
- Ranibizumab 0.5mg, THR-317 8mg
- Where
- 37 sites in Belgium, France and 5 more
- Volunteers
- 70 people
- Sponsor
- Oxurion
Retinitis Pigmentosa
The Effect of Oral Administration of 9-cis β Carotene Rich Powder of the Alga Dunaliella Bardawil
Retinitis pigmentosa is a genetically disease consisting of progressive retinal degeneration starting in the rods. Its prevalence is 1:4000 people and is the fourth most common blinding disease in Israel in 2004 [7% of all…
- Trial name
- NCT01680510
- Testing
- Alga Dunaliella Bardawil
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Macular Degeneration
Celecoxib to Treat Macular Degeneration in Patients Receiving Photodynamic Therapy
This study will determine whether the drug celecoxib (Celebrex® (Registered Trademark)) can help stabilize or improve vision in patients with age-related macular degeneration (AMD) who are receiving photodynamic therapy, or PDT…
- Trial name
- NCT00043680
- Testing
- Celecoxib
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Eye Institute (NEI)
Irvine-Gass Syndrome
Treatment of Macular Edema After Cataract Surgery with Subconjunctival Aflibercept
This research study is being conducted to determine the safety and tolerability of subconjunctival injections of aflibercept in the treatment of pseudophakic cystoid macular edema that has not responded well to first-line…
- Trial name
- ACME (NCT03396861)
- Testing
- Aflibercept
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Tufts Medical Center
Maculopathy
AVIGA3 (Cohort 2.0)
Age-Macular Degeneration (AMD) is a common eye condition and a leading cause of vision loss among people age 50 and older. It causes damage to the macula, a small area near the centre of the retina needed for sharp, central…
- Trial name
- AVIGA3 (NCT07255859)
- Testing
- Amsler Grid, AVIGA
- Where
- Singapore
- Volunteers
- 60 people
- Sponsor
- Tan Tock Seng Hospital
Diabetic Retinopathy, Diabetes Mellitus
Serum Endocan, Alarin, and Galanin-Like Peptide Levels in Diabetic Retinopathy
This prospective cross-sectional study aims to evaluate the association between serum endocan, alarin, and galanin-like peptide levels and the stages of diabetic retinopathy (DR), as well as their relationship with optical…
- Conditions
- Diabetic Retinopathy, Diabetes Mellitus, Retinal Microvascular Disease
- Trial name
- NCT07434362
- Testing
- Venous Blood Sampling, Optical Coherence Tomography (OCT)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Diabetes Type 1 or 2 With Diabetic Retinopathy
Incidence of Macular Edema After Panretinal Photocoagulation (PRPC) Performed in a Single Session Versus Four Sessions in Diabetic Patients.
The aim of this study is to show that PRPC performed in a single session using a Pascal laser leads to better management of the disease (better rate of regression of neovessels, lower risk of a loss of visual acuity in the long…
- Trial name
- Pascal (NCT01766362)
- Testing
- PRPC using Pascal laser
- Where
- 3 sites in France
- Volunteers
- 83 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Retinal Disease
Changes in Retinal Nerve Fiber Layer Thickness Detected by OCT in Diabetic Retinopathy After Panretinal Photocoagulation
Panretinal photocoagulation reduces the risk of visual loss by 50% in patients with diabetic retinopathy. It is recognized that laser expansion into the retina may be associated with photoreceptor loss, retinal pigment epithelial…
- Trial name
- NCT03786146
- Volunteers
- 30 people
- Sponsor
- Assiut University
Age-related Macular Degeneration (AMD)
Pivotal Trial of an Automated AI-based System for Early Diagnosis and Prediction of Late Age-related Macular Degeneration
The purpose of this study is to perform a pivotal trial of iPredict, an automated AI-based system for early diagnosis and prediction of late AMD in primary care and ophthalmology settings.
- Trial name
- NCT07084883
- Testing
- No intervention.
- Where
- United States
- Volunteers
- 1,076 people, healthy volunteers welcome
- Sponsor
- iHealthScreen Inc
Premature, Skin to Skin Contact
Impact of Standardized Skin-to-Skin Care on Clinical Outcomes in Infants Born ≤ 32 Weeks: A Multicenter Study
This study is a multi-center, prospective pre-post clinical study conducted under the leadership of the Turkish Neonatal Society.
- Conditions
- Premature, Skin to Skin Contact, Breast Feeding, Necrotizing Enterocolitis
- Trial name
- TR-SSCinNICU (NCT06672913)
- Testing
- skin to skin contact care
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Baskent University Ankara Hospital
Proliferative Diabetic Retinopathy, Diabetic Retinopathy
Continuous Delivery of Ranibizumab Via the Port Delivery System for Proliferative Diabetic Retinopathy-related Vitreous Hemorrhage With Pars Plana Vitrectomy and Limited PRP.
In prolifertive diabetic retinopathy (PDR) eyes with bleeding known as vitreous hemorrhage (VH) requiring a surgical procedure to remove the vitreous, called a vitrectomy, we will determine if the benefit and safety of adding a…
- Conditions
- Proliferative Diabetic Retinopathy, Diabetic Retinopathy, Diabetes
- Trial name
- 4 PORT (NCT07864480)
- Testing
- PDS Implant filled with 100 mg/mL Ranibizumab, Ranibizumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Southeast Retina Center, Georgia
Proliferative Vitreoretinopathy
Triamcinolone Acetonide in Silicone-Filled Eyes as Adjunctive Treatment for Proliferative Vitreoretinopathy
To evaluate the effect of triamcinolone acetonide in silicone-filled eyes on the outcome of surgery for PVR.
- Trial name
- NCT00373282
- Testing
- Triamcinolone acetonide
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Diabetic Retinopathy, Macular Edema
Triple Therapy of Pars Plana Vitrectomy and Grid/Focal Laser for Diabetic Macular Edema (DME)
This study is designed to report 3-year result of triple therapy of vitrectomy, intravitreal triamcinolone and macular laser photocoagulation for intractable diabetic macular edema.
- Trial name
- NCT01202461
- Testing
- Triple therapy of vitrectomy, IVTA and grid/focal laser photocoagulation
- Where
- South Korea
- Volunteers
- 41 people
- Sponsor
- Samsung Medical Center
Wet Macular Degeneration, Cataract Extraction
Management of Patients With Neovascular Age-related Macular Degeneration Undergoing Cataract Surgery
To-date there have been only very few studies to examine the effect of cataract surgery to patients with wet age-related macular degeneration.
- Trial name
- NCT03944070
- Testing
- Ranibizumab
- Where
- Greece
- Volunteers
- 16 people
- Sponsor
- Ophthalmica Eye Institute
Retinal Vein Occlusion
Ultra-wide Fluorescein Angiography in Patients With Central Retinal Vein Occlusion Treated by Afilbercept
In patients with macular edema secondary to CRVO, Aflibercept demonstrated efficacy and safety in 2 parallel trials, interventional phase III studies, COPERNICUS study performed in United States and GALILEO study performed in…
- Trial name
- HERMES (NCT02880644)
- Where
- 9 sites in France
- Volunteers
- 65 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Age-Related Macular Degeneration
Study Assessing the Efficacy and Safety of Intravitreal Injections of DE-122 in Combination With Lucentis® Compared to Lucentis® Monotherapy in Wet Age-related Macular Degeneration Subjects
To assess the safety and efficacy of repeated intravitreal injections of DE-122 (low dose and high dose) given in combination with Lucentis® in subjects with wet age-related macular degeneration (AMD) compared with Lucentis®…
- Trial name
- NCT03211234
- Testing
- 2.0 mg DE-122 Injectable Solution + Lucentis, 4.0 mg DE-122 Injectable Solution + Lucentis, Lucentis
- Where
- 14 sites in United States, Philippines
- Volunteers
- 76 people
- Sponsor
- Santen Inc.
Retinal Artery Occlusion
The Effect of A2A Adrenoceptor Stimulation on the Diameter of Retinal Arterioles During Hypoxia in Vivo
The purpose is to investigate how the adenosine affects the diameter regulation of retinal arterioles during changes in oxygen tension.
- Trial name
- NCT03090087
- Testing
- Hypoxia, Regadenoson
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Retinopathy of Prematurity Both Eyes, Retinal Disease
Safety and Efficacy of 18 mm Short Vitrectomy Probe for Pediatric Vitreoretinal Surgeries
This study aims to study the safety and efficacy of using an 18 mm short vitrectomy probe for pediatric vitreoretinal surgeries and to investigate the surgeon's comfort and reliability of using the shorter probe.
- Conditions
- Retinopathy of Prematurity Both Eyes, Retinal Disease, Persistent Fetal Vasculature, Coats Disease
- Trial name
- NCT06520410
- Testing
- Pars plana vitrectomy with a 18 mm short vitrector
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung Memorial Hospital
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