Clinical trials: Retinal Disorder
Diabetes, Diabetic Retinopathy
Incentives in Diabetic Eye Assessment by Screening
This trial is a randomised controlled trial to assess whether annual attendance rates at diabetic eye screening appointments in Kensington, Chelsea and Westminster could be improved by offering invitees a small financial…
- Trial name
- IDEAS (NCT02339909)
- Testing
- Fixed financial incentive, Probabilistic financial incentive, Control
- Volunteers
- 1,051 people
- Sponsor
- Imperial College London
Macular Holes
GaslEss Macular Hole Surgery
Macular holes are a hole in the centre of the retina, the light-sensing layer in the back of the eye. They cause a central 'blind spot' in the vision, which can be very disabling for patients.
- Trial name
- GEM (NCT06079593)
- Testing
- Gasless Macular hole surgery, Standard Macular hole surgery
- Volunteers
- 60 people
- Sponsor
- King's College Hospital NHS Trust
Age-Related Macular Degeneration, Branch Retinal Vein Occlusion With Macular Edema
A Study to Evaluate the Usability of the SB11 PFS in Trial Participants With Wet AMD, Macular Oedema Secondary to RVO, or mCNV
This is a open label, multicenter, Phase II study to evaluate the usability of the pre-filled syringe (PFS) of SB11 (ranibizumab biosimilar).
- Conditions
- Age-Related Macular Degeneration, Branch Retinal Vein Occlusion With Macular Edema, Central Retinal Vein Occlusion With Macular Edema, Myopic Choroidal Neovascularization
- Trial name
- NCT07550504
- Testing
- SB11 PFS
- Where
- 2 sites in Poland
- Volunteers
- 30 people
- Sponsor
- Samsung Bioepis Co., Ltd.
Stickler Syndrome Type 1, Stickler Syndrome Type 2
Retinal Detachment Prevention (Laser Prophylaxis) in Stickler Syndrome (SS)
The goal of this clinical trial is to prospectively document to what extent the OSC/SS prophylactic laser retinopexy procedure works to prevent retinal detachment in SS in children and adults.
- Trial name
- OSC/SS (NCT07146516)
- Testing
- Prophylactic (non-invasive) Laser Retinopexy
- Where
- 6 sites in United States
- Volunteers
- 500 people
- Sponsor
- Helen Keller Eye Research Foundation
Age-Related Macular Degeneration, Geographic Atrophy
Long-Term Follow-up Safety Study of Human Central Nervous System Stem Cells in Subjects With Geographic Atrophy of Age-Related Macular Degeneration
This study is being done to determine the long-term safety and possible benefits of transplanted Human Central Nervous System Stem Cells (HuCNS-SC) for patients with Geographic Atrophy of Age-Related Macular Degeneration.
- Trial name
- NCT02137915
- Testing
- Human Central Nervous System Stem Cells
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- StemCells, Inc.
Age-Related Macular Degeneration
Treatment of Age-related Macular Degeneration Using Retinal Stem and Progenitor Cells
Treatment of age-related macular degeneration using retinal stem and progenitor cells
- Trial name
- NCT05187104
- Testing
- Cultured retinal stem and progenitor cells, Standard treatment according to the clinical protocols
- Where
- Belarus
- Volunteers
- 20 people
- Sponsor
- Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
Macular Edema Secondary to Branch Retinal Vein Occlusion
Ranibizumab Intravitreal Injections Versus Sham Control in Patients With Branch Retinal Vein Occlusion (BRVO)
Provided efficacy and safety data on intravitreal injections of ranibizumab 0.5 mg in patients with visual impairment due to macular edema secondary to BRVO
- Trial name
- Blossom (NCT01976338)
- Testing
- Ranibizumab 0.5 mg
- Where
- 33 sites in China, Hong Kong and 4 more
- Volunteers
- 283 people
- Sponsor
- Novartis Pharmaceuticals
Proliferative Diabetic Retinopathy, PDR
The Individually-Marked Panretinal Laser phoTocoagulation for Proliferative Diabetic Retinopathy Study (TREAT)
Background Diabetic eye disease is the most frequent complication among the 320,000 Danes with diabetes. The formation of new vessels (PDR) in the inner part of the eye (retina) is a feared complication and a leading cause of…
- Conditions
- Proliferative Diabetic Retinopathy, PDR, Diabetes
- Trial name
- NCT03113006
- Testing
- Panretinal Photocoagulation
- Where
- Denmark
- Volunteers
- 53 people
- Sponsor
- Odense University Hospital
Diabetic Retinopathy, Macular Degeneration
Screening for Studies on Retinovascular Diseases
This screening protocol is designed to help recruit patients for National Eye Institute (NEI) studies of the retina, such as diabetic retinopathy and macular degeneration.
- Conditions
- Diabetic Retinopathy, Macular Degeneration, Pathologic Neovascularization, Retinal Disease
- Trial name
- NCT00001733
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Diabetic Retinopathy, Type 2 Diabetes
Enriched Eggs for Retina Health in Type 2 Diabetes
Diabetes mellitus has been declared a major public health issue. Among the complications of the disease, retinopathy can have a significant impact on mobility and quality of life for individuals living with diabetes.
- Trial name
- NCT04496817
- Testing
- Docosahexaenoic Acid and Lutein Enriched Eggs, Regular Eggs
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Retinal Artery Occlusion
Reconstruction of Pathological Changes of the Ophthalmic Artery in Patients With Retinal Artery Occlusion
Retinal artery occlusions (RAO) cause deterioration in visual acuity and visual fields. In computational fluid dynamics (CFD) studies [1] 10% of ascending emboli caused RAO, the residual 90% embolized into the cerebral arteries.
- Trial name
- NCT02679716
- Testing
- MRI of the cerebral arteries
- Where
- 2 sites in Austria
- Volunteers
- 30 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
ROP, Jaundice, Neonatal
Hyperbilirubinemia and Retinopathy of Prematurity in Preterm Infants: a Retrospective Study.
The goal of this retrospective observational study is to [learn about the correlation between hyperbilirubinemia and retinopathy of prematurity in preterm infants.
- Conditions
- ROP, Jaundice, Neonatal, Premature, Very Low Birth Weight Infant
- Trial name
- biliROP (NCT05806684)
- Testing
- ROP
- Where
- Italy
- Volunteers
- 1,586 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Age-Related Macular Degeneration
A Study of the Safety and Tolerability of ASP7317 in Senior Adults Who Are Losing Their Clear, Sharp Central Vision Due to Geographic Atrophy Secondary to Dry Age-related Macular Degeneration
Age-related macular degeneration (AMD) is an eye disease which causes people to lose their sharp central vision over time. Aging damages the macula, which is in the middle of the retina - the light-sensitive part at the back of…
- Trial name
- NCT03178149
- Testing
- ASP7317, tacrolimus, trimethoprim-sulfamethoxazole
- Where
- 20 sites in United States
- Volunteers
- 42 people
- Sponsor
- Astellas Institute for Regenerative Medicine
Retinitis Pigmentosa
Intravitreal Injection of MSCs in Retinitis Pigmentosa
The purpose of this study is to determine the feasibility and safety of adult human bone marrow-derived mesenchymal stem cells by intravitreal injection in patients with retinitis pigmentosa.
- Trial name
- NCT01531348
- Testing
- BM-MSC
- Where
- Thailand
- Volunteers
- 14 people
- Sponsor
- Mahidol University
Central Retinal Vein Occlusion
Bevacizumab for Central Retinal Vein Occlusion Study
Central retinal vein occlusion is a leading cause of severe visual impairment. Until now, no treatment has been available to improve visual acuity.
- Trial name
- NCT00906685
- Testing
- bevacizumab
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Anders Kvanta
Retinitis Pigmentosa
Object Finder for a Retinal Prosthesis
The proposed project seeks to provide object recognition as a feature in a retinal implant system. Participants will be able to direct an object recognition application to find a desired object in the field of view of the…
- Trial name
- NCT04319809
- Testing
- Object recognition subsystem
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Minnesota HealthSolutions
Retinal Vein Occlusion
Study of Retinal Oxygenation in Central Retinal Vein Occlusion
The purpose of the study is to test if oxygen saturation in retinal vessels is correlated with clinical parameters, such as visual acuity, central retinal thickness and presence of neovascularization.
- Trial name
- NCT02523339
- Where
- 8 sites in Austria, Czechia and 5 more
- Volunteers
- 117 people
- Sponsor
- University of Iceland
Stargardt Disease
Safety and Efficacy of Emixustat in Stargardt Disease
The purpose of this study is to determine if emixustat hydrochloride reduces the rate of progression of macular atrophy compared to placebo in subjects with Stargardt disease. Funding Source -- FDA OOPD
- Trial name
- SeaSTAR (NCT03772665)
- Testing
- Emixustat
- Where
- 29 sites in United States, Brazil and 9 more
- Volunteers
- 194 people
- Sponsor
- Kubota Vision Inc.
Age-Related Macular Degeneration
Effects of Xanthophylls on Optical Density
The objective of the study was to investigate the influence of a intervention with lutein und zeaxanthin from crucifers on the optical density of the macular pigment of patients with non exudative age-related maculopathy.
- Trial name
- NCT01316198
- Testing
- Verum
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University of Jena
Macular Hole, Retinal Detachment
Effect of Topical Aqueous Suppressants on Intraocular Gas Duration Following Pars Plana Vitrectomy
The purpose of this study is to see if glaucoma eye drops (dorzolamide-timolol) have any effect on the duration of an intraocular gas bubble following pars plana vitrectomy.
- Trial name
- NCT01257698
- Testing
- Dorzolamide 2%-timolol 0.5% topical eyedrops
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Mid Atlantic Retina
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