Clinical trials: Retinal Disorder
Diabetic Retinopathy
Integrating DR Into Mainstream Health System in Bangladesh
Diabetes mellitus is a leading cause of death and disability. Diabetic Retinopathy (DR) is an eye disease that affects the eyesight of about 21.3% persons with diabetes in Bangladesh in a way that is irreversible because of the…
- Trial name
- NCT03658980
- Testing
- Health Education Intervention
- Where
- Bangladesh
- Volunteers
- 299 people
- Sponsor
- Hiroshima University
Retinal Detachment
Using Triamcinolone Acetonide to Reduce Pain After Scleral Buckle Surgery
PURPOSE: Scleral buckle surgery is a widely used ophthalmic surgery for the correction of rhegmatogenous retinal detachment. Studies suggest that eye pain is a common and underestimated occurrence after scleral buckle surgery…
- Trial name
- NCT04701593
- Testing
- Triamcinolone Acetonide 40mg/mL
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Virginia Polytechnic Institute and State University
Retinal Disease
Extension Study for the Evaluation of Finasteride in the Treatment of Chronic Central Serous Chorioretinopathy
Background: Central serous chorioretinopathy (CSC) is a disease in which fluid accumulates under the retina and can cause distorted vision.
- Trial name
- CSC-Ext (NCT01227993)
- Testing
- Finasteride
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- National Eye Institute (NEI)
Zellweger Spectrum Disorder
Longitudinal Prospective Natural History Study of Retinopathy in Zellweger Spectrum Disorder
The goal of this observational study is to define the course of the retinal degeneration in a ZSD patient cohort. The objective of this study is to gather information so the investigators can: 1.
- Trial name
- ZSDvision (NCT06190626)
- Where
- 3 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Wet Macular Degeneration, Diabetic Macular Edema
Artificial Intelligence Diagnostic Aid
The investigators have worked with software designers to develop a software that allows us to analyse current adherence to guidelines on Ophthalmic conditions such as Age related Macular Degeneration (AMD), Diabetic Macular Edema…
- Conditions
- Wet Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion
- Trial name
- AID (NCT05675540)
- Testing
- Macusense Assessment Software
- Where
- United Kingdom
- Volunteers
- 422 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
X-Linked Retinitis Pigmentosa (XLRP)
A Phase 2 Open-label Study to Evaluate the Safety of Laruparetigene Zovaparvovec Administered Bilaterally in Male Participants With X-Linked Retinitis Pigmentosa
The purpose of this Phase 2 Study is to see if the investigational study drug, laruparetigene zovaparvovec, also known as AGTC-501, given in both eyes, is safe and works to preserve and/or improve vision and other symptoms of…
- Trial name
- Landscape (NCT07174726)
- Testing
- Adeno-associated virus vector expressing a human RPGR gene
- Where
- 6 sites in United States
- Volunteers
- 10 people
- Sponsor
- Beacon Therapeutics
Branch Retinal Vein Occlusion, Retinal Blood Flow
Assessment of Retinal Vessel Diameters and Red Blood Velocities in Patients With BRVO and Healthy Subjects
Assessment of retinal vessel calibers combined with bidirectional Fourier domain optical coherence tomography (FDOCT) for measurement of retinal blood velocities is a new and sophisticated method for assessing retinal blood flow…
- Conditions
- Branch Retinal Vein Occlusion, Retinal Blood Flow, Retinal Oxygen Saturation
- Trial name
- NCT01746615
- Testing
- Dynamic Vessel Analyzer, Bidirectional Fourier-Domain Optical Coherence Tomography (FDOCT)
- Where
- Austria
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Neovascular Age-Related Macular Degeneration
A Depot Formulation of Sunitinib Malate (GB-102) in Subjects With Neovascular (Wet) Age-related Macular Degeneration
The purpose of this study is to evaluate the safety and efficacy of single and repeated intravitreal injections of GB-102 in subjects with neovascular (wet) age-related macular degeneration.
- Trial name
- NCT03249740
- Testing
- GB-102, Aflibercept
- Where
- 8 sites in United States
- Volunteers
- 32 people
- Sponsor
- Graybug Vision
Macular Disease
Effect of Vascular Endothelial Growth Factor Blockers on Aqueous Humor Dynamics
The objective of this research is to determine the effects of anti-VEGF drugs (bevacizumab, ranibizumab or aflibercept) on aqueous humor dynamics (AHD) in patients with retinal vascular disease.
- Trial name
- NCT01994174
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- University of Nebraska
Diabetic Retinopathy
Using Calcium Dobesilate to Treat Chinese Patients With Mild to Moderate Non-proliferative Diabetic Retinopathy
Calcium dobesilate has been recommended to treat diabetic retinopathy due to its potential in protecting against retinal vascular damage.
- Trial name
- CALM-DR (NCT04283162)
- Testing
- Calcium Dobesilate, conventional treatment
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Zhongda Hospital
Choroidal Neovascularization, Macular Degeneration
Macular Photocoagulation Study (MPS)
To evaluate laser treatment of choroidal neovascularization (CNV) through randomized, controlled clinical trials. The Macular Photocoagulation Study (MPS) consisted of three sets of randomized, controlled clinical trials.
- Conditions
- Choroidal Neovascularization, Macular Degeneration, Histoplasmosis
- Trial name
- NCT00000158
- Testing
- Argon Blue-Green Laser Photocoagulation
- Sponsor
- National Eye Institute (NEI)
Retinitis Pigmentosa
A Dose Ranging Study to Evaluate the Safety and Potential Efficacy of rhNGF in Patients With Retinitis Pigmentosa (RP)
The primary objective of the study is to assess the safety and tolerability of two dose regimens of recombinant human nerve growth factor (rhNGF) eye drops solution administered over 6 months versus a vehicle control in patients…
- Trial name
- Lumos (NCT02110225)
- Testing
- rhNGF 60 µg/ml eye drops solution, rhNGF 180 µg/ml eye drops solution
- Where
- 5 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Dompé Farmaceutici S.p.A
Diabetic Retinopathy, Vitreomacular Traction
Methotrexate Infusion and Intrasilicone Injection During Diabetic Vitrectomy
The goal of this interventional clinical trial is to assess anatomical and functional outcomes of methotrexate use in irrigating fluid during parsplana vitrectomy combined with intrasilicone injection at end of surgery in…
- Trial name
- NCT06038968
- Testing
- Methotrexate 25 MG/ML, parsplana vitrectomy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Minia University
Lupus Erythematosus, Lupus Erythematosus, Systemic
Comparison of Complement Factors and Genetic Polymorphisms of AMD Between Patients With Systemic Lupus Erythematosus (SLE) With and Without Retinal "Pseudo-drusen-like" Deposits: Case-control Study (PL-AMD)
The rationale of this research is to determine if patients with lupus and presenting retinal "pseudo-drusen-like" deposits have genetic and complement-related similarities with AMD patients.
- Conditions
- Lupus Erythematosus, Lupus Erythematosus, Systemic, Age Related Macular Degeneration
- Trial name
- PL-AMD (NCT03504540)
- Testing
- Blood test
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Diabetes Mellitus, Glaucoma
Smartphone Screening for Eye Diseases
To validate new screening instruments for eye disease, increase eye care access in underserved communities, and provide a scientifically implemented method to set up programs for eye disease screening.
- Conditions
- Diabetes Mellitus, Glaucoma, Age Related Macular Degeneration, ROP
- Trial name
- NCT03076697
- Testing
- Fundus photography
- Volunteers
- 472 people
- Sponsor
- University of Michigan
Macular Edema, Retinal Vein Occlusion
Safety and Effectiveness of Bevacizumab Intravitreal Injections in the Treatment of Macular Edema Secondary to Retinal Vein Occlusion
Lack of an effective treatment for macular edema secondary to central retinal vein occlusion and the bad response to grid laser treatment in patients with macular edema secondary to branch retinal vein occlusion, together with…
- Trial name
- EBOVER (NCT00970957)
- Testing
- Avastin Intravitreal Injection
- Where
- 13 sites in Spain
- Volunteers
- 107 people
- Sponsor
- Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA
AIDS
The Effects of Genetic Differences Among AIDS Patients on Cytomegalovirus Retinitis
This study will evaluate the role of certain gene variants on the onset and course of cytomegalovirus (CMV) retinitis-a severe infection affecting the eye-in patients with AIDS.
- Trial name
- NCT00341172
- Where
- United States
- Volunteers
- 2,232 people
- Sponsor
- National Cancer Institute (NCI)
Diabetic Retinopathy
Evaluation of Doxycycline Verses Placebo for the Treatment of Severe Nonproliferative or Mild or Moderate Proliferative Diabetic Retinopathy
This 24 month randomized research study will evaluate whether doxycycline can 1) slow the deterioration or improve retinal function and/or 2) induce regression, or slow progression, of diabetic retinopathy in participants over 18…
- Trial name
- POC1 (NCT00511875)
- Testing
- doxycycline monohydrate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Thomas Gardner
Leber Congenital Amaurosis
Phase 1/2 Safety and Efficacy Study of AAV-RPE65 Vector to Treat Leber Congenital Amaurosis
The purpose of the study is to evaluate the safety and efficacy of an adeno-associated virus vector expressing RPE65 in patients with Leber congenital amaurosis caused by mutations in the RPE65 gene. Funding Source - FDA OOPD
- Trial name
- NCT00749957
- Testing
- rAAV2-CB-hRPE65
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Beacon Therapeutics
Neovascular Age-related Macular Degeneration
Safety and Efficacy of Switching From Aflibercept to Ranibizumab in Patients With nAMD
AMD (Age Related Macular Degeneration) is the leading cause of severe visual loss and blindness registration in the UK . It is a disease which affects the retina (the nerve and blood vessel network at the back of the eye…
- Trial name
- SAFARI (NCT02161575)
- Testing
- Ranibizumab
- Where
- 28 sites in Germany, United Kingdom
- Volunteers
- 103 people
- Sponsor
- Novartis Pharmaceuticals
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