Clinical trials: Retinal Disorder
Retinal Vein Occlusion
Retrospective Data Analysis of Patients Treated for Macular Edema Due to Central Retinal Vein Occlusion
The objective of this retrospective chart review is to evaluate drug utilization, usage patterns and indication of effectiveness Eylea in the routine clinical (real-life) management of patients who suffer from ME (Macular Edema)…
- Trial name
- RETRO CRVO (NCT02645747)
- Testing
- Aflibercept (Eylea, BAY86-5321)
- Where
- Belgium
- Volunteers
- 126 people
- Sponsor
- Bayer
Central Retinal Vein Occlusion
Bevacizumab for Central Retinal Vein Occlusion Study
Central retinal vein occlusion is a leading cause of severe visual impairment. Until now, no treatment has been available to improve visual acuity.
- Trial name
- NCT00906685
- Testing
- bevacizumab
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Anders Kvanta
Diabetes Mellitus, Diabetic Retinopathy
Study to Evaluate the Effectiveness of a Program Developed to Improve Eye Care for Veterans With Diabetes
The study's primary objective is to determine whether the PRSS improves the optimal timing of photocoagulation in diabetic patients in VA.
- Trial name
- NCT00119535
- Testing
- Implementation of Proactive Diabetes Eye Care Program
- Where
- 3 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- US Department of Veterans Affairs
Retinal Detachment Rhegmatogenous, Vitrectomy
Influence of Tamponade on Retinal Shift in Eyes Undergoing Vitrectomy for Rhegmatogenous Retinal Detachment: A Comparison of Gas Versus Silicone Oil in a Pakistani Population
Rhegmatogenous retinal detachment (RRD) is a vision-threatening condition with an estimated incidence of approximately 1 in 10,000 individuals annually.
- Conditions
- Retinal Detachment Rhegmatogenous, Vitrectomy, Retina Disorder
- Trial name
- TARS (NCT07495319)
- Testing
- Pars plana vitrectomy
- Where
- Pakistan
- Volunteers
- 78 people
- Sponsor
- Wardah
Type 1 Diabetes, Neuropathy
Corneal Confocal Microscopy to Detect Diabetic Neuropathy in Children
The overall aim of this study is to confirm the utility of corneal confocal microscopy (CCM) as a new technique to rapidly and non-invasively assess diabetic neuropathy (DN) in children.
- Conditions
- Type 1 Diabetes, Neuropathy, Retinopathy
- Trial name
- CCM (NCT02321904)
- Testing
- Corneal Confocal Microscopy, Nerve Conduction Studies, Quantitative sensory testing
- Where
- Canada
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Epiretinal Membrane, Macular Hole
Fourier Transformed Infrared Spectroscopy in Macular Surgery
Epiretinal membranes (ERM) are disorders leading to vision loss and metamorphopsia. Vitrectomy with membrane peeling has developed to be the gold-standard in treatment of ERM.
- Trial name
- NCT03452748
- Testing
- FTIR spectroscopy
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Macular Degeneration, Diabetic Retinopathy
Metabolic Mapping to Measure Retinal Metabolism
This study will test whether a new non-invasive technique can quickly and precisely measure retinal metabolism (the amount of energy retinal cells use). The retina is the part of the eye that sends information to the brain.
- Conditions
- Macular Degeneration, Diabetic Retinopathy, Hippel-Landau Disease, Mitochondria
- Trial name
- NCT00385333
- Testing
- Feasibility Study - Imaging System
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- National Eye Institute (NEI)
Age-related Macular Degeneration
Deciphering AMD by Deep Phenotyping and Machine Learning- Prospective Study - PINNACLE
We will conduct a prospective non-interventional study including 400 early AMD patients (=600 untreated early AMD eyes, including both unilateral (AREDS IV) and bilateral (≥AREDS II)) over a minimum of 1 year to specifically…
- Trial name
- PINNACLE (NCT04269304)
- Where
- 12 sites in Austria, Switzerland and 1 more
- Volunteers
- 429 people
- Sponsor
- University of Southampton
Macular Edema
Comparison of Combined Intravitreal Bevacizumab and Oral Acetazolamide Versus Intravitreal Bevacizumab Alone for the Treatment of Macular Edema Secondary to Retinal Vein Occlusions
In this study, which will be performed as a randomized clinical trial, all patients with macular edema with central involvement (central macular thickness greater than 300 μm) and corrected vision less than or equal to 20/40 and…
- Trial name
- NCT05290948
- Testing
- intravitreal injection of bevacizumab with acetazolamide tablets, intravitreal injection of bevacizumab
- Where
- Iran
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Proliferative Diabetic Retinopathy
Efficacy and Safety Comparison of IVR and IVC Before Vitrectomy in Proliferative Diabetic Retinopathy
Proliferative diabetic retinopathy (PDR) is the most common causes of irreversible blindness in diabetic retinopathy (DR).Although pars plana vitrectomy (PPV) is the cornerstone for treatment of advanced PDR, related…
- Trial name
- NCT05414149
- Testing
- preoperative intravitreal injections of ranibizumab or conbercept
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University People's Hospital
Choroidal Neovascularization, Age Related Macular Degeneration
SD-OCT-guided Intravitreal Ranibizumab Treatment in Choroidal Neovascularization Due to Myopia
This investigator initiated pilot study is designed to investigate the efficacy and safety of SD-OCT-guided intravitreal ranibizumab treatment in choroidal neovascularization (CNV) due to myopia.
- Trial name
- NCT03409250
- Testing
- Ranibizumab, Lucentis
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vista Klinik
Diabetic Eye Diseases, Diabetic Retinopathy
Shanghai Diabetic Eye Study in Diabetics
The purpose of the Shanghai Diabetic Eye Study (SDES) was to guide and regulate eye health screening of two hundred thousand people with diabetes in the communities in 16 districts in Shanghai, build up the ranks with the general…
- Trial name
- SDES (NCT03579797)
- Testing
- Screening, referral, follow-up and health management
- Where
- China
- Volunteers
- 200,000 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Diabetic Retinopathy
Collaborative Care for Depression and Diabetic Retinopathy in African Americans
In this feasibility/pilot study, we will develop, refine, and evaluate the feasibility of a novel mental health/ophthalmologic intervention called, "Collaborative Care for Depression and Diabetic Retinopathy" (CC-DDR), which aims…
- Trial name
- CC-DDR (NCT02121340)
- Testing
- Behavioral Activation
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Thomas Jefferson University
Diabetic Retinopathy, Age-Related Macular Degeneration
Function and Structure Imaging in Different Retinal Diseases: Retinal Leakage Analyzer Versus Optical Coherence Tomography
The main objective of this observational study is to characterize and correlate functional and structural changes at the retinal level using the Retinal Leakage Analyzer (RLA) and the Optical Coherence Tomograph (OCT).
- Conditions
- Diabetic Retinopathy, Age-Related Macular Degeneration, Macular Edema
- Trial name
- NCT00797524
- Where
- Portugal
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Wet Age Related Macular Degeneration
Phase 3 Study of Intravitreal OLN324 in Adults With Neovascular (Wet) Age-related Macular Degeneration (nAMD) (OLN324-CP-04)
This is a Phase 3 study of an investigational drug called OLN324, which is being developed by Ollin Biosciences as a treatment for patients with neovascular (wet) age-related macular degeneration (nAMD).
- Trial name
- MOJAVE (NCT07816315)
- Testing
- OLN324, Aflibercept
- Volunteers
- 500 people
- Sponsor
- Ollin Biosciences, Inc.
Myopia
Association Between Retinal Microvasculature and Optic Disc Alterations in Non-pathological High Myopia With OCTA
Non-pathological high myopia patients and controls undergoing a comprehensive ophthalmologic examination are included. The Optical Coherence Tomography Angiography (OCTA) software automatically segments these full-thickness…
- Trial name
- NCT04631991
- Testing
- Comprehensive ophthalmologic examination
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Akdeniz University
Parkinson Disease, Healthy Adult Participants
Brain Dopamine Biomarker
This study is being conducted at the Morsani College of Medicine to determine whether signals recorded from the eyes and brain can be used as a noninvasive way to monitor dopamine function.
- Trial name
- B3-4D (NCT07748715)
- Testing
- Levadopa/Carbidopa eyedrops, Levodopa/Carbidopa (Sinemet)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Macular Degeneration
Improving Vision in Adults With Macular Degeneration
The purpose of this study is to test whether a kind of brain stimulation called anodal transcranial direct current stimulation (a-tDCS) can improve the ability of people with age-related macular degeneration (AMD) or juvenile…
- Trial name
- NCT04111068
- Testing
- anodal tDCS Active Stimulation
- Where
- 2 sites in Canada, Hong Kong
- Volunteers
- 21 people
- Sponsor
- University of Waterloo
Bilateral Retinoblastoma, Childhood Intraocular Retinoblastoma
A Study to Give Treatment Inside the Eye to Treat Retinoblastoma
This phase II trial tests the safety and side effects of adding melphalan (by injecting it into the eye) to standard chemotherapy in early treatment of patients with retinoblastoma (RB).
- Conditions
- Bilateral Retinoblastoma, Childhood Intraocular Retinoblastoma, Group D Retinoblastoma, Stage I Retinoblastoma
- Trial name
- NCT05504291
- Testing
- Biospecimen Collection, Carboplatin, Etoposide
- Where
- 20 sites in United States, Australia and 1 more
- Volunteers
- 26 people
- Sponsor
- Children's Oncology Group
Diabetic Retinopathy
Study on Exosome Changes in Patients With Proliferative Diabetic Retinopathy
Diabetic retinopathy is a common complication of diabetes and one of the leading causes of low vision and blindness in adults. In recent years, the prevalence of diabetes and the incidence of diabetic retinopathy have increased…
- Trial name
- NCT06198543
- Volunteers
- 60 people
- Sponsor
- Xuanwu Hospital, Beijing
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.