Clinical trials: Retinal Disorder
Ischemic Stroke, Transient Ischemic Attack (TIA)
Ambulatory Stroke Unit Treatment for Elderly Patients
ARTIFICE is a prospective, multicenter, randomized, controlled, exploratory non-inferiority trial evaluating whether an ambulatory stroke unit model (aSU) is non-inferior to conventional inpatient stroke unit care (SU) in…
- Conditions
- Ischemic Stroke, Transient Ischemic Attack (TIA), Retinal Ischemia
- Trial name
- ARTIFICE (NCT07420374)
- Testing
- Ambulatory Stroke Unit Care, Conventional Stroke Unit Care
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- University Hospital Heidelberg
Retinitis Pigmentosa
Long-term Safety of UC-MSC Transplantation in Patients With Retinitis Pigmentosa
The study will perform to follow-up UC-MSCs and CM transplantation. 18 patients will be called back to be examined after 5 years of UC-MSC and/or CM transplantation.
- Trial name
- NCT05786287
- Testing
- Conditioned Medium (CM), Umbilical Cord Mesenchymal Stem Cell (UC-MSC)
- Where
- 2 sites in Indonesia
- Volunteers
- 18 people
- Sponsor
- PT. Prodia Stem Cell Indonesia
Age-Related Macular Degeneration, Dry Age-related Macular Degeneration
Microcurrent Stimulation Therapy for Nonexudative Age-related Macular Degeneration (i-SIGHT)
Evaluate the safety and efficacy of transpalpebral microcurrent stimulation (MCS) therapy for patients with nonexudative (dry) age-related macular degeneration (AMD).
- Conditions
- Age-Related Macular Degeneration, Dry Age-related Macular Degeneration, Nonexudative Age-related Macular Degeneration
- Trial name
- i-SIGHT (NCT05447650)
- Testing
- i-Lumen(TM) AMD
- Where
- 10 sites in United States
- Volunteers
- 95 people
- Sponsor
- i-Lumen Scientific, Inc.
Age-Related Macular Degeneration (AMD)
MacuMira Microcurrent Stimulation for Dark Adaptation in Dry Age-Related Macular Degeneration
Age-related macular degeneration (AMD) is an eye condition that affects the retina and can lead to progressive vision loss. This study will evaluate the effects of MacuMira microcurrent stimulation on dark adaptation in adults…
- Trial name
- NCT07917715
- Testing
- Transpalpebral microcurrent electrical stimulation
- Where
- 3 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Clarity Eye Institute
Schizophrenia, Bipolar I Disorder
ERG Components in Schizophrenia and Bipolar Disorder Type I
This study will further assess ERG components obtained with different ERG devices, to be considered in a prediction model for each diagnosis.
- Trial name
- NCT03788811
- Testing
- ERG assessment (RSPA)
- Where
- 19 sites in United States, Australia and 1 more
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- diaMentis Inc.
Leber Congenital Amaurosis
Safety Study in Subjects With Leber Congenital Amaurosis
The purpose of this study is to determine whether gene transfer will be safe and effective in the treatment of Leber Congenital Amaurosis (LCA).
- Trial name
- NCT00516477
- Testing
- voretigene neparvovec-rzyl
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Spark Therapeutics, Inc.
Retinal Vein Occlusion, Retinal Vein Thrombosis
Atorvastatin for the Treatment of Retinal Vein Occlusion
The ATORVO study is designed to determine whether atorvastatin (Lipitor) can improve vision, when compared to placebo
- Conditions
- Retinal Vein Occlusion, Retinal Vein Thrombosis, Central Retinal Vein Occlusion, Branch Retinal Vein Occlusion
- Trial name
- ATORVO (NCT00517257)
- Testing
- Atorvastatin
- Where
- Canada
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Retinopathy of Prematurity
Pan-VEGF Blockade for the Treatment of Retinopathy of Prematurity
Retinopathy of Prematurity (ROP) is a leading cause of blindness in children in developed countries around the world, and an increasing cause of blindness in developing countries. The retina lines the inside of the eye.
- Trial name
- BLOCK-ROP (NCT00702819)
- Testing
- Bevacizumab
- Where
- 11 sites in United States, Canada
- Volunteers
- 2 people
- Sponsor
- Vision Research Foundation
Maculopathy, Age-Related
Study of the Combination of Anecortave Acetate and Triamcinolone Acetonide for the Treatment of Exudative Age-Related Macular Degeneration (AMD)
The purpose of this study is to evaluate the safety of combining juxtasclerally administered anecortave acetate 15 mg with triamcinolone acetate 4 mg administered intravitreally following photodynamic therapy with verteporfin for…
- Trial name
- NCT00211419
- Testing
- Anecortave Acetate 15 mg, Triamcinolone Acetate 4 mg, Photodynamic Therapy with Verteporfin
- Where
- United States
- Sponsor
- Manhattan Eye, Ear & Throat Hospital
Obesity, Childhood, Hyperphagia
Early Genetic Identification of Obesity
TITLE: Whole genetic approach in Early Genetic Identification of Obesity (WEGIO) DESIGN: Multicenter epidemiological study STUDY POPULATION: Participants at risk for a syndromic or a monogenic genetic obesity, incl.
- Conditions
- Obesity, Childhood, Hyperphagia, Retinopathy, Syndactyly
- Trial name
- WEGIO (NCT06239064)
- Testing
- Genetic testing via blood collection
- Where
- 37 sites in Germany
- Volunteers
- 1,000 people
- Sponsor
- Rolfs Consulting und Verwaltungs-GmbH (RCV)
Retinitis Pigmentosa
PMCF Study for Partial Vision Restoration Using the Subretinal Implant RETINA IMPLANT Alpha AMS
This study is a post-market clinical follow-up (PMCF) study to monitor the safety, lifetime and efficacy of patients using the CE-certified RETINA IMPLANT Alpha AMS.
- Trial name
- NCT02588430
- Where
- Germany
- Sponsor
- Retina Implant AG
Neovascular Age Related Macular Degeneration
Retinal Effects After Combined Photodynamic Therapy (PDT) With Intravitreal Triamcinolone
Background: To identify characteristic morphological changes of the retina, their change over time and the association with visual function after combined photodynamic therapy (PDT) and intravitreal triamcinolone (IVTA).
- Trial name
- NCT00685100
- Testing
- PDT plus intravitreal triamcinolone
- Volunteers
- 40 people
- Sponsor
- Medical University of Vienna
Age-related Macular Degeneration
Multicenter Real-life Observational Study Switched Aflibercept or Ranibizumab to Faricimab in Patients With AMD.
Age-related macular degeneration (AMD) is a degenerative retinal disease. The prognosis of the exudative form was transformed by the introduction of the anti-VEGF monoclonal antibody treatments ranibizumab [1] and aflibercept [2]…
- Trial name
- FAR-WEST (NCT06271330)
- Testing
- Faricimab
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Nantes University Hospital
Retinopathy of Prematurity
Stress Induced by Screening for Retinopathy of Prematurity - Should Speculum and Indentation Rather be Avoided
The purpose is to assess the hypothesis that indirect ophthalmoscopy for retinopathy of prematurity eye examination (ROPEE) screening without the use of a lid speculum and scleral indentation (speculum-free, SpF) is less…
- Trial name
- stressROP (NCT04408807)
- Testing
- Speculum-free (SpF) fundoscopy, Speculum (Sp) fundoscopy
- Where
- Greece
- Volunteers
- 37 people
- Sponsor
- Aristotle University Of Thessaloniki
Age-Related Macular Degeneration
Study of Dark Adaptation in Age-Related Macular Degeneration
Background: Age-related macular degeneration (AMD) is a leading cause of vision loss in individuals over 55 years of age. It can cause permanent loss of central vision, which is important for seeing fine details and long…
- Trial name
- NCT01352975
- Where
- United States
- Volunteers
- 217 people
- Sponsor
- National Eye Institute (NEI)
Epiretinal Membrane, Vitreomacular Traction
Comparison of Two Techniques for Epiretinal or Internal Limiting Membrane Peel
Epiretinal membranes (ERM) are cellular membranes on the surface of the retina that result in distortion of the vision (metamorphopsia), and decreased best-corrected visual acuity.
- Trial name
- NCT00892619
- Testing
- using ILM forceps alone, Breaking and peeling with end-grasping forceps
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Michael E. DeBakey VA Medical Center
Geographic Atrophy
A Study of the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Intravitreal Injections of FCFD4514S in Patients With Geographic Atrophy
The Phase Ia, open-label, multicenter study will consist of a single-dose, dose-escalation study of the safety, tolerability, pharmacokinetics, and immunogenicity of an intravitreal (ITV) injection of FCFD4514S in patients with…
- Trial name
- NCT00973011
- Testing
- FCFD4514S
- Volunteers
- 18 people
- Sponsor
- Genentech, Inc.
Open Angle Glaucoma, Low Tension Glaucoma
Validation of Retinal Oximetry in Glaucoma Patients: a Structural and Functional Correlation
Retinal ischemia is thought to play an important role in the pathogenesis of glaucoma. Up until today, very little is known about the metabolic alterations in the retina of glaucoma patients, since only techniques for surrogate…
- Trial name
- NCT01391247
- Where
- Belgium
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Age-Related Macular Degeneration
Direct Discrimination of Quantum States by the Human Eye
Age-related macular degeneration (AMD), is a debilitating eye disease that causes a loss of central vision. The prevalence of AMD increases exponentially with age and causes a significant impact through both medical expenses and…
- Trial name
- NCT05913063
- Testing
- Structured Light Imaging Microscopy
- Where
- Hong Kong
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Centre for Eye and Vision Research
Retinitis Pigmentosa
Clinical Trial of Lutein for Patients With Retinitis Pigmentosa Receiving Vitamin A
The purpose of this trial is to determine whether lutein in addition to vitamin A will slow the course of retinitis pigmentosa.
- Trial name
- NCT00346333
- Testing
- Lutein, Cornstarch control
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- National Eye Institute (NEI)
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