Clinical trials: Retinal Disorders
Age Related Macular Degeneration, Diabetic Retinopathy
Oral Acetazolamide, Brimonidine Tartarate, and Anterior Chamber Paracentesis for Ocular Hypertension Control After Intravitreal Bevacizumab
The purpose of this study is to evaluate the effects of anterior chamber paracentesis, brimonidine and oral acetazolamide to reduce intra-ocular pressure variations after intravitreal bevacizumab injection.
- Trial name
- NCT00864838
- Testing
- Acetazolamide, Brimonidine tartarate, Anterior chamber paracentesis
- Volunteers
- 56 people
- Sponsor
- University of Sao Paulo
Macular Degeneration
Influence of Blue Light Filtering Intraocular Lenses on Daytime Levels of Melatonin
The "blue light hazard" has been reported to cause retinal damage (oxidative stress), particularly to the central fovea due to its energetic, shorter wavelength visible photons, which is why blue-light filtering intraocular…
- Trial name
- BluMel (NCT00444249)
- Testing
- White Alcon IOL, Yellow Alcon IOL, White Hoya IOL
- Where
- Austria
- Volunteers
- 136 people
- Sponsor
- The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery
Optic Neuritis
Effect of Vitamin D on Retinal Changes in Patient With Optic Neuritis by Optic Coherence Tomography
This study examines the effect of vitamin D on Retinal changes in patient with optic Neuritis.
- Trial name
- NCT01465893
- Testing
- Vitamin D, Vitamin D withheld
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Isfahan University of Medical Sciences
Epiretinal Membrane
Vitrectomy Combined With Intravitreal Dexamethasone Implant for Idiopathic Epiretinal Membrane With Macular Oedema
The goal of this clinical trial is to evaluate the efficacy and safety of 25-gauge pars plana vitrectomy combined with intravitreal dexamethasone implant for the treatment of idiopathic epiretinal membrane with cystoid macular…
- Trial name
- NCT06232616
- Testing
- vitrectomy combined with intravitreal dexamethasone implant
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Prematurity
Supply With Micronutrients (Purine and Pyrimidine) in Infants: a Prospective and Observational Study
Concentrations of micronutrients (especially purine and pyrimidine) in cord blood, blood of mothers and infants and human milk is studied
- Trial name
- NCT03532633
- Testing
- cord blood, blood sample infant, blood sample mother
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- University Hospital Tuebingen
Diabetic Retinopathy
Vascular Remodeling and the Effects of Angiogenic Inhibition in Diabetic Retinopathy
The retinal vasculature changes dramatically in patients with diabetic retinopathy especially between non-proliferative and proliferative disease. The retinal vasculature can be imaged and quantified using special dyes.
- Trial name
- NCT00411333
- Testing
- triamcinolone acetonide (Kenalog)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Macular Degeneration
Treat & Extend Treatment With 0.5mg Ranibizumab vs Monthly Treatment With 0.5mg Ranibizumab
TREX is a phase IIIb, multicenter, randomized, controlled clinical study. Subjects will be randomized 1:2 to "monthly" (control arm) or "treat and extend" protocol (comparator arm) respectively.
- Trial name
- T-REX (NCT01748292)
- Testing
- 0.5 mg ranibizumab
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- Charles C Wykoff, PhD, MD
Covid19, Retina Injury
COVID-19 Patient Cohort: Retinal Damage in Non-invasive Retinal Imaging (OCTA)
The objective of this research is to build a collection of non-invasive retinal imaging (OCT and OCTA) in order to investigate the incidence and impact of retinal damage in patients who have or have had COVID-19.
- Trial name
- NCT04881253
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Diabetes Mellitus, Diabetic Retinopathy (DR)
Improving Patient-centered Care for Diabetes in Bangladesh Through "Dynamic Integration" of Vision Care on the Supply Side
The goal of this clinical trial is to determine whether integration of vision care into the DM treatment system, by providing specific recommendations to doctors for management of diabetes alongside feedback on positive eye exams…
- Trial name
- NCT06968637
- Testing
- care recommendations
- Where
- 2 sites in Bangladesh
- Volunteers
- 336 people
- Sponsor
- Orbis
Retinal Disease
Navigated OCT Imaging With the P200TxE
The P200TxE will be used to obtain peripheral OCT (optical coherence tomography) images.
- Trial name
- NCT04003831
- Testing
- Device: P200TxE
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Optos, PLC
Tuberculosis (TB), Uveitis
Six-months Versus Nine-months ATT for Ocular TB
The goal of this clinical trial is to learn if 6-months anti-TB therapy is not worse than 9-months therapy for the treatment of tubercular posterior uveitis.
- Conditions
- Tuberculosis (TB), Uveitis, Retinal Vasculitis, Choroiditis
- Trial name
- NCT06613919
- Testing
- Anti-Tuberculosis Treatment
- Where
- 3 sites in Burma, India and 1 more
- Volunteers
- 58 people
- Sponsor
- L.V. Prasad Eye Institute
Retinal Vasculitis
Biological Markers in Retinal Vasculitis
This study will look for biological markers of primary retinal vasculitis that can be useful in understanding what causes the disease. It will evaluate its progression, and develop and monitor treatments.
- Trial name
- NCT00050492
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Eye Institute (NEI)
Strabismus, Retinal Thickening
Choroidal and Retinal Thickness Following Strabismus Surgery
Prospective study, conducted at Tanta University Ophthalmology Department Measurement of macular and choroidal thickness before and after strabismus surgery
- Trial name
- NCT04285177
- Testing
- Strabismus surgery
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Tanta University
Brain and Central Nervous System Tumors, Intraocular Melanoma
Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer
RATIONALE: Radiolabeled monoclonal antibodies, such as iodine I 131 monoclonal antibody 3F8, can find tumor cells and carry tumor-killing substances to them without harming normal cells.
- Conditions
- Brain and Central Nervous System Tumors, Intraocular Melanoma, Lung Cancer, Melanoma (Skin)
- Trial name
- NCT00445965
- Testing
- DNA analysis, immunologic technique, pharmacological study
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Epiretinal Membrane Surgery
Post-surgical Functional Results in Patients With Epiretinal Membrane Undergoing Controlled Macular Detachment
This study aims to evaluate postsurgical functional changes in patients with advanced epiretinal membrane (ERM) (stages 3 and 4) by integrating a controlled macular detachment with a balanced salt solution to the conventional ERM…
- Trial name
- DMER25 (NCT07095907)
- Testing
- Pars plana vitrectomy with epiretinal membrane peeling and controlled macular detachment
- Where
- Mexico
- Volunteers
- 36 people
- Sponsor
- Asociación para Evitar la Ceguera en México
Macular Holes
Human Amniotic Membrane Plug for Large Macular Holes
This is a prospective, interventional, consecutive case series conducted in Alexandria university. The aim of the study is to evaluate the therapeutic efficacy of human amniotic membrane in promoting closure of large macular…
- Trial name
- NCT03917602
- Testing
- human amniotic membrane plug with vitrectomy
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- University of Alexandria
Diabetes, Diabetic Retinopathy
Genetic Association of Diabetic Retinopathy-1
The primary purpose of the study is to investigate allele frequencies of candidate genes in Chinese diabetic patients with or without known diabetic retinopathy.
- Trial name
- DMR-1 (NCT01298245)
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Retinopathy of Prematurity, Neurodevelopmental Disorders
Analyzing Retinal Microanatomy in ROP
Retinopathy of prematurity (ROP) is a disorder of development of the neural retina and its vasculature that may impact vision in vulnerable preterm neonates for a lifetime.
- Conditions
- Retinopathy of Prematurity, Neurodevelopmental Disorders, Macular Edema
- Trial name
- BabySTEPS (NCT02887157)
- Testing
- Swept Source OCT, Magnetic Resonance Imaging, Scavenged blood collection
- Where
- 4 sites in United States
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- Duke University
Diabetic Retinopathy
Evaluation of RC28-E Injection in Diabetic Retinopathy
This is a randomized, open-label, multicenter study of the efficacy and safety of RC28-E injection (a chimric decoy receptor trap fusion protein by dual blockage of VEGF and FGF-2) in the treatment of patients with moderately…
- Trial name
- NCT04782128
- Testing
- RC28-E injection
- Where
- China
- Volunteers
- 120 people
- Sponsor
- RemeGen Co., Ltd.
Age Related Macular Degeneration
A Pharmacokinetic Study: Ranibizumab, Aflibercept and the Effect of Vitrectomy.
To study the effect of pars plana vitrectomy on the intravitreal pharmacokinetics of ranibizumab and to compare the half-life of ranibizumab and aflibercept.
- Trial name
- VITCLEAR (NCT02174211)
- Testing
- Ranibizumab, Aflibercept
- Where
- United Kingdom
- Volunteers
- 59 people
- Sponsor
- King's College Hospital NHS Trust
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