Clinical trials: Retinal Disorders
Vogt Koyanagi Harada Disease
Suprachoroidal Triamcinolone Acetonide in Harada's Retinal Detachment
Suprachoroidal injection, a novel technique for delivering ocular therapies, may facilitate targeted therapeutic delivery to the choroidal and retinal structures than intravitreal injection
- Trial name
- NCT05031143
- Testing
- Suprachoroidal Triamcinolone acetonide injection for serous retinal detachment in VKH disease
- Where
- Egypt
- Volunteers
- 6 people
- Sponsor
- Benha University
Age-related Macular Degeneration, Cataract
Age-Related Eye Disease Study 2 (AREDS2)
Oral supplementation with the Age-Related Eye Disease Study (AREDS) formulation (antioxidant vitamins C and E, beta carotene, and zinc) has been shown to reduce the risk of progression to advanced age-related macular degeneration…
- Trial name
- AREDS2 (NCT00345176)
- Testing
- Lutein/zeaxanthin, DHA/EPA, Lutein/zeaxanthin and DHA/EPA
- Where
- 91 sites in United States
- Volunteers
- 4,203 people
- Sponsor
- National Eye Institute (NEI)
Artificial Intelligence, Retinal Diseases
Real-world of AI in Diagnosing Retinal Diseases
The objective of this study is to apply an artificial intelligence algorithm to diagnose multi-retinal diseases in real-world settings.
- Trial name
- NCT05981950
- Testing
- artificial intelligence algorithm
- Where
- China
- Volunteers
- 100,000 people
- Sponsor
- Beijing Tongren Hospital
Ischemic Stroke, Transient Ischemic Attack (TIA)
Ambulatory Stroke Unit Treatment for Elderly Patients
ARTIFICE is a prospective, multicenter, randomized, controlled, exploratory non-inferiority trial evaluating whether an ambulatory stroke unit model (aSU) is non-inferior to conventional inpatient stroke unit care (SU) in…
- Conditions
- Ischemic Stroke, Transient Ischemic Attack (TIA), Retinal Ischemia
- Trial name
- ARTIFICE (NCT07420374)
- Testing
- Ambulatory Stroke Unit Care, Conventional Stroke Unit Care
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- University Hospital Heidelberg
Adverse Effect of Cardiovascular Medications (Diagnosis)
Effect of PCSK9 Inhibitor on Retinal Microvessels in Patients With Coronary Heart Disease After Intensive Lipid-lowering Therapy
In patients with coronary heart disease who were treated with PCSK9 inhibitor evolocumab for intensive lipid-lowering therapy, the changes of retinal microvessels were measured with OCTA (Optical Coherence Tomography…
- Trial name
- NCT05802108
- Testing
- Evolocumab combined with statins, Statin
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zibo Central Hospital
Macular Degeneration
A Study of Abicipar Pegol in Patients With Neovascular Age-related Macular Degeneration
This is a safety and efficacy study of abicipar pegol in patients with neovascular age-related macular degeneration to establish comparability between Japanese and non-Japanese.
- Trial name
- NCT02181517
- Testing
- abicipar pegol, ranibizumab
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Allergan
Diabetic Retinopathy, Macular Oedema
Ranibizumab Treatment of Diabetic Macular Oedema With Bimonthly Monitoring After a Phase of Initial Treatment
This study evaluates a new investigational treatment regimen of three consecutive monthly doses of ranibizumab followed by an as-needed treatment regimen, with monthly follow-up for the first three months then two-monthly…
- Trial name
- RELIGHT (NCT01257815)
- Testing
- Ranibizumab
- Where
- 15 sites in United Kingdom
- Volunteers
- 111 people
- Sponsor
- Novartis Pharmaceuticals
Diabetic Retinopathy
Study to Evaluate Clinical Efficacy and Safety of Nuvastatic™ - C5OSEW5050ESA in Diabetic Retinopathy.
Diabetic retinopathy (DR) is a common complication of diabetes mellitus that leads to loss of vision and blindness among working age adults.
- Trial name
- NCT04552600
- Testing
- Nuvastatic
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Natureceuticals Sdn Bhd
Cerebra-retinal Angiopathy
COL4A1 Gene Related Cerebra-retinal Angiopathy
This prospective multicenter cohort study aims to define the clinical, radiological and mutational spectrum of the disease related to COL4A1 gene.
- Trial name
- COL4A1 (NCT01097564)
- Testing
- COL4A1 genetic testing
- Where
- France
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetic Vitreous Hemorrhage, Intravitreal Injections
Outcomes of Intravitreal Ranibizumab Injection for Diabetic Vitreous Hemorrhage
This prospective interventional cohort study evaluates the outcomes of intravitreal ranibizumab injection in patients with diabetic vitreous hemorrhage secondary to proliferative diabetic retinopathy.
- Conditions
- Diabetic Vitreous Hemorrhage, Intravitreal Injections, Ranibizumab
- Trial name
- RANI-VH (NCT07690800)
- Testing
- Ranibizumab
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Benha University
Burkitt Lymphoma, Retinoblastoma
Mobile Health Case Management System for Reducing Pediatric Treatment Abandonment
Digital case management systems have the potential to increase compliance with protocol-driven treatment, reduce treatment abandonment and ultimately help to close the discrepancy in pediatric cancer outcomes between Low and…
- Conditions
- Burkitt Lymphoma, Retinoblastoma, Diffuse Large B-cell Lymphoma
- Trial name
- NCT03677128
- Testing
- mNavigator
- Where
- Tanzania
- Volunteers
- 75 people
- Sponsor
- Duke University
Branch Retinal Vein Occlusion, Macular Edema
Navigated Laser In Branch Retinal Vein Occlusion Study
Branch retinal vein occlusion (BRVO) is often complicated by macular edema, possibly leading to severe visual loss or blindness.
- Trial name
- NIRVANA (NCT03651011)
- Testing
- Aflibercept Injection [Eylea], Navigated laser photocoagulation
- Where
- 2 sites in Denmark
- Volunteers
- 47 people
- Sponsor
- Odense University Hospital
Retinal Detachment
Evaluation of Visual Functions After Pars Plana Vitrectomy With and Without Internal Limiting Membrane Peeling in RRD
Internal limiting membrane peeling is performed during vitrectomy for macular diseases such as macular holes, macular edema due to diabetic retinopathy and retinal vein occlusion.
- Trial name
- NCT04139811
- Testing
- Pars Plana Vitrectomy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Minia University
Proliferative Diabetic Retinopathy
Macular Tractional Retinoschisis in Proliferative Diabetic Retinopathy
Objective: To evaluate the clinical manifestations and surgical prognosis of macular tractional retinoschisis in proliferative diabetic retinopathy. Design: Retrospective case series.
- Trial name
- NCT01312207
- Where
- Taiwan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Diabetic Retinopathy
Assessment of EyeArt Performance With Retinal Cameras
The study evaluates the performance of the EyeArt system for detecting diabetic retinopathy from images captured using retinal cameras and operators.
- Trial name
- NCT04984200
- Testing
- Retinal imaging, Mydriatic Agent
- Where
- United States
- Volunteers
- 246 people
- Sponsor
- Eyenuk, Inc.
Macular Edema, Diabetic Macular Edema
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of IVT MHU650 in Macular Edema Patients
This was an open-label, multi-center, FIH study with a single ascending dose (SAD) design that assessed the safety, tolerability and pharmacokinetics (PK) of a single IVT dose of MHU650 in up to 24 participants with macular edema.
- Conditions
- Macular Edema, Diabetic Macular Edema, Neovascular Age-related Macular Degeneration, Retinal Vein Occlusion
- Trial name
- NCT04635800
- Testing
- MHU650
- Where
- 6 sites in United States, Puerto Rico
- Volunteers
- 21 people
- Sponsor
- Novartis Pharmaceuticals
Cytomegalovirus Retinitis, HIV Infections
A Study of Two Forms of Ganciclovir in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS
To compare the time to progression of Cytomegalovirus (CMV) retinitis among each of three doses of oral ganciclovir, as well as to intravenous therapy, when given as maintenance for 26 weeks.
- Trial name
- NCT00002330
- Testing
- Ganciclovir
- Where
- 36 sites in United States, Canada
- Volunteers
- 280 people
- Sponsor
- Roche Global Development
Adolescent, Pediatric Obesity
Controlled Evaluation of an Exercise Program for Overweight Adolescents
Physical activity decreases as young people get older, especially during the shift from early to late adolescence. Unfortunately, around 81% of school-aged children worldwide between the ages of 11 and 17 do not meet the…
- Conditions
- Adolescent, Pediatric Obesity, Exercise Therapy, Health Promotion
- Trial name
- Now! (NCT06923865)
- Testing
- training group
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- University Hospital, Basel, Switzerland
Retinitis Pigmentosa, Inherited Retinal Dystrophy
Minocycline Treatment in Retinitis Pigmentosa
The aim of this study is to evaluate the efficacy and safety of oral minocycline (100mg/d), administered for 6 months, for the treatment of patients with retinitis pigments(RP).
- Conditions
- Retinitis Pigmentosa, Inherited Retinal Dystrophy, Retina Disorder
- Trial name
- NCT04068207
- Testing
- Minocycline
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Sun Yat-sen University
Macular Holes
Comparative Analysis of Large Macular Hole Surgeries
This study compares the anatomical and visual outcomes in a large series of patients affected by idiopathic macular holes larger than 400 µm treated using pars plana vitrectomy and gas tamponade combined with internal limiting…
- Trial name
- CAOLMHS (NCT04116892)
- Testing
- the Cover group, the Fill group, the peeling group
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
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