Clinical trials: Retinal Disorders
Retinoblastoma, Secondary Primary Malignancies After Retinoblastoma
New Strategies to Detect Cancers in Carriers of Mutations in RB1
Rationale: Individuals with a cancer predisposition due to a mutation in the paradigm tumor suppressor gene RB1, have a high risk to develop the childhood cancer retinoblastoma (Rb).
- Trial name
- NIRBTEST (NCT04164134)
- Testing
- blood draw
- Where
- 3 sites in France, Germany and 1 more
- Volunteers
- 378 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Retinal Vasculitis
Optical Coherence Tomography (OCT) in Retinal Vasculitis
Retinal vasculitis is a sight-threatening inflammation that involves the blood vessels of the retina, the tissue that lines the inside of the eye.
- Trial name
- NCT01998464
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Oregon Health and Science University
Retinal Detachment
Flexibility, Efficacy, and Safety of a Foldable Capsular Vitreous Body in the Treatment of Severe Retinal Detachment
The purpose of this study is to determine the feasibility, primary safety and efficacy of foldable capsular vitreous body (FCVB) in the treatment of retinal detachment, based on the multi-center clinical trial.
- Trial name
- NCT01261533
- Testing
- foldable capsular vitreous body(FCVB)
- Where
- 9 sites in China
- Volunteers
- 122 people
- Sponsor
- GuangZhou WeiShiBo Biotechnology Co., ltd
Geographic Atrophy, Age-related Macular Degeneration
A Study to Investigate Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), and Immunogenicity of RO7669330 in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)
The main purpose of this study is to assess the ocular and systemic safety and tolerability of RO7669330 in participants with GA secondary to AMD in at least one eye in Part 1, or both eyes in Part 2, after multiple unilateral…
- Trial name
- NCT06961370
- Testing
- RO7669330, Syfovre™, Izervay™
- Where
- 17 sites in United States
- Volunteers
- 27 people
- Sponsor
- Hoffmann-La Roche
Diffuse Diabetic Macular Edema
Vitrectomy and Bevacizumab for Diffuse Diabetic Macular Edema
To Evaluate combined effect of vitrectomy and bevacizumab to stabilize retinal thickness and visual acuity in patients with diffuse diabetic macular edema and their relation to renal disease.
- Trial name
- NCT00571142
- Testing
- Bevacizumab + Pars plana vitrectomy
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Asociación para Evitar la Ceguera en México
Age-Related Macular Degeneration (ARMD)
Study of Ranibizumab Administered in Conjunction With Photodynamic Therapy With Verteporfin in Patients With Subfoveal Choroidal Neovascularization and Age-Related Macular Degeneration
Ranibizumab is derived from a murine monoclonal anti- vascular endothelial growth factor (VEGF) antibody and can penetrate through the many retinal cell layers following intravitreal injection.
- Trial name
- NCT00288561
- Testing
- ranibizumab
- Where
- Switzerland
- Sponsor
- Novartis
Risk Factors for Age Related Macular Degeneration
Effects of Sea Buckthorn Oil and Lutein on Eye Health
Low macular pigment optical density has been associated with increased risk of age-related macular degeneration, an important cause of vision problems in the elderly population.
- Trial name
- SBEYE (NCT02379169)
- Testing
- Sea buckthorn oil & lutein
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Optic Neuritis, Multiple Sclerosis
Neuroprotection With Phenytoin in Optic Neuritis
Optic neuritis is caused by inflammation of the optic nerve and causes loss of vision in the affected eye. It is often associated with multiple sclerosis.
- Trial name
- NCT01451593
- Testing
- Phenytoin
- Where
- 2 sites in United Kingdom
- Volunteers
- 92 people
- Sponsor
- University College, London
Retinopathy of Prematurity Both Eyes
Ranibizumab Vs Bevacizumab for Type 1 Retinopathy of Prematurity
Retinopathy of prematurity (ROP) with inadequate growth and development of retinal blood vessels in premature infants is one of the foremost reasons for childhood blindness.
- Trial name
- NCT05033106
- Testing
- Bevacizumab, Ranibizumab
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Zagazig University
Retinal Detachment
Duration of Silicone Oil Tamponade on Foveal and Parafoveal Thickness in Rhegmatogenous Retinal Detachment
Our study observes and analyses the influence of the duration of tamponade with silicone oil on the foveal and parafoveal thickness.
- Trial name
- siliconeoil (NCT05817630)
- Testing
- Silicone oil Tamponade for Retinal Detachment
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Dar El Oyoun Hospital
Glaucoma, Myopia
Corrected Measurement of the Retinal Nerve Fiber Layer Thickness by Optic Disc Configuration With the Cirrus HD OCT
Because the measurement of the retinal nerve fiber layer thickness is very sensitive to the position of measurement, it may be incorrect in patients with the tilted disc.
- Trial name
- NCT00741130
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Macular Edema, Visual Acuity
Dexamethasone-Implant for the Treatment of Macula Edema Due to Irvine Gass Syndrome
To analyze macula edema formation after cataract surgery called Irvine-Gass-Syndrome.
- Trial name
- NCT01945892
- Testing
- Ozurdex
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Neovascular Age-related Macular Degeneration
A Randomized, Double-masked, Multicenter,Sham-controlled, Safety and Efficacy Study of KH902 in Patients With Wet AMD
This study is designed to prove and confirm the efficacy and safety of multiple injections of human recombinant vascular endothelial growth factor receptor-Fc fusion protein (KH902) in patients with choroidal neovascularization…
- Trial name
- PHOENIX (NCT01436864)
- Testing
- Recombinant Human VEGF Receptor-Fc Fusion Protein
- Where
- 11 sites in China
- Volunteers
- 125 people
- Sponsor
- Chengdu Kanghong Biotech Co., Ltd.
Epiretinal Membrane
Vitrectomy Combined With Intravitreal Dexamethasone Implant for Idiopathic Epiretinal Membrane With Macular Oedema
The goal of this clinical trial is to evaluate the efficacy and safety of 25-gauge pars plana vitrectomy combined with intravitreal dexamethasone implant for the treatment of idiopathic epiretinal membrane with cystoid macular…
- Trial name
- NCT06232616
- Testing
- vitrectomy combined with intravitreal dexamethasone implant
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Type 2 Diabetes Mellitus, Non-Proliferative Diabetic Retinopathy
Blood-retinal Barrier Imaging and Neuropsychiatric Sequela in Type 2 Diabetes Mellitus
In Type 2 Diabetes mellitus patients we will: 1. quantify vasculopathy and blood-retinal barrier (BRB) leakage 2. measure blood-brain barrier (BBB) permeability and neuroanatomical changes 3.
- Conditions
- Type 2 Diabetes Mellitus, Non-Proliferative Diabetic Retinopathy, Diabetic Macular Edema
- Trial name
- NCT01107132
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Soroka University Medical Center
Diabetic Macular Edema, Neovascular (Wet) Age-Related Macular Degeneration
Effectiveness of Multidisciplinary Protocolised Interventions on IVT Non-adherence Rates
The purpose of this research study is to test whether a personalised care approach improves adherence compared to standard care.
- Conditions
- Diabetic Macular Edema, Neovascular (Wet) Age-Related Macular Degeneration, Intravitreal Injection
- Trial name
- ADHERE (NCT07567898)
- Testing
- multidisciplinary protocolized intervention (MPI), Routine medical care & monitoring
- Volunteers
- 200 people
- Sponsor
- Singapore Eye Research Institute
Neuronal Ceroid Lipofuscinosis Type 2
Intravitreal ERT to Prevent Retinal Disease Progression in Children With CLN2
This is a phase I/II randomized, masked, clinical trial to determine the safety and efficacy of intravitreal administration of cerliponase alfa.
- Trial name
- NCT05152914
- Testing
- Cerliponase Alfa
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- David L Rogers, MD
Retinal Detachment
Clinical Investigation of the Safety and Effectiveness of the ABV-1701 Ocular Endotamponade (OE)
A Prospective Multi-Site Open Label Randomized Controlled Clinical Investigation of the Safety and Effectiveness of the ABV-1701 Ocular Endotamponade (OE)
- Trial name
- NCT05414747
- Testing
- ABV-1701, SF6 Gas
- Where
- 4 sites in Australia, Thailand
- Volunteers
- 40 people
- Sponsor
- BioFirst Corporation
Glaucoma, Ocular Hypertension
Implementing AI-based Glaucoma Screening Within Federally Qualified Health Centers
The goal of this clinical trial is to learn if implementation of an eye screening program at Federally Qualified Health Center (FQHC) clinics provides results that participants may have glaucoma, and/or other eye conditions…
- Trial name
- AI-RONA (NCT06629649)
- Testing
- Glaucoma screening using an AI-algorithm and screening for diabetic retinopathy, cataract, and visual acuity impairment.
- Where
- United States
- Volunteers
- 1,800 people
- Sponsor
- University of Alabama at Birmingham
Age-Related Macular Degeneration, Alzheiner's Disease
Study of Retinal Findings in People With Signs and Symptoms of Alzheimer s Disease Enrolled in 09-M-0198
Background: Alzheimer s disease affects the brain and causes memory and thinking problems in older people. Macular degeneration (MD) is an eye condition.
- Conditions
- Age-Related Macular Degeneration, Alzheiner's Disease, AMD
- Trial name
- NCT02226835
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
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