Clinical trials: Retinal Vascular Disorder
Diabetes Mellitus, Diabetic Retinopathy
Retinal Adaptation to Intensified Insulin Therapy and Bariatric Surgery in Patients With Diabetes
Retinal function is highly dependent on the glucose supply. Thus, functional adaptations occur in response to both acute and long-term changes in glycaemia.
- Trial name
- NCT01517490
- Testing
- Insulin pump, Multiple daily insulin injections, Bariatric surgery
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Retinal Vein Occlusion
Retrospective Analysis of the Clinical Characteristics of Retinal Vein Occlusion
To explore the clinical characteristics of patients with RVO, and to analyze the relationship between RVO and various underlying diseases, ocular conditions, lifestyle, imaging findings and treatment response.
- Trial name
- NCT06757595
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Zhongnan Hospital
Diabetic Retinopathy
Extension Study of Long-term Safety and Tolerability of Octreotide Acetate in Patients With Moderately Severe or Severe Non-proliferative Diabetic Retinopathy or Low Risk Proliferative Diabetic Retinopathy
This multicenter, open-label extension study will evaluate the long-term tolerability and safety for patients completing study CSMS995 0802.
- Trial name
- NCT00248131
- Testing
- Octreotide acetate in microspheres
- Volunteers
- 260 people
- Sponsor
- Novartis Pharmaceuticals
Central Retinal Vein Occlusion
Lucentis for Central Retinal Vein Occlusion (CRVO)
The purpose of this study is to determine whether ranibizumab will be effective in reducing if not eliminating the macular edema associated with the disease, central retinal vein occlusion (CRVO).
- Trial name
- NCT00406796
- Testing
- Ranibizumab
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- California Retina Consultants
Macular Edema, Central Retinal Vein Occlusion
A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Macular Edema Secondary to Central Retinal or Hemiretinal Vein Occlusion
This is a Phase III, multicenter, randomized, double-masked, active comparator-controlled, parallel-group study evaluating the efficacy, safety, and pharmacokinetics of faricimab administered by intravitreal (IVT) injection at…
- Conditions
- Macular Edema, Central Retinal Vein Occlusion, Hemiretinal Vein Occlusion
- Trial name
- COMINO (NCT04740931)
- Testing
- Faricimab, Aflibercept
- Where
- 194 sites in United States, Argentina and 20 more
- Volunteers
- 729 people
- Sponsor
- Hoffmann-La Roche
Splanchnic Vein Thrombosis, Cerebral Vein Thrombosis
DOAC in Unusual Site Venous Thrombosis
Unusual site venous thromboembolism (VTE) refers to thrombosis occurring in venous districts outside the veins of the lower extremities and the pulmonary arteries, and includes splanchnic vein thrombosis (SVT), cerebral vein…
- Conditions
- Splanchnic Vein Thrombosis, Cerebral Vein Thrombosis, Ovarian Vein Thrombosis, Renal Vein Thrombosis
- Trial name
- DUST (NCT03778502)
- Testing
- Direct Oral Anticoagulants
- Where
- 24 sites in United States, Canada and 8 more
- Volunteers
- 358 people
- Sponsor
- University of Malta
Retinal Disease, Diabetic Retinopathy
Color Fundus Photograph With Experts Labelling
This trial aims to provide a digital retinal image dataset from Pakistan, graded by three specialists according to the severity of Diabetic Retinopathy. The dataset aims to improve research and patient care.
- Trial name
- NCT06287645
- Testing
- Color Fundus Photography/Non-Mydriatic Opthalmic Cameras
- Where
- Pakistan
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Pakistan Council of Scientific and Industrial Research
Diabetic Retinopathy
AutoDx-DR Prospective Clinical Validation Study Protocol
In this study, we will prospectively evaluate the accuracy of a deep-learning based software algorithm in the detection of diabetic retinopathy from 60° wide single-field retinal fundus images.
- Trial name
- NCT04627272
- Testing
- AutoDX-DR
- Volunteers
- 1,539 people
- Sponsor
- Hill-Rom
Retinal Vein Occlusion
Retrospective Data Analysis of Patients Treated for Macular Edema Due to Central Retinal Vein Occlusion
The objective of this retrospective chart review is to evaluate drug utilization, usage patterns and indication of effectiveness Eylea in the routine clinical (real-life) management of patients who suffer from ME (Macular Edema)…
- Trial name
- RETRO CRVO (NCT02645747)
- Testing
- Aflibercept (Eylea, BAY86-5321)
- Where
- Belgium
- Volunteers
- 126 people
- Sponsor
- Bayer
Stargardt Disease, Diabetic Retinopathy
Oxidative Stress In Stargardt Disease, Age Related Macular Degeneration and Diabetic Retinopathy
In this study, markers of oxidative stress will be measured in the aqueous humour of stargardt disease, age related macular degeneration and diabetic retinopathy patients compared to controls.
- Conditions
- Stargardt Disease, Diabetic Retinopathy, Macular Degeneration (Age Related)
- Trial name
- NCT02875704
- Testing
- Anterior Chamber (AC) Tap
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Johns Hopkins University
Diabetic Retinopathy (DR), Center-Involved Diabetic Macular Edema (CI-DME)
RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Diabetic Retinopathy (DR) With and Without Center Involved-Diabetic Macular Edema (CI-DME)
ABBV-RGX-314 is being developed as a novel, potential one-time gene therapy treatment for the treatment of Diabetic Retinopathy (DR) with and without Center-Involved Diabetic Macular Edema (CI-DME).
- Trial name
- ALTITUDE® (NCT04567550)
- Testing
- ABBV-RGX-314 Dose 1, ABBV-RGX-314 Dose 2, ABBV-RGX-314 Dose 3
- Where
- 25 sites in United States
- Volunteers
- 139 people
- Sponsor
- AbbVie
Glaucoma and Ocular Hypertension, Diabetic Macular Edema
Effect of Dexamethasone Implant on Optic Disc
This study evaluates the effect of dexamethasone implant which is an intraocular corticosteroid on the optic nerve fibers. Retinal nerve fiber thicknesses and optic nerve head pitting rates were measured before and 6 months after…
- Conditions
- Glaucoma and Ocular Hypertension, Diabetic Macular Edema, Intravenous Drug Usage, Optic Disk Disorders
- Trial name
- NCT03927118
- Testing
- intravitreal dexamethasone implant application
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Macular Degeneration, Age-related Macular Degeneration
A Study To Evaluate The Safety, Tolerability And Pk Of Pazopanib Eye Drops In Healthy Adult And Elderly Subjects.
This is a two-part study to evaluate the safety, tolerability and pharmacokinetics of single (Part A) and repeat (Part B) eye drop doses of pazopanib in healthy adult and elderly subjects.
- Trial name
- NCT00463320
- Testing
- Pazopanib eye drops and Allergen Refresh Plus eye drops
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Age-Related Macular Degeneration, Diabetic Retinopathy
Defining Retinal Structures Using Hyperspectral Retinal Imaging
This study evaluates hyperspectral retinal imaging as a novel, non-invasive imaging technique to characterise retinal and optic nerve structures in healthy individuals and patients with eye disease.
- Conditions
- Age-Related Macular Degeneration, Diabetic Retinopathy, Glaucoma, Retinal Diseases
- Trial name
- NCT07555574
- Testing
- Hyperspectral camera
- Where
- Australia
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Center for Eye Research Australia
Diabetic Retinopathy
ARTIFICIAL INTELLIGENCE FOR MASS SCREENING OF THE DIABETIC RETINOPATHY IN THE CHERNIVTSI REGION (Pilot Study)
The purpose of this study is to create a patient-centric environment for early detection of DR with AI-driven solutions.
- Trial name
- AIMDR (NCT06112691)
- Testing
- taking fundus photos using non-mydriatic fundus camera - FundusScope Rodenstock
- Where
- Ukraine
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- The Filatov Institute of Eye Diseases and Tissue Therapy
Vasculopathy, Retinal, With Cerebral Leukodystrophy, Cerebroretinal Vasculopathy, Hereditary
Aclarubicin for the Treatment of Retinal Vasculopathy With Cerebral Leukodystrophy
The goal of the investigator is to utilize Aclarubicin to treat patients with Retinal Vasculopathy with Cerebral Leukodystrophy (RVCL), a rare and devastating genetic disease with no available specific treatment.
- Trial name
- RVCL (NCT02723448)
- Testing
- aclarubicin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Washington University School of Medicine
Glaucoma, Diabetic Retinopathy
Glaucoma Algorithm Validation Study in African Population - the MAGIC Study
Artificial Intelligence (AI) algorithms require validation in a variety of populations to ensure widespread clinical applicability.
- Trial name
- MAGIC (NCT06552247)
- Testing
- Fundus Picture AI testing
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centro Hospitalar Universitário Lisboa Norte
Optical Coherence Tomography, Diabetic Retinopathy
A Longitudinal Study of Choroidal Changes After Cataract Surgery in Eyes With Diabetic Retinopathy
To determine the influence of phacoemulsification on choroidal vasculature in patients with diabetic retinopathy (DR) undergoing cataract surgery
- Conditions
- Optical Coherence Tomography, Diabetic Retinopathy, Choroid
- Trial name
- NCT04499768
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Ruijin Hospital
Hypertension
Effect of Losartan on Retinal Endothelial Function in Patients With Essential Hypertension
Essential hypertension is commonly associated with impaired endothelial function. The retinal vasculature is morphologically and functionally related to the cerebral vessels because of the common origin from the internal carotid…
- Trial name
- NCT00152633
- Testing
- Losartan, Metoprolol
- Where
- Germany
- Sponsor
- University of Erlangen-Nürnberg Medical School
Diabetic Neuropathies, Diabetic Foot
Thermal Screening for Early Diabetic Peripheral Neuropathy (DPN)
The goal of this research is to develop better tools for diagnosing illness of the feet and legs of people who have diabetes. Investigators will use thermal videos of the foot to aid in the refinement of a system designed to…
- Conditions
- Diabetic Neuropathies, Diabetic Foot, Diabetic Retinopathy
- Trial name
- NCT03069729
- Testing
- no intervention
- Where
- United States
- Volunteers
- 331 people, healthy volunteers welcome
- Sponsor
- VisionQuest Biomedical LLC
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