Clinical trials: Retinal Vascular Disorder
Diabetic Retinopathy
Prospective Trial of Dexamethasone implAnt for Treatment Naïve diabeTic Macular Edema
The purpose of the investigator's study is to evaluate the efficacy and safety profile of the pro re nata (PRN) regimen to 12 months by using intravitreal dexamethasone implant in eyes with treatment-naive diabetic macular edema…
- Trial name
- DANTE (NCT04448496)
- Testing
- Dexamethasone implant
- Where
- 7 sites in South Korea
- Volunteers
- 49 people
- Sponsor
- Yeungnam University College of Medicine
Diabetic Retinopathy
Correlation of Biochemical Indexes and Retinal Hemodynamic in Patients With Different Degrees of Diabetic Retinopathy
All OCTA data and biochemical indexes of diabetic patients were acquired. A prediction model of diabetic retinopathy was built, and the random forest method was used to identify sensitive indicators.
- Trial name
- NCT05902650
- Testing
- imaging
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Mingzhe Cao
Diabetic Retinopathy
MONITORING OF MODERATE DIABETIC RETINOPATHY BY TELE-EXPERTISE
The aim of this study is to evaluate the monitoring of moderate diabetic retinopathy by tele-expertise
- Trial name
- TELERETINODIAB (NCT03437018)
- Testing
- moderate diabetic retinopathy follow-up by tele-expertise
- Where
- France
- Volunteers
- 97 people
- Sponsor
- Centre Hospitalier Sud Francilien
DIABETES MELLITUS, DIABETIC RETINOPATHY
Contrast Sensitivity and Diabetic Macular Edema
Contrast sensitivity is a tool use to evaluate the visual function in all patients. It can be modified by different pathologies or by age.
- Conditions
- DIABETES MELLITUS, DIABETIC RETINOPATHY, MACULAR EDEMA
- Trial name
- NCT02217306
- Where
- Mexico
- Volunteers
- 132 people
- Sponsor
- Hospital Juarez de Mexico
Central Retinal Vein Occlusion
Bevacizumab for Central Retinal Vein Occlusion Study
Central retinal vein occlusion is a leading cause of severe visual impairment. Until now, no treatment has been available to improve visual acuity.
- Trial name
- NCT00906685
- Testing
- bevacizumab
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Anders Kvanta
Central Retinal Artery Occlusion
A Study of the Efficacy and Safety of KUS121 in Participants With Acute Non-Arteritic Central Retinal Artery Occlusion (CRAO)
Central retinal artery occlusion (CRAO) is an ophthalmologic emergency which leads to severe and permanent vision loss. There is no evidence-based therapy for CRAO.
- Trial name
- GION (NCT06178055)
- Testing
- KUS121 high dose, KUS121 low dose
- Where
- 11 sites in United States
- Volunteers
- 17 people
- Sponsor
- Kyoto Drug Discovery and Development Co., Ltd.
Diabetic Retinopathy, Diabetic Macular Edema
Adaptive Optics for Ophthalmic Technologies
This is a feasibility study to assess the use of wide field adaptive optics optical coherence tomography (WF-AO-OCT) to determine whether there are structural differences in the peripheral retina in participants diagnosed with…
- Trial name
- NCT02826655
- Testing
- WF-AO-OCT
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Duke University
Vessels; Anomaly
Analysis of Retinal Vessel Pulsations With Electrocardiographic Gating
Analysis of Retinal Vessel Analyzer (RVA) recordings of retinal vessel pulsations, and putting them in context of intraocular pressure (IOP) pulsations by means of electrocardiographic (ECG) gating, in order to determine the lead…
- Trial name
- NCT04709809
- Testing
- Retinal Vessel Analyzer recordings with electrocardiographic (ECG) gating
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Diabetic Retinopathy
Simple, Mobile-based Artificial Intelligence AlgoRithms in the Detection of Diabetic ReTinopathy (SMART) Study
This is an observational cross sectional study aimed to evaluate the performance of the artificial intelligence algorithm in detecting any grade of diabetic retinopathy using retinal images from patients with diabetes.
- Trial name
- SMART (NCT03572699)
- Testing
- diabetic retinopathy
- Where
- India
- Volunteers
- 900 people
- Sponsor
- Medios Technologies Pte. Ltd
Age-related Macular Degeneration, Neovascular Age-related Macular Degeneration
A 3-month Study to Assess the Safety of ONS-5010 in Subjects With Visual Impairment Due to Retinal Disorders
The study will evaluate the safety of ophthalmic bevacizumab in subjects diagnosed with a retinal condition that would benefit from treatment with intravitreal injection of bevacizumab, including: exudative age-related macular…
- Conditions
- Age-related Macular Degeneration, Neovascular Age-related Macular Degeneration, Wet Macular Degeneration, BRVO - Branch Retinal Vein Occlusion
- Trial name
- NCT04516278
- Testing
- bevacizumab
- Where
- 20 sites in United States
- Volunteers
- 197 people
- Sponsor
- Outlook Therapeutics, Inc.
Diabetic Macular Edema, Retinal Disease
Assess the Efficacy and Safety of Repeat Intravitreal Injections of Foselutoclax (UBX1325) in Patients With DME (ASPIRE)
The goal of this clinical trial is to assess the efficacy and safety of multiple doses of foselutoclax (UBX1325) in patients with Diabetic Macular Edema.
- Conditions
- Diabetic Macular Edema, Retinal Disease, Macular Edema, Diabetes Mellitus
- Trial name
- NCT06011798
- Testing
- Aflibercept, foselutoclax
- Where
- 19 sites in United States
- Volunteers
- 52 people
- Sponsor
- Unity Biotechnology, Inc.
Retinal Vein Occlusion, Macular Oedema
Retrospective Data Collection Study in Patients Receiving Two or More OZURDEX® Injections for Macular Oedema Secondary to Retinal Vein Occlusion
The purpose of this study is to use retrospective data to evaluate the efficacy, safety and re-injection interval of OZURDEX® in the treatment of macular oedema due to retinal vein occlusion (RVO) in patients who received…
- Trial name
- NCT01566526
- Testing
- dexamethasone intravitreal implant 0.7 mg
- Where
- Belgium
- Volunteers
- 26 people
- Sponsor
- Allergan
Wet Macular Degeneration, Diabetic Macular Edema
Artificial Intelligence Diagnostic Aid
The investigators have worked with software designers to develop a software that allows us to analyse current adherence to guidelines on Ophthalmic conditions such as Age related Macular Degeneration (AMD), Diabetic Macular Edema…
- Conditions
- Wet Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion
- Trial name
- AID (NCT05675540)
- Testing
- Macusense Assessment Software
- Where
- United Kingdom
- Volunteers
- 422 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Mitochondrial Disorders, Mitochondrial Genetic Disorders
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)
The North American Mitochondrial Disease Consortium (NAMDC) maintains a patient contact registry and tissue biorepository for patients with mitochondrial disorders.
- Conditions
- Mitochondrial Disorders, Mitochondrial Genetic Disorders, Mitochondrial Diseases, Disorder of Mitochondrial Respiratory Chain Complexes
- Trial name
- NAMDC (NCT01694940)
- Where
- 17 sites in United States, Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Columbia University
Type 2 Diabetes (T2DM), Diabetic Nephropathies
A Multicenter Randomized Double-Blind Trial of Chrocare CDSS for Integrated Management of Type 2 Diabetes
This is a multicenter, randomized, double-blind, parallel-group clinical study for adults with type 2 diabetes and early diabetic kidney or retinal complications.
- Conditions
- Type 2 Diabetes (T2DM), Diabetic Nephropathies, Diabetic Retinopathy (DR)
- Trial name
- Chrocare-DM (NCT07833228)
- Testing
- AI large language model-based clinical decision support system, Standard diabetes integrated management formulated by endocrinologists
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Diabetic Macular Oedema
Near Infrared Photobiomodulation Treatment for Diabetic Macular Oedema
This pilot study aims to establish that treatment with near infrared light (NIR) reduces diabetic macular oedema in patients suffering diabetic retinopathy by exerting a positive beneficial effect at retinal cellular level.
- Trial name
- NIRD (NCT02181400)
- Testing
- Ellex Integre NIR laser
- Where
- Australia
- Volunteers
- 21 people
- Sponsor
- University of Sydney
Age-Related Macular Degeneration
Ocular, Vascular, and Genetic Findings in AMD Patients
Observation of findings associated with AMD
- Trial name
- NCT06015633
- Testing
- No intervention
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- OcuDyne, Inc.
Diabetic Retinopathy
Evaluation of Blood-retinal Barrier Functional Alterations by Optical Coherence Tomography
The purpose of this study is to identify alterations of the blood-retinal barrier (BRB) in diabetic retinas using a novel non-invasive approach based on the Fourier domain high-definition optical coherence tomograph (OCT).
- Trial name
- CNTM025A OCT (NCT01220804)
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Diabetic Macular Edema, Diabetic Retinopathy
Effect of Levosulpiride on Retinal Alterations in Patients With Diabetic Retinopathy and Diabetic Macular Edema
This is a randomized, double-blind, placebo-controlled trial to evaluate the safety and efficacy of levosulpiride to improve retinal alterations due to diabetic macular edema and diabetic retinopathy
- Trial name
- NCT03161652
- Testing
- DME lactose pill, DME levosulpiride, DR lactose pill
- Where
- 2 sites in Mexico
- Volunteers
- 120 people
- Sponsor
- Carmen Clapp
Pseudoxanthoma Elasticum, Tomography, Optical Coherence
CHOPXE - Analysis of Choriocapillaris Flow Deficits in Patients With Pseudoxanthoma Elasticum
This observational study sets out to compare choriocapillaris flow deficits between healthy control subjects and patients with pseudoxanthoma elasticum.
- Conditions
- Pseudoxanthoma Elasticum, Tomography, Optical Coherence, Retinal Disease
- Trial name
- CHOPXE (NCT07006649)
- Testing
- Opthtalmologic diagnosis tests
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
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