Clinical trials: Retinal Vascular Disorder
Neovascular Age-related Macular Degeneration (nAMD), Diabetic Macular Edema (DME)
A Phase I Study of GenSci148 Intravitreal Injection for Neovascular Age-related Macular Degeneration, Diabetic Macular Edema and Retinal Vein Occlusion
This is a Phase I, multicenter, open-label, dose-escalation study conducted in two parts to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of GenSci148 administered via intravitreal (IVT)…
- Conditions
- Neovascular Age-related Macular Degeneration (nAMD), Diabetic Macular Edema (DME), Retinal Vein Occlusion (RVO)
- Trial name
- GenSci148-101 (NCT07817615)
- Testing
- GenSci148 Injection
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Diabetes, Diabetic Retinopathy
Effects of Fenofibrate on Endothelial Progenitor Cells in Diabetes
Long-standing diabetes is often complicated by retinopathy. The mechanisms that induce the development of diabetic retinopathy are incompletely understood and include alterations in bone marrow derived vasculogenic cells called…
- Trial name
- NCT01927315
- Testing
- Fenofibrate 145 mg
- Where
- Italy
- Volunteers
- 41 people
- Sponsor
- University of Padova
Macular Degeneration
Identification and Treatment of Feeder Vessels in Macular Degeneration
This study will try to identify and treat feeder vessels in age-related macular degeneration. The macula is the part of the retina in the back of the eye that determines central or best vision.
- Trial name
- NCT00018070
- Testing
- Angiography, Laser Treatment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Eye Institute (NEI)
Diabetic Retinopathy, Vitreous Hemorrhage Due to Diabetes Mellitus
Pre-operative Vabysmo in Patients With Non-clearing Vitreous Hemorrhage Secondary to Proliferative Diabetic Retinopathy
In this phase IV, randomized, double-masked, sham-controlled study the investigators hope to determine the efficacy in peri-operative faricimab (Vabysmo) compared to sham in limiting complications from pars plana vitrectomy for…
- Trial name
- NCT06191094
- Testing
- Faricimab Injection
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Colorado, Denver
Diabetic Retinopathy
Self-testing Diagnosis Imaging Model for Diabetic Retinopathy
This is a prospective clinical study. At the Shaoguan Diabetic Eye Screening Programme, patients ages 30-80 will undergo the two diagnostic models: (1) in a remote diagnostic clinic site, patients undergo a self-testing device…
- Trial name
- NCT05223556
- Testing
- Full Self-Diagnostic device in a remote diagnostic imaging site, Human imager operated diagnostic device in the hospital
- Where
- China
- Volunteers
- 167 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Diabetes Mellitus, Diabetic Retinopathy
Multicenter RCT of Eye-Brain Imaging in Diabetes Neurovascular Coupling
This study intends to take the critical pathological mechanism of diabetic neurovascular coupling injury (NCI) as the starting point and utilize multi-modal imaging (MMI) technology of the eyes and brain as a means to conduct…
- Conditions
- Diabetes Mellitus, Diabetic Retinopathy, Cognitive Impairment, Neurovascular Coupling
- Trial name
- TCM-MMI (NCT06813274)
- Testing
- hypoglycemic treatment, Tangshen'an Granules, Ginkgo Leaf Tablets
- Where
- 3 sites in China
- Volunteers
- 160 people
- Sponsor
- Hejiang Ye
Diabetic Retinopathy
The Santa Cruz Diabetic Retinopathy Utilizing Artificial Intelligence Study
In this clinical trial, we plan to evaluate the usefulness of artificial intelligence (AI) software paired with a handheld retinal camera to compare diabetic retinopathy status in Bolivian patients as read by retina specialists…
- Trial name
- SC-DRAI (NCT03912961)
- Testing
- Picture of the retina with a handheld retinal camera
- Where
- 3 sites in Bolivia
- Volunteers
- 1,034 people
- Sponsor
- Retina Global
Non-proliferative Diabetic Retinopathy (NPDR), Diabetic Retinal Microangiopathy
A Preliminary Exploratory Clinical Trial to Evaluate the Efficacy of NPDR-01 Eye Drops in the Treatment of Non-Proliferative Diabetic Retinopathy
This study aims to explore the preliminary clinical efficacy and safety of NPDR-01 eye drops in patients with non-proliferative diabetic retinopathy (NPDR).
- Conditions
- Non-proliferative Diabetic Retinopathy (NPDR), Diabetic Retinal Microangiopathy, Retinal Microaneurysms, Diabetic Retinopathy
- Trial name
- NCT07198815
- Testing
- Investigational Eye Drops (NPDR-01)
- Volunteers
- 10 people
- Sponsor
- Sichuan Academy of Medical Sciences
Retinal Artery Occlusion, Magnetic Resonance Imaging
Pre and Post-arterial Recanalization Imaging of Central Retinal Artery Occlusions (CRAO)
Central retinal artery occlusions (CRAO) are the equivalent of an ischemic stroke at the retinal level. They share the same risk factors and common pathology.
- Conditions
- Retinal Artery Occlusion, Magnetic Resonance Imaging, Diagnosis, Etiology
- Trial name
- I-RECANAL (NCT03313817)
- Testing
- Additional MRI sequences
- Where
- France
- Volunteers
- 63 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Behcet's Disease
The Efficacy of Methylprednisolone in the Treatment of Patients With Ocular Involvement in Behcet's Disease
The goal of this study is to examine the efficacy of 1gram/day intravenous pulses of methylprednisolone on 3 consecutive days in Behcet's patients with ocular involvement.
- Trial name
- NCT01306955
- Testing
- methylorednisolone, dextrose water 5%
- Where
- Iran
- Volunteers
- 34 people
- Sponsor
- Tehran University of Medical Sciences
Diabetic Retinopathy
Intravitreal Triamcinolone Acetonide for Treatment of Refractory Diffuse Diabetic Macular Edema
Phase I/II study with intravitreal triamcinolone acetonide microspheres(RETAAC)for treatment of diffuse diabetic macular edema unresponsive to laser photocoagulation.
- Trial name
- NCT00407849
- Testing
- triamcinolone acetonide
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Federal University of São Paulo
Pigment Epithelial Detachment
iSONEP to Treat Persistent Pigment Epithelial Detachment (PED) in Subjects With Exudative Age-Related Macular Degeneration (AMD) or Polypoidal Choroidal Vasculopathy (PCV)
LT1009-Oph-002 is a Phase 1b study designed to evaluate the safety and potential efficacy of iSONEP following one, two or three injections of iSONEP, as needed, for the treatment of Pigment Epithelial Detachment (PED) secondary…
- Trial name
- PED (NCT01334255)
- Testing
- iSONEP (sonepcizumab/LT1009)
- Where
- 5 sites in United States
- Volunteers
- 12 people
- Sponsor
- Lpath, Inc.
Diabetic Macular Edema, Diabetic Retinopathy
A Phase 2 Study of Intravitreal AVD-104 in Diabetic Macular Edema
A Phase 2 study to determine the safety and preliminary efficacy of intravitreal injections of AVD-104, a novel glyco-mimetic nanoparticle, in reducing macular edema associated with diabetic retinopathy.
- Trial name
- NCT06181227
- Testing
- AVD-104
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Aviceda Therapeutics, Inc.
Neurodegenerative Disorders
Development of IPS from Donated Somatic Cells of Patients with Neurological Diseases
Human fibroblasts and possibly other human somatic cells may be reprogrammed into induced pluripotent stem (iPS) cells by the forced expression of transcription factors (1-5).
- Trial name
- NCT00874783
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Macular Edema, Retinal Vein Occlusion
Fluocinolone Acetonide Intravitreal Inserts for Vein Occlusion in Retina
This study will assess the safety and efficacy of FA Intravitreal Inserts in subjects with macular edema secondary to RVO.
- Trial name
- FAVOR (NCT00770770)
- Testing
- Fluocinolone Acetonide
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Alimera Sciences
Neovascular Glaucoma, Type 2 Diabetes
Observation of Iris Blood Flow Via OCTA in Diabetic Neovascular Glaucoma
The goal of this observational study is to quantify iris blood flow via non-invasive eye scanning for evaluating ocular lesions in adults aged 18 years and older, including healthy volunteers, patients with type 2 diabetes…
- Trial name
- NCT07722910
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Qilu Hospital of Shandong University
Diabetic Macular Edema
Suprachoroidal Injection of CLS-TA Alone or With Aflibercept in Subjects With Diabetic Macular Edema
This study is designed to demonstrate the safety and tolerability of suprachoroidal CLS-TA alone or in combination with intravitreal aflibercept in subjects with diabetic macular edema associated with diabetes mellitus.
- Trial name
- HULK (NCT02949024)
- Testing
- IVT Aflibercept, SC CLS-TA
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Clearside Biomedical, Inc.
Age-Related Macular Degeneration
Sirolimus Versus Anti-Vascular Endothelial Growth Factor (antiVEGF) for Wet AMD
Phase 2 clinical trial, single site, randomized, subject-masked study to determine safety and efficacy of intravitreal injections of Sirolimus in subjects with wet Age-Related Macular Degeneration (wet AMD) with persistent…
- Trial name
- NCT02357342
- Testing
- Sirolimus, Standard of Care intravitreal injections of anti-VEGF
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Maturi, Raj K., M.D., P.C.
Diabetes, Diabetic Retinopathy
Project Open - Use of Administrative Health Data to Increase Diabetic Retinopathy Screening
Early detection through regular diabetic retinopathy screening (DRS) is an effective method of preventing vision loss by enabling earlier intervention and timely treatment.
- Trial name
- NCT05074342
- Where
- Canada
- Volunteers
- 2,000 people
- Sponsor
- University Health Network, Toronto
Diabetic Retinopathy
Long-term Retinal Changes After Topical Citicoline Administration in Patients With Mild Signs of Diabetic Retinopathy in Type 1 Diabetes Mellitus.
Citicoline (cytidine-5'-diphosphocholine) is an essential precursor in the synthesis of phosphatidylcholine, a component of cell membranes.
- Trial name
- NCT04009980
- Testing
- OMK2 group
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione G.B. Bietti, IRCCS
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