Clinical trials: Retinal Vascular Disorder
Genetic Polymorphism, Macular Degeneration
Does Complement Factor H Gene Polymorphism Play a Role in the Regulation of Vascular Tone in the Choroid?
Age related macular degeneration (AMD) is a multifactorial disease with a strong genetic component. Most importantly a genetic polymorphism in the gene encoding for the complement factor H (CFH) has been recently identified which…
- Conditions
- Genetic Polymorphism, Macular Degeneration, Regional Blood Flow, Ocular Physiology
- Trial name
- NCT00708929
- Testing
- Squatting
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Behcet's Disease, Panuveitis
Interferon-alpha2a Versus Cyclosporin A for Severe Ocular Behcet's Disease (INCYTOB)
The purpose of this study is to investigate if interferon-alpha2a is superior to the standard treatment with cyclosporin A for the treatment of severe ocular manifestations of Behcet's disease.
- Conditions
- Behcet's Disease, Panuveitis, Posterior Uveitis, Retinal Vasculitis
- Trial name
- INCYTOB (NCT00167583)
- Testing
- Cyclosporin A, Interferon-alpha2a
- Where
- Germany
- Volunteers
- 37 people
- Sponsor
- University Hospital Tuebingen
Central Retinal Artery Occlusion
Safety and Efficacy After Selective Intra-arterial Thrombolysis for Central Retinal Artery Occlusion
Central retinal artery occlusion (CRAO) is an ophthalmic emergency which leads to devastating visual function defects and poor prognosis.
- Trial name
- NCT05562284
- Testing
- intra-arterial thrombolysis, conservative treatments
- Where
- China
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Retinal Vein Occlusion
Prospective, Non-interventional, Multi-center Post-authorization Safety Study of Eylea for Central Retinal Vein Occlusion (CRVO)
This is a prospective, non-interventional, multi center post-authorization safety study that includes patients with a diagnosis of CRVO.
- Trial name
- JPMS-CRVO (NCT02040220)
- Testing
- Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)
- Where
- Japan
- Volunteers
- 385 people
- Sponsor
- Bayer
Diabetic Retinopathy
Effect of Lipid Lowering Agents on Diabetic Retinopathy and Cardiovascular Risk of Diabetic Patients
The investigator study evaluate the effect of different lipid lowering agents on the progression of diabetic retinopathy and other reduction of cardiovascular risk of diabetic patients
- Trial name
- NCT04140201
- Testing
- Simvastatin 40mg, Fenofibrate 200mg, Omega 3 fatty acid
- Volunteers
- 80 people
- Sponsor
- Alaa Hassan ElBaz
Diabetic Retinopathy
Study of Effectiveness of Telemedicine in Identifying Diabetic Retinopathy Cases
The aim of this study is to compare the effectiveness of identifying diabetic retinopathy using tele-medicine based Digital Retinal Imaging in Diabetes Clinics with that of the conventional referral system.
- Trial name
- DRTM (NCT02085681)
- Testing
- Tele-medicine, Conventional referral
- Where
- India
- Volunteers
- 801 people
- Sponsor
- Aravind Eye Care System
Macular Edema, Diabetic
A Phase 2, Multi-Center Study To Compare The Efficacy And Safety Of A Chemokine CCR2/5 Receptor Antagonist With Ranibizumab In Adults With Diabetic Macular Edema
The study hypothesis under test is that administration of the CCR2/5 antagonist has the potential to be as effective as the current treatment options for subjects with diabetic macular edema.
- Trial name
- NCT01994291
- Testing
- Ranibizumab, PF-04634817
- Where
- 63 sites in United States, Bulgaria and 7 more
- Volunteers
- 199 people
- Sponsor
- Pfizer
Central Retinal Vein Occlusion
Lucentis for Macular Edema Associated With Central Retinal Vein Occlusion
The purpose of this study is to determine whether ranibizumab (Lucentis) will be effective in reducing if not eliminating the macular edema associated with the disease, central retinal vein occlusion (CRVO).
- Trial name
- NCT01028248
- Testing
- Ranibizumab (Lucentis)
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- California Retina Consultants
Diabetic Retinopathy
Collaborative Care for Depression and Diabetic Retinopathy in African Americans
In this feasibility/pilot study, we will develop, refine, and evaluate the feasibility of a novel mental health/ophthalmologic intervention called, "Collaborative Care for Depression and Diabetic Retinopathy" (CC-DDR), which aims…
- Trial name
- CC-DDR (NCT02121340)
- Testing
- Behavioral Activation
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Thomas Jefferson University
Central Retinal Vein Occlusion
The Effectiveness of Intravitreal Avastin Injection for CRVO
to determine the effectivness of intravitreal avastin injection on visual acuity on people that suffer from central retinal vein occlusion
- Trial name
- NCT01678248
- Where
- Israel
- Volunteers
- 68 people
- Sponsor
- Ziv Hospital
Diabetic Retinopathy
Evaluation of Progression of Diabetic Retinopathy With Rapid Correction of Hyperglycemia
The investigators are doing this research for two reasons. The first is to see how the retina (back of your eye) changes when your blood sugar is treated with medication for the first time.
- Trial name
- NCT02326259
- Testing
- Initiation of treatment of diabetes
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Temple University
Macular Degeneration
Evaluation of Physician and Patient Knowledge of Safety and Safe Use Information for Aflibercept
The study will be an observational, cross-sectional study of knowledge, understanding, and self-reported behavior among a sample of physicians and patients with recent aflibercept experience in a total of up to five European…
- Trial name
- NCT02615496
- Testing
- Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)
- Where
- 5 sites in France, Germany and 3 more
- Volunteers
- 716 people
- Sponsor
- Bayer
Diabetic Retinopathy
OCTA in Epivascular Glia After Dex Implant
The aim of this prospective study was for the first time, to analyze specific morphologic features in diabetic eyes with macular oedema, such as changes of the foveal avascular zone and the presence of epivascular glia, and see…
- Trial name
- NCT05600179
- Testing
- Dexamethasone intravitreal implant
- Where
- Italy
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Federico II University
Diabetic Retinopathy, Diabetic Macular Edema
Intravitreal Triamcinolone Acetonide for Diabetic Macular Edema
Efficacy duration of triamcinolone acetonide (steroid) for treatment of diabetic macular edema. Furthermore, dosage dependency of triamcinolone acetonide comparing a high dosage versus a low dosage.
- Trial name
- NCT00476918
- Testing
- Intravitreal injection (triamcinolone acetonide)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Heidelberg University
Retinal Vein Occlusion, Macular Edema
Bevacizumab Versus Ranibizumab in Treatment of Macular Edema From Vein Occlusion
Antagonists of the vascular endothelial growth factor (VEGF) pathway are effective in treating macular edema resulting from retinal vein occlusion (RVO).
- Trial name
- CRAVE (NCT01428388)
- Testing
- Intravitreal injection of bevacizumab, Intravitreal injection of ranibizumab (0.5 mg per dose)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Barnes Retina Institute
Type2 Diabetes, Diabetic Retinopathy
Tangningtongluo Tablet in the Treatment of Non-proliferative Diabetic Retinopathy
This trial is planned to collect relevant clinical data to evaluate the prevention efficacy and safety of Tangningtongluo tablets on the non-proliferation period of diabetic retinopathy.
- Trial name
- NCT05007262
- Testing
- Tangningtongluo tablets, Calcium dobesilate capsules
- Where
- 13 sites in China
- Volunteers
- 240 people
- Sponsor
- Guizhou Bailing Group Pharmaceutical Co Ltd
Type 2 Diabetes Mellitus
Shiga Progression of Diabetes, Nephropathy and Retinopathy
The purpose of this study is to investigate whether the oral anti-diabetic drug, Thiazolidine (TZD) is effective in suppression of onset or progressin of diabetic nephropathy in Japanese type 2 diabetic patients.
- Trial name
- SHIP-DINER (NCT00846716)
- Testing
- Pioglitazone add on to SU or biguanide, SU or Biguanide
- Where
- Japan
- Volunteers
- 400 people
- Sponsor
- Shiga University
Cardiovascular Abnormalities, Vascular Diseases
Correlating the Measure of Retinal Vascular Density Through Angio-OCT with Calcium Score
Recent case-control studies have proven that the retinal vascularization mirrors the cardiac vascularization: more the coronary network is altered, more the density of retinal vessels is reduced.
- Conditions
- Cardiovascular Abnormalities, Vascular Diseases, Retinal Vascular
- Trial name
- ANOSCA (NCT05624255)
- Testing
- Ophthalmologic consultation
- Where
- France
- Volunteers
- 101 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Macular Degeneration, Diabetic Retinopathy (DR)
Artificial Intelligence-assisted Diagnosis in Ophthalmology
This is a retrospective, multicenter, observational study designed to develop and validate an artificial intelligence (AI) system capable of detecting and classifying major ophthalmic diseases (glaucoma, cataract, diabetic…
- Conditions
- Macular Degeneration, Diabetic Retinopathy (DR), Glaucoma, Keratoconus
- Trial name
- AI-OPHTH-CR (NCT07497815)
- Testing
- No interventions
- Where
- 2 sites in Costa Rica
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Marisse Masis-Solano
Diabetic Retinopathy, Type 2 Diabetes Mellitus
The Relationship Between Advanced Glycation Endproducts and Diabetes
The overall purpose of this COMIRB application is to perform a cross-sectional pilot study to aid in the design of a prospective epidemiologic study for an NIH grant application.
- Trial name
- NCT02662010
- Where
- United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver