Clinical trials: Retinal Vascular Disorder
Diabetic Retinopathy, Artificial Intelligence
Screening for Diabetic Retinopathy in Pharmacies With Artificial Intelligence Enhanced Retinophotography
Diabetic retinopathy is frequent, potentially severe with visual threat, health costly and represents a major public health problem.
- Conditions
- Diabetic Retinopathy, Artificial Intelligence, Diabetes Mellitus
- Trial name
- DIABeyeIA (NCT05452993)
- Testing
- Analysed Retinophotography
- Where
- France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Caen
Branch Retinal Vein Occlusion
Evaluation of the Usefulness of a PRN Regimen Using Ranibizumab for Macular Edema Due to Branch Retinal Vein Occlusion
Monthly intravitreal ranibizumab (IVR) during the first 6 month had great effect for macular edema with branch retinal vein occlusion (BVO) both in visual and anatomical outcome.
- Trial name
- NCT02478515
- Testing
- Ranibizumab
- Where
- Japan
- Volunteers
- 27 people
- Sponsor
- Nagoya City University
Wet Macular Degeneration, Diabetic Macular Edema
Artificial Intelligence Diagnostic Aid
The investigators have worked with software designers to develop a software that allows us to analyse current adherence to guidelines on Ophthalmic conditions such as Age related Macular Degeneration (AMD), Diabetic Macular Edema…
- Conditions
- Wet Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion
- Trial name
- AID (NCT05675540)
- Testing
- Macusense Assessment Software
- Where
- United Kingdom
- Volunteers
- 422 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Diabetic Retinopathy
Performance of the Electroretinogram, Performed and Interpreted by an Advanced Practice Nurse, in the Screening for Diabetic Retinopathy.
Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus and the leading cause of preventable blindness in working-age individuals. Early screening for DR is a public health issue.
- Trial name
- ERGDIAB (NCT06782997)
- Testing
- Electroretinogram
- Where
- France
- Volunteers
- 270 people
- Sponsor
- CHU de Reims
Central Retinal Vein Occlusion
Intravitreal Bevasizumab Versus Intravitreal Triamcinolone in Central Retinal Vein Occlusion (CRVO)
This randomized clinical trial is conducted to evaluate the effect of three intravitreal injections of bevasizumab versus two intravitreal injections of triamcinolone in acute central retinal vein occlusion.
- Trial name
- NCT01178697
- Testing
- Bevasizumab, Triamcinolone Acetonide
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Retinal Artery Occlusion, Fibrinolysis
EAGLE - Multicenter Study of the European Assessment Group for Lysis in the Eye
The aim of the EAGLE Study is to compare the efficacy of conservative medical treatment and local intraarterial fibrinolysis in patients with central retinal artery occlusion and to evaluate benefit and risk for the patient of…
- Conditions
- Retinal Artery Occlusion, Fibrinolysis, Visual Acuity, Stroke
- Trial name
- EAGLE (NCT00637468)
- Testing
- Intravenous injection of heparin, Intravenous injection of acetazolamide, Local intra-arterial fibrinolysis
- Where
- 21 sites in Austria, Germany and 1 more
- Volunteers
- 84 people
- Sponsor
- University Hospital Freiburg
Diabetic Retinopathy (DR)
To Evaluate the Efficacy and Safety of N-acetyl Cysteine Administration in Patients With Diabetic Retinopathy
N-acetylcysteine (NAC) emerges as a crucial factor in mitigating oxidative stress and inhibiting vascular endothelial activation in diabetic patients, through its effect on VEGF expression as VEGF is involved in the development…
- Trial name
- NCT07634991
- Testing
- N Acetyl cysteine, 1200mg (high dose)
- Where
- 2 sites in Egypt
- Volunteers
- 76 people
- Sponsor
- Ain Shams University
Diabetic Retinopathy
Artificial Intelligence for Diagnosing Diabetic Retinopathy in Primary Care
This is a clinical trial to evaluate the effects of universal screening for diabetic retinopathy (DR) and diabetic macular edema (DME) using artificial intelligence (AI) in the interpretation of fundus photographs obtained by…
- Trial name
- AID-DR (NCT07236879)
- Testing
- Mobile retinography interpreted by artificial intelligence, Mobile retinography interpreted by ophthalmologists
- Where
- Brazil
- Volunteers
- 922 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Diabetic Retinopathy
Analysis of Risk Factors of Diabetic Retinopathy
The aim of the study is to analyse the risk factors involved in the development of diabetic retinopathy.
- Trial name
- NCT06154746
- Testing
- slit lamb & OCT
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Diabetic Retinopathy
Video-based Patient Education Intervention for Diabetic Eye Screening in Latinx Communities
An online survey (n=1,500) and 4 focus groups will be conducted with Latinx patients with diabetes (n=20) to obtain preliminary data regarding whether and how patient and clinician video testimonial interventions (n=6) increase…
- Trial name
- NCT06257082
- Testing
- Online Survey
- Where
- United States
- Volunteers
- 1,526 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Diabetic Retinopathy
A Multi-center Study on the Artificial Intelligence Enabled Diabetic Retinopathy Screening Based on Fundus Images
Early detection and intervention of diabetic retinopathy (DR) is critical in preventing DR-related vision loss among type 1 (T1DM) and type 2 diabetic mellitus (T2DM) patients, currently estimated at over 100 million in China…
- Trial name
- NCT03602989
- Testing
- AI-enabled Diabetic Retinopathy Screening Software
- Where
- 3 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Shenzhen SiBright Co., Ltd.
Cataract, Refractive Error
Community-Based Eye Screening With Structured Referral Tracking for Preventing Avoidable Blindness in Adults in Rawalpindi, Pakistan
This cluster randomized controlled trial aims to evaluate the effectiveness of a Structured Referral Tracking (SRT) intervention in improving referral completion among adults identified with avoidable blindness during…
- Conditions
- Cataract, Refractive Error, Diabetic Retinopathy
- Trial name
- SIGHT (NCT07611682)
- Testing
- Structured Referral Tracking (SRT)
- Where
- Pakistan
- Volunteers
- 500 people
- Sponsor
- Health Services Academy, Islamabad, Pakistan
Age-related Macular Degeneration, Coronary Artery Disease
Ranibizumab and the Risk of Arterial Thromboembolic Events
The investigators assume that ranibizumab might be dangerous in patients with history of coronary artery disease or cerebrovascular events.
- Conditions
- Age-related Macular Degeneration, Coronary Artery Disease, Cerebrovascular Disorders
- Trial name
- RATE (NCT01319188)
- Testing
- 0.5 mg of ranibizumab, 0.5 mg of ranibizumab + photodynamic therapy
- Where
- 2 sites in Netherlands, Russia
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Ural State Medical University
Intracranial Atherosclerosis
ICAS Screen Based on RIC
Intracranial atherosclerosis stenosis (ICAS) is a leading cause of ischemic stroke worldwide and increase the global burden of stroke, especially in the Asian population.
- Trial name
- RICAS (NCT06610578)
- Testing
- fundus imaging
- Where
- China
- Volunteers
- 2,100 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Macular Edema, Branch Retinal Vein Occlusion
REtinal Vein OccLUsion Treatment With Scatter Laser Guided by UWFA in combiNAtion With Ranibizumab Study
Branch retinal vein occlusion is a leading cause of vision loss. Treatment with ranibizumab (vascular endothelial growth factor (VEGF) inhibitor) on a monthly basis has been associated with improved vision results.
- Trial name
- Revolution (NCT01247220)
- Testing
- Ranibizumab, Peripheral Laser
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Retina Associates of Florida, P.A.
Diabetic Eye Diseases, Diabetic Retinopathy
Shanghai Diabetic Eye Study in Diabetics
The purpose of the Shanghai Diabetic Eye Study (SDES) was to guide and regulate eye health screening of two hundred thousand people with diabetes in the communities in 16 districts in Shanghai, build up the ranks with the general…
- Trial name
- SDES (NCT03579797)
- Testing
- Screening, referral, follow-up and health management
- Where
- China
- Volunteers
- 200,000 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Diabetic Retinopathy, Diabetes Mellitus, Type 2
Confronting Unequal Eye Care in Pennsylvania
Pt. 1 Diabetic retinopathy is a common eye condition among diabetic adults and can lead to severe vision impairment and even blindness.
- Conditions
- Diabetic Retinopathy, Diabetes Mellitus, Type 2, Glaucoma
- Trial name
- NCT01179555
- Testing
- Behavioral Activation, Supportive Therapy
- Where
- 3 sites in United States
- Volunteers
- 206 people
- Sponsor
- Wills Eye
Diabetes Mellitus, Diabetic Retinopathy
Retinal Adaptation to Intensified Insulin Therapy and Bariatric Surgery in Patients With Diabetes
Retinal function is highly dependent on the glucose supply. Thus, functional adaptations occur in response to both acute and long-term changes in glycaemia.
- Trial name
- NCT01517490
- Testing
- Insulin pump, Multiple daily insulin injections, Bariatric surgery
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Diabetic Retinopathy
Green Laser Photocoagulation Study in Proliferative Diabetic Retinopathy
To Demonstrate that indigenous green laser produces similar treatment effect on the retina when compared with already available green laser.
- Trial name
- NCT00355680
- Testing
- Green Laser (Aurolas, Aurolab), Green Laser (Iridex)
- Where
- India
- Volunteers
- 24 people
- Sponsor
- Aurolab
Diabetic Retinopathy, Retinal Diseases
Intravitreal Ranibizumab Combined With Panretinal Photocoagulation in Patients With Proliferative Diabetic Retinopathy
To evaluate the efficacy of combination therapy with ranibizumab (RBZ) and panretinal photocoagulation (PRP) versus PRP alone in patients with treatment-naive bilateral proliferative diabetic retinopathy (PDR) as measured by mean…
- Conditions
- Diabetic Retinopathy, Retinal Diseases, Eye Diseases, Diabetic Angiopathies
- Trial name
- NCT01746563
- Testing
- Ranibizumab, Laser therapy
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
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