Clinical trials: Retinopathy, Diabetic
Glaucoma, Diabetic Retinopathy
Uptake of Comprehensive Eye Examination Trial
1. To evaluate a educational intervention promoting acceptance of comprehensive eye examination in rural Guangdong. 2. To evaluate the impact of acceptance of comprehensive eye examination in rural Guangdong.
- Trial name
- NCT01743781
- Testing
- video
- Where
- China
- Volunteers
- 459 people
- Sponsor
- Sun Yat-sen University
Diabetic Macular Edema, Obstructive Sleep Apnea
Obstructive Sleep Apnea and Diabetic Macular Edema Inflammatory Mediators
Obstructive sleep apnea (OSA) is characterized by intermittent nocturnal hypoxemia, frequent arousals, fragmented sleep and daytime sleepiness.
- Conditions
- Diabetic Macular Edema, Obstructive Sleep Apnea, Diabetic Retinopathy
- Trial name
- NCT04648618
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Uptown Eye Specialists
Diabetic Macular Edema
Pilot Study for the Evaluation of Intravitreal Infliximab in the Treatment of Diabetic Macular Edema
The purpose of this study is to determine if intravitreal infliximab is a safe and effective treatment for macular edema secondary to diabetes.
- Trial name
- NCT00959725
- Testing
- Infliximab (intravitreal, 2.0mg/0.05ml)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Retinal Disease
Evaluation and Treatment of Patients With Retinal Disease
This study offers evaluation and treatment for patients with certain diseases of the retina (the layer of light-sensitive tissue that lines the inside of the eyeball).
- Trial name
- NCT00005784
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Eye Institute (NEI)
Diabetic Macular Edema, Sleep Apnea
Diabetic Macular Edema - Obstructive Sleep Apnea Relationship Study
The purpose of this study is to evaluate the relationship between DME and obstructive sleep apnea (OSA). OSA impacts millions of North Americans, many of whom are undiagnosed.
- Conditions
- Diabetic Macular Edema, Sleep Apnea, Non Proliferative Diabetic Retinopathy
- Trial name
- DME-OSA (NCT03597815)
- Testing
- Aflibercept 40 MG/ML [Eylea], OSA diagnostic test - overnight sleep study, CPAP therapy for OSA positive patients
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Uptown Eye Specialists
Epiretinal Membrane, Macular Hole
Association of Lutein, Zeaxanthin and Brilliant Blue in Chromovitrectomy
The aim of this study is to test the efficacy of the combination of dye Lutein, Zeaxanthin and brilliant blue to stain the internal limiting membrane as well as the epiretinal membranes during the Vitrectomy surgery.
- Conditions
- Epiretinal Membrane, Macular Hole, Proliferative Diabetic Retinopathy
- Trial name
- NCT01627977
- Testing
- Dye of Lutein, Zeaxanthin and Brilliant Blue
- Where
- Brazil
- Volunteers
- 18 people
- Sponsor
- Federal University of São Paulo
Diabetic Retinopathy
Correlation Between Macular Ischemia and Peripheral Ischemia in Patients With Diabetes
The contribution of OCT- angiography (OCT-A) allows to consider, in a more or less long term, a drastic reduction in the use of fluorescein angiographies in diabetic retinopathy.
- Trial name
- CORISMAP (NCT02876744)
- Testing
- ophthalmologic examination
- Where
- France
- Volunteers
- 101 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Diabetic Non-proliferative Retinopathy, Type2 Diabetes
Clinical Study of Tang Wang Prescription Intervene Diabetic Non-proliferative Retinopathy
This study include 384 Participants with diabetic non-proliferative retinopathy Design Method: Randomized, double blind, placebo controlled and multicenter clinical study.
- Trial name
- NCT03025399
- Testing
- Tangwang prescription
- Volunteers
- 384 people
- Sponsor
- Fengmei Lian
Diabetic Retinopathy
Camera Qualification Study
A multi-center study to evaluate the performance of an automated device for the detection of diabetic retinopathy with the use of an additional fundus camera with IDx-DR.
- Trial name
- NCT05808699
- Testing
- handheld fundus camera
- Where
- 9 sites in United States
- Volunteers
- 626 people
- Sponsor
- Digital Diagnostics, Inc.
Diabetic Retinopathy, DR, Diabetic Mellitus
Efficacy and Safety of AEYE Diagnostic Screening (AEYE-DS) Software Device for Detection of Diabetic Retinopathy From Digital Funduscopic Images
The goal of this clinical trial is to learn about the performance of the AEYE-DS Software Device to automatically detect more than mild Diabetic Retinopathy (mtmDR) in adult participants diagnosed with Diabetic Mellitus (DM)…
- Trial name
- NCT06241664
- Testing
- AEYE-DS Software
- Where
- United States
- Volunteers
- 601 people
- Sponsor
- AEYE Health Inc
Intraocular Inflammation, Suspected Endophthalmitis
A Study of the Incidence of Intraocular Inflammation and Suspected Endophthalmitis Among Patients Treated With Aflibercept, Vial and Pre-filled Syringe, 2014-2022
Specific study objectives include: To describe patient and provider characteristics for aflibercept patients and aflibercept user injections by aflibercept dispensing device, overall, and stratified by time (quarterly, annually).
- Trial name
- NCT05791695
- Testing
- Non Applicable
- Where
- United States
- Volunteers
- 155,413 people
- Sponsor
- Regeneron Pharmaceuticals
Proliferative Diabetic Retinopathy, Diabetic Macular Edema
Effect of Macugen(Pegaptanib)on Surgical Outcomes and VEGF Levels in Diabetic Patients With PDR (Diabetic Retinopathy or CSDME (Macular Edema)
Patients with proliferative diabetic retinopathy or clinically significant diabetic macular edema requiring surgical intervention will receive a pre-operative injection of Macugen.
- Trial name
- PEGAP001 (NCT00446381)
- Testing
- Macugen (pegaptanib)
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Diabetic Retinopathy
Assessment of EyeArt Performance With Retinal Cameras
The study evaluates the performance of the EyeArt system for detecting diabetic retinopathy from images captured using retinal cameras and operators.
- Trial name
- NCT04984200
- Testing
- Retinal imaging, Mydriatic Agent
- Where
- United States
- Volunteers
- 246 people
- Sponsor
- Eyenuk, Inc.
Neovascular (Wet) Age-related Macular Degeneration
Observation of Treatment Patterns With Lucentis® in Real-life Conditions in All Approved Indications
This study is designed as an observational, non-interventional, multicenter, open label, single arm study in patients being treated with Lucentis® for any approved indication included in the local product posology.
- Trial name
- PACIFIC (NCT04847895)
- Testing
- Lucentis
- Where
- 175 sites in Germany, Netherlands and 1 more
- Volunteers
- 5,500 people
- Sponsor
- Novartis Pharmaceuticals
Severe Diabetic Retinopathy, Central Retinal Vein Occlusion
Treatment of Rubeosis Iridis With Open-Label Anecortave Acetate Sterile Suspension ( 15 mg.).
To provide use of Anecortave Acetate Sterile Suspension of 15mg for a series of five patients with rubeosis iridis. Rubeosis iridis refers to neovascularization of the iris.
- Conditions
- Severe Diabetic Retinopathy, Central Retinal Vein Occlusion, Chronic Inflammation, Infectious Diseases
- Trial name
- NCT00211471
- Testing
- anecortave acetate
- Where
- United States
- Sponsor
- Manhattan Eye, Ear & Throat Hospital
Diabetes Mellitus, Macular Edema
Intravitreal Aflibercept Injection in Vision Impairment Due to DME
To determine the efficacy of intravitreally (IVT) administered VEGF Trap-Eye on the best-corrected visual acuity (BCVA) assessed by the early treatment diabetic retinopathy study (ETDRS) chart in subjects with diabetic macular…
- Trial name
- VIVID-DME (NCT01331681)
- Testing
- VEGF Trap-Eye (BAY86-5321), Macular Laser Photocoagulation (Control)
- Where
- 73 sites in Australia, Austria and 9 more
- Volunteers
- 406 people
- Sponsor
- Bayer
Diabetic Macular Oedema
Quantification of Rising the Osmotic Pressure in Diabetic Intraretinal Fluid Accumulation (Diabetic Macular Oedema)
Diabetic macular oedema is characterized by fluid accumulation in the retinal tissue from leaking retinal vessels, the capillaries. This state can lead to severe visual loss and blindness.
- Trial name
- NCT00333671
- Testing
- Glycerol
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Diabetic Retinopathy, Diabetic Retinopathy Associated with Type 2 Diabetes Mellitus
Early Retinal Neurodegeneration As Risk Factor, Biomarker and Pharmacological Target of Diabetic Retinopathy
Despite the evidence that diabetic retinopathy (DR) remains the first cause of blindness among the working-age population, it lacks a specific preventive treatment.
- Trial name
- 2022-12376008 (NCT06582472)
- Testing
- Ophthalmological examination including imaging assessments, confocal analysis of cornea, Dynamic Vessel Analyzer (DVA)
- Where
- 2 sites in Italy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- IRCCS Ospedale San Raffaele
Macular Edema
A Study to Evaluate an Updated Dexamethasone Intravitreal (Into the Eye) Applicator in Adult Participants With Macular Edema Due to Diseases of the Retina
The Dexamethasone Posterior Segment Drug Delivery System (DEX PS DDS) Applicator is used to deliver an implant with medicine to the eye. AbbVie is updating the DEX PS DDS Applicator.
- Trial name
- NCT04976777
- Testing
- Updated DEX PS DDS Applicator, Approved DEX PS DDS Applicator, Dexamethasone
- Where
- 7 sites in United States
- Volunteers
- 54 people
- Sponsor
- AbbVie
Type 1 Diabetes Mellitus
Endothelial Dysfunction and Diabetes
The aim of the study is to progress in the understanding of the early retinal vascular and neural abnormalities in patients with diabetes, using a new device, the Dynamic Vessel Analyzer.
- Trial name
- DENDI (NCT01097551)
- Testing
- Trinitrin, Neosynephrine 10% collyrium, Iontophoresis with acetylcholine delivery
- Where
- France
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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