Clinical trials: Retinopathy, Diabetic
Retinitis Pigmentosa, Maculopathy, Age Related
High Resolution Retina Imaging
To increase the clinical experience of using the rtx1 camera in various retinal disorders and to follow the evolution of structural alterations during retinal diseases using adaptive optics imaging with the rtx1 camera
- Conditions
- Retinitis Pigmentosa, Maculopathy, Age Related, Macular Dystrophy, Macular Edema
- Trial name
- IHR (NCT04128150)
- Where
- 3 sites in France
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Diabetes Mellitus, Diabetic Retinopathy
Retinal Adaptation to Intensified Insulin Therapy and Bariatric Surgery in Patients With Diabetes
Retinal function is highly dependent on the glucose supply. Thus, functional adaptations occur in response to both acute and long-term changes in glycaemia.
- Trial name
- NCT01517490
- Testing
- Insulin pump, Multiple daily insulin injections, Bariatric surgery
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Retinal Diseases
Efficacy of Ranibizumab Therapy With Aflibercept in Patients With Diabetic Macular Edema
The purpose of this study in to compare the efficacy of treatment of diabetic macular edema (DME) using Ranibizumab (Lucenti®), Aflibercept (Eylea®) and Aflibercept (Eylea®) plus Ranibizumab (Lucentis®).
- Trial name
- NCT02646670
- Testing
- Ranibizumab, Aflibercept, Ranibizumab and Aflibercept
- Volunteers
- 20 people
- Sponsor
- Instituto de Olhos de Goiania
Diabetic Retinopathy
Extension Study of Long-term Safety and Tolerability of Octreotide Acetate in Patients With Moderately Severe or Severe Non-proliferative Diabetic Retinopathy or Low Risk Proliferative Diabetic Retinopathy
This multicenter, open-label extension study will evaluate the long-term tolerability and safety for patients completing study CSMS995 0802.
- Trial name
- NCT00248131
- Testing
- Octreotide acetate in microspheres
- Volunteers
- 260 people
- Sponsor
- Novartis Pharmaceuticals
Retinal Disease, Diabetic Retinopathy
Color Fundus Photograph With Experts Labelling
This trial aims to provide a digital retinal image dataset from Pakistan, graded by three specialists according to the severity of Diabetic Retinopathy. The dataset aims to improve research and patient care.
- Trial name
- NCT06287645
- Testing
- Color Fundus Photography/Non-Mydriatic Opthalmic Cameras
- Where
- Pakistan
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Pakistan Council of Scientific and Industrial Research
Diabetic Retinopathy
AutoDx-DR Prospective Clinical Validation Study Protocol
In this study, we will prospectively evaluate the accuracy of a deep-learning based software algorithm in the detection of diabetic retinopathy from 60° wide single-field retinal fundus images.
- Trial name
- NCT04627272
- Testing
- AutoDX-DR
- Volunteers
- 1,539 people
- Sponsor
- Hill-Rom
Stargardt Disease, Diabetic Retinopathy
Oxidative Stress In Stargardt Disease, Age Related Macular Degeneration and Diabetic Retinopathy
In this study, markers of oxidative stress will be measured in the aqueous humour of stargardt disease, age related macular degeneration and diabetic retinopathy patients compared to controls.
- Conditions
- Stargardt Disease, Diabetic Retinopathy, Macular Degeneration (Age Related)
- Trial name
- NCT02875704
- Testing
- Anterior Chamber (AC) Tap
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Johns Hopkins University
Diabetic Macular Edema, Macular Edema, Cystoid
Effect of Intravitreal Long Acting Dexamethasone Implant, Ozurdex in Patients With Diabetic Macular Edema
This study is undertaken to determine the effect of intravitreal long acting dexamethasone implant,(Ozurdex®)in patients with diabetic macular edema.Diabetic macular edema is important cause of visual impairment in patients with…
- Conditions
- Diabetic Macular Edema, Macular Edema, Cystoid, Vision Disorders, Clinically Significant Macular Edema
- Trial name
- NCT01698749
- Testing
- long acting intravitreal dexamethasone implant
- Where
- India
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Proliferative Diabetic Retinopathy
Ranibizumab for Treatment of Persistent Diabetic Neovascularization Assessed by Wide-Field Imaging
Diabetic neovascularization refers to a type of diabetic retinopathy which is worsening by the abnormal growth of blood vessels in the back of the eye, damaging the retina.
- Trial name
- NCT00606138
- Testing
- ranibizumab, Laser photocoagulation
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Rush University Medical Center
Diabetic Retinopathy (DR), Center-Involved Diabetic Macular Edema (CI-DME)
RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Diabetic Retinopathy (DR) With and Without Center Involved-Diabetic Macular Edema (CI-DME)
ABBV-RGX-314 is being developed as a novel, potential one-time gene therapy treatment for the treatment of Diabetic Retinopathy (DR) with and without Center-Involved Diabetic Macular Edema (CI-DME).
- Trial name
- ALTITUDE® (NCT04567550)
- Testing
- ABBV-RGX-314 Dose 1, ABBV-RGX-314 Dose 2, ABBV-RGX-314 Dose 3
- Where
- 25 sites in United States
- Volunteers
- 139 people
- Sponsor
- AbbVie
Age-Related Macular Degeneration, Diabetic Retinopathy
Defining Retinal Structures Using Hyperspectral Retinal Imaging
This study evaluates hyperspectral retinal imaging as a novel, non-invasive imaging technique to characterise retinal and optic nerve structures in healthy individuals and patients with eye disease.
- Conditions
- Age-Related Macular Degeneration, Diabetic Retinopathy, Glaucoma, Retinal Diseases
- Trial name
- NCT07555574
- Testing
- Hyperspectral camera
- Where
- Australia
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Center for Eye Research Australia
Diabetic Retinopathy
ARTIFICIAL INTELLIGENCE FOR MASS SCREENING OF THE DIABETIC RETINOPATHY IN THE CHERNIVTSI REGION (Pilot Study)
The purpose of this study is to create a patient-centric environment for early detection of DR with AI-driven solutions.
- Trial name
- AIMDR (NCT06112691)
- Testing
- taking fundus photos using non-mydriatic fundus camera - FundusScope Rodenstock
- Where
- Ukraine
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- The Filatov Institute of Eye Diseases and Tissue Therapy
Proliferative Diabetic Retinopathy
Efficacy and Safety Comparison of IVR and IVC Before Vitrectomy in Proliferative Diabetic Retinopathy
Proliferative diabetic retinopathy (PDR) is the most common causes of irreversible blindness in diabetic retinopathy (DR).Although pars plana vitrectomy (PPV) is the cornerstone for treatment of advanced PDR, related…
- Trial name
- NCT05414149
- Testing
- preoperative intravitreal injections of ranibizumab or conbercept
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University People's Hospital
Glaucoma, Diabetic Retinopathy
Glaucoma Algorithm Validation Study in African Population - the MAGIC Study
Artificial Intelligence (AI) algorithms require validation in a variety of populations to ensure widespread clinical applicability.
- Trial name
- MAGIC (NCT06552247)
- Testing
- Fundus Picture AI testing
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centro Hospitalar Universitário Lisboa Norte
Optical Coherence Tomography, Diabetic Retinopathy
A Longitudinal Study of Choroidal Changes After Cataract Surgery in Eyes With Diabetic Retinopathy
To determine the influence of phacoemulsification on choroidal vasculature in patients with diabetic retinopathy (DR) undergoing cataract surgery
- Conditions
- Optical Coherence Tomography, Diabetic Retinopathy, Choroid
- Trial name
- NCT04499768
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Ruijin Hospital
Diabetic Neuropathies, Diabetic Foot
Thermal Screening for Early Diabetic Peripheral Neuropathy (DPN)
The goal of this research is to develop better tools for diagnosing illness of the feet and legs of people who have diabetes. Investigators will use thermal videos of the foot to aid in the refinement of a system designed to…
- Conditions
- Diabetic Neuropathies, Diabetic Foot, Diabetic Retinopathy
- Trial name
- NCT03069729
- Testing
- no intervention
- Where
- United States
- Volunteers
- 331 people, healthy volunteers welcome
- Sponsor
- VisionQuest Biomedical LLC
Macular Edema, Diabetic Retinopathy
Combined Triple Therapy in Diabetic Retinopathy (DRP)
The aim of this pilot study was to investigate the effects of an intravitreal combination therapy using triamcinolone and bevacizumab in patients with macular edema due to diabetic retinopathy.
- Trial name
- NCT00806169
- Testing
- triamcinolone and bevacizumab
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Diabetic Retinopathy
Study on Precision Treatment of Diabetic Retinopathy Macular Edema Guided by Real-time OCT During Operation
Select Proliferative Proliferative diabetic retinopathy(PDR) patients who are planning to undergo vitrectomy for informed notification. After obtaining informed consent, vitrectomy will be performed.
- Trial name
- NCT05138029
- Testing
- Ranibizumab Injection [Lucentis], Inner limiting membrane stripping, Dexamethasone intravitreal implant
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Affiliated Hospital of Nantong University
Retinopathy, Retinal Vein Occlusion
Feasibility and Safety of MB-102 in Ocular Angiography as Compared to Fluorescein Sodium
The objective of this study is to evaluate the safety and image quality of the investigational dye, MB-102, compared to the control dye (fluorescein sodium) in healthy and diseased eyes using fluorescent angiography for retinal…
- Conditions
- Retinopathy, Retinal Vein Occlusion, Diabetic Retinopathy, Macular Degeneration
- Trial name
- NCT04008121
- Testing
- Fluorescein sodium and Zeiss FF450 fundus camera, MB-102 and Zeiss FF450 fundus camera, Fluorescein sodium and commercially available optical angiography imaging system
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- MediBeacon
Diabetic Retinopathy
Intravitreal Bevacizumab for Management of Active Progressive Proliferative Diabetic Retinopathy (PDR)
To evaluate the effect of intravitreal bevacizumab on the course of diabetic retinopathy in cases with the signs of active progressive PDR
- Trial name
- NCT00370721
- Testing
- bevacizumab
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
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