Clinical trials: Retinopathy, Diabetic
Diabetic Retinopathy, Diabetic Macular Edema
Epidemiologic Assessment of Diabetic Retinopathy in Egypt Using Ultrawide Field Fundus Photographs
In 2013, it was estimated that 16% (7.5 million) of all Egyptian adults between the ages of 20 and 79 years have type 2 diabetes and 2.6 million have diabetic retinopathy.
- Conditions
- Diabetic Retinopathy, Diabetic Macular Edema, Retinal Disease
- Trial name
- NCT04935749
- Testing
- Ultra wide-field retinal imaging
- Where
- Egypt
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Diffuse Diabetic Macular Edema
Vitrectomy and Bevacizumab for Diffuse Diabetic Macular Edema
To Evaluate combined effect of vitrectomy and bevacizumab to stabilize retinal thickness and visual acuity in patients with diffuse diabetic macular edema and their relation to renal disease.
- Trial name
- NCT00571142
- Testing
- Bevacizumab + Pars plana vitrectomy
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Asociación para Evitar la Ceguera en México
Diabetic Retinopathy, Diabetic Macular Edema
Efficacy of Dorzolamide as an Adjuvant After Focal Photocoagulation in Clinically Significant Macular Edema
Photocoagulation is the standard treatment in the focal EMCS, disrupts vascular leakage and allows the pigment epithelium remove the intraretinal fluid is effective in reducing the incidence of visual loss but can reduce contrast…
- Trial name
- NCT02227745
- Testing
- Dorzolamide hydrochloride (2%)
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Hospital Juarez de Mexico
Diabetes Mellitus, Diabetic Retinopathy
Sleep, Diabetic Retinopathy and Melatonin
This study explores the use of melatonin in patients with diabetic retinopathy
- Trial name
- NCT04547439
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Illinois Chicago
Diabetic Retinopathy
The Efficacy of Intravitreal Aflibercept Injection in Improvement of Retinal Nonperfusion in Diabetic Retinopathy
Retinal nonperfusion drives vision-threatening complications such as pathological neovascularization, which can lead to neovascular glaucoma, vitreous hemorrhage, or tractional retinal detachments and macular edema in diabetic…
- Trial name
- NCT03006081
- Testing
- Intravitreal Aflibercept injection
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Asan Medical Center
Macular Edema, Diabetic Macular Edema
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of IVT MHU650 in Macular Edema Patients
This was an open-label, multi-center, FIH study with a single ascending dose (SAD) design that assessed the safety, tolerability and pharmacokinetics (PK) of a single IVT dose of MHU650 in up to 24 participants with macular edema.
- Conditions
- Macular Edema, Diabetic Macular Edema, Neovascular Age-related Macular Degeneration, Retinal Vein Occlusion
- Trial name
- NCT04635800
- Testing
- MHU650
- Where
- 6 sites in United States, Puerto Rico
- Volunteers
- 21 people
- Sponsor
- Novartis Pharmaceuticals
Diabetic Retinopathy, Diabetic Eye Problems
Detection and Classification of Diabetic Retinopathy From Posterior Pole Images With A Deep Learning Model
The duration of diabetes is directly related to eye complications. Diabetic retinopathy affects 80 percent of those who have had diabetes for 20 years or more.
- Conditions
- Diabetic Retinopathy, Diabetic Eye Problems, Diabetic Macular Edema
- Trial name
- NCT04805541
- Testing
- Color Fundus Photography, Mydriatic Agent, EyeCheckup - AI Based DR Screening
- Where
- Turkey (Türkiye)
- Volunteers
- 900 people
- Sponsor
- Ural Telekomunikasyon Sanayi Ticaret Anonim Sirketi
Diabetic Retinopathy
Multicenter Diagnostic Clinical Performance Study For Automated Detection of Diabetic Retinopathy
This study is a retrospective study to assess the efficacy and accuracy of the EyeCheckup software in screening for diabetic retinopathy in healthcare settings.
- Trial name
- NCT05471986
- Testing
- Color Fundus Photography/Non-Mydriatic Opthalmic Cameras
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Ural Telekomunikasyon Sanayi Ticaret Anonim Sirketi
Age Related Macular Degeneration, Intravitreal Injections
Aflibercept in Recurrent or Persistent CNV
Age-related macular degeneration (AMD) and diabetic retinopathy are among the most common disorders causing visual disability in elderly people. AMD leads to dysfunction and loss of photoreceptors in the central retina.
- Conditions
- Age Related Macular Degeneration, Intravitreal Injections, Diabetic Macular Edema
- Trial name
- OPHTH-010915 (NCT02669953)
- Testing
- Aflibercept
- Where
- Austria
- Volunteers
- 80 people
- Sponsor
- Medical University of Vienna
Healthy Subjects, Diabetic Retinopathy
Comparison of Retinal Oxygenation and Retinal Vessel Diameters in Healthy Subjects and Patients With Diabetic Retinopathy or Retinal Vein Occlusion Between DVA and Oxymap
To date two different instruments are commercially available to measure retinal oxygen saturation and retinal vessel diameters: Dynamic Vessel Analyzer (DVA) and Oxymap.
- Conditions
- Healthy Subjects, Diabetic Retinopathy, Retinal Vein Occlusion
- Trial name
- DVA-Oxymap (NCT02521116)
- Testing
- Dynamic Vessel Analyzer, Oxymap T1
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Diabetic Retinopathy, Glaucoma, Neovascular
Intravitreal Ranibizumab Injection as Adjuvant in the Treatment of Postvitrectomy Diabetic Vitreous Hemorrhage Accompanied by Neovascular Glaucoma
To determine the efficacy of intravitreal ranibizumab injection as adjuvant therapy in the treatment of postvitrectomy diabetic vitreous hemorrhage (PDVH) accompanied by neovascular glaucoma (NVG) as a means of preventing…
- Trial name
- NCT02647515
- Testing
- ranibizumab
- Volunteers
- 18 people
- Sponsor
- Ruijin Hospital
Diabetic Retinopathy (DR)
Assessment of AI Program 'DRISTi' as a Screening Tool
A study will be conducted to demonstrate that DRISTi will correctly diagnose Diabetic Retinopathy (e.g., mtmDR, PDR, DME) in eyes of patients with diabetes.
- Trial name
- NCT07222293
- Testing
- Fundus Image Grading
- Where
- 2 sites in United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Artelus AI
Diabetic Retinopathy
Diabetic Retinopathy Screening in Private Practice
Introduction: Diabetic mellitus (DM) is a prevalent disease in Hong Kong (HK) and diabetic retinopathy (DR) is one of the most common complications of DM.
- Trial name
- NCT02866734
- Testing
- Free screening group, Pay screening group ($150), Pay screening group ($300)
- Where
- Hong Kong
- Volunteers
- 238 people
- Sponsor
- The University of Hong Kong
Diabetic Retinopathy, Age Related Macular Degeneration
AI-Assisted Detection of Posterior Segment Diseases: DR, AMD, RVO, and Glaucoma
The purpose of this multi-center study is to evaluate the extent to which AI-assisted fundus image interpretation improves the diagnostic performance of ophthalmologists.
- Conditions
- Diabetic Retinopathy, Age Related Macular Degeneration, Retinal Vein Occlusion, Glaucoma
- Trial name
- NCT07318428
- Testing
- VUNO Med-Fundus AI
- Where
- 5 sites in South Korea
- Volunteers
- 10 people
- Sponsor
- Inje University
Retinal Detachment, Vitrectomy
Comparative Study of 1000 Centistoke Versus 5000 Centistoke Silicone Oil for Repair of Complex Retinal Detachments
The purpose of this study is to assess the retinal redetachment rates with 1000 centistoke versus 5000 centistoke silicone oil tamponade for repair of complex retinal detachments.
- Conditions
- Retinal Detachment, Vitrectomy, Proliferative Vitreoretinopathy, Diabetic Retinopathy
- Trial name
- NCT01255293
- Testing
- 1000 centistoke silicone oil, 5000 centistoke silicone oil
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Mid Atlantic Retina
Diabetic Retinal Disease
Longitudinal Study of Retinal Function in Eyes Treated for Diabetic Macular Edema With Anti-VEGF Agents
A considerable hurdle to the development of novel, more effective therapies for diabetic retinal disease is the limited number of primary endpoints available for use in regulatory trials.
- Trial name
- AS (NCT07567833)
- Testing
- Anti-Vascular Endothelial Growth Factor
- Where
- 8 sites in United States
- Volunteers
- 100 people
- Sponsor
- Jaeb Center for Health Research
Cornea, Retina
Spectral-domain Optical Coherence Tomography of the Eye
An increasing number of clinical studies on SD-OCT of ocular pathologies and potential new clinical applications has recently been published in the peer-reviewed literature.
- Conditions
- Cornea, Retina, Refractive Surgery, Macular Edema
- Trial name
- NCT02614625
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Augenabteilung Allgemeines Krankenhaus Linz
Diabetic Macular Edema
Visual Outcomes and the Predictive Factors in Chinese Patients With Diabetic Macular Edema Treated With Ranibizumab
The aim of this study is to evaluate the one-year visual outcome and prognostic factors after intraocular injections of ranibizumab under pro re nata treatment regimen for the patients with diabetic macular edema (DME).
- Trial name
- IVRDME (NCT03973138)
- Testing
- Ranibizumab
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sun Yat-sen University
Diabetic Retinopathy
Evaluation of Retinal Changes in Systemic Darbepoetin Alpha Treatment in Patients With Diabetes Mellitus
The purpose of this study is to determine whether systemic administration of darbepoetin alpha results in the progression or regression of diabetic macular edema.
- Trial name
- EPOinDR (NCT00704652)
- Where
- Austria
- Volunteers
- 5 people
- Sponsor
- Medical University of Vienna
Proliferative Diabetic Retinopathy
PRP vs Bevacizumab for PDR Treatment
Protocol S by DRCR.net has shown that receive Ranibizumab as anti-vascular endothelial growth factor (anti-VEGF) therapy with deferred panretinal photocoagulation (PRP) are non-inferior to those in eyes that receive standard…
- Trial name
- NCT02705274
- Testing
- Bevacizumab, Panretinal photocoagulation
- Where
- Syria
- Volunteers
- 30 people
- Sponsor
- Marashi Eye Clinic
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