Clinical trials: Retinopathy, Diabetic
Non-Proliferative Diabetic Retinopathy
Intravitreal and Intracameral DEX in NPDR
To investigate the effects of intravitreal and intracameral injection of dexamethasone during cataract phacoemulsification in patients with mild to moderate non-proliferative diabetic retinopathy
- Trial name
- NCT06951087
- Testing
- Dexamethasone sodium phosphate
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Affiliated Hospital of Nantong University
Diabetic Retinopathy
RetinaVue Diabetic Screening
the purpose of this study is to examine whether the deployment of a non-mydriatic color fundus camera in a rural prime care setting is feasible and improves the detection rate of diabetic retinopathy in patients where adherence…
- Trial name
- NCT03343730
- Testing
- Non-mydriatic color fundus photography with the RetinaVue camera, Referral for dilated eye exam with an eye care professional
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Bassett Healthcare
Diabetic Retinopathy, Diabetic Macular Edema
Laser-Ranibizumab-Triamcinolone for Diabetic Macular Edema
The purpose of the study is to find out which is a better treatment for diabetic macular edema (DME): laser alone, laser combined with an intravitreal injection of triamcinolone, laser combined with an intravitreal injection of…
- Trial name
- LRT for DME (NCT00444600)
- Testing
- Triamcinolone Acetonide + laser, Ranibizumab + laser, Ranibizumab + deferred laser
- Where
- 50 sites in United States
- Volunteers
- 691 people
- Sponsor
- Jaeb Center for Health Research
Vitreous Detachment, Diabetic Retinopathy
Assessment of Intravitreous Injections of Vitrase for Inducing Posterior Vitreous Detachment
The purpose of this study is to assess the efficacy of intravitreous injections of Vitrase to induce posterior vitreous detachment(PVD) in subjects with moderate to severe non-proliferative diabetic retinopathy.
- Trial name
- NCT00198471
- Testing
- Vitrase
- Where
- 4 sites in United States
- Volunteers
- 10 people
- Sponsor
- Bausch & Lomb Incorporated
on Vitreomacular Interface Abnormalities in Diabetic Retinopathy
Vitreomacular Interface Abnormalities in Diabetic Retinopathy Using OCT
to evaluate vitreomacular interface abnormalities in diabetic retinopathy by using Ocular Coherence Tomography (OCT)
- Trial name
- NCT03686436
- Testing
- ocular coherence tomography
- Volunteers
- 50 people
- Sponsor
- Assiut University
Patients With Proliferative Diabetic Retinopathy Who Have Active Fibrovascular Proliferation
Pars Plana Vitrectomy for Diabetic Fibrovascular Proliferation With and Without Internal Limiting Membrane Peeling
Internal limiting membrane peeling in diabetic vitrectomy will help prevent postoperative epiretinal membrane formation
- Trial name
- NCT00556244
- Testing
- ILM peeling
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Diabetic Macular Edema
To Compare Brolucizumab to Aflibercept in Chinese Patients With Visual Impairment Due to Diabetic Macular Edema
The purpose of this study was to evaluate the efficacy and safety of brolucizumab in treatment of Chinese patients with visual impairment due to Diabetic Macular Edema.
- Trial name
- KINGLET (NCT04058067)
- Testing
- Brolucizumab, Aflibercept
- Where
- 24 sites in China
- Volunteers
- 266 people
- Sponsor
- Novartis Pharmaceuticals
Diabetic Retinopathy
Evaluating How the Treatments in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Study Affect Diabetic Retinopathy (The ACCORD Eye Study)
Diabetic retinopathy (DR) is an eye disease that can occur in people with diabetes and can cause poor vision or blindness. The Action to Control Cardiovascular Risk in Diabetes (ACCORD) study is examining the effect of various…
- Trial name
- NCT00542178
- Testing
- Hypoglycemic Agents, Standard glycemia control, Intensive BP treatment
- Where
- 7 sites in United States, Canada
- Volunteers
- 3,472 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Diabetic Retinopathy
Triamcinolone as Adjunctive Treatment to Laser Panretinal Photocoagulation for Proliferative Diabetic Retinopathy
The purpose of the study is to evaluate intravitreal injection of triamcinolone acetonide after laser panretinal photocoagulation in the treatment of proliferative diabetic retinopathy.
- Trial name
- NCT00443521
- Testing
- Triamcinolone Acetonide 4 mg intravitreal injection, Panretinal photocoagulation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
DIABETES MELLITUS, DIABETIC RETINOPATHY
Contrast Sensitivity and Diabetic Macular Edema
Contrast sensitivity is a tool use to evaluate the visual function in all patients. It can be modified by different pathologies or by age.
- Conditions
- DIABETES MELLITUS, DIABETIC RETINOPATHY, MACULAR EDEMA
- Trial name
- NCT02217306
- Where
- Mexico
- Volunteers
- 132 people
- Sponsor
- Hospital Juarez de Mexico
Diabetes Mellitus, Macular Edema
Clinical Trial on Alpha Lipoic Acid in Diabetic Macular Edema
To evaluate the effect of alpha lipoic acid (ALA) on the occurrence of diabetic macular edema.
- Trial name
- RETIPON (NCT01208948)
- Testing
- 1,2 dithiolane 3 valeric acid
- Where
- Germany
- Volunteers
- 520 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Diabetic Retinopathy
A Study That Uses Data From Routine Eye Examinations of Patients Participating in Studies FIDELIO-DKD and FIGARO-DKD to Explore Whether Finerenone Can Delay the Progression of a Diabetes Complication That Affects the Eyes (Diabetic Retinopathy, DR)
Diabetic retinopathy (DR) is a diabetes complication caused by damage to the small blood vessels inside the retina at the back of the eye. Diabetic retinopathy may cause mild vision problems or eventually blindness.
- Trial name
- DeFineDR (NCT04795726)
- Testing
- Finerenone (BAY94-8862)
- Where
- 11 sites in Bulgaria, United Kingdom
- Volunteers
- 70 people
- Sponsor
- Bayer
Diabetic Retinopathy
Eye Screening in German Secondary Diabetes Care Centers
In patients with confirmed diagnosis of diabetes, an eye examination and a comprehensive survey are conducted after recruitment in secondary diabetes care centers.
- Trial name
- DiabCheckophta (NCT02311504)
- Testing
- OCT examination
- Where
- Germany
- Volunteers
- 831 people
- Sponsor
- University Hospital Tuebingen
Diabetes Mellitus, Diabetic Retinopathy
Study to Evaluate the Effectiveness of a Program Developed to Improve Eye Care for Veterans With Diabetes
The study's primary objective is to determine whether the PRSS improves the optimal timing of photocoagulation in diabetic patients in VA.
- Trial name
- NCT00119535
- Testing
- Implementation of Proactive Diabetes Eye Care Program
- Where
- 3 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- US Department of Veterans Affairs
Diabetic Retinopathy, Sickle Cell Trait
Diabetic Retinopathy and Sickle Trait
To more clearly ascertain the relationship between ocular manifestations of sickle cell disease and diabetes, specifically; whether the presence of sickle cell trait exacerbates the disease progression of diabetic retinopathy.
- Trial name
- NCT00720317
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Medical University of South Carolina
Diabetic Retinopathy
Study of Efficacy of Ranibizumab in Different Regimens in Patients With Diabetic Macula Edema
The purpose of this study was to demonstrate that the change of best corrected visual acuity (BCVA) was comparable in patients treated with ranibizumab at the discretion of the investigator vs.
- Trial name
- DIVERSE (NCT02366468)
- Testing
- ranibizumab 0.5 mg
- Where
- 30 sites in Germany
- Volunteers
- 135 people
- Sponsor
- Novartis Pharmaceuticals
Diabetes, Diabetic Retinopathy
Retinal Blood Flow and Microthrombi in Type 1 Diabetes
The project aims to find mechanisms for the abnormal retinal blood flow that in diabetic patients often precedes any evidence of clinical retinopathy and may contribute to the development of retinopathy.
- Trial name
- NCT00406991
- Testing
- aspirin, clopidogrel
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Schepens Eye Research Institute
Type 1 Diabetes, Type 2 Diabetes
ACCESS: AI for pediatriC diabetiC Eye examS Study
The purpose of this study is to determine if providing in clinic point-of-care autonomous AI diabetic retinopathy exams improves screening rates compared to standard of care referral to an eye care provider, in a randomized…
- Trial name
- ACCESS (NCT05131451)
- Testing
- Point of Care Autonomous AI diabetic retinopathy exam
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Johns Hopkins University
Diabetic Macular Edema, Diabetic Retinopathy
ADVM-022 Intravitreal Gene Therapy for DME
A Phase 2, Multi-Center, Randomized, Double-Masked*, Active Controlled Study of ADVM-022 (AAV.7m8-aflibercept) in Subjects with Diabetic Macular Edema [INFINITY]
- Trial name
- INFINITY (NCT04418427)
- Testing
- 6E11 vg/eye of ADVM-022, 2E11 vg/eye of ADVM-022, Aflibercept
- Where
- 14 sites in United States, Puerto Rico
- Volunteers
- 36 people
- Sponsor
- Adverum Biotechnologies, Inc.
Diabetic Macular Edema, Neovascular Age-Related Macular Degeneration
Changes in Intraocular Pressure After Intravitreal Injection
Intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections introduce additional fluid volume into the eye, which can cause an acute, transient elevation in intraocular pressure (IOP).
- Conditions
- Diabetic Macular Edema, Neovascular Age-Related Macular Degeneration, Retinal Vein Occlusion, Ocular Hypertension
- Trial name
- NCT07826286
- Volunteers
- 50 people
- Sponsor
- Assiut University
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