Clinical trials: Retinopathy, Diabetic
Diabetic Retinopathy
Intravitreal Bevacizumab vs Photocoagulation for Proliferative Diabetic Retinopathy
The purpose of the study is to evaluate the safety and efficacy of 2.5 mg of intravitreal bevacizumab in one eye, versus panretinal photocoagulation in the contralateral eye, for the treatment of patients with untreated symmetric…
- Trial name
- NCT00347698
- Testing
- intravitreal injection of bevacizumab, panretinal photocoagulation
- Where
- Mexico
- Sponsor
- Asociación para Evitar la Ceguera en México
Moderate Non-proliferative Diabetic Retinopathy
The Use of Alpha Lipoic Acid for the Treatment and Prevention of Diabetic Retinopathy
The purpose of this study is to evaluate the role of alpha lipoic acid in patients who have moderate non-proliferative diabetic retinopathy.
- Trial name
- ALA-TPD (NCT01880372)
- Testing
- Alpha Lipoic Acid
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Ferris State University
Diabetic Retinopathy (DR)
Preliminary Assessment of an Automated Tool for Diabetic Retinopathy Screening
This study is being done to evaluate the performance of a software that uses artificial intelligence to analyze photographs of the retina to help detect diabetic retinopathy.
- Trial name
- NCT07404657
- Testing
- automatic analysis of fundus images performed by the software tool based on artificial intelligence
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- Centervue SpA
Macular Edema
Safety and Effect on Central Retinal Thickness of BI 1026706 in Patients With Diabetic Macular Edema
This is a proof of mechanism trial to explore the effect of BI 1026706 on the central retinal thickness and to evaluate safety and tolerability of BI 1026706 administered orally for 12 weeks in patients with mild vision…
- Trial name
- NCT02732951
- Testing
- BI 1026706
- Where
- 35 sites in Belgium, France and 6 more
- Volunteers
- 105 people
- Sponsor
- Boehringer Ingelheim
Diabetic Retinopathy, Dyslipidemias
Effects of Oral Fenofibrate on Retinal Thickness and Macular Volume
Lipid levels in the blood are proposed to play a role in the progression of diabetic retinopathy. Lipid levels can be controlled with dyslipidemic drugs, such as fenofibrate.
- Conditions
- Diabetic Retinopathy, Dyslipidemias, Diabetes Mellitus
- Trial name
- NCT04885153
- Testing
- Fenofibrate
- Volunteers
- 36 people
- Sponsor
- Universitas Indonesia
Chronic Diseases, Low Vision
Living Successfully With Chronic Eye Diseases
The need for low vision services (LVS) will increase exponentially over the coming years due to the anticipated and exponential growth in the ageing population in Singapore and a rise in chronic non-communicable eye diseases.
- Conditions
- Chronic Diseases, Low Vision, Diabetic Retinopathy, Glaucoma
- Trial name
- ADAPT-LAH (NCT01879501)
- Testing
- Low Vision Self-Management Program
- Where
- Singapore
- Volunteers
- 160 people
- Sponsor
- Singapore Eye Research Institute
Proliferative Diabetic Retinopathy (PDR)
Laser Photocoagulation and Ranibizumab Treatment in Proliferative Diabetic Retinopathy
To evaluate the effects of PRP as monotherapy or with combination of intravitreal Ranibizumab injection on microvascular density changes of the macula of eyes with PDR using OCTA
- Trial name
- PRP VS PRP&RZB (NCT07819253)
- Testing
- Ranibizumab 0.5 mg, laser photocoagulation (PRP)
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Aswan University
Macular Edema, Macular Degeneration
Implementation of the Intravitreal Injection Administered by Nurses
Introduction: Intravitreal injections involve medication administration into the eye to treat ocular diseases and protect vision.
- Conditions
- Macular Edema, Macular Degeneration, Diabetic Macular Edema
- Trial name
- NCT06511700
- Testing
- It is a implementation a program incorporating nurses trained in administering intravitreal injections within the functional unit of Ophthalmology following the usual technique
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Corporacion Parc Tauli
Diabetic Retinopathy
Vascular Reparative Mechanism in Diabetes
The purpose of this research study is to study blood stem cells in diabetic patients and normal patients. We would like to better understand if these cells, called endothelial precursor cells (EPCs), are not working as expected…
- Trial name
- RAAS (NCT02119689)
- Testing
- Diabetic Patients, Healthy Controls
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
no Obvious Abnormalities, Diabetic Retinopathy (DR)
Retinal Clinical Assessment With AI-derived Quantitative Information
This randomized controlled trial evaluates whether providing clinicians with AI-derived quantitative retinal information improves the quality and efficiency of retinal clinical assessment.
- Conditions
- no Obvious Abnormalities, Diabetic Retinopathy (DR), AMD, Cup-to-disc Ratio Bigger Than 0.5
- Trial name
- NCT07291960
- Testing
- AI-derived retinal quantitative information-assisted reporting
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Diabetic Retinopathy
Circadian Amplification in Diabetic Retinopathy
This study will test the effects of a 6-week comprehensive circadian optimization intervention Amplify-RHYTHM in patients with diabetic retinopathy.
- Trial name
- NCT06183476
- Testing
- Amplify-RHYTHM
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Illinois Chicago
Proliferative Diabetic Retinopathy
Gene Expression in Patients With Epiretinal Membranes
The purpose of this study was to investigate the expression of selected genes both in epiretinal membranes (ERMs) and peripheral blood mononuclear cells (PBMCs) from patients with primary and secondary epiretinal membranes in…
- Trial name
- NCT01946451
- Where
- Poland
- Sponsor
- Medical University of Silesia
Ophthalmology, Macular Edema
Evaluation of Changes in Visual Acuity in Patients With Diabetic Macular Edema (DME) Starting Treatment With an Approved Anti-VEGF Therapy
POLARIS : A non-interventional study in patients with diabetic macular edema (DME) with central involvement to assess the effectiveness of existing anti-vascular endothelial growth factor (anti-VEGF) treatment regimens.
- Conditions
- Ophthalmology, Macular Edema, Macular Degeneration
- Trial name
- POLARIS (NCT01771081)
- Testing
- Ranibizumab (or other DME treatment)
- Where
- 8 sites in France, Germany and 6 more
- Volunteers
- 911 people
- Sponsor
- Bayer
Proliferative Diabetic Retinopathy
Gas Tamponade for Prevention of Postoperative Vitreous Hemorrhage in Diabetics
Hypothesis: Patients undergoing pars plana vitrectomy for the indication of diabetic vitreous hemorrhage will have a lower incidence of postoperative vitreous hemorrhaging during the 6-month trial period when vitreous…
- Trial name
- NCT04380077
- Testing
- vitrectomy with sulfur hexafluoride gas, vitrectomy with balanced salt solution
- Where
- Mexico
- Volunteers
- 150 people
- Sponsor
- Rush Eye Associates
Diabetic Retinopathy (DR), Visual Perception
Study on the Recovery of Visual Perceptual Function Dysfunction in Patients With Diabetes
Investigators aim to investigate the effectiveness of visual perceptual learning on visual perceptual function in participants with diabetic retinopathy and to provide novel therapeutic insights for visual functional…
- Trial name
- NCT07095777
- Testing
- visual perceptual learning
- Where
- China
- Volunteers
- 36 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Diabetic Retinopathy
Preoperative Bevacizumab and Ziv-Aflibercept Administration in PDR Subjects Undergoing PPV
To compare outcomes in subjects receiving different doses and treatment intervals of intravitreal bevacizumab or ziv-aflibercept preoperatively administered prior to undergoing vitrectomy for complications of proliferative…
- Trial name
- NCT02590094
- Testing
- Intravitreal bevacizumab or intravitreal ziv-aflibercept
- Where
- Mexico
- Volunteers
- 568 people
- Sponsor
- Panhandle Eye Group, LLP
Diabetic Retinopathy
Photobiomodulation for the Treatment of Diabetic Macular Edema
The current application proposes to conduct a prospective, clinical trial in diabetic subjects with diabetic macular edema (DME) to evaluate the therapeutic efficacy of 670 nm photobiomodulation on validated clinical outcome…
- Trial name
- PTDME (NCT02457975)
- Testing
- 670nm PBM, intravitreous VEGF-inhibitors
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Medical College of Wisconsin
Diabetes
The Effect of Dopamine on Diabetic Retinopathy
The purpose of this study is to evaluate the use of electroretinogram (ERG) using a novel handheld system, RETeval, and evaluate contrast sensitivity testing in detecting pre-clinical retinopathy on a tablet device.
- Trial name
- Dopamine DR (NCT02706977)
- Testing
- Low Dose Sinemet CR, High Dose Sinemet CR, RETeval Electroretinogram (ERG) Testing
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Emory University
To Evaluate the Added Value of the Use of Artificial Intelligence in the Diagnosis of Referable Diabetic Retinopathy in a Teaching Hospital Setting
Performance Evaluation of Artificial Intelligence Assisted Diabetic Retinopathy Grading in the Leuven University Hospital: Can Technology Improve the Resident?
To evaluate the added value of the use of artificial intelligence in the diagnosis of referable diabetic retinopathy in a teaching hospital setting
- Trial name
- PEARL (NCT05260281)
- Testing
- MONA algorithm
- Volunteers
- 139 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Retinal Vasculitis
Incidence of Retinal Vasculitis Among Patients Receiving Aflibercept: A US Real-World Evidence Study
This study will describe and estimate the incidence of Retinal Vasculitis (RV) events among patients and patient eyes receiving aflibercept intravitreal (IVT) (Eylea®, aflibercept 2mg) therapy in US clinical practice.
- Trial name
- NCT07105228
- Testing
- aflibercept 2mg
- Where
- United States
- Volunteers
- 290,000 people
- Sponsor
- Regeneron Pharmaceuticals
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