Clinical trials: Retinopathy, Diabetic
Age-related Macular Degeneration, Diabetic Macular Edema
Systemic Pharmacokinetics Following Intravitreal Injections of Anti-VEGF
Comparable data for bevacizumab and aflibercept are lacking, as are studies comparing the systemic levels of ranibizumab, bevacizumab, and aflibercept and their relative effects on circulating vascular endothelial growth factor.
- Conditions
- Age-related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion
- Trial name
- NCT02118831
- Testing
- Blood Sample Collection, Aflibercept, Bevacizumab
- Volunteers
- 56 people
- Sponsor
- California Retina Consultants
Diabetic Vitreous Hemorrhage, Intravitreal Injections
Outcomes of Intravitreal Ranibizumab Injection for Diabetic Vitreous Hemorrhage
This prospective interventional cohort study evaluates the outcomes of intravitreal ranibizumab injection in patients with diabetic vitreous hemorrhage secondary to proliferative diabetic retinopathy.
- Conditions
- Diabetic Vitreous Hemorrhage, Intravitreal Injections, Ranibizumab
- Trial name
- RANI-VH (NCT07690800)
- Testing
- Ranibizumab
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Benha University
Diabetic Macular Edema
Oxulumis®, Suprachoroidal Drug Administration of Triesence® in Diabetic Macular Edema
The purpose of this clinical investigation is to evaluate the safety and tolerability of using the Oxulumis® microcatheterization device to administer Triesence® to the suprachoroidal space in participants with DME.
- Trial name
- NCT05172401
- Testing
- Oxulumis® suprachoroidal microcatheterization administration of Triesence®
- Sponsor
- Oxular Limited
Age-related Macular Degeneration, Diabetic Retinopathy
Povidone Iodine vs AVEnova: A Pre-injection Disinfection Study (PAVE Study)
To compare the efficacy and comfort of two FDA approved pre-injection antiseptics when used for intravitreal injections.
- Conditions
- Age-related Macular Degeneration, Diabetic Retinopathy, Diabetic Macular Edema
- Trial name
- PAVE (NCT04018482)
- Testing
- Povidone Iodine, Hypochlorous Acid
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- California Retina Consultants
Diabetic Macular Edema, Branch Retinal Vein Occlusion
EffiCacy, Safety and ToLErability of a Novel Ocular ANtiseptic for Ocular Use (CLEAN)
This is a randomized, double-masked, multicenter, study to evaluate the efficacy, safety, and tolerability of IRX-101 versus 5% povidone-iodine (PI) in subjects receiving intravitreal anti-VEGF injections.
- Conditions
- Diabetic Macular Edema, Branch Retinal Vein Occlusion, Glaucoma/Closed Angle Glaucoma
- Trial name
- CLEAN (NCT05127525)
- Testing
- IRX-101, Control
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- iRenix Medical, Inc.
Vitreous Hemorrhage, Diabetic Retinopathy
Safety and Efficacy Study of Vitrase for Clearance of Severe Vitreous Hemorrhage
The purpose of this study is to determine if intravitreal injection of Vitrase (ovine hyaluronidase) clears vitreous hemorrhage
- Trial name
- NCT00198497
- Testing
- Vitrase
- Where
- 58 sites in Australia, Brazil and 7 more
- Volunteers
- 510 people
- Sponsor
- Bausch & Lomb Incorporated
Diabetic Retinopathy
Study on Exosome Changes in Patients With Proliferative Diabetic Retinopathy
Diabetic retinopathy is a common complication of diabetes and one of the leading causes of low vision and blindness in adults. In recent years, the prevalence of diabetes and the incidence of diabetic retinopathy have increased…
- Trial name
- NCT06198543
- Volunteers
- 60 people
- Sponsor
- Xuanwu Hospital, Beijing
Diabetic Macular Edema, Diabetic Retinopathy
Long-Term Follow-up Study of ADVM-022 in DME (INFINITY-EXT)
This is a prospective, observational study designed to evaluate the long-term safety and tolerability of ADVM-022 in participants with diabetic macular edema (DME).
- Trial name
- NCT05607810
- Testing
- ADVM-022
- Where
- 7 sites in United States, Puerto Rico
- Volunteers
- 22 people
- Sponsor
- Adverum Biotechnologies, Inc.
Age-Related Macular Degeneration, Diabetic Retinopathy
Retinal Imaging Using NOTAL-OCT
Comparison between retinal measurements, done by the Notal-OCT imaging and a commercial OCT (Optical Coherence Tomography)
- Trial name
- NCT03374020
- Testing
- Notal OCT
- Volunteers
- 33 people
- Sponsor
- Notal Vision Ltd.
Proliferative Diabetic Retinopathy
Efficacy of PreOperative Bevacizumab for Diabetic Eye Disease
Reports of the use of intravitreal bevacizumab (Avastin, Genentech) for the reduction of neovascularization in proliferative diabetic retinopathy have demonstrated significant regression in the number of new vessels.
- Trial name
- NCT01041690
- Testing
- Bevacizumab
- Where
- Egypt
- Volunteers
- 19 people
- Sponsor
- Cairo University
Retinal Disease, Diabetic Retinopathy
Diagnostic Possibilities in Ophthalmological Diseases Using Swept Source Optical Coherence Tomography
In this pilot study we want to investigate morphological features acquired by the novel image modality and gain information regarding disease pathomechanism, development and future possible influence on disease management for…
- Conditions
- Retinal Disease, Diabetic Retinopathy, Macular Degeneration
- Trial name
- NCT06074731
- Testing
- SS-OCT system Plex Elite 9000
- Where
- Austria
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Johannes Kepler University of Linz
Diabetic Retinopathy
Intravitreal Aflibercept as Indicated by Real-Time Objective Imaging to Achieve Diabetic Retinopathy Improvement
The PRIME trial will assess the safety of 2 mg intravitreal aflibercept injections (IAI) to achieve and maintain DRSS improvements (2 or more steps) in patients with a baseline DRSS level of 47A to 71A inclusive through 104 weeks…
- Trial name
- NCT03531294
- Testing
- Aflibercept Injection
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Greater Houston Retina Research
Dry AMD, Diabetic Retinopathy (DR)
Microperimetry Changes in Retinal Function in Macular Disorders
The purpose of this study is to measure precisely how sensitive the central part of the retina - the light-sensitive film at the back of the eye, is to light.
- Trial name
- MAIAStud (NCT07170683)
- Testing
- MAIA Microperimetry, Microperimetry, Visual Acuity Measurement (logMAR)
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Proliferative Diabetic Retinopathy, VEGF Overexpression
Day Regimes of CONbercept on CytokinEs of PDR Patients Undergoing Vitrectomy - Trial (CONCEPT)
Patients with proliferative diabetic retinopathy requiring surgical intervention will receive a pre-operative injection of Conbercept.
- Trial name
- CONCEPT (NCT03506750)
- Testing
- IVC, Blood and aqueous humor at the time of IVC, Collect blood, aqueous humor, and initial vitreous at the time of surgery.
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Diabetic Retinopathy
Monocyte Chemoattractant Protein-1 2518A/G Polymorphism
The pathogenesis of proliferative diabetic retinopathy (PDR) remains poorly understood. Recent studies have implicated that monocyte chemoattractant protein-1 (MCP-1) is associated with diabetic microvascular or macrovascular…
- Trial name
- MCP-1 (NCT02077127)
- Where
- China
- Volunteers
- 1,043 people
- Sponsor
- Harbin Medical University
Proliferative Diabetic Retinopathy
Intravitreal Bevacizumab vs Laser vs Combination of Bevacizumab and Modified Laser in PDR
In this randomized 3-armed clinical trial, 105 eyes with PDR will be included and divided randomly into 3 groups: IVB group (35 eyes) that receive 4 monthly IVB injections and then rescue IVB, PRP group (35 eyes) that undergo…
- Trial name
- NCT04800679
- Testing
- receive 4 monthly IVB injections and then rescue IVB, PRP group, IVB injections and a modified laser
- Where
- Iran
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Diabetic Retinopathy
Artificial Intelligence for Diagnosing Diabetic Retinopathy in Primary Care
This is a clinical trial to evaluate the effects of universal screening for diabetic retinopathy (DR) and diabetic macular edema (DME) using artificial intelligence (AI) in the interpretation of fundus photographs obtained by…
- Trial name
- AID-DR (NCT07236879)
- Testing
- Mobile retinography interpreted by artificial intelligence, Mobile retinography interpreted by ophthalmologists
- Where
- Brazil
- Volunteers
- 922 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Diabetic Retinopathy
A Safety and Efficacy Study of Vitreosolve® for Non-Proliferative Diabetic Retinopathy Subjects
The purpose of this study is to determine the safety and efficacy of Vitreosolve in diabetic retinopathy patients.
- Trial name
- NCT00664183
- Testing
- Vitreosolve
- Where
- 17 sites in United States, India
- Volunteers
- 400 people
- Sponsor
- Vitreoretinal Technologies, Inc.
Diabetic Retinopathy
Performance of the Electroretinogram, Performed and Interpreted by an Advanced Practice Nurse, in the Screening for Diabetic Retinopathy.
Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus and the leading cause of preventable blindness in working-age individuals. Early screening for DR is a public health issue.
- Trial name
- ERGDIAB (NCT06782997)
- Testing
- Electroretinogram
- Where
- France
- Volunteers
- 270 people
- Sponsor
- CHU de Reims
Diabetic Retinopathy, Non-Proliferative Diabetic Retinopathy
Remote Ischemic Conditioning for Non-Proliferative Diabetic Retinopathy
The goal of this clinical trial is to evaluate whether remote ischemic conditioning (RIC) is a safe and effective treatment for non-proliferative diabetic retinopathy (NPDR) in adults aged 40-80 years with type 2 diabetes.
- Conditions
- Diabetic Retinopathy, Non-Proliferative Diabetic Retinopathy, Remote Ischemic Conditioning, Diabetes Mellitus, Type 2
- Trial name
- RIC-NPDR (NCT06713720)
- Testing
- Remote Ischemic Conditioning Device
- Where
- 2 sites in China
- Volunteers
- 68 people
- Sponsor
- Xuxiang Zhang, MD
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