Clinical trials: Retinopathy, Diabetic
Diabetic Macular Edema
Ranibizumab "Treat and Extend" in Diabetic Macular Edma
This study is designed to explore a more individualized treatment regime based on achievement of disease stability to define a personal optimal treatment interval with ranibizumab in patients with visual impairment due to…
- Trial name
- OPTIMAL (NCT01297569)
- Testing
- Ranibizumab
- Where
- Norway
- Volunteers
- 7 people
- Sponsor
- Novartis Pharmaceuticals
Diabetic Retinopathy
Levodopa for Diabetic Retinopathy
The purpose of this study is to determine optimum dosing strategies of levodopa and determine the physiologic mechanisms that provide the therapeutic response to restore abnormalities in the electrical conductivity of the retina…
- Trial name
- NCT07444892
- Testing
- Levodopa
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Emory University
Diabetes Mellitus, Macular Edema
Efficacy and Safety Study of Intravitreal Triamcinolone to Treat Diffuse Diabetic Macular Edema
The purpose of this study is to determine whether intravitreal injection of Triamcinolone Acetonide is effective in the treatment of Clinically Significant Diffuse Macular Edema due to Type 2 Diabetes Mellitus.
- Trial name
- NCT00309192
- Testing
- Triamcinolone Acetonide, Grid laser
- Where
- 7 sites in Spain
- Volunteers
- 292 people
- Sponsor
- Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA
Diabetes Mellitus, Diabetic Retinopathy
A Systematic Study of Retinal Structure and Function in Diabetic Macular Oedema
Diabetic retinopathy(DR) is a sight threatening condition that occurs in persons with diabetes. DR arises as a consequence of damage to the retinal blood vessels and is related to the high and fluctuating sugar levels in the…
- Conditions
- Diabetes Mellitus, Diabetic Retinopathy, Diabetic Macular Edema
- Trial name
- NCT02876393
- Where
- United Kingdom
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Diabetes, Diabetic Retinopathy
Improve Timely Referral Flow and Compliance of Diabetic Retinopathy Patients
An effective referral system helps to ensure a close relationship between all levels of the health system and ensures clients receive optimum care at the appropriate level and at affordable cost, and hospital facilities are used…
- Trial name
- NCT04834648
- Testing
- Structured Counseling
- Where
- Nepal
- Volunteers
- 150 people
- Sponsor
- Seva Foundation
Diabetic Retinopathy (DR)
Diabetic Retinopathy Prevalence And Risk Factors
The goal of this retrospective observational study is to evaluate the prevalence and severity of diabetic retinopathy (DR) and to identify associated risk factors among patients with diabetes mellitus at Gia Dinh Family Hospital…
- Trial name
- DR-CENTRAL (NCT07468058)
- Testing
- fundus examination and optical coherence tomography (OCT)
- Where
- Vietnam
- Volunteers
- 300 people
- Sponsor
- Da Nang Family General Hospital
Retinal Disease, Corneal Disease
Tissue Studies of Human Eye Diseases
The purpose of this project is to diagnose and evaluate ocular and related tissues with various diseases such as conjunctival, corneal, uveal, vitreoretinal and optic nerve disorders, ocular degenerative, metabolic or genetic…
- Conditions
- Retinal Disease, Corneal Disease, Diabetic Retinopathy, Uveitis
- Trial name
- NCT00001310
- Where
- United States
- Volunteers
- 3,833 people
- Sponsor
- National Eye Institute (NEI)
Diabetic Retinopathy
Integrating DR Into Mainstream Health System in Bangladesh
Diabetes mellitus is a leading cause of death and disability. Diabetic Retinopathy (DR) is an eye disease that affects the eyesight of about 21.3% persons with diabetes in Bangladesh in a way that is irreversible because of the…
- Trial name
- NCT03658980
- Testing
- Health Education Intervention
- Where
- Bangladesh
- Volunteers
- 299 people
- Sponsor
- Hiroshima University
Wet Macular Degeneration, Diabetic Macular Edema
Artificial Intelligence Diagnostic Aid
The investigators have worked with software designers to develop a software that allows us to analyse current adherence to guidelines on Ophthalmic conditions such as Age related Macular Degeneration (AMD), Diabetic Macular Edema…
- Conditions
- Wet Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion
- Trial name
- AID (NCT05675540)
- Testing
- Macusense Assessment Software
- Where
- United Kingdom
- Volunteers
- 422 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Diabetic Retinopathy
Using Calcium Dobesilate to Treat Chinese Patients With Mild to Moderate Non-proliferative Diabetic Retinopathy
Calcium dobesilate has been recommended to treat diabetic retinopathy due to its potential in protecting against retinal vascular damage.
- Trial name
- CALM-DR (NCT04283162)
- Testing
- Calcium Dobesilate, conventional treatment
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Zhongda Hospital
Diabetic Retinopathy, Vitreomacular Traction
Methotrexate Infusion and Intrasilicone Injection During Diabetic Vitrectomy
The goal of this interventional clinical trial is to assess anatomical and functional outcomes of methotrexate use in irrigating fluid during parsplana vitrectomy combined with intrasilicone injection at end of surgery in…
- Trial name
- NCT06038968
- Testing
- Methotrexate 25 MG/ML, parsplana vitrectomy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Minia University
Diabetes Mellitus, Glaucoma
Smartphone Screening for Eye Diseases
To validate new screening instruments for eye disease, increase eye care access in underserved communities, and provide a scientifically implemented method to set up programs for eye disease screening.
- Conditions
- Diabetes Mellitus, Glaucoma, Age Related Macular Degeneration, ROP
- Trial name
- NCT03076697
- Testing
- Fundus photography
- Volunteers
- 472 people
- Sponsor
- University of Michigan
Diabetic Retinopathy
Evaluation of Doxycycline Verses Placebo for the Treatment of Severe Nonproliferative or Mild or Moderate Proliferative Diabetic Retinopathy
This 24 month randomized research study will evaluate whether doxycycline can 1) slow the deterioration or improve retinal function and/or 2) induce regression, or slow progression, of diabetic retinopathy in participants over 18…
- Trial name
- POC1 (NCT00511875)
- Testing
- doxycycline monohydrate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Thomas Gardner
Proliferative Diabetic Retinopathy, Macular Edema
Morphological and Functional Retinal Changes Following Retinal Photocoagulation
Imaging of retinal morphological changes with time secondary to laser treatment as assessed with high definition optical coherence tomography (OCT).
- Trial name
- pascal (NCT00682240)
- Testing
- laser treatment with PASCAL®, laser treatment with conventional laser system
- Where
- Austria
- Volunteers
- 64 people
- Sponsor
- Medical University of Vienna
Diabetes Mellitus
Assess Screening for Diabetic Retinopathy Using Retinal Camera in Family Medicine Clinic
The long-term goal for this study is to improve compliance of screening for diabetic retinopathy among subjects with diabetes. Researchers are also doing this research to determine the ability of appropriately trained family…
- Trial name
- NCT03828890
- Testing
- Screening eye exam using Optos technology
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Diabetic Retinopathy
Progression of Diabetic Retinopathy. Identification of Signs and Surrogate Outcomes
Progression of Diabetic Retinopathy. Identification of Signs and Surrogate outcomes (PROGRESS)
- Trial name
- PROGRESS (NCT03010397)
- Where
- Portugal
- Volunteers
- 212 people
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Diabetic Retinopathy
INflammatory MediatorS in the PathophysIology of Diabetic REtinopathy Study
The central hypothesis is that inflammation mediators are biomarkers of both systemic diabetes and Diabetic Retinopathy (DR) progression in the aqueous and that sustained topical ketorolac application reduces/suppresses those…
- Trial name
- INSPIRE (NCT04505566)
- Testing
- Ketorolac 0.45% ophthalmic solution, Aqueous PGE2 and inflammatory cytokines measurements
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Stephen J. Kim, MD
Diabete Mellitus, Diabetic Retinopathy
Multi-modal Imaging and Artificial Intelligence Diagnostic System for Multi-level Clinical Application
This study is to build an multi-modal artificial intelligence ophthalmological imaging diagnostic system covering multi-level medical institutions.
- Trial name
- NCT03899623
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Diabetes Mellitus, Type 2
A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes
This study will look at the long-term effects of semaglutide (active medicine) on diabetic eye disease when compared to placebo (dummy medicine). The study will be performed in people with type 2 diabetes.
- Trial name
- FOCUS (NCT03811561)
- Testing
- Semaglutide
- Where
- 230 sites in United States, Brazil and 17 more
- Volunteers
- 1,500 people
- Sponsor
- Novo Nordisk A/S
Diabetic Retinopathy, Low Vision
Diabetic Retinopathy Tethered Augmented Reality With Eye4 Study
Diabetes has reached epidemic levels in North America and with it, diabetic retinopathy is increasingly affecting the vision of millions of people.
- Trial name
- DRTARES (NCT05491746)
- Testing
- Eye4
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Eyedaptic
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