Clinical trials: Retinopathy, open to volunteers
Neovascular (Wet) Age-related Macular Degeneration (AMD)
OCT Angiography in Wet AMD
The primary goals of this study are to use optical coherence tomography (OCT) angiography (blood vessel mapping) to: 1. diagnose the presence of new blood vessels in wet age-related macular degeneration (AMD) 2.
- Trial name
- NCT02253030
- Testing
- Optical Coherence Tomography
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Diabetic Foot, Diabetes Mellitus
Early Percutaneous Transluminal Angioplasty in Diabetic Foot Syndrome (PTA-DFS)
The planned study is a Randomized Controlled Monocentric Trial, which will provide evidence on whether early angiography in percutaneous transluminal angioplasty (PTA) readiness ("immediate" treatment, within 48h) has advantages…
- Conditions
- Diabetic Foot, Diabetes Mellitus, Peripheral Arterial Disease, Diabetic Neuropathies
- Trial name
- PTA-DFS (NCT06124586)
- Testing
- Percutaneous transluminal angioplasty
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Cytomegalovirus Retinitis, Ganciclovir Eye Drops
Clinical Study of High Concentration Ganciclovir Eye Drops in the Treatment of Cytomegalovirus Retinitis
Clinical study of high concentration ganciclovir eye drops in the treatment of cytomegalovirus retinitis
- Trial name
- NCT05911503
- Testing
- 2% Ganciclovir Eye Drops
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Tianjin Medical University
Retinopathy of Prematurity
Oral Propranolol for Prevention of Threshold Retinopathy of Prematurity
Extremely premature infants are at risk of developing a potentially blinding eye disease, called retinopathy of prematurity (ROP).
- Trial name
- RoProp (NCT03083431)
- Testing
- Propranolol
- Where
- 3 sites in Germany, Switzerland and 1 more
- Volunteers
- 276 people
- Sponsor
- University of Zurich
Retinal Dystrophies, Geographic Atrophy
Real-time Acoustic Biofeedback for Enhancing Fixation Stability: A Proof-of-concept Study to Improve Ophthalmic Imaging Diagnostic Quality
The goal of this Proof of Concept Feasibility Study is to improve the fixation stability in patients with fixation loss due to blindness or central vision loss using a patented acoustic real-time feedback device.
- Conditions
- Retinal Dystrophies, Geographic Atrophy, Blindness
- Trial name
- NCT07529041
- Testing
- A device providing acoustic real-time biofeedback
- Where
- Germany
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Medical Center Goettingen
Age-related Macular Degeneration (ARMD), Choroidal Neovascularization
Long Term Efficacy of Faricimab Using a Treat and Extend Regimen for Type 3 Macular Neovascularization
Type 3 macular neovascularization (MNV) is a subtype of neovascular age-related macular degeneration accounting for 10-20% of cases, notable for high rates of bilateral involvement and risk of profound vision loss, particularly…
- Conditions
- Age-related Macular Degeneration (ARMD), Choroidal Neovascularization, Anti-vascular Endothelial Growth Factor
- Trial name
- NCT07187804
- Testing
- Intravitreal faricimab injection
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Kim's Eye Hospital
Wet Age Related Macular Degeneration
Phase 3 Study of Intravitreal OLN324 in Adults With Neovascular (Wet) Age-related Macular Degeneration (nAMD) (OLN324-CP-04)
This is a Phase 3 study of an investigational drug called OLN324, which is being developed by Ollin Biosciences as a treatment for patients with neovascular (wet) age-related macular degeneration (nAMD).
- Trial name
- MOJAVE (NCT07816315)
- Testing
- OLN324, Aflibercept
- Volunteers
- 500 people
- Sponsor
- Ollin Biosciences, Inc.
Retinal Detachment, Macular Edema
OCT Macula Biomarkers Before Silicone Oil Removal and Visual Outcome After Silicone Oil Removal
Silicone oil is commonly used as a temporary intraocular tamponade to support the retina during vitreoretinal surgery for complex retinal detachment and other severe retinal conditions.
- Conditions
- Retinal Detachment, Macular Edema, Silicone Oil Tamponade, Epiretinal Membrane
- Trial name
- NCT07865468
- Volunteers
- 30 people
- Sponsor
- Assiut University
Retinitis Pigmentosa (RP), Age Related Macular Degeneration
Evaluating a New Peptide Therapy for Retinal Diseases: AMD, Diabetic Retinopathy, and Dystrophies
Summary of the Study This clinical trial evaluates a novel peptide-based therapy for treating retinal dystrophies, age-related macular degeneration (AMD), and diabetic retinopathy (DR).
- Conditions
- Retinitis Pigmentosa (RP), Age Related Macular Degeneration, Diabetic Retinopathy
- Trial name
- Retino (NCT06787482)
- Testing
- ACE Retino
- Where
- 2 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Ace Cells Lab Limited
Non-Proliferative Diabetic Retinopathy
Intravitreal and Intracameral DEX in NPDR
To investigate the effects of intravitreal and intracameral injection of dexamethasone during cataract phacoemulsification in patients with mild to moderate non-proliferative diabetic retinopathy
- Trial name
- NCT06951087
- Testing
- Dexamethasone sodium phosphate
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Affiliated Hospital of Nantong University
Idiopathic Macular Hole, Macular Hole
Intraocular Gas Tamponade for Treatment of Large Idiopathic Macular Holes
The goal of this clinical trial is to evaluate the visual and anatomical outcomes of large (410-1000 μm) full-thickness macular holes repair surgery using perfluoropropane (15% C3F8), sulfur hexafluoride (20% SF6) gas tamponade.
- Conditions
- Idiopathic Macular Hole, Macular Hole, Macular Holes, Full Thickness Macular Hole
- Trial name
- NCT06927544
- Testing
- Pars plana vitrectomy
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- The Filatov Institute of Eye Diseases and Tissue Therapy
Diabetes, Diabetic Retinopathy
Optimization and Evaluation of the Diagnosis and Treatment System for Diabetic Retinopathy in Type 2 Diabetes Mellitus
This study aims to integrate clinical indicators and features of fundus images, combined with metabolomics, to construct an early warning model for diabetic retinopathy (DR) in type 2 diabetes.
- Conditions
- Diabetes, Diabetic Retinopathy, Type 2 Diabetes Mellitus (T2DM)
- Trial name
- NCT06821399
- Testing
- Fundus Examination, Metabolomics analysis
- Where
- 3 sites in China
- Volunteers
- 2,920 people
- Sponsor
- Yufan Wang
Retinal Displacement After Retinal Detachment Surgery
Influence of Perfluorocarbon Liquid (LIQUID) During Pars Plana Vitrectomy on Retinal Vessel Displacement in Primary Macula-involving Rhegmatogenous Retinal Detachment
Rhegmatogenous retinal detachment (RRD) is an acute, sight threatening condition, with an incidence of approximately 10 per 100,000 people.
- Trial name
- LIQUID (NCT07027098)
- Testing
- Perflurocarbon liquid, Without Perflurocarbon liquid
- Where
- United Kingdom
- Volunteers
- 292 people
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
Diabetic Retinopathy
Investigating the Retardation Effect of OCTA-Guided Targeted Photocoagulation on the Progression of Non-Perfusion Areas in Diabetic Retinopathy Patients
This study aims to evaluate the impact of widefield OCTA-guided selective photocoagulation on the progression of diabetic retinopathy (DR) by comparing the control of non-perfusion (NP) areas, DR grading, and management of other…
- Trial name
- NCT06821633
- Testing
- Targeted laser photocoagulation guided by OCTA (Optical Coherence Tomography Angiography)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sichuan Provincial People's Hospital
Frailty, Age-Related Macular Degeneration
Visual Frailty in Ageing
The goal of this observational study is to define visual frailty and refine monitoring for an ageing population. It involves piloting a visual frailty assessment tool in a cohort of patients aged 60 and above with a known…
- Conditions
- Frailty, Age-Related Macular Degeneration, Functional Status, Mental Health
- Trial name
- VFiA (NCT06604104)
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Age - Related Macular Degeneration (AMD)
Enhanced Vision and Imaging Tests for Enabling Treatment Trials in Early and Intermediate AMD
This monocentric prospective longitudinal observational study will validate fundus-tracked dark adaptometry as an endpoint for future treatment trials in early and intermediate age-related macular degeneration (AMD).
- Trial name
- EVITE-AMD (NCT07515521)
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Maximilian Pfau
Age-Related Macular Degeneration
Effect of Omega-3 Fatty Acid Supplementation on Dry-AMD Progression
This randomized, double-blind, placebo-controlled study aims to evaluate the effect of krill oil supplementation in patients with dry age-related macular degeneration (AMD).
- Trial name
- OMEGA-AMD (NCT05465252)
- Testing
- Krill Oil, Olive Oil
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Diabetes Mellitus, Type 2, Diabetic Retinopathy
Exploring the Effectiveness of AI Generative Models for Diabetic Patients
We plan to explore the usability of Generative AI-Chatbot for Diabetic Patient
- Conditions
- Diabetes Mellitus, Type 2, Diabetic Retinopathy, Diabetes
- Trial name
- NCT05883072
- Testing
- Exploring AI-Chatbot
- Where
- Pakistan
- Volunteers
- 300 people
- Sponsor
- Pakistan Council of Scientific and Industrial Research
Macular Oedema, Cataract Surgery
Comparing Efficacy of Bromfenac 0.09%, Nepafenac 0.3% and Diclofenac 0.1% in Patients After Cataract Surgery
The goal of this clinical trial is to learn which of the drugs bromfenac 0.09%, nepafenac 0.3% and diclofenac 0.1% has better efficacy in treatment and prevention of cystoid macular oedema after cataract surgery.
- Conditions
- Macular Oedema, Cataract Surgery, NSAID (Non-Steroidal Anti-Inflammatory Drug)
- Trial name
- BND (NCT07178639)
- Testing
- Bromfenac 0.09 % Ophthalmic Solution, Nepafenac 0.3% Oph Susp, diclofenac 0.1% ophthalmic susp.
- Where
- Czechia
- Volunteers
- 150 people
- Sponsor
- Nemocnice Kolín
Non-Proliferative Diabetic Retinopathy
Clinical Study on the Efficacy and Safety of TNTL in the Treatment of Non-proliferative Diabetic Retinopathy
The goal of this clinical trial is to learn if drug TNTL works to treat non-proliferative diabetic retinopathy in adults. It will also learn about the safety of drug TNTL. The main questions it aims to answer are: 1.
- Trial name
- TNTL (NCT06817265)
- Testing
- TNTL, TNTL simulation preparation
- Where
- 30 sites in China
- Volunteers
- 360 people
- Sponsor
- Beletalent (Zhuhai) Pharmaceutical Co., Ltd