Clinical trials: Retrospective
Corneal Transplant Rejection
Risk Factors for Human Corneal Graft Failure : a Monocentric Retrospective Observational Cohort
Keratoplasty is one of the most common grafts and penetrating keratoplasty is still the technique most used in the world, ahead of lamellar grafts, and is estimated to represent 70% of the total.
- Trial name
- NCT04791696
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
ALK-positive Non-small-cell Lung Cancer
Study to Evaluate Clinical Real World Outcomes of Lorlatinib After Alectinib in ALK-Positive NSCLC Japanese Patients
To evaluate the clinical real world outcomes of lorlatinib in second/later line setting anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitor (TKI) to TKI sequence sequence treatment after failure of alectinib as a…
- Trial name
- NCT04979988
- Testing
- Lortlatinib
- Where
- 16 sites in Japan
- Volunteers
- 51 people
- Sponsor
- Pfizer
Leukemia, Lymphoblastic, Acute, ALL, Childhood
Optimal Methods of Disease Detection in Children and Young Adults With Acute Lymphoblastic Leukemia in the Pediatric Oncology Branch
Background: Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. It occurs when a bone marrow cell develops errors in its DNA. Certain tests are used to help detect the disease.
- Trial name
- NCT03627208
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Cancer Institute (NCI)
Autism Spectrum Disorder
Play Based Approach Among Autism
This pilot study evaluates the effectiveness of the B.A.S.I.C.S. framework, a multimodal play-based intervention designed for children with autism spectrum disorder (ASD).
- Trial name
- NCT07814040
- Testing
- B.A.S.I.C.S FRAMEWORK, Conventional Physiotherapy
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Saveetha University
Maternal; Chorioamnionitis, Affecting Fetus, Early-Onset Sepses, Neonatal
A Chart Review of Newborns With the Presence of Confirmed or Suspected Maternal Chorioamnionitis and Utilization of the Early Onset Sepsis Calculator
This study will review practices in relation to chorioamnionitis (CAM) before and after to the implementation of the Neonatal Early-Onset Sepsis (EOS) Risk Calculator to determine the effect in the nursery at Banner - University…
- Trial name
- NCT04513691
- Testing
- EOS Calculator
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Pediatrix
Pediatric and Adolescent Differentiated Thyroid Carcinoma, SEER Database Analysis
Clinical and Surgical Outcomes of Thyroid Carcinoma in Children and Adolescents
This study aims to investigate the differences in clinical characteristics, causes of death, long-term survival, and surgical approaches between pediatric and adolescent follicular and papillary carcinoma by exploring data from…
- Trial name
- CPSO-TC (NCT06592118)
- Testing
- Different Pathological Types (FTC vs PTC)
- Volunteers
- 3,068 people
- Sponsor
- Dezhou Hospital Qilu Hospital of Shandong University
Osteoporosis, Postmenopausal
Real-world Effectiveness and Cardiovascular Safety Study of Abaloparatide in Postmenopausal Women
The purpose of the study is to evaluate the real-world effectiveness and cardiovascular safety of ABL compared with TPTD during the 18-month period after treatment initiation in propensity score (PS)-matched cohorts
- Trial name
- NCT04974723
- Testing
- Abaloparatide, Teriparatide
- Where
- United States
- Volunteers
- 22,054 people
- Sponsor
- Radius Health, Inc.
Accuracy, Operation Time
Retrospective Study on the Application of Tooth-bone Dual-support Osteotomy/Location Plate in "Surgery-first" Orthognathic Treatment
The goal of this observational study is to learn the accuracy of tooth-bone dual-support osteotomy/location guide plate compared with conventional CAD/CAM interocclusal splints in "surgery-first" orthognathic surgeries.
- Trial name
- NCT07622758
- Testing
- orthognathic surgery
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College
Non-Small Cell Lung Cancer
A Retrospective Study of the Effectiveness and Safety of Nivolumab in Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC) Patients in Japan
A Retrospective Study of the Effectiveness and Safety of Nivolumab in Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC) Patients in Japan
- Trial name
- NCT03273790
- Where
- Japan
- Volunteers
- 939 people
- Sponsor
- Bristol-Myers Squibb
Limb Length Discrepancy
A Review of Precice Intramedullary Limb Lengthening (IMLL) System for Limb Lengthening Procedures in Children.
This study will look at how safe and effective limb lengthening surgeries are for the femur and tibia in children 12 years old and younger.
- Trial name
- NCT06714110
- Testing
- Intramedullary Limb Lengthening Device, External Fixator Limb Lengthening Device
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- NuVasive
Congenital Disorders
Adult Congenital Heart Disease Surgery
It is now estimated that the number of adults with congenital heart disease in the U.S is over 800,000. Unfortunately, these patients, in some way, have become a lost population.
- Trial name
- NCT00446160
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Emory University
Organ Preservation, Liver Transplantation
Long-term Outcomes After Hypothermic Oxygenated Machine Perfusion of Donor Livers Using Real-world Data
End-ischemic hypothermic oxygenated machine perfusion (HOPE) of human donor livers mitigates ischemia-reperfusion injury, resulting in a reduction of post-reperfusion syndrome, early allograft dysfunction and biliary…
- Conditions
- Organ Preservation, Liver Transplantation, Hypothermic Machine Perfusion
- Trial name
- HOPE-REAL (NCT05520320)
- Testing
- Hypothermic oxygenated machine perfusion (any device)
- Where
- 2 sites in Netherlands, Switzerland
- Volunteers
- 1,202 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Congenital Disorders
Children and Adolescents Receiving Mechanical and Prosthetic Valves
The primary objective of this retrospective study of valve replacement is to document long-term survival and occurrence of valve related complications such as described in the literature; anticoagulant related bleeding event …
- Trial name
- NCT00268008
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Children's Healthcare of Atlanta
COVID19- Infection with SARS-CoV-2 Virus
Impact of the COVID-19 Pandemic on Central Precocious Puberty: a Retrospective Cohort Study from Turkey
Objective: This study investigates the clinical and demographic characteristics of girls diagnosed with central precocious puberty (CPP) in the pre-pandemic and pandemic periods to assess potential changes during the COVID-19…
- Trial name
- COVID-19-PP (NCT06823076)
- Where
- Turkey (Türkiye)
- Volunteers
- 192 people
- Sponsor
- Umraniye Education and Research Hospital
Iron Deposition, Dialysis
Iron Deposits in the Pancreas by MRI Method of Dialysis Patients With Hemosiderosis Iatrogenic (ERDFP)
Recently, a multidisciplinary scientific conference proposed to consider iron overload in dialysis patients as pathological only in the event of demonstration of radiological (in MRI), pancreatic or cardiac ferric deposits.
- Conditions
- Iron Deposition, Dialysis, Iatrogenic Hemosiderosis
- Trial name
- ERDFP (NCT05593068)
- Testing
- MRI
- Where
- France
- Volunteers
- 185 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Metastatic Colorectal Adenocarcinoma
Trifluridine/Tipiracil Plus Bevacizumab Versus Trifluridine/Tipiracil Monotherapy in Refractory Metastatic Colorectal Cancer
This study is a retrospective study to compare the efficacy and safety between trifluridine/tipiracil (TAS-102) plus bevacizumab (BEV) with TAS-102 monotherapy in refractory metastatic colorectal cancer (mCRC) from November 2020…
- Trial name
- NCT05869097
- Testing
- Trifluridine/Tipiracil, Bevacizumab
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Hunan Cancer Hospital
Congenital Heart Disease
Relationship of Brain Natriuretic Peptide (BNP) Levels to Cardiac Diagnosis, Operation Performed, Post-operative Course and Outcome
The purpose of this study is to assess brain natriuretic peptide levels to evaluate the relationship of those levels with the diagnosis of congenital cardiac disease, operation performed, post-operative course, and outcome.
- Trial name
- NCT00238810
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Healthcare of Atlanta
Allergic Bronchopulmonary Aspergillosis
Multicenter Registration Study on Allergic Bronchopulmonary Aspergillosis
To understand the current diagnosis and treatment status of ABPA patients, observe their clinical characteristics, prognosis, and treatment outcomes, and identify the relevant factors for poor prognosis in patients.
- Trial name
- NCT06645210
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Peking University Third Hospital
Fuchs' Endothelial Corneal Dystrophy, Descemet Membrane Endothelial Keratoplasty
Predictive Factors of Graft Detachment Following Dmek
The aim of this study was to identify the predictive factors of graft detachment after Descemet Membrane Endothelial Keratoplasty (DMEK) surgery.
- Conditions
- Fuchs' Endothelial Corneal Dystrophy, Descemet Membrane Endothelial Keratoplasty, Pseudophakic Bullous Keratopathy, Graft Detachment
- Trial name
- PDF DMEKDETACH (NCT05531760)
- Testing
- Descemet Membrane Endothelial Keratoplasty
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Short Bowel Syndrome (SBS)
Retrospective Study on Participants With Short Bowel Syndrome and Chronic Intestinal Failure That Underwent Transplantation in Brazil
The main aim of this study is to capture management and treatment outcome data in participants with short bowel syndrome and chronic intestinal failure (SBS-IF) that underwent intestinal transplantation in Brazil.
- Trial name
- NCT05113082
- Where
- Brazil
- Volunteers
- 7 people
- Sponsor
- Takeda
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