Clinical trials: Reward
Healthy
The Effects of Losartan on Reward Reinforcement Learning
This study aims to investigate whether a single dose of losartan (50 mg) can affect learning from positive and negative outcomes and its related neural mechanisms.
- Trial name
- NCT04604938
- Testing
- Losartan
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Schizophrenia, Depression
Validating Reward-related Biomarkers (RTOC)
Deficits or abnormalities in reward processing are present in a number of psychiatric disorders. The overarching objective of the study is to conduct initial validation work towards optimising three experimental tasks - which…
- Conditions
- Schizophrenia, Depression, Motivation, Anhedonia, Physical
- Trial name
- RTOC (NCT04024371)
- Testing
- Self-rating Questionnaires, Measures of Reward processing/reinforcement learning, Additional Schizophrenia-specific Questionnaires and Interviews
- Where
- 4 sites in Germany, Greece and 2 more
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Healthy Volunteers
Feedbacks' Influence on Decision Making Processes
The purpose of this research is to identify and probe the neural networks involved in feedback processing. It aims at translating this knowledge to clinical populations in which this network is disrupted or compromised.
- Trial name
- Feedbacks (NCT02816632)
- Testing
- mRI, Effect of Galvanic Vestibular Stimulation on decision making processes
- Where
- France
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Healthy Volunteers - Male and Female
Resting-state Imaging and Chronic Consumption of Non-Nutritive SweetenerS
Non-nutritive sweeteners are used as a substitute for simple sugars to improve the palatability of food products without increasing their sugar and calorie content.
- Trial name
- RNSS (NCT07183254)
- Testing
- administration of questionnaires, carrying out a MRI scan, Can distribution visit for subjects in the "non/low" sweetener consumption group
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Stress (Psychology)
Effects of Brief Nature Exposure on Brain Functioning and Stress Reactivity
This study is focused on understanding the impact of time spent in nature (relative to an urban control) on stress, neural, and cardiac functioning in people experiencing high levels of stress, depression, and anxiety.
- Trial name
- NCT07508800
- Testing
- Nature vs. Urban walks
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- National Institutes of Health (NIH)
Obesity, Appetitive Behavior
Regulation of Energy Balance and Metabolism - Mechanisms Behind and Beyond Obesity and Weight Loss
The study aims to investigate homeostatic and hedonic mechanisms regulating appetite, energy balance and metabolism in obesity and the effects of three distinct obesity treatments on these regulatory mechanisms.
- Trial name
- BALANCE (NCT03550339)
- Testing
- SURG, DIET, HAES
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Alcohol Addiction
Study of the Opioid Modulation of the Effect of Alcohol on the Dopaminergic Reward System
About 10% of the calculable loss of health and quality of life in industrial countries can be attributed to excessive alcohol consumption.
- Trial name
- NCT03854942
- Testing
- Naltrexone
- Where
- Germany
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Alcohol Drinking, Opioid Use, Unspecified
Opioid Modulation and Neural Reward Activation in Healthy Adults
This is a double blind study of the effects of opioid antagonism on the brain's reward response. The investigators will recruit participants to undergo two scans, one on active medication and one on placebo.
- Trial name
- NCT04854551
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver