Clinical trials: Reward
Obesity, Emotional Eating
Evaluation of Anhedonia and Emotional Eating in Individuals Using GLP-1 Receptor Agonists
This prospective observational study evaluates the longitudinal changes in anhedonia levels and emotional eating behaviors among adult individuals initiating glucagon-like peptide-1 (GLP-1) receptor agonist therapy for weight…
- Conditions
- Obesity, Emotional Eating, Anhedonia
- Trial name
- NCT07803185
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Bulimia Nervosa
Neurobiology of Bulimia Nervosa
This pilot study experimentally manipulates ovarian hormones to examine the direct impact of estrogen (E2) and progesterone (P4) on binge eating symptom burden and the behavioral reward response in women with bulimia nervosa…
- Trial name
- NCT04225221
- Testing
- Estradiol, Micronized progesterone, Leuprolide Acetate
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of North Carolina, Chapel Hill
Healthy
Effect of Gabapentin on GABA Concentration and Emotional Processing
This study will use magnetic resonance spectroscopy (MRS) and the drug gabapentin to examine the role of the brain chemical gamma-amino-butyric acid (GABA) in regulating emotions in healthy people.
- Trial name
- NCT00094510
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Mental Health (NIMH)
Outpatients / Inpatients With Depression
Study on the Optimal Diagnosis and Treatment Strategy of Major Depressive Disorder Based on Anhedonia
This study is a multicenter clinical research and focuses on the exploring of optimal diagnosis and treatment strategies of MDD based on anhedonia.
- Trial name
- NCT05389046
- Testing
- Escitalopram, Escitalopram+Aripiprazole, Escitalopram+omega-3 PUFAs
- Where
- 3 sites in China
- Volunteers
- 252 people
- Sponsor
- Peking University
Stress Eating, Reward-based Eating
Bringing Awareness Into Eating
The purpose of this study is to test an app-based mindful eating intervention to decrease the reward value of unhealthy food.
- Conditions
- Stress Eating, Reward-based Eating, Craving-related Eating
- Trial name
- NCT04021745
- Testing
- App-based mindful eating
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Brown University
Substance Abuse, Sleep Disturbances
Exploring Substance Use, Sleep Disturbances and Reward Sensitivity
According to foreign medical studies, substance use is closely related to reward sensitivity and sleep patterns. The purpose of this research is to understand the relationship between these three factors, which will help improve…
- Trial name
- NCT07028346
- Testing
- Cognitive Behavioral Therapy for Insomnia, Sleep Education
- Volunteers
- 154 people
- Sponsor
- Kwai Chung Hospital
Heavy Drinking
Perceived Alcohol Rewards and Risks Study
The identification of mechanisms that underlie how people reduce or eliminate alcohol use is a critical public health issue. Understanding these mechanisms can inform how to effectively intervene with problem drinkers.
- Trial name
- PARS (NCT04710095)
- Testing
- Brief Alcohol Intervention, Control Condition
- Volunteers
- 60 people
- Sponsor
- University of California, Los Angeles
Type 2 Diabetes Mellitus, Obesity
DECREASE: Dapagliflozin Plus Exenatide on Central REgulation of Appetite in diabeteS typE 2
This is a 16 week, phase 4, randomized and placebo controlled trial, investigating the separate and combined effects of Sodium Glucose coTransporter 2 (SGLT2) inhibition with dapagliflozin and Glucagon Like peptide-1 (GLP-1)…
- Trial name
- DECREASE (NCT03361098)
- Testing
- Dapagliflozin 10mg, Exenatide
- Where
- Netherlands
- Volunteers
- 65 people
- Sponsor
- Amsterdam UMC, location VUmc
Addiction Nicotine
Self-activation in Individuals With and Without Nicotine Dependence
The purpose of this study is to see if a non-medication intervention can increase motivation and reward processing to non-drug reward cues (for example, a picture of one's favorite food) in individuals with and without nicotine…
- Trial name
- NCT03170258
- Testing
- Neurofeedback (from fMRI and/or EEG)
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Duke University
Binge-Eating Disorder, Obesity
Precursors of Binge Eating Disorder in a Clinical Sample of Adolescents With Obesity
BACKGROUND: Binge eating disorder (BED) is the worldwide most-prevalent eating disorder. It is associated with psychiatric comorbidities and obesity, a high impact in life functioning, and high morbidity and mortality.
- Conditions
- Binge-Eating Disorder, Obesity, Eating Disorders, BED
- Trial name
- PREC-BED (NCT06387719)
- Testing
- Magnetic resonance imaging
- Where
- Spain
- Volunteers
- 102 people
- Sponsor
- Fundació Sant Joan de Déu
Depression Mild, Depression Moderate
An Online Intervention Targeting Depression and Low Reward Sensitivity
This study aims to evaluate and compare the effectiveness of different online interventions targeting reward sensitivity and depressive symptoms.
- Trial name
- NCT05402150
- Testing
- Behavioral Activation, Mindulness and Gratitude, Combination of Behavioral Activation and Mindfulness and Gratitude
- Where
- Germany
- Volunteers
- 224 people
- Sponsor
- Philipps University Marburg
Healthy
A Study To Examine Safety, Pharmacokinetics, And Pharmacodynamic Of Pf 06412562 In Healthy Males
This study is designed to investigate the safety, tolerability pharmacokinetics and pharmacodynamic effects of PF-06412562 following multiple dose administration as MR tablets in healthy adult males.
- Trial name
- NCT02306876
- Testing
- PF-06412562 3mg BID, PF-06412562 15mg BID
- Where
- 3 sites in United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Pfizer
Anxiety Disorders and Symptoms, Depression
Novel Behavioral Intervention to Enhance Social Connections in Anxiety and Depression
The overall goal of this project is to develop a novel transdiagnostic behavioral treatment -- social approach training -- intended to enhance positive social connections in individuals with elevated anxiety and/or depression.
- Trial name
- NCT03196544
- Testing
- Social Approach Training (5 sessions), Social Approach Training (10 sessions)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of California, San Diego
Overweight, Obesity
Cue-Reward Learning and Weight Gain in Youth
The objective of the study is to compare children at low risk for obesity (two healthy weight parents) to children at high risk for obesity (two overweight parents) in their response rate to food taste and in their rate of…
- Trial name
- ChildLearn (NCT03254576)
- Testing
- Functional MRI
- Where
- United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Obesity
Reward Mechanisms in Obesity
The study aims to investigate the effects of 3.0 mg of liraglutide on reward brain circuits in human obesity and to better understand its effects on weight loss (in patients without diabetes).
- Trial name
- LIRAOB (NCT03347890)
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Zoltan Pataky
Major Depressive Disorder, Substance Use Disorder
Defining Neurobiological Links Between Substance Use and Mental Illness
Background: Nicotine dependence leads to about 480,000 deaths every year in the United States. People with major depressive disorder (MDD) are twice as likely to use nicotine compared to the general population.
- Conditions
- Major Depressive Disorder, Substance Use Disorder, Normal Physiology
- Trial name
- NCT05538910
- Testing
- Nicotine Patch
- Where
- United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Schizophrenia
Impact of Inflammation on Reward Circuits, Motivational Deficits and Negative Symptoms in Schizophrenia
This study will recruit persons with schizophrenia or schizoaffective disorder and will use an oral glucose tolerance test to test the hypothesis that insulin resistance drives inflammation.
- Trial name
- NCT03818516
- Testing
- Oral Glucose Tolerance Test (OGTT)
- Where
- 6 sites in United States
- Volunteers
- 12 people
- Sponsor
- Emory University
Stress, Psychological
Stress-Induced Inflammation and Reward Processing
Anhedonia, or loss of interest or pleasure, is a key feature of depression and transdiagnostic construct in psychopathology. Both theory and compelling evidence from preclinical models implicates stress-induced inflammation as a…
- Trial name
- NCT03828604
- Testing
- Stress; Trier Social Stress Task
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Social Anxiety Disorder (SAD), Attention
Smartphone Sensors to Assess Symptom Relief in Patients With Social Anxiety Disorder Undergoing Treatment
The goal of this study is to examine if a digital behavior-based framework, utilizing the BHQ app, can effectively monitor social anxiety symptoms and evaluate the symptom-reducing impact of attentional training for adults…
- Conditions
- Social Anxiety Disorder (SAD), Attention, Smartphones, Smartphone Application
- Trial name
- NCT06732999
- Testing
- Gaze-Contingent Music Reward Therapy (GC-MRT
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Tel Aviv University
Healthy Normal Weight
Meal Texture and Satiety
The aim of the present study is to compare the nutritional compensation between iso-caloric meals of various textures (liquid vs solid) in health young adults.
- Trial name
- FEED (NCT04041752)
- Testing
- SOLID, LIQUID_P, LIQUID_L
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand