Clinical trials: Reward Sensitivity
Anxiety Disorders, Public Speaking Fear
Reward Processes and Rehearsal in Exposure Therapy
The purpose of this study is to 1) examine the importance of self-reported relief following exposure and 2) test whether positive-focused rehearsal following exposure can improve treatment outcomes for participants who endorse…
- Trial name
- NCT06132425
- Testing
- Exposure, Rehearsal
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of California, Los Angeles
Alcohol Use, Unspecified
Estradiol Effects on Alcohol Across the Menstrual Cycle
This study will provide the first rigorous integrative test of the hypothesis that rapid rises in estradiol (a female hormone) increase the rewarding and disinhibiting effects of alcohol and that such increased sensitivity…
- Trial name
- NCT04595682
- Testing
- Alcohol
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mark Fillmore
Psychosis
Determining the Role of Social Reward Learning in Social Anhedonia
This is a clinical trial study that aims to evaluate the specificity of the relationship between reduced sensitivity to social reward and social anhedonia at both behavioral and neural levels.
- Trial name
- SAMI (NCT05617898)
- Testing
- Motivational Interviewing, Nutrition Didactic Training
- Where
- 2 sites in United States
- Volunteers
- 152 people
- Sponsor
- University of Alabama at Birmingham
Depression, Anxiety
Treatment for Affect Dimensions
The purpose of this study is to evaluate the efficacy and targets of Positive Affect Treatment, a psychotherapy specifically aimed at enhancing reward sensitivity in individuals with low positive affect (a core feature of…
- Trial name
- TAD (NCT03439748)
- Testing
- Positive Affect Treatment, Negative Affect Treatment
- Where
- 2 sites in United States
- Volunteers
- 85 people
- Sponsor
- University of California, Los Angeles
Healthy
Cognitive, Emotional, and Neural Responses to Acute Inflammation
This study is a pilot study to examine the effects of acute inflammation on cognition and emotion in healthy participants using a between-subjects, randomized, double-blind design.
- Trial name
- NCT03294564
- Testing
- Typhoid Vi Polysaccharide Vaccine
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Anxiety Disorders, Anxiety
Pramipexole to Enhance Social Connections
This study seeks to understand if the medication pramipexole improves social connectedness and functioning in adults (ages 18-50) who experience anxiety or depression.
- Conditions
- Anxiety Disorders, Anxiety, Depression, Social Disconnection
- Trial name
- NCT06269146
- Testing
- Pramipexole Pill
- Where
- 2 sites in United States
- Volunteers
- 108 people
- Sponsor
- University of California, San Diego
Internet Gaming Disorder, Internet Addiction
Neurotrophic Factors, Impulsivity, and Reward Sensitivity in Children With Internet Gaming Disorder
Research and knowledge regarding the neurobiology of behavioral addictions and Internet Gaming Disorder (IGD) remain limited compared to substance and alcohol use disorders.
- Trial name
- NCT07590180
- Testing
- Clinical Evaluation and Biochemical Sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Istanbul Saglik Bilimleri University
Substance Abuse, Sleep Disturbances
Exploring Substance Use, Sleep Disturbances and Reward Sensitivity
According to foreign medical studies, substance use is closely related to reward sensitivity and sleep patterns. The purpose of this research is to understand the relationship between these three factors, which will help improve…
- Trial name
- NCT07028346
- Testing
- Cognitive Behavioral Therapy for Insomnia, Sleep Education
- Volunteers
- 154 people
- Sponsor
- Kwai Chung Hospital
Depression, Anxiety
Affect Treatment for Depression and Anxiety
The purpose of this study is to evaluate the efficacy and mediators of change in Positive Affect Treatment, a psychotherapy specifically aimed at enhancing reward sensitivity in individuals with low positive affect (a core…
- Trial name
- NCT05203861
- Testing
- Positive Affect Treatment, Negative Affect Treatment
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of California, Los Angeles
Acquired Brain Injury
Rewards Sensitivity After Brain Injury
A study measuring rewards sensitivity in individuals with acquired brain injury at an acute rehabilitation level.
- Trial name
- NCT06510023
- Testing
- Type of reward presented
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Binge-Eating Disorder
Binges and Neural Variability
People who suffer from binge eating disorder experience recurrent episodes of binge eating.During these episodes, they consume an unusually large amount of food in a short amount of time and experience loss of control over…
- Trial name
- BEDVAR (NCT04184856)
- Testing
- fMRI
- Where
- Germany
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Healthy, Brain Insulin Sensitivity
Long-Term Effects of Walnut Consumption on Brain Function
Rationale: Healthy foods, including mixed nuts, may improve brain function, which is essential for cognitive and metabolic health, and may contribute to improved food intake regulation.
- Conditions
- Healthy, Brain Insulin Sensitivity, Cerebral Blood Flow, Brain Vascular Function
- Trial name
- WalBrain (NCT07422220)
- Testing
- Walnuts
- Where
- Netherlands
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Learning Disabilities
Effects of Oxytocin on Reinforcement Learning
The main aim of the study is to investigate whether intranasal oxytocin (24IU) influences reward sensitivity and performance monitoring during reinforcement learning.
- Trial name
- NCT03846271
- Testing
- intranasal oxytocin
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Bipolar Disorder
Reward and Punishment Sensitivity in Bipolar Disorders
Bipolar disorder (BD) represents a chronic mood disorder and one of the leading causes of disability worldwide. Complexity of its clinical presentations leads to delayed diagnosis and difficult management in routine clinical…
- Trial name
- Recodec-BP (NCT04237610)
- Testing
- behavioral assessment
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Healthy Volunteers
Effect of Intragastric Administration of Fatty Acids on Generalized Reward Sensitivity
This study aim to investigate the influence of intragastrically infused fatty acid on the generalization of responses to reward within the food domain and between financial and sexual domains.
- Trial name
- NCT02984150
- Testing
- dodecanoic acid, saline
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Depression, Anxiety Disorders and Symptoms
Amplification of Positivity to Enhance Social Connections in Anxiety and Depression
The overall goal of this project is to develop a novel transdiagnostic behavioral treatment -- Amplification of Positivity (AMP) -- intended to enhance positive social connections in individuals with elevated anxiety and/or…
- Trial name
- NCT04945239
- Testing
- Amplification of Positivity Training (6 Sessions), Stress Management Training (6 Sessions)
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- University of California, San Diego
Depression, Inflammation
Tofacitinib in Depression (TIDE)
This study will test whether 7-10 day administration of the anti-inflammatory drug, tofacitinib, has positive effects on people experiencing treatment-resistant depression compared to placebo.
- Trial name
- TIDE (NCT04141904)
- Testing
- Tofacitinib 5 MG [Xeljanz]
- Where
- United Kingdom
- Volunteers
- 2 people
- Sponsor
- University of Oxford