Clinical trials: RhA - Rheumatoid Arthritis
Rheumatoid Arthritis
Rheumatoid Arthritis, Planned Behavıor Theory And Nurse Counselıng
Ensuring disease management begins with comprehensive education and drug therapy. Symptoms such as deformities, pain and fatigue, which are most common in rheumatoid arthritis patients, seriously affect the daily activities of…
- Trial name
- NCT05039372
- Testing
- TRAINING AND CONSULTANCY
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Hasan Kalyoncu University
Rheumatoid Arthritis (RA)
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ASP5094 Following Multiple Intravenous Doses in Subjects With Rheumatoid Arthritis on Methotrexate
The purpose of this study is to evaluate the safety, tolerability and pharmacokinetics of multiple ascending intravenous doses of ASP5094 in male and female subjects with rheumatoid arthritis (RA) on methotrexate (MTX).
- Trial name
- NCT02698657
- Testing
- ASP5094
- Where
- 13 sites in United States, Poland
- Volunteers
- 30 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Rheumatoid Arthritis
A Phase III Transition Study of DRL Rituximab to Reference Medicinal Products
The objective of the current study is to assess the immunogenicity and safety of transitioning subjects with RA to DRL_RI from US-rituximab/EU-rituximab to continued treatment with US-rituximab/EU-rituximab.
- Trial name
- RI-01-007 (NCT04268771)
- Testing
- Experimental: Arm A: DRL_RI, Arm B: Rituxan®/Mabthera®
- Where
- 26 sites in United States
- Volunteers
- 140 people
- Sponsor
- Dr. Reddy's Laboratories Limited
Autoimmune Disease, Crohn Disease
Fluorine F 18 Clofarabine PET/CT in Imaging Patients With Autoimmune or Inflammatory Diseases
This pilot trial studies how well fluorine F 18 clofarabine positron emission tomography (PET)/computed tomography (CT) works in imaging patients with autoimmune or inflammatory diseases.
- Conditions
- Autoimmune Disease, Crohn Disease, Inflammatory Disorder, Rheumatoid Arthritis
- Trial name
- NCT02925351
- Testing
- Computed Tomography, Fluorine F 18 Clofarabine, Positron Emission Tomography
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Rheumatoid Arthritis
An Open-label Study With Tocilizumab in Patients With Rheumatoid Arthritis in a Local Environment
This open-label, multi-center study in a local environment will evaluate the safety and the effect on disease activity with regard to reduction in signs and symptoms over 6 months of treatment in patients with moderate to severe…
- Trial name
- NCT01254331
- Testing
- tocilizumab [RoActemra]
- Where
- 6 sites in Tunisia
- Volunteers
- 51 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
MSB11456 in Participants With Moderately to Severely Active Rheumatoid Arthritis
The purpose of the study is to compare the efficacy, safety and immunogenicity of MSB11456 and EU approved RoActemra® in participants with moderately to severely active rheumatoid arthritis.
- Trial name
- NCT04512001
- Testing
- MSB11456, EU-approved RoActemra
- Where
- 85 sites in Bulgaria, Czechia and 7 more
- Volunteers
- 604 people
- Sponsor
- Fresenius Kabi SwissBioSim GmbH
Rheumatoid Arthritis
Dose Reduction for Early Rheumatoid Arthritis Patients With Low Disease Activity
This is an international (Nordic) trial designed to compare the safety and efficacy of active conventional therapy (ACT) and three biologic treatments (Certolizumab-pegol, Abatacept or Tocilizumab) in subjects with early…
- Trial name
- NCT02466581
- Testing
- Sulphasalazine + Hydroxychloroquine OR Prednisolone, Cimzia, Orencia
- Where
- 8 sites in Sweden
- Volunteers
- 25 people
- Sponsor
- Karolinska Institutet
Rheumatoid Arthritis
Prediction of Response to Certolizumab Pegol Treatment by Functional MRI of the Brain
By using functional MRI the investigators have recently shown that TNFi elicit rapid changes in brain function linked to the perception of RA [5].
- Trial name
- PreCePRA (NCT01864265)
- Testing
- Certolizumab Pegol
- Where
- 6 sites in Germany, Portugal and 1 more
- Volunteers
- 156 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Rheumatoid Arthritis
A Study of ARRY-438162 in Patients With Rheumatoid Arthritis
This is a Phase 2 study, involving a 12-week treatment period, designed to evaluate the effectiveness of investigational study drug ARRY-438162 in treating rheumatoid arthritis in patients on stable doses of methotrexate, and to…
- Trial name
- NCT00650767
- Testing
- ARRY-438162, MEK inhibitor; oral
- Where
- 35 sites in United States, Argentina and 5 more
- Volunteers
- 201 people
- Sponsor
- Array Biopharma, now a wholly owned subsidiary of Pfizer
Rheumatoid Arthritis
Vascular Occlusion and Rheumatoid Arthritis
Resistance exercise plus vascular occlusion may induce greater improvements in strength and muscle mass resistance training alone.
- Trial name
- NCT01483157
- Testing
- vascular occlusion with exercise trainig, high intensity resistance training
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
Rheumatoid Arthritis (RA)
Comparison of Oral Administration of a JAK Inhibitor in Rheumatoid Arthritis
The aim of this study is to offer patients two treatment options: morning or evening administration of a JAK inhibitor prescribed within the framework of its marketing authorization, according to the EULAR response.
- Trial name
- JAK-INHI (NCT07674134)
- Where
- Monaco
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Princesse Grace
Osteoarthritis, Rheumatoid Arthritis
Exceed ABT Acetabular Cup Cementless System
A Post-market Clinical Follow-up Study to provide safety, performance and clinical benefits data on the Exceed ABT acetabular cup (implants and instruments) when used in combination with ceramic liners or polyethylene…
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Correction of Functional Deformity
- Trial name
- NCT04255394
- Volunteers
- 677 people
- Sponsor
- Zimmer Biomet
Arthritis, Rheumatoid
A Phase 2 Study to Evaluate the Safety, Tolerability, and Activity of Fontolizumab in Subjects With Active Rheumatoid Arthritis
To evaluate the efficacy of fontolizumab in subjects with active rheumatoid arthritis as determined by a 50% improvement of an American College of Rheumatology criteria (ACR50) response at Week 14 (Stage A of study).
- Trial name
- NCT00281294
- Testing
- Fontolizumab
- Where
- 9 sites in United States
- Volunteers
- 40 people
- Sponsor
- PDL BioPharma, Inc.
Rheumatoid Arthritis
Effectiveness and Safety of Tofacitinib in Korean Patients With Rheumatoid Arthritis
The objectives of this single center, prospective, non-interventional inception cohort is to understand patient characteristics, general treatment patterns, effectiveness, and safety of Tofacitinib for rheumatoid arthritis…
- Trial name
- NCT03011281
- Testing
- Tofacitinib
- Where
- South Korea
- Volunteers
- 378 people
- Sponsor
- Hanyang University
Rheumatoid Arthritis
A Retrospective Observational Study on the Use of Biologics in Monotherapy in Patients With Rheumatoid Arthritis
This retrospective, observational, multi-center study will evaluate the use of biological agents (e.g. RoActemra/Actemra [tocilizumab]) in monotherapy in patients with rheumatoid arthritis.
- Trial name
- NCT01834807
- Where
- 14 sites in Belgium
- Volunteers
- 180 people
- Sponsor
- Hoffmann-La Roche
Healthy, Rheumatoid Arthritis
MAD Study of IA-14069
The purpose of this study is to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple ascending oral doses of IA-14069 in healthy subjects and in patients with RA on stable dosese of MTX, with…
- Trial name
- NCT05533372
- Testing
- IA-14069, Methotrexate
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- ILAb Co., Ltd.
Back Pain, Coronary Artery Disease
Detecting and Addressing Preclinical Disability
The Physical Functioning Inventory (PFI) is a standardized patient reported outcome measure that assesses preclinical disability.
- Conditions
- Back Pain, Coronary Artery Disease, Chronic Obstructive Pulmonary Disease, Diabetes
- Trial name
- NCT01979081
- Testing
- Tailored advice from a physiotherapist and/or an occupational therapist through the myOSCAR patient portal
- Where
- Canada
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- McMaster University
Arthritis, Rheumatoid
Efficacy and Safety of GSK3196165 (Otilimab) Versus Placebo and Sarilumab in Participants With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Biological Disease-modifying Antirheumatic Drug (DMARDs) and/or Janus Kinase (JAK) Inhibitors
This study (contRAst 3 [202018: NCT04134728]) is a Phase 3, randomized, multicenter, double-blind study to assess the safety and efficacy of GSK3196165 in combination with conventional (cs) DMARD[s]) or the treatment of adult…
- Trial name
- contRAst 3 (NCT04134728)
- Testing
- GSK3196165 (Otilimab), Sarilumab, csDMARDs
- Where
- 131 sites in United States, Argentina and 13 more
- Volunteers
- 550 people
- Sponsor
- GlaxoSmithKline
Rheumatoid Arthritis
A Study of Subcutaneous Tocilizumab as Monotherapy and/or in Combination With Non-Biologic Disease Modifying Anti-Rheumatic Drugs (DMARDs) in Participants With Rheumatoid Arthritis
This Phase IIIb, multicenter, open label, single arm study will evaluate the safety and efficacy of subcutaneous (SC) tocilizumab as monotherapy or in combination with methotrexate or other non-biologic DMARDs in participants…
- Trial name
- NCT01941095
- Testing
- Azathioprine, Chloroquine, Hydroxychloroquine
- Where
- 10 sites in Greece
- Volunteers
- 100 people
- Sponsor
- Hoffmann-La Roche
Arthritis, Rheumatoid
Abatacept vs Tocilizumab for the Treatment of RA in TNF Alpha Inhibitor Inadequate Responders
Rheumatoid arthritis (RA) is the most common inflammatory rheumatoid disease in France, affecting 0.3% of the general population.
- Trial name
- SUNSTAR (NCT03227419)
- Testing
- Tocilizumab Prefilled Syringe, Abatacept Prefilled Syringe
- Where
- 26 sites in France
- Volunteers
- 224 people
- Sponsor
- Lille Catholic University
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