Clinical trials: RhA - Rheumatoid Arthritis
Rheumatoid Arthritis, Psoriatic Arthritis
Centocor Microarray Study of Patients
Specific Aim 1. To determine the transcriptome of peripheral blood mononuclear cells isolated monocytes and target tissues in IMIDs. Specific Aim 2.
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Psoriasis, Crohn's Disease
- Trial name
- NCT00462072
- Testing
- Infliximab
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Arthritis, Rheumatoid
Comparison Of 4 CP-690,550 Doses Vs. Placebo, Each Combined With Methotrexate, For The Treatment Of Rheumatoid Arthritis in Japan
The purpose of this study is to determine the effectiveness and safety, over 3 months, of 4 dose regimens of CP-690,550, combined with methotrexate, for the treatment with active rheumatoid arthritis.
- Trial name
- NCT00603512
- Testing
- CP-690,550
- Where
- 18 sites in Japan
- Volunteers
- 140 people
- Sponsor
- Pfizer
Rheumatoid Arthritis, Osteoarthritis
Cementless Alumina-Alumina Total Hip and Hybrid
Evaluate the safety and efficacy of the CeramTec Acetabular Alumina Insert and CeramTec Alumina head when used with the Foundation Porous Coated Acetabular Shell and an Encore hip stem.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Post-traumatic Arthritis, Avascular Necrosis
- Trial name
- NCT00764530
- Testing
- Alumina/Alumina, Standard
- Where
- 3 sites in United States
- Volunteers
- 342 people
- Sponsor
- Encore Medical, L.P.
Juvenile Chronic Polyarthritis, Juvenile Idiopathic Arthritis
Trial of Early Aggressive Drug Therapy in Juvenile Idiopathic Arthritis
The purpose of this study is to compare two aggressive drug regimens for children with poly-juvenile idiopathic arthritis (JIA) and extended oligo JIA.
- Conditions
- Juvenile Chronic Polyarthritis, Juvenile Idiopathic Arthritis, Juvenile Rheumatoid Arthritis
- Trial name
- NCT00443430
- Testing
- methotrexate, methotrexate - etanercept - prednisolone arm
- Where
- 15 sites in United States
- Volunteers
- 85 people
- Sponsor
- Seattle Children's Hospital
Rheumatoid Arthritis, Pharmacokinetics of ASP2408
A Study To Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of ASP2408 After Multiple Dose Subcutaneous Injections in Patients With Rheumatoid Arthritis on Methotrexate
The purpose of this study is to assess the safety, tolerability and pharmacokinetics (PK) of two dosing regimens of multiple, subcutaneous (sc) injections of ASP2408 in patients with Rheumatoid Arthritis (RA) on Methotrexate…
- Trial name
- NCT02052375
- Testing
- ASP2408
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Rheumatoid Arthritis
A Study of JNJ-67484703 in Participants With Active Rheumatoid Arthritis
The purpose of this study is to evaluate safety and tolerability of JNJ-67484703 administrations in participants with active rheumatoid arthritis (RA).
- Trial name
- NCT04985812
- Testing
- JNJ-67484703
- Where
- 11 sites in United States, Georgia and 4 more
- Volunteers
- 44 people
- Sponsor
- Janssen Research & Development, LLC
Rheumatoid Arthritis
Efficiency of a Tight Monitoring by a Nurse Practitioner of Rheumatoid Arthritis (RA) Patients in Remission
Rheumatoid arthritis (RA) is a progressive disease that affects mainly small and medium joints and, in the absence of appropriate background therapy, leads to progressive joint destruction, functional, psychological, social and…
- Trial name
- SIERRA (NCT03027999)
- Testing
- tight nursing follow-up
- Where
- 2 sites in France
- Volunteers
- 51 people
- Sponsor
- University Hospital, Rouen
Joint Disease, Rheumatoid Arthritis
an On-demand Program to EmpoweR Active Self-management (OPERAS)
Self-management is a key component of successful chronic disease management and patients can benefit from learning about how daily activities and treatments relate to their symptoms and health status on an ongoing basis.
- Trial name
- OPERAS (NCT03404245)
- Testing
- Education, Fitbit/self-management app, physiotherapist counselling., Same intervention with a 6 month delay
- Where
- Canada
- Volunteers
- 132 people
- Sponsor
- University of British Columbia
Rheumatoid Arthritis
A Study of Immune Cells in Patients With Rheumatoid Arthritis During Different Types of Anti-TNF Alpha Treatments (Study P05521)
This 14-week study will observe the gene expression of certain immune cells in patients with rheumatoid arthritis who receive etanercept, infliximab, and adalimumab.
- Trial name
- NCT00724672
- Testing
- etanercept, infliximab, adalimumab
- Sponsor
- Merck Sharp & Dohme LLC
Rheumatoid Arthritis（RA）
Infliximab and Classic DMARDs in the Rheumatoid Arthritis Patients
A prospective, multi-centric, cohort study to observe the efficacy difference between intensive classic DMARDs and Infliximab(IFX) with methotrexate(MTX) treatment in sever rheumatoid arthritis(RA) 28 joints disease activity…
- Trial name
- INNOVATION (NCT01915537)
- Testing
- Infliximab group, Classic DMARDs treatment group
- Where
- 3 sites in China
- Volunteers
- 170 people
- Sponsor
- Zhang, Xiao, M.D.
Arthritis, Rheumatoid, Biological Therapy
Assessment of the Clinical and Medico-economic Impact of SinnoTest® in Patients With Rheumatoid Arthritis
Rheumatoid arthritis (RA) is one of the main chronic inflammatory rheumatic diseases (RCI), with a prevalence of about 0.4% of the population.
- Trial name
- SINNO-RA (NCT04117165)
- Testing
- Biotherapy Prescription with SinnoTest® software, Patient Current Care
- Where
- 16 sites in France
- Sponsor
- University Hospital, Grenoble
Arthritis, Psoriatic, Psoriasis
Study Evaluating the Cost of the Treatments of the Refractory Psoriatic Arthritis to the Conventional Therapy
The purpose of this study is to conduct an economic analysis on the cost of conventional therapy as compared to biologic therapy and the direct/indirect costs of disease management in patients with refractory psoriatic arthritis…
- Trial name
- NCT00303186
- Where
- 9 sites in Italy
- Volunteers
- 107 people
- Sponsor
- Pfizer
Rheumatoid Arthritis (RA)
QLS12010 in Participants With Moderate-to-severe Rheumatoid Arthritis
The objective of this randomized, double-blind, placebo-controlled phase II clinical trial is to investigate the safety and efficacy of QLS12010 in subjects with moderate-to-severe rheumatoid arthritis.The main questions it aims…
- Trial name
- NCT07377773
- Testing
- QLS12010
- Volunteers
- 180 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Rheumatoid Arthritis
A Safety and Efficacy Study for Infliximab (Remicade) With Methotrexate in Patients With Early Rheumatoid Arthritis
The purpose of this study is to evaluate the efficacy and safety of infliximab (Remicade) in patients with early rheumatoid arthritis.
- Trial name
- NCT00236028
- Testing
- Infliximab
- Volunteers
- 607 people
- Sponsor
- Centocor, Inc.
Rheumatoid Arthritis
Impact of Clinical Pharmacy Services Provided for Patients With Active Rheumatoid Arthritis
Enrolment of clinical pharmacy services in RA patients as a part of health care system has been investigated at many studies but not investigated in active RA patients before.
- Trial name
- NCT03743181
- Testing
- pharmaceutical care services
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- hager omar mohammed siddik
Autoimmune Pancytopenia, Autoimmune Lymphoproliferative Syndrome (ALPS)
Sirolimus for Autoimmune Disease of Blood Cells
Treatment for patients with autoimmune destruction of blood cells is poor. The part of the body that fights infections is called the immune system and white blood cells (WBCs) are part of the immune system.
- Conditions
- Autoimmune Pancytopenia, Autoimmune Lymphoproliferative Syndrome (ALPS), Evans Syndrome, Idiopathic Thrombocytopenic Purpura
- Trial name
- NCT00392951
- Testing
- sirolimus
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's Hospital of Philadelphia
Arthritis, Rheumatoid
A Phase 3 Study Comparing 2 Doses of CP-690,550 vs. Placebo for Treatment of Rheumatoid Arthritis
This Phase 3 study is intended to provide evidence of the efficacy and safety of CP 690,550 when dosed 5 mg and 10 mg twice a day as monotherapy in adult patients with moderate to severe Rheumatoid Arthritis.
- Trial name
- NCT00814307
- Testing
- CP-690,550
- Where
- 95 sites in United States, Brazil and 14 more
- Volunteers
- 611 people
- Sponsor
- Pfizer
Rheumatoid Arthritis
Efficacy and Safety Study of TAS5315 Compared With Placebo in Participants With Rheumatoid Arthritis.
The purpose of this study is to assess the efficacy and safety of TAS5315 in combination with methotrexate in a 12 week or 36 week in participants with rheumatoid arthritis with inadequate response to methotrexate.
- Trial name
- NCT03605251
- Testing
- TAS5315 low dose, TAS5315 high dose
- Where
- Japan
- Volunteers
- 91 people
- Sponsor
- Taiho Pharmaceutical Co., Ltd.
Healthy, Rheumatoid Arthritis
Phase 1 Single and Multiple Dose Study of FPA008 in Healthy Volunteers and Rheumatoid Arthritis Subjects
This is a Phase 1, randomized, double-blind, placebo-controlled study designed in 3 parts to assess the safety, tolerability, and PK of single and multiple ascending doses of FPA008 in adult healthy volunteers (Parts 1 and 2) and…
- Trial name
- NCT01962337
- Testing
- FPA008
- Where
- 6 sites in Hungary, Netherlands and 1 more
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Five Prime Therapeutics, Inc.
Atherosclerosis, Cardiovascular Diseases
Atherosclerosis in Rheumatoid Arthritis
To test the theory that accelerated inflammation-promoted atherosclerosis occurs in patients with rheumatoid arthritis (RA).
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Heart Diseases, Inflammation
- Trial name
- NCT00037336
- Sponsor
- Vanderbilt University
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