Clinical trials: RhA - Rheumatoid Arthritis
Axial Spondyloarthritis, Arthritis, Rheumatoid
The Role of Microbiome on Biological Therapy Efficacy in axSpA and RA
Spondyloarthritis (SpA) and Rheumatoid arthritis (RA) are among the most common chronic inflammatory rheumatic diseases. Introduction of Tumor Necrosis Factor alpha inhibitors (TNFi) to the therapeutic strategy improved acute…
- Trial name
- MicroSpA & RA (NCT04973787)
- Testing
- biological disease-modifying antirheumatic drugs (bDMARDs)
- Where
- 10 sites in Portugal
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa
Axial Spondyloarthritis (AxSpA), Non-radiographic Evidence-AxSpA
A Multicenter, Postmarketing Study Evaluating the Concentration of Cimzia® in Mature Breast Milk of Lactating Mothers
The primary objectives of this study are to assess whether there is transfer of Certolizumab Pegol (CZP) into breast milk of lactating mothers who are receiving an established dosing regimen of CZP by evaluating the concentration…
- Conditions
- Axial Spondyloarthritis (AxSpA), Non-radiographic Evidence-AxSpA, Ankylosing Spondylitis, Crohn's Disease
- Trial name
- CRADLE (NCT02154425)
- Testing
- Breast milk sampling, Certolizumab Pegol
- Where
- 6 sites in United States, Netherlands and 1 more
- Volunteers
- 17 people
- Sponsor
- UCB BIOSCIENCES, Inc.
Rheumatoid Arthritis
A Phase III Study of Abatacept in Japanese Subjects With Rheumatoid Arthritis
The purpose of this study is to demonstrate the safety of chronic use of abatacept in Japanese Subjects with Rheumatoid Arthritis (RA) having completed clinical studies IM101-071, IM101-034, and also Disease Modifying…
- Trial name
- NCT00484289
- Testing
- Abatacept
- Where
- 39 sites in Japan
- Volunteers
- 217 people
- Sponsor
- Bristol-Myers Squibb
Rheumatoid Arthritis
Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in Rheumatoid Arthritis
Rheumatoid arthritis is an autoimmune disease characterized by synovial inflammation and joint destruction that follows a relapsing- remitting course.Disease activity assessment is important for rheumatoid arthritis management…
- Trial name
- NCT03617250
- Testing
- Disease Activity Score-28
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Rheumatoid Arthritis
Oral Metagenomic Biomarkers in Rheumatoid Arthritis
Rheumatoid Arthritis (RA) is a chronic and potentially severe autoimmune disease affecting 2 million in the United States. The role of environmental factors in modulating autoimmunity pathogenesis has been clearly described and…
- Trial name
- NCT02544334
- Testing
- Dental Plaque, Multi-dimensional health assessment questionnaire (MDHAQ), Saliva Collection
- Where
- 2 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Florida
Autoimmune Disease
Confirmation of Systemic Autoimmune Diseases in the Agricultural Health Study
Autoimmune diseases may involve nearly any organ and are characterized by abnormal activation or response of certain cells. Evidence suggests that farm work, exposure to silica from farming activities and exposure to pesticides…
- Trial name
- NCT00341198
- Where
- 3 sites in United States
- Volunteers
- 700 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Rheumatoid Arthritis
A Clinical Trial to Study the Effects of Revamilast in Patients With Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a systemic autoimmune and chronic inflammatory disease that causes progressive damage to joints of the body, affecting the functional capacity.
- Trial name
- TERRA (NCT01430507)
- Testing
- Revamilast
- Where
- 36 sites in India, Philippines and 3 more
- Volunteers
- 406 people
- Sponsor
- Glenmark Pharmaceuticals Ltd. India
Arthritis, Rheumatoid
Study to Assess if ABP 798 is Safe & Effective in Treating Moderate to Severe Rheumatoid Arthritis (RA) Compared to Rituximab
This trial is designed to determine what effects the human body has on the investigational medicine, ABP 798, and what effects the body has on the investigational medicine after you have been given it, and if this is comparable…
- Trial name
- NCT02792699
- Testing
- ABP 798, Rituximab (US), Rituximab (EU)
- Where
- 55 sites in United States, Bulgaria and 4 more
- Volunteers
- 311 people
- Sponsor
- Amgen
Juvenile Idiopathic Arthritis, Rheumatoid Arthritis
Pharmacokinetics and Pharmacodynamics of Biologic Drugs in Obese Patients With Arthritis
The purpose of this study is to learn more about how adult and children's bodies use etanercept and how bodyweight influences how well etanercept works.
- Conditions
- Juvenile Idiopathic Arthritis, Rheumatoid Arthritis, Obesity
- Trial name
- PRECISE (NCT04585711)
- Testing
- Etanercept Optimal dosing
- Where
- United States
- Sponsor
- Duke University
Inflammatory Arthritis, Rheumatoid Arthritis
The CCP Study: Coordinated Programme to Prevent Arthritis - Can We Identify Arthritis at a Pre-clinical Stage ?
This is a 12-month, prospective, observational cohort trial involving Primary Care Trusts (PCTs) wishing to take part in the study and the Early Arthritis Clinic (Anti-CCP sub-clinic) at Chapel Allerton Hospital.
- Trial name
- CCP (NCT02012764)
- Where
- United Kingdom
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Rheumatoid Arthritis
Meditation-Based Stress Reduction in Rheumatoid Arthritis
The purpose of this study is to determine whether a mindfulness meditation-based stress reduction program is useful in relieving symptoms associated with rheumatoid arthritis (RA).
- Trial name
- NCT00071292
- Testing
- stress reduction program, meditation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Rheumatoid Arthritis, Crohn's Disease
Certolizumab Pegol for the Treatment of Patients With Active Rheumatoid Arthritis (RA) and Crohn's Disease (CD)
This is an observational trial in Rheumatoid Arthritis and Crohn's Disease patients treated with Cimzia aiming to evaluate the risk and incidence of Tuberculosis.
- Trial name
- NCT01577264
- Where
- 45 sites in Russia
- Volunteers
- 199 people
- Sponsor
- UCB Pharma
Rheumatoid Arthritis
Efficacy and Safety of Traditional Chinese Medicine (TCM) Comprehensive Therapy in Patients With Rheumatoid Arthritis
This is prospective randomized, controlled study to evaluate the efficacy and safety of Qingre Huoxue comprehensive therapy in treating of patients with early Rheumatoid Arthritis (RA).
- Trial name
- NCT02551575
- Testing
- Treatment of MTX and HCQ, Treatment of TCM, Integrative Medicine
- Where
- China
- Volunteers
- 468 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Rheumatoid Arthritis, Systemic Lupus Erythematosus
The Effect of Deep Breathing and Transcutaneus Electrical Nerve Stimulation on Heart Rate Variability
This interventional study aims to investigate the effect of deep breathing (DB) and transcutaneous electrical vagus nerve stimulation (tVNS) on heart rate variability (HRV) in healthy participants and patients with rheumatoid…
- Conditions
- Rheumatoid Arthritis, Systemic Lupus Erythematosus, Healthy Participants
- Trial name
- NCT05157334
- Testing
- Non-invasive auricular electrical transcutaneous vagus nerve stimulation, Deep breathing
- Where
- Denmark
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Rheumatoid Arthritis
Evaluation of SC Injected Tc 99m Tilmanocept Localization in Active RA Subjects by SPECT and SPECT/CT Imaging
Determine the localization of Tc 99m tilmanocept by SPECT and SPECT/CT imaging in subjects with active RA and concordance with clinical symptomology.
- Trial name
- NCT02683421
- Testing
- Tilmanocept
- Where
- 2 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Navidea Biopharmaceuticals
Rheumatoid Arthritis (RA)
Formation of Antibodies and Subsequent Prediction of Clinical Response in Patients With Rheumatoid Arthritis Treated With Four TNF Blocking Agents
The rationale for this study is to further explore if development of antibodies against TNF-α blocking agents is associated with reduced clinical effect/worsened clinical outcome.
- Trial name
- NCT01691014
- Testing
- non-interventional study
- Where
- 13 sites in Denmark
- Volunteers
- 79 people
- Sponsor
- Pfizer
Rheumatoid Arthritis, Healthy Volunteers
A Study in Normal Healthy People, Testing Different Versions of a Pill That Will be Used to Treat Rheumatoid Arthritis.
The study will try, in 2 separate parts, each using 12 research subjects, to see how a new form of the pill CE 224,535 gets released into the bloodstream and whether that is affected by food.
- Trial name
- NCT00838058
- Testing
- CE-224,535, CE 224,535
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Pfizer
Joint Disease
PMCF Study for PROFEMUR® Am Femoral Components and PROCOTYL® O HA Coated Acetabular Components
MicroPort Orthopedics (MPO) is conducting this post market clinical follow-up (PMCF) study to evaluate the safety and efficacy of its total hip arthroplasty (THA) and resurfacing components marketed in the European Union (EU).
- Trial name
- NCT02507258
- Testing
- PROFEMUR® Am Femoral Stem w/ PROCOTYL® O Shell
- Where
- France
- Sponsor
- MicroPort Orthopedics Inc.
Rheumatoid Arthritis
Nerve Block of the Proximal Interphalangeal Joints PIPs in Rheumatoid Arthritis (RA) Patients: a Prospective Pilot Study
Researchers will include 83 rheumatoid arthritis patients (either early or established) diagnosed after 2010 ACR/EULAR criteria with bilateral hand arthritis aged 18 or above.
- Trial name
- NCT04130178
- Testing
- Nerve block, Saline injection
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Sohag University
Rheumatoid Arthritis
Proof-of-Concept Study With BMS-817399 to Treat Moderate to Severe Rheumatoid Arthritis
The purpose of this study is to assess whether BMS-817399 in combination with Methotrexate is effective in treating moderate to severe rheumatoid arthritis.
- Trial name
- RA (NCT01404585)
- Testing
- BMS-817399
- Where
- 29 sites in United States, Argentina and 5 more
- Volunteers
- 123 people
- Sponsor
- Bristol-Myers Squibb
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