Clinical trials: RhA - Rheumatoid Arthritis
Rheumatoid Arthritis
RHEUPP - A Rheumatological Follow-up Management App
The purpose of this Non-inferiority Randomized Clinical Trial is to evaluate the effectiveness of RHEUPP App during telehealth follow-up in a population of Rheumatoid Arthritis patients from a Tertiary Rheumatology Service in…
- Trial name
- RHEUPP (NCT06217172)
- Testing
- RHEUPP App, Usual Follow-up
- Volunteers
- 88 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Rheumatoid Arthritis
Sarilumab Effect on the Pharmacokinetics of Simvastatin
Primary Objective: To evaluate the effect of a single 200 mg subcutaneous injection of sarilumab on the pharmacokinetics of simvastatin in patients with rheumatoid arthritis Secondary Objective: To describe the safety and…
- Trial name
- NCT02017639
- Testing
- sarilumab SAR153191 (REGN88), simvastatin
- Where
- 5 sites in United States, Moldova and 1 more
- Volunteers
- 19 people
- Sponsor
- Sanofi
Rheumatoid Arthritis
An Exploratory Study of Changes in Synovial Immune Responses Following BMS-188667 Therapy in Subjects With Active Rheumatoid Arthritis on Background DMARDs Who Have Failed Anti-TNF Therapy
Study to assess changes in synovial tissue before and after treatment with Abatacept in subjects with RA who remained on their background disease modifying anti-arthritis medications but who have failed previous therapy with…
- Trial name
- NCT00162201
- Testing
- Abatacept
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- Bristol-Myers Squibb
Rheumatoid Arthritis (RA)
Study of Tocilizumab in Combination With Methotrexate for Treatment of Moderate to Severe Rheumatoid Arthritis Patients
This is a Phase III study to evaluate efficacy and safety of Tocilizumab in patients with Rheumatoid Arthritis.
- Trial name
- NCT01258712
- Testing
- Tocilizumab + methotrexate(MTX)
- Where
- 12 sites in Taiwan
- Volunteers
- 86 people
- Sponsor
- Chugai Pharma Taiwan
Rheumatoid Arthritis
A Pilot Study of MabThera (Rituximab) Evaluated by MRI in Patients With Rheumatoid Arthritis.
This single arm study will measure the effect of MabThera in combination with methotrexate on the progression of synovitis, the extent of bone marrow edema, and the number of erosions in the wrist and hand of patients with…
- Trial name
- NCT00502853
- Testing
- rituximab [MabThera/Rituxan], Methotrexate
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Hoffmann-La Roche
Knee Osteoarthritis, Post-traumatic Osteoarthritis
Clinical Evaluation of Vanguard DD RP
This is a single cohort, prospective study of performance and safety of the Vanguard Deep Dish Rotating Platform (DD RP) cementless fixation with the goal to acquire clinical outcomes data and evaluate the performance of the…
- Conditions
- Knee Osteoarthritis, Post-traumatic Osteoarthritis, Rheumatoid Arthritis
- Trial name
- NCT04076202
- Testing
- Cementless Vanguard DD RP
- Where
- Austria
- Volunteers
- 113 people
- Sponsor
- Zimmer Biomet
Rheumatoid Arthritis
A Study to Investigate How JNJ-39758979 May Affect the Plasma Levels of Methotrexate in Rheumatoid Arthritis Participants
The purpose of this study is to evaluate the effects of JNJ-39758979 on the pharmacokinetics (how the body handles a drug) of methotrexate in participants with rheumatoid arthritis.
- Trial name
- NCT01442545
- Testing
- JNJ-39758979 / MTX
- Where
- 5 sites in United States, Germany
- Volunteers
- 21 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Rheumatoid Arthritis (RA)
Safety and Efficacy of MK-8457 and Methotrexate (MTX) in Participants With Active Rheumatoid Arthritis Despite MTX Therapy (P08683, MK-8457-008)
The purpose of this study is to assess the safety and efficacy of MK-8457 + Methotrexate (MTX) in participants with active rheumatoid arthritis (RA) despite MTX therapy.
- Trial name
- NCT01569152
- Testing
- MK-8457 100 mg, Methotrexate
- Volunteers
- 82 people
- Sponsor
- Merck Sharp & Dohme LLC
Type2diabetes, Rheumatoid Arthritis
Understanding Ayurveda Disease Conditions and Treatment Responses
The goal of this observational study is to assess Prakriti \& Vikriti in patients visiting OPD of IIISM department, SRM hospital.
- Conditions
- Type2diabetes, Rheumatoid Arthritis, Osteo Arthritis Knee, Skin Diseases
- Trial name
- NCT06167226
- Testing
- Personalized Ayurveda treatment protocol
- Where
- India
- Volunteers
- 497 people
- Sponsor
- Ayurai Private Limited
Rheumatoid Arthritis (RA)
Therapy of Niacin for Rheumatoid Arthritis
This study is a study to evaluate the safety and efficacy of administering niacin sustained-release capsules to rheumatoid arthritis with hyperlipidemia patients.
- Trial name
- NCT07004725
- Testing
- niacin sustained release capsules
- Volunteers
- 60 people
- Sponsor
- Peking University People's Hospital
Rheumatoid Arthritis
MabionCD20® Compared to MabThera® in Patients With Rheumatoid Arthritis
The purpose of this study is to evaluate biosimilarity between test product MabionCD20® and the reference product - MabThera® (rituximab) and to demonstrate comparative safety and tolerability of a single course of treatment of…
- Trial name
- NCT02468791
- Testing
- Rituximab
- Where
- 51 sites in Bosnia and Herzegovina, Georgia and 3 more
- Volunteers
- 709 people
- Sponsor
- Mabion SA
Arthritis, Rheumatoid
Subject Insights to Understand Rheumatoid Arthritis (RA)
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease affecting the joints and can lead to joint pain, swelling, redness and stiffness and can cause deformity, loss of strength and immobility.
- Trial name
- NCT03285191
- Testing
- Numerical rating scale, Real-time data capture app
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- GlaxoSmithKline
Rheumatoid Arthritis With Adequate Bone Quality, Inflammatory Arthritis
PMCF Study on the Safety and Performance of the Zimmer® Maxera™ Acetabular System in Total Hip Arthroplasty
This study is a multicenter, prospective, non-controlled post market clinical follow-up study. The objectives of this study are to confirm the safety and performance of the commercially available Zimmer® Maxera™ Acetabular System…
- Conditions
- Rheumatoid Arthritis With Adequate Bone Quality, Inflammatory Arthritis, Osteoarthritis, Hip, Avascular Necrosis
- Trial name
- NCT03372278
- Where
- 8 sites in Australia, Belgium and 6 more
- Volunteers
- 250 people
- Sponsor
- Zimmer Biomet
Arthritis, Rheumatoid
Biomarkers of Anti-TNF-α Therapy Efficacy in Rheumatoid Arthritis to Define Unresponsive Patients
The primary objective of this study was to validate the ability of an 8-gene biomarker set to differentiate between participants who met or did not meet European League Against Rheumatism (EULAR) Disease Activity Score (DAS)-28…
- Trial name
- BATTER-UP (NCT01211678)
- Where
- 30 sites in United States
- Volunteers
- 301 people
- Sponsor
- Biogen
Arthritis, Psoriatic, Autoimmune Diseases
Genetic and Immune Studies of Rheumatoid Arthritis and Related Conditions
This protocol will examine blood, synovial fluid and synovial tissue from patients with rheumatoid arthritis and other chronic inflammatory joint diseases to study genetic and immunologic factors involved in the cause…
- Conditions
- Arthritis, Psoriatic, Autoimmune Diseases, Joint Diseases, Osteoarthritis
- Trial name
- NCT00001291
- Where
- United States
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Rheumatoid Arthritis
Long-Circulating Liposomal Prednisolone Versus Pulse Intramuscular Methylprednisolone in Patients With Active Rheumatoid Arthritis
Trial to study the safety of a single, intravenous administration of long-circulating liposomal prednisolone disodium phosphate in patients with active rheumatoid arthritis.
- Trial name
- NCT00241982
- Testing
- long-circulating liposomal prednisolone
- Where
- Netherlands
- Volunteers
- 22 people
- Sponsor
- Radboud University Medical Center
Rheumatoid Arthritis
A Biomarker Study of Secukinumab in Rheumatoid Arthritis (RA) Patients
This study aims to confirm if patients with a specific biomarker might have a better response to secukinumab treatment. To meet this purpose, exploratory biomarker studies will be done.
- Trial name
- NCT01426789
- Testing
- Secukinumab
- Where
- 36 sites in United States, Belgium and 3 more
- Volunteers
- 100 people
- Sponsor
- Novartis Pharmaceuticals
Rheumatoid Arthritis
A Study on Rheumatoid Arthritis Patients Treated With Rituximab
The purpose of the study is to obtain an overall picture of rituximab treatments and treatment responses in RA patients.
- Trial name
- NCT02622503
- Testing
- Rituximab
- Where
- 5 sites in Finland
- Volunteers
- 81 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis, Ankylosing Spondylitis
Comparative Effectiveness and Safety of Biosimilar and Legacy Drugs
In Canada and worldwide there is a need for updated independent real-world comparative effectiveness and safety data related to biologic drugs including biosimilar drugs.
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Ulcerative Colitis, Crohn's Disease
- Trial name
- NCT03729674
- Testing
- Biosimilar, Originator (legacy) drug
- Where
- Canada
- Volunteers
- 800 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Rheumatoid Arthritis
The Effects of Mesenchymal Stem Cell Secretome in Rheumatoid Arthritis Patients
This research is a clinical trial of administering mesenchymal stem cell secretome to rheumatoid arthritis patients.
- Trial name
- NCT05925647
- Testing
- Messenchymal stem cell secretome
- Where
- Indonesia
- Volunteers
- 15 people
- Sponsor
- Universitas Sebelas Maret
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