Clinical trials: RhA - Rheumatoid Arthritis
Active Rheumatoid Arthritis
To Evaluate The Efficacy And Safety Of Sunpharma1505 Compared With Reference1505 In Subjects With Active Rheumatoid Arthritis
This study is designated to evaluate the safety and efficacy of Sunpharma1505 in subjects with active rheumatoid arthritis who are experiencing a flare/exacerbation.
- Trial name
- NCT02534896
- Testing
- Treatment I, Treatment II, Treatment III
- Where
- 20 sites in Belgium, Netherlands
- Volunteers
- 150 people
- Sponsor
- Sun Pharmaceutical Industries Limited
Ankle Rheumatoid Arthritis, Arthritis of Ankle
Exactech Vantage Total Ankle System Post Market Clinical Follow-Up - US Only
The objectives of this study are to evaluate the performance and safety of the Vantage Total Ankle System. This study will follow subjects for a period of up to 10 years post-surgery.
- Conditions
- Ankle Rheumatoid Arthritis, Arthritis of Ankle, Failure, Prosthesis
- Trial name
- NCT05619588
- Where
- 2 sites in United States
- Volunteers
- 370 people
- Sponsor
- Exactech
Rheumatoid Arthritis
Methotrexate Polyglutamate Levels as a Marker for the Clinical Outcome in the Treatment of Rheumatoid Arthritis
The primary objective is to determine whether erythrocyte polyglutamate levels are associated with objective clinical response in patients with rheumatoid arthritis after oral administration of low-dose methotrexate.The secondary…
- Trial name
- NCT00695188
- Testing
- methotrexate
- Where
- 2 sites in Austria
- Volunteers
- 19 people
- Sponsor
- Ludwig-Boltzmann Institut fuer Rheumatologie, Balneologie und Rehabilitation
Rheumatoid Arthritis
Drug Concentration, Immunogenicity, and Efficacy Study in Patients With Rheumatoid Arthritis Currently Treated With Etanercept, Adalimumab, or Infliximab
The purpose of this study is to examine the relationship between anti-drug antibodies, serum drug concentrations, and clinical response for rheumatoid arthritis patients being treated with etanercept, adalimumab or infliximab.
- Trial name
- ANTIBODY-RA (NCT01981473)
- Testing
- no intervention
- Where
- 54 sites in United States, Argentina and 3 more
- Volunteers
- 605 people
- Sponsor
- Pfizer
Osteoarthritis, Knee, Osteoarthritis, Hip
Role of Topical Vancomycin in Reducing Infections in Hip and Knee Arthroplasty
The study is designed to assess the efficacy of vancomycin powder and dilute povidone-iodine lavage (VIP protocol) in reducing the PJI after primary Total Hip Arthroplasty (THA) and Total Knee Arthroplasty (TKA).
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Rheumatoid Arthritis, Avascular Necrosis of Hip
- Trial name
- NCT05972603
- Testing
- 1.0 g Vancomycin powder into the wound, 0,35% povidone-iodine solution lavage
- Where
- Poland
- Volunteers
- 1,000 people
- Sponsor
- Independent Public Healthcare Center in Rypin
Non-inflammatory Degenerative Joint Disease (NIDJD), Avascular Necrosis
Sidus(TM) Post Market Clinical Follow-up (PMCF) Study
This post market clinical follow-up study is designed to confirm safety and performance of the Sidus Stem-Free Shoulder when used in hemi or total shoulder arthroplasty.
- Conditions
- Non-inflammatory Degenerative Joint Disease (NIDJD), Avascular Necrosis, Osteoarthritis, Inflammatory Joint Disease (IJD)
- Trial name
- NCT01700543
- Testing
- Shoulder Arthroplasty
- Where
- 8 sites in Austria, France and 3 more
- Volunteers
- 152 people
- Sponsor
- Zimmer Biomet
Rheumatoid Arthritis
Intervention With Long-chain n-3 Polyunsaturated Fatty Acids From Microalgae Oil in Patients With Rheumatoid Arthritis
The study was performed to investigate the effects of a daily consumption of n-3 LC-PUFA supplemented products (sausage, tomato spread, milk beverage) on disease activity, inflammatory markers, and cardiovascular risk factors in…
- Trial name
- NCT01742468
- Testing
- long-chain n-3 PUFA, sunflower oil
- Where
- 2 sites in Germany
- Volunteers
- 38 people
- Sponsor
- University of Jena
Rheumatoid Arthritis
VACcination In Methotrexate Treated Rheumatoid Arthritis Patients
To estimate the rate of immunological answer 1 month after antipneumococcal vaccination by the conjugated vaccine Prevenar13 ® in patients suffered from rheumatoid polyarthritis and who begin a treatement by methotrexate either…
- Trial name
- VACIMRA (NCT01942174)
- Testing
- Prevenar 13, Pneumo23 / Pneumovax, Methotrexate - Immediate
- Where
- 21 sites in France, Monaco
- Volunteers
- 276 people
- Sponsor
- University Hospital, Montpellier
Rheumatoid Arthritis
Comparative Pharmacokinetic Trial of RGB-03 and MabThera
Pharmacokinetic properties, efficacy, safety and tolerability of RGB-03 and MabThera will be compared in patients suffering from Rheumatoid Arthritis.
- Trial name
- NCT02371096
- Testing
- MabThera (rituximab), RGB-03
- Sponsor
- Gedeon Richter Plc.
Rheumatoid Arthritis
Evaluation of Effectiveness of Two Dosing Regimens of Fostamatinib Compared to Placebo in Patients With Rheumatoid Arthritis (RA) Who Are Taking Methotrexate But Not Responding.
The purpose of the study is to evaluate the effectiveness of two dosing regimens of fostamatinib compared to placebo, in patients with rheumatoid arthritis (RA) who are taking methotrexate but not responding.
- Trial name
- OSKIRA - 1 (NCT01197521)
- Testing
- fostamatinib
- Where
- 127 sites in United States, Argentina and 15 more
- Volunteers
- 923 people
- Sponsor
- AstraZeneca
Rheumatoid Arthritis
Safety and Effectiveness Study of RWJ-445380 Cathepsin-S Inhibitor in Patients With Active Rheumatoid Arthritis Despite Methotrexate Therapy
The primary objective of the study is to evaluate the safety and tolerability of 100, 200, and 300 mg/day doses of RWJ-445380 for up to 12 weeks in patients with active Rheumatoid Arthritis despite methotrexate therapy.
- Trial name
- NCT00425321
- Testing
- RWJ-445380 100 mg, RWJ-445380 200 mg, RWJ-445380 300 mg
- Where
- 42 sites in United States, Argentina and 5 more
- Volunteers
- 259 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Rheumatoid Arthritis
Magnetic Resonance Image Verified Early Response to Certolizumab Pegol in Subjects With Active Rheumatoid Arthritis (RA)
Phase IIIb study to determine early response to Certolizumab Pegol (CZP) with Magnetic Resonance Imaging (MRI) score Outcome Measures in Rheumatoid Arthritis (RA) Clinical Trials (OMERACT) RA MRI Scoring System (RAMRIS) in…
- Trial name
- MARVELOUS (NCT01235598)
- Testing
- Certolizumab Pegol (CZP) 200 mg, Certolizumab Pegol (CZP) 400 mg
- Where
- 10 sites in Denmark, Netherlands and 2 more
- Volunteers
- 41 people
- Sponsor
- UCB Pharma
Rheumatoid Arthritis, Cardiovascular Diseases
NSAIDs vs. Coxibs in the Presence of Aspirin
The objectives of this single site, randomized, crossover study is to evaluate the pharmacodynamic interactions between aspirin, NSAIDs and Coxibs with respect to platelet function, biomarkers of inflammation and endothelial…
- Trial name
- NCT03699293
- Testing
- celecoxib 200mg capsule, naproxen sodium 550mg tablet, Aspirin 81mg tablet
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Platelet and Thrombosis Research, LLC
Rheumatoid Arthritis
Filgotinib in Combination With Methotrexate in Adults With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Methotrexate
The primary objective of this study is to evaluate the effects of filgotinib versus placebo for the treatment of signs and symptoms of rheumatoid arthritis (RA) as measured by the percentage of participants achieving an American…
- Trial name
- FINCH 1 (NCT02889796)
- Testing
- Filgotinib, Adalimumab, MTX
- Where
- 230 sites in United States, Argentina and 28 more
- Volunteers
- 1,759 people
- Sponsor
- Gilead Sciences
Rheumatoid Arthritis
A Study of CH-4051 in Patients With Rheumatoid Arthritis (RA)
The purpose of this study is to determine if CH-4051 is a safe and effective treatment for rheumatoid arthritis.
- Trial name
- MOTION (NCT01116141)
- Testing
- CH-4051, Methotrexate (MTX), Folic Acid
- Volunteers
- 250 people
- Sponsor
- Chelsea Therapeutics
Progression of Rheumatoid Arthritis, Osteoarthritis of Multiple Joints
To Examine Whether or Not the Primary Causes of OA or RA Might be Bone Alterations
Generally, osteoarthris (OA) is considered as primarily cartilage disease. However, as we and others have previously reported, a portion of OA might be caused primarily by bone alterations.
- Trial name
- NCT02327650
- Testing
- The examinations for bones in joints of OA and RA patients
- Where
- 2 sites in Japan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shinshu University
Rheumatoid Arthritis
Phase 1b/2 Study of IV Sarilumab in Adult With RA
This is a Phase 1/Phase 2 study with: 5-arms design for Part A; and a single arm for Part B. The purpose of this study is to measure PK parameters and safety with sarilumab intravenous (IV) with or without concomitant oral…
- Trial name
- OPALS (NCT07704580)
- Testing
- Sarilumab, SAR153191 SC, Sarilumab, SAR153191 IV
- Where
- 12 sites in United States
- Volunteers
- 140 people
- Sponsor
- Sanofi
Rheumatoid Arthritis, Osteoporosis
Efficacy of Monthly Ibandronate in Women With RA and Reduced Bone Mineral Density Receiving Long-term Steroids
This study was to investigate the efficacy of oral monthly ibandronate in the management of glucocorticoid induced osteoporosis in women with rheumatoid arthritis.
- Conditions
- Rheumatoid Arthritis, Osteoporosis, Osteopenia
- Trial name
- NCT01287533
- Testing
- Ibandronate
- Where
- South Korea
- Volunteers
- 167 people
- Sponsor
- Yeong-Wook Song
Rheumatoid Arthritis, Metabolic Syndrome
Serum Asprosin, Metabolic Syndrome, and Cardiometabolic Risk in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease associated with a significantly increased risk of cardiovascular disease and metabolic syndrome (MetS).
- Conditions
- Rheumatoid Arthritis, Metabolic Syndrome, Cardiovascular Diseases
- Trial name
- NCT07793747
- Volunteers
- 75 people
- Sponsor
- Assiut University
Knee Osteoarthritis, Hip Osteoarthritis
Quality of Life Related to Health in Spa Users
Hypothesis: The spa therapy treatment could improve health-related quality of life (HRQOL) in subjects with knee and/or hip osteoarthritis, and patients with rheumatoid arthritis.
- Conditions
- Knee Osteoarthritis, Hip Osteoarthritis, Rheumatoid Arthritis
- Trial name
- NCT03952897
- Testing
- balneotherapy
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- University of Castilla-La Mancha
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