Clinical trials: Rheumatic Arthritis
Osteoarthritis
A Study of the Patterns of Use of Etoricoxib in France (MK-0663-148)
This postmarketing study will examine the use of etoricoxib (Arcoxia®) in routine clinical practice in France as well as the use of celecoxib (Celebrex®).
- Trial name
- COXIBUS (NCT01572675)
- Testing
- etorocoxib, celecoxib
- Volunteers
- 547 people
- Sponsor
- Organon and Co
Rheumatoid Arthritis
A Study to Investigate Efficacy and Safety of AZD1163 in Participants With Rheumatoid Arthritis
Phase II study in participants with moderately-to-severely active rheumatoid Arthritis (RA) to evaluate efficacy and safety of AZD1163.
- Trial name
- LaunchPAD-RA (NCT07276581)
- Testing
- AZD1163
- Where
- 147 sites in United States, Argentina and 15 more
- Volunteers
- 320 people
- Sponsor
- AstraZeneca
Osteoarthritis, RheumatoId Arthritis
Zimmer POLAR - Total Knee Arthroplasty (TKA)
The primary objective of this study is to obtain implant survivorship and clinical outcomes data for commercially available Persona fixed bearing knee implants used in total knee arthroplasty.
- Conditions
- Osteoarthritis, RheumatoId Arthritis, Traumatic Arthritis, Polyarthritis
- Trial name
- NCT01859130
- Testing
- Zimmer Persona Total Knee System
- Where
- 4 sites in United States
- Volunteers
- 299 people
- Sponsor
- Zimmer Biomet
Osteoarthritis
Vitamin E-Diffused Highly Cross-Linked Polyethylene Liner
Vitamin E incorporated highly cross linked polyethylene (E-XLPE) was developed to increase oxidative resistance of highly cross-linked polyethylene (XLPE) without affecting mechanical properties.
- Trial name
- NCT02801019
- Testing
- E-poly, ArComXL
- Volunteers
- 70 people
- Sponsor
- Sahlgrenska University Hospital
Osteoarthritis
Hand Ultrasonography: Clinical and Functional Correlation in Symptomatic Osteoarthritis (OA)
Objective: To evaluate the correlation / association between inflammatory ultrasonography findings and clinical /functional assessment in symptomatic hand OA interphalangeal joints (IP).
- Trial name
- NCT02324192
- Testing
- Ultrasonography
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of São Paulo
Osteoarthritis
Dynamic 4DCT to Examine Wrist Carpal Mechanics
Osteoarthritis can develop after an injury like a broken bone. Problems with how the bones line up can lead to abnormal loading which will destroy the cartilage that covers and protects the bones.
- Trial name
- NCT04402502
- Testing
- Ultrasound Imaging
- Where
- Canada
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Rheumatoid Arthritis
Tofacitinib (Xeljanz) Special Investigation for Rheumatoid Arthritis
The objective of this Surveillance is to verify the following subject matters concerning Tofacitinib (Xeljanz) under general practice.
- Trial name
- NCT01932372
- Testing
- Tofacitinib (Xeljanz), Etanercept, other Biologics, Disease-modifying antirheumatic drugs (DMARDs), etc
- Where
- Japan
- Volunteers
- 9,968 people
- Sponsor
- Pfizer
Osteoarthritis
Evaluation of Short-term Effects of Tourniquet Use in Different Ways During Total Knee Arthroplasty
To study the short-term effects of tourniquet use in different ways in total knee arthroplasty,60 patients were randomly divided into 2 groups (30 cases/group): group A using the tourniquet throughout the operation, and group B…
- Trial name
- NCT02102581
- Testing
- short time tourniquet
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Gout, Low Medication Adherence
SToRytelling to Improve DiseasE Outcomes in GOut: The STRIDE-GO2 Study
The objective is to test the efficacy of a patient-centered, culturally relevant narrative intervention, or "storytelling," based on the solid conceptual foundation of the narrative communication theory and the constructs of the…
- Conditions
- Gout, Low Medication Adherence, Health Related Quality of Life
- Trial name
- STRIDE-GO2 (NCT02741700)
- Testing
- Gout Storytelling Video Intervention
- Where
- 3 sites in United States
- Volunteers
- 306 people
- Sponsor
- VA Office of Research and Development
Orthopedic Disorder, Arthritis Shoulder
Blueprint® Mixed Reality Pilot Study
A pilot Single-Arm, Multicenter, Prospective, Post-Market 6 months Follow-Up Clinical Investigation to Evaluate the Safety and Effectiveness of the Blueprint Mixed Reality HOLOBLUEPRINT™ (HOLOBLUEPRINT™).
- Conditions
- Orthopedic Disorder, Arthritis Shoulder, Arthritis, Degenerative, Cuff Tear Arthropathy
- Trial name
- BLUEMR (NCT06080412)
- Where
- 4 sites in France
- Volunteers
- 44 people
- Sponsor
- Stryker Trauma and Extremities
Coxarthrosis, Pain, Postoperative
Lumbar ESPB in Hip Replacement Surgery
In this study, continuous erector spinae plane block (ESPB) will be compared to continuous epidural analgesia in patients undergoing elective hip replacement surgery.
- Conditions
- Coxarthrosis, Pain, Postoperative, Pain, Acute, Pain, Chronic
- Trial name
- ESPB_HIP (NCT06282666)
- Testing
- Spinal anesthesia, lumbar erector spinae plane block, Epidural analgesia
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Lublin
Knee Osteoarthritis
Study on Efficacy and Safety of Chondroitin Sulfate + Glucosamine Hydrochloride Versus Celecoxib in Knee Osteoarthritis
The purpose of this study is to determine whether the combination of Chondroitin sulfate (CS) and Glucosamine Hydrochloride (GH) has similar efficacy to Celecoxib (CE) in the treatment of patients with moderate to severe knee…
- Trial name
- MOVES (NCT01425853)
- Testing
- Chondroitin/Glucosamine (Droglican), Celecoxib
- Where
- Spain
- Volunteers
- 606 people
- Sponsor
- Bioiberica
Osteoarthritis
The Press Fit Condylar (P.F.C.) Sigma Rotating Platform (RP) TC3 Revision Knee in Revision Knee Arthroplasty
The purpose of this study is to evaluate the long-term clinical and functional performance of the P.F.C. Sigma Rotating Platform TC3 knee system in revision knee surgery and to determine whether the implant design results in a…
- Trial name
- TC3 (NCT00733681)
- Testing
- PFC Sigma RP TC3 Revision knee system
- Where
- 9 sites in France, Germany and 2 more
- Volunteers
- 181 people
- Sponsor
- DePuy International
Knee Osteoarthritis
The Effects of Specialized Footwear in Osteoarthritis
This study evaluates the effects of specialized footwear on pain and knee loading in knee osteoarthritis. The hypothesis is that this footwear will lead to decreased knee loading and knee pain.
- Trial name
- NCT01597830
- Testing
- Mobility shoe, control shoe
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Rush University Medical Center
Xerostomia, Sjogren's Syndrome
Gingival Wetness and Gingival Crevicular Fluid Volume in Patients With Dry Mouth
The investigators questioned whether patients with dry mouth complaints display any reduction in residual saliva coating the gingiva and other selected mucosal surfaces.
- Trial name
- NCT00750828
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Hacettepe University
Osteoarthritis, Degenerative Joint Disease
Efficacy of Intraoperative Injections on Postoperative Pain Control During Total Hip Replacement
The purpose of this study is to clarify the efficacy of a multidrug versus single drug periarticular injection when only standard operative and postoperative pain management protocols used and the control group is exposed to what…
- Trial name
- NCT03119038
- Testing
- Bupivicaine + epinephrine, Bupivacaine, Ropivacaine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Rheumatoid Arthritis, JAK Inhibitor
Efficacy and Safety of Selective JAK 1 Inhibitor Filgotinib in Active Rheumatoid Arthritis Patients With Inadequate Response to Methotrexate
The administration of Janus kinase (JAK) inhibitors as well as biological disease-modifying anti-rheumatic drugs has dramatically improved even the clinical outcomes in rheumatoid arthritis (RA) patients with inadequate response…
- Conditions
- Rheumatoid Arthritis, JAK Inhibitor, IL-6 Inhibitor, Musculoskeletal Ultrasound
- Trial name
- TRANSFORM (NCT05090410)
- Testing
- filgotinib 200mg/day, subcutaneous tocilizumab 162mg/biweekly
- Where
- Japan
- Volunteers
- 400 people
- Sponsor
- Atsushi Kawakami
Knee Osteoarthritis
Telehealth Exercise and Mindfulness for Pain in Osteoarthritis
This is a parallel-arm mixed-methods randomized controlled trial to investigate the feasibility of telehealth delivered mindful exercise vs. usual exercise interventions for people with knee osteoarthritis.
- Trial name
- TEMPO (NCT05524116)
- Testing
- Mindful Exercise program, Exercise
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Boston University Charles River Campus
Sjogren Syndrome
Biopsy Based Study to Understand Mechanism of Action of Ianalumab in Salivary Glands and Explore Relationships With Clinical Assessments.
This study aims at elucidating the mechanism of action of ianalumab in salivary glands and explore relationships with clinical assessments
- Trial name
- NCT05124925
- Testing
- Ianalumab
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Novartis Pharmaceuticals
Rheumatoid Arthritis
Fexofenadine in Patients With Active Rheumatoid Arthritis
Rheumatoid arthritis (RA) is an inflammatory autoimmune polyarthritis affecting ∼1% of the world population, resulting in the loss of joint function and progressive structural damage in affected joints.
- Trial name
- NCT05264025
- Testing
- Fexofenadine
- Where
- 2 sites in Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- October 6 University