Clinical trials: Rheumatic Disease
Rheumatoid Arthritis
Long Term Evaluation of Sarilumab in Rheumatoid Arthritis Patients (SARIL-RA-EXTEND)
Main Study: Primary Objective: Assess the long term safety of sarilumab in participants with rheumatoid arthritis (RA). Secondary Objective: Assess the long term efficacy of sarilumab in participants with RA.
- Trial name
- NCT01146652
- Testing
- SAR153191 (REGN88)
- Where
- 335 sites in United States, Argentina and 38 more
- Volunteers
- 2,023 people
- Sponsor
- Sanofi
Rheumatoid Arthritis
Safety and Efficacy of Intravenous ACZ885 and Oral Methotrexate Therapy in Patients With Early Rheumatoid Arthritis
This study was intended to evaluate the safety and efficacy of intravenous (IV) ACZ885 and oral methotrexate (MTX) therapy in patients with early rheumatoid arthritis (RA)
- Trial name
- NCT00487825
- Testing
- Canakinumab (investigational), Methotrexate (MTX)
- Where
- 22 sites in United States, Belgium and 4 more
- Volunteers
- 78 people
- Sponsor
- Novartis
Still's Disease Adult Onset
An Efficacy and Safety Study of GNR-086 (Canakinumab Biosimilar) and Ilaris® in Patients With Adult-onset Still's Disease
This is a randomized single-blind comparative parallel group study of the efficacy and safety of canakinumab biosimilar GNR-086 (JSC \"GENERIUM\", Russia) and Ilaris® (Novartis Pharma Stein AG, Switzerland) in the…
- Trial name
- NCT06497491
- Testing
- GNR-086, Ilaris®
- Where
- 17 sites in Russia
- Volunteers
- 118 people
- Sponsor
- AO GENERIUM
Rheumatoid Arthritis
Study to Assess the Safety, Tolerability, and Pharmacokinetics of AMP-110 in Subjects With Rheumatoid Arthritis
This is a Phase 1, single-dose, placebo-controlled, dose-escalation,multi-center, first time in human study of AMP-110 in adult subjects with rheumatoid arthritis.
- Trial name
- NCT01878123
- Testing
- AMP-110
- Where
- 3 sites in United States
- Volunteers
- 26 people
- Sponsor
- MedImmune LLC
Knee Osteoarthritis, Osteo Arthritis Knee
Microfragmented Adipose Tissue Compared to Saline Injection for the Treatment of Knee Osteoarthritis
The goal of this clinical trial is to examine the effect of a single autologous, intra-articular injection of MFat versus saline injection for the treatment of pain and function associated with K/L grade 2/3 knee Osteoarthritis.
- Trial name
- ARISE2 (NCT06121882)
- Testing
- Microfragmented Adipose Tissue derived using the Lipogems® System, Saline Injection
- Where
- 16 sites in United States
- Volunteers
- 173 people
- Sponsor
- Lipogems International spa
Osteoarthritis of the Knee
Effect Of Meloxicam Versus Placebo In Mainland Chinese Patients With Osteoarthritis Of The Knee
This study is to validate the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) tool in mainland Chinese patients with osteoarthritis of the knee .
- Trial name
- NCT01430559
- Testing
- Meloxicam
- Where
- 25 sites in China
- Volunteers
- 408 people, healthy volunteers welcome
- Sponsor
- Pfizer
Rheumatoid Arthritis
Study Conducted in Subjects With Rheumatoid Arthritis Who Have Moderate to Severe Disease Activity Despite Methotrexate Therapy With or Without Other Non Biologic Disease Modifying Antirheumatic Drugs (DMARDs)for at Least 12 Weeks Prior to Screening
To compare the maintenance of efficacy of the combination of etanercept 50 mg once weekly plus methotrexate with or without other disease modifying antirheumatic drugs therapy with that of methotrexate with or without other…
- Trial name
- NCT01578850
- Testing
- Etanercept
- Where
- 62 sites in Brazil, China and 17 more
- Volunteers
- 491 people
- Sponsor
- Pfizer
Osteoarthritis, Hip
Study to Evaluate a Procedure for Intra-articular Injection of FX006 in Patients With Osteoarthritis of the Hip
This is a multi-center, single-arm, open-label study of FX006 in patients with hip OA. A maximum number of approximately 30 patients may be enrolled in this protocol.
- Trial name
- NCT04065074
- Testing
- FX006 32 mg
- Where
- 5 sites in United States
- Volunteers
- 16 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Fibromyalgia
Tool for Fibromyalgia Diagnosis and Effect of Extra Virgin Olive Oil
PRONACERA THERAPEUTICS S.L. is a young biotechnological company focused on the development of genetic diagnostic tools and treatments for pathologies in different medical areas such as reproduction, fibromyalgia and rare diseases…
- Trial name
- FIBROKIT (NCT05921409)
- Testing
- Extra Virgin Olive oil-supplemented Mediterranean Diet Intervention, Olive oil-supplemented Mediterranean Diet Intervention
- Where
- Spain
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Pronacera Therapeutics SL
Osteoarthritis
A Trial of SB-061 in Osteoarthritis of the Knee
This study evaluates a novel agent, SB-061, for the treatment of osteoarthritis of the knee. Half of the patients will receive the agent via intra-articular injection and half will receive a placebo injection.
- Trial name
- MODIFY-OA (NCT02802709)
- Testing
- SB-061
- Where
- 2 sites in Estonia
- Volunteers
- 90 people
- Sponsor
- Symic OA Co.
Rheumatologic Disorder
Identifying Novel Biomarkers in Early Rheumatology Patients
Patients new to a rheumatology practice will be asked if they want to consent to their blood sample, medical records, and hand/foot x-rays (with sharp scores) for the analysis and correlation with the diagnosis they will receive…
- Trial name
- NCT03843658
- Testing
- There is no intervention, but a diagnosis.
- Volunteers
- 300 people
- Sponsor
- Arthritis Northwest PLLC
Osteoarthritis of the Knee
Efficacy and Safety Study of PG201 Tablet in Patients With Osteoarthritis
The objective of this study was to explore the efficacy, dose-response and safety of PG201 tablet in Korean patients with osteoarthritis.
- Trial name
- NCT01122485
- Testing
- PG201
- Sponsor
- Helixmith Co., Ltd.
Osteoarthritis, Knee
GMK-UNI Anatomical UKA: Fixation of Cemented vs Cementless Designs
Unicompartmental knee arthroplasty (UKA) is the principal surgical alternative to the total knee arthroplasty (TKA) in patients with end-stage unicompartmental tibiofemoral osteoarthritis (OA) of the knee.
- Trial name
- NCT03522025
- Testing
- Unicompartmental Knee Arthroplasty (UKA)
- Where
- 5 sites in France, Switzerland
- Volunteers
- 70 people
- Sponsor
- Medacta International SA
Gout
Allopurinol Outcome Study
This is a study of allopurinol in gout patients with hyperuricemia that will evaluate the safety and serum urate (sUA) lowering capability of allopurinol as a urate lowering therapy (ULT) for up to six months.
- Trial name
- LASSO (NCT01391325)
- Testing
- Allopurinol
- Where
- 173 sites in United States, Australia and 5 more
- Volunteers
- 1,735 people
- Sponsor
- Ardea Biosciences, Inc.
Degenerative Joint Disease of Hip, Osteoarthritis, Hip
Maxera Large Cups - Canada
This study is monocentric, retrospective and prospective, non-controlled, consecutive series Post-Market Clinical Follow-up Study to Provide Safety, Performance and Clinical Benefits Data of the Largest Zimmer® Maxera™ Cup…
- Conditions
- Degenerative Joint Disease of Hip, Osteoarthritis, Hip, Avascular Necrosis of Hip, Post-Traumatic Osteoarthritis of Hip
- Trial name
- Maxera Canada (NCT04348968)
- Testing
- Total hip arthroplasty
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Hip
Analysis of a Tapered Porous Coated Stem and a Cementless Hemispherical Acetabular Component
This prospective study will evaluate the hip function and quality of life of patients operated for total hip arthroplasty with Masterloc femoral stem and MPACT acetabular cup.
- Trial name
- NCT03168750
- Testing
- Femoral Component:Medacta Masterloc Stem and Medacta MPACT cup.
- Where
- 3 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medacta USA
Osteoarthritis
A Study of Pain Relief in Osteoarthritis
The purpose of this study is to compare the safety and pain-relieving ability of Vicodin CR to placebo in subjects with osteoarthritis (OA) of the hip or knee.
- Trial name
- NCT00298974
- Testing
- hydrocodone / acetaminophen extended release
- Where
- 83 sites in United States
- Volunteers
- 873 people
- Sponsor
- Abbott
Rheumatoid Arthritis
Effects of Tofacitinib (CP-690,550) on Magnetic Resonance Imaging (MRI)- Assessed Joint Structure In Early Rheumatoid Arthritis (RA)
Evaluation of efficacy and safety of tofacitinib (CP-690,550) for the treatment of early rheumatoid arthritis in adult patients with moderate to severe disease who are methotrexate naïve.
- Trial name
- NCT01164579
- Testing
- Tasocitinib plus Methotrexate
- Where
- 40 sites in United States, Argentina and 7 more
- Volunteers
- 109 people
- Sponsor
- Pfizer
Avascular Necrosis, Osteoarthritis
Zimmer Continuum Metal on Polyethylene (MoP) PostMarket Clinical Followup (PMCF) Study
This is a prospective, multi-center, non-randomized, non-controlled study designed to obtain survival and outcome data on the Continuum Metal on Polyethylene Acetabular System when used in primary total hip arthroplasty.
- Conditions
- Avascular Necrosis, Osteoarthritis, Inflammatory Arthritis, Post-traumatic Arthritis
- Trial name
- NCT01307384
- Testing
- Continuum Metal on Polyethylene Acetabular System
- Where
- 2 sites in United States
- Volunteers
- 195 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Knee, Musculoskeletal Diseases
A Study of the Safety and Efficacy of Hylan G-F 20 (Synvisc) in Patients With Symptomatic Osteoarthritis of the Knee
This clinical study is to evaluate the safety and efficacy of hylan G-F 20 (Synvisc) in patients with symptomatic knee osteoarthritis (OA).
- Trial name
- NCT00131352
- Testing
- hylan G-F 20, Phosphate Buffered Saline
- Where
- 21 sites in Belgium, Czechia and 4 more
- Volunteers
- 253 people
- Sponsor
- Genzyme, a Sanofi Company