Clinical trials: Rheumatic Diseases
Fibromyalgia, Anxiety
The Relationship Between Diaphragm Muscle Thickness and Fibromyalgia
Fibromyalgia syndrome is characterized by chronic pain, fatigue, sleep problems and functional symptoms. Fatigue, anxiety and depression disorders, poor quality of life, sleep disorders, decreased concentration, and impaired…
- Conditions
- Fibromyalgia, Anxiety, Depression, Diaphragm Issues
- Trial name
- NCT06396949
- Testing
- Fibromyalgia study form, Pulmonary function test, Ultrasonographic Diaphragm Thickness Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Osteoarthritis of Knee
Genicular Radiofrequency Ablation Versus Pulsed Radiofrequency
This study investigates the effectiveness of two treatments-genicular nerve radiofrequency ablation and pulsed radiofrequency-in reducing pain and improving function in osteoarthritis patients.
- Trial name
- GRFT-PRF (NCT06894147)
- Testing
- Genicular nerve pulse radiofrequency
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ankara City Hospital Bilkent
Gout
Efficacy and Safety of Oral Febuxostat in Participants With Gout
The purpose of this study is to compare the efficacy and safety of febuxostat, once Daily (QD), to allopurinol in subjects with hyperuricemia and gout.
- Trial name
- CONFIRMS (NCT00430248)
- Testing
- Febuxostat, Allopurinol
- Where
- 258 sites in United States
- Volunteers
- 2,269 people
- Sponsor
- Takeda
Rheumatoid Arthritis, Lung Diseases
Investigate the Development and Progression of Lung Disease in Rheumatoid Arthritis Over Time
The purpose of this study is to investigate the link between the lungs and rheumatoid arthritis (RA). Additionally, to understand why RA patients get lung disease, how to treat, and prevent the disease.
- Trial name
- RA-LD (NCT03616158)
- Where
- United States
- Volunteers
- 340 people
- Sponsor
- National Jewish Health
Osteoarthritis, Knee
Probiotic Supplements in Osteoarthritis
The current study aims to evaluate the effectiveness of adding probiotics to the standard of care in improving OA patient-related outcomes such as pain, stiffness, and physical activity.
- Trial name
- NCT07364578
- Testing
- Probiotic Formula, Control
- Where
- Egypt
- Volunteers
- 146 people
- Sponsor
- Beni-Suef University
Fibromyalgia
Effectiveness of Creatine on Pain, Fatigue, and Muscle Architectural Variables in Patients Witg Fibromyalgia.
Creatine, a non-protein organic amino acid, is synthesized from arginine, glycine, and methionine. The use of creatine has been shown to be effective in healthy subjects, providing benefits primarily in terms of strength, which…
- Trial name
- SECPFMAPFM (NCT06675708)
- Testing
- Creatine, Dextrose
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Camilo Jose Cela University
Osteoarthritis
Functional Outcome in Two Types of Total Knee Replacement Surgery for People With Osteoarthritis
When performing total knee replacement surgery, the surgeon has a choice as to which type of surgical technique to use. The standard technique at the Royal Infirmary in Edinburgh is the so-called 'medial parapatellar' exposure.
- Trial name
- NCT01576445
- Testing
- Mid-vastus approach, medial parapatellar approach
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Queen Margaret University
Fibromyalgia
The Effects of Energy Healing in Fibromyalgia
This study aims to study the clinical effects of Energy Healing using fMRI and determine its application to Fibromyalgia patients.
- Trial name
- NCT06552728
- Testing
- Energy Healing
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Mitral Valve Stenosis
Three Dimensional Versus Two Dimensional Echocardiography in Assessment of Severity and Scoring of Rheumatic Mitral Stenosis.
Although the prevalence of rheumatic fever is decreasing in developed countries, it still affects numerous areas in the non- industrialized world.
- Trial name
- NCT04968431
- Testing
- 2D Echocardiography, 3D Echocardiography
- Volunteers
- 60 people
- Sponsor
- Assiut University
Knee Osteoarthritis, Total Knee Arthroplasty
Remimazolam Total Intravenous Anesthesia Under Analgesia Nociception Index-guidance
The investigators hypothesized that intraoperative opioid consumption would be different between remimazolam and propofol if the ANI-guided remifentanil continuous infusion rate was adjusted when the depth of anesthesia was…
- Conditions
- Knee Osteoarthritis, Total Knee Arthroplasty, Remimazolam
- Trial name
- NCT05322902
- Testing
- remimazolam group, propofol group
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Gangnam Severance Hospital
Knee Osteoarthritis, Total Knee Replacement
TKR Rehabilitation Through the Immersive Virtual Reality in Aquatic Scenarios
This study is a multicenter non-randomized single-blind controlled trial, aimed at investigating the feasibility and efficacy of hydrotherapy based on IVR, for the patients with TKR(Total Knee Replacement), on the function, gait…
- Trial name
- HYDROKNEERVANA (NCT04241172)
- Testing
- Experimental: Immersive Virtual Reality (HIVR), Traditional Hydrotherapy (TH), Traditional Rehabilitation (TR)
- Where
- Italy
- Volunteers
- 96 people
- Sponsor
- IRCCS San Raffaele Roma
Revision Total Knee Arthroplasty, Osteoarthritis, Knee
Gut Microbiome in Orthopaedics: Revision Total Knee Arthroplasty
Many patients who receive knee replacement surgery must return for a revision (or repeat) surgery due to ongoing pain, stiffness, infection, or implant loosening.
- Trial name
- GUMBO (NCT06951477)
- Testing
- Revision Total Knee Arthroplasty
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Knee Osteoarthritis
Balneotherapy With Acquabios Thermal Water in Knee Osteoarthritis
The aim of the study is the evaluation of the effect of balneotherapy with Acquabios bicarbonate-alkaline-sodium thermal water in ameliorating some signs and symptoms of knee osteoarthritis in human subjects suffering from this…
- Trial name
- NCT05352477
- Testing
- Balneotherapy with thermal water, Balneotherapy with tap water
- Volunteers
- 88 people
- Sponsor
- University of Roma La Sapienza
Arthritis, Rheumatoid
Exercise Training in Patients With Rheumatoid Arthritis and Cryotherapy
The main objective of this project is to study, in patients with rheumatoid arthritis, the effects of an intermittent type exercise associated with cryotherapy on the level of inflammation during its recovery.
- Trial name
- RhumatEx (NCT02855801)
- Testing
- constant exercise, cryotherapy, intermittent exercise
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Osteoarthritis
A Study of MK0663 and an Approved Drug in the Treatment of Osteoarthritis (0663-077)(COMPLETED)
The purpose of this study is to compare the safety and effectiveness of an investigational drug and an approved drug in the treatment of osteoarthritis of the knee and hip.
- Trial name
- NCT00092781
- Testing
- MK0663, etoricoxib, Comparator: celecoxib
- Volunteers
- 500 people
- Sponsor
- Organon and Co
Any Non-traumatic Musculoskeletal Condition
Testing a Brief Reassurance Message Before a Musculoskeletal Clinic Visit
The goal of this clinical trial is to learn if a brief, reassuring pre-visit message affects patients' expectations and planned follow-up care in adults with common musculoskeletal conditions.
- Trial name
- NCT07330492
- Testing
- Nudge intervention
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- University of Texas at Austin
Rheumatoid Arthritis
Comparison of Combination Disease Modifying Antirheumatic Drugs With Methotrexate Therapy in Early Rheumatoid Arthritis
This study will be conducted to find out how well a patient of rheumatoid arthritis (RA) will respond to disease-modifying antirheumatic drugs (DMARDs).
- Trial name
- NCT02644499
- Testing
- Methotrexate, Leflunomide, Hydroxychloroquine
- Where
- India
- Volunteers
- 186 people
- Sponsor
- Jawaharlal Institute of Postgraduate Medical Education & Research
Pain, Osteoarthritis, Hip
Placebo-controlled Trial With OROS Hydromorphone Hydrochloride to Treat Patients With Moderate to Severe Pain Induced by Osteoarthritis of the Hip or the Knee
This clinical trial tests the pain relieving effectiveness of OROS hydromorphone, a once-daily formulation of a strong opioid against placebo in patients, who are suffering from pain due to osteoarthritis of the hip or the knee…
- Conditions
- Pain, Osteoarthritis, Hip, Osteoarthritis, Knee
- Trial name
- NCT00980798
- Testing
- OROS hydromorphone HCl
- Where
- 12 sites in Czechia, Romania and 2 more
- Volunteers
- 288 people
- Sponsor
- Janssen-Cilag International NV
Knee Osteoarthritis
The Efficacy of Exercise and Alternative Applications of NMES on Pain and Function in Patients With Knee OA
The aim of the study was to investigate the efficacy of exercise and different size electrodes of neuromuscular electrical stimulation (NMES) applications on pain, range of motion (ROM), muscle strength, function status and…
- Trial name
- NCT03571698
- Testing
- Neuromuscular Electrical Stimulator
- Volunteers
- 60 people
- Sponsor
- Istanbul University
Fibromyalgia
Pain Neuroscience Education as Treatment in Fibromyalgia Affected Patients
Fibromyalgia (FM) is a chronic, complex and disabling clinical entity that has an average global prevalence of 2.7%. It occurs mainly in women in a 3: 1 ratio.
- Trial name
- NCT03947502
- Testing
- Educational intervention in neurobiology of pain
- Volunteers
- 140 people
- Sponsor
- Osatzen Sociedad Vasca Medicina Familiar y Comunitaria