Clinical trials: Rheumatic Disorder
Sjorgren's Syndrome
Intraglandular Treatment With Adipose-derived Mesenchymal Stem Cells in Patients With Xerostomia Due to Sjögren's Disease
Living with dry mouth significantly impacts daily life, causing constant discomfort. It makes it harder to talk, eat solid food (increasing the risk of malnutrition), swallow, and sleep well.
- Trial name
- ASSIX (NCT06805448)
- Testing
- MSC, Saline Water (Control)
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Polymyalgia Rheumatica (PMR), Giant Cell Arteritis (GCA)
Predictive Factors for Treatment Response in Patients With Newly-diagnosed Polymyalgia Rheumatica and Giant Cell Arteritis
This prospective study is to explore different predictive factors for response to steroid treatment in patients with PMR and/or GCA.
- Trial name
- NCT05479448
- Testing
- Data collection for cellular analyses (Immune subset composition, GCR expression, in vitro steroid responsiveness), Data collection for exploratory analyses of endogenous steroid hormones, Data collection for correlation between clinical defined and lab defined GC responsivness
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Basel, Switzerland
Inflammatory and Non-inflammatory Bone and Joint Diseases
"Translating Articular Biomarkers Into Diagnoses"
Early diagnosis is a key factor in the prevention and management of rheumatic diseases. Rheumatic diseases are classically diagnosed based on criteria combining clinical, biological and radiological features.
- Trial name
- ARTBioSes (NCT06312943)
- Testing
- Collection of joint fluid or tissue sample
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Osteoporosis, Rheumatoid Arthritis
Performance of CT Parameters Compared to Bone Mineral Density to Detect Bone Fragility in Rheumatoid Arthritis
Objective: To evaluate the performance of CT parameters (SBAC-L1 and fractal analysis) compared to BMD (gold standard) to detect vertebral fractures in rheumatoid arthritis
- Conditions
- Osteoporosis, Rheumatoid Arthritis, Vertebral Fracture
- Trial name
- NCT04413448
- Where
- France
- Volunteers
- 260 people
- Sponsor
- Central Hospital, Nancy, France
Osteoarthritis, Knee
Effects of Neurodynamics of Pain and Function in Patients With Knee Osteoarthrosis
Osteoarthritis is defined as a degenerative joint disease characterised by a decrease in joint space due to cartilage loss and the presence of subchondral sclerosis and osteophytes.
- Trial name
- NCT05375448
- Testing
- Neural mobilisation
- Where
- 2 sites in Spain
- Volunteers
- 50 people
- Sponsor
- CEU San Pablo University
Osteoarthritis, Knee
Comparison of Efficacy of Intra-articular Morphine vs Methylprednisolone in Patients With Knee Osteoarthritis.
Prospective randomized double-blind controlled study. Participating patients with knee pain secondary to knee osteoarthritis will be randomized to either the DepoMedrol 40mg + 0.25% Bupivacaine (total Volume 5 ml) vs Morphine 3mg…
- Trial name
- NCT06163755
- Testing
- Methylprednisolone 40 MG Injection
- Sponsor
- Henry Ford Health System
Osteoarthritis
A Study Comparing 4 Dose Regimens of PLA-695, Naproxen, and Placebo In Subjects With Osteoarthritis Of The Knee
Objectives: Primary:To assess the efficacy and safety of PLA-695 in subjects with active osteoarthritis (OA) of the knee. Secondary:To determine the pharmacokinetics (PK) and pharmacodynamics (PD) of PLA-695 among dose levels.
- Trial name
- NCT00396955
- Testing
- PLA-695
- Where
- 83 sites in United States, Argentina and 8 more
- Volunteers
- 560 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Systemic Juvenile Idiopathic Arthritis, Hereditary Periodic Fevers
A Study of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis or Hereditary Periodic Fevers Who Participated in the CACZ885G2301E1, CACZ885G2306 or CACZ885N2301 Studies
The objective of this extension protocol is to collect safety data (serious and non-serious adverse events) and to provide continuous canakinumab to patients in France who completed study CACZ885G2301E1(NCT00891046), CACZ885G2306…
- Trial name
- NCT02334748
- Testing
- canakinumab
- Where
- 3 sites in France
- Volunteers
- 31 people
- Sponsor
- Novartis Pharmaceuticals
Osteoarthritis
Vitamin D With Omega-3 or Metformin in Osteoarthritis
To determine the efficacy of vitamin D with omega-3 or metformin for reducing knee symptoms and effusion synovitis in patients with symptomatic knee osteoarthritis.
- Trial name
- NCT06328426
- Testing
- Vitamin D, Omega-3, Metformin
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Hip Osteoarthritis, Postoperative Pain
Total Periarticular Infiltration Vs Posterior Periarticular Infiltration Plus PENG Block for Hip Analgesia
In a recent study, direct periarticular local anesthetic infiltration (PAI) showed a greater incidence of early quadriceps weakness (33% at 3 hours and 13% at 6 hours) than pericapsular nerve group block (PENGB) in total hip…
- Trial name
- NCT06075004
- Testing
- Periarticular Local Anesthetic Infiltration, Posterior Periarticular Local Anesthetic Infiltration plus Pericapsular Nerve Group Block
- Where
- Chile
- Volunteers
- 74 people
- Sponsor
- University of Chile
Rheumatoid Arthritis
Evaluation of Rheumatoid Arthritis Disease Education Literature
Rheumatoid arthritis is an inflammatory disease that results in joint inflammation, pain and swelling. It may progress to advance stages that render patients unable to carry out their daily activities.
- Trial name
- ERADEL (NCT03336684)
- Testing
- Patient education
- Where
- 2 sites in Pakistan
- Volunteers
- 376 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Rheumatoid Arthritis
Impact of Subcutaneous Abatacept in Rheumatoid Arthritis Assessing Inhibition of Structural Damage
The hypothesis of this study is that subcutaneous Abatacept is effective in reducing synovial inflammation, osteitis, and erosions in Rheumatoid Arthritis as assessed by low field extremity MRI and X-ray.
- Trial name
- NCT01333878
- Testing
- Subcutaneous Abatacept
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Orrin M Troum, M.D. and Medical Associates
Rheumatoid Arthritis (RA)
Clinical Study Comparing Diosmin vs Rebamipide as Adjuvant Therapies vs Conventional Therapy in Patients With Rheumatoid Arthritis
This study will be a randomized controlled parallel study that will be conducted on 66 patients with active rheumatoid arthritis who will be diagnosed with RA according to American College of Rheumatology (ACR)/European League…
- Trial name
- NCT07745426
- Testing
- Diosmin, Rebamipide 100mg, Convential medical treatment
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Tanta University
Sjogren's Syndrome, Overactive Bladder Syndrome
Beta-3 Agonist and Anti-muscarinic Agent for Sjogren's Syndrome With Overactive Bladder
Overactive bladder is more prevalent among the Sjogren syndrome's population compare to the general population. Both anti-muscarinic agent and beta-3 agonist are recommended as second line treatment for overactive bladder…
- Trial name
- NCT04909255
- Testing
- mirabegron, oxybutynin, tolterodine, solifenacin
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- China Medical University Hospital
Knee Osteoarthritis
Effects of Nigella Sativa Oil on Pain Intensity and Physical Functions in Patients With Knee Osteoarthritis
Purpose: The study was conducted to determine the effect of 1 ml of nigella sativa oil applied for 2 minutes three times a day for 21 days on pain severity and physical functions in patients with knee osteoarthritis (OA).
- Trial name
- NCT05541185
- Testing
- Nigella sativa oil, Naproxen and lidocaine gel, Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Sultan ÇEÇEN
Fibromyalgia
Multicomponent Therapy for Fibromyalgia
Therapy for fibromyalgia is a well discussed topic in literature, yet not thoroughly evidence-based. Several unicomponent therapies seem to be benificial.
- Trial name
- NCT03319355
- Testing
- cognitive behavioral therapy
- Volunteers
- 136 people
- Sponsor
- University Ghent
Osteoarthritis, Meniscus Lesion
A Study on Different Treatments for Knee Osteoarthritis Caused by Damaged Roots of the Medial Meniscus.
Medial meniscus posterior root tears (MMPRT) account for 20% or more of all meniscus tears, but the diagnosis and treatment of this condition continues to plague the general population due to the complexity of the diagnosis and…
- Trial name
- NCT06707948
- Testing
- Arthroscopic meniscus surgery
- Volunteers
- 69 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Rheumatoid Arthritis
A Phase I/III Study to Evaluate Efficacy, PK and Safety Between CT-P13 SC and CT-P13 IV in Patients With Active RA
This is a Phase I/III Study to Evaluate Efficacy, Pharmacokinetics and Safety between CT-P13 SC and CT-P13 IV in Patients with Active Rheumatoid Arthritis (RA).
- Trial name
- NCT03147248
- Testing
- CT-P13
- Where
- South Korea
- Volunteers
- 407 people
- Sponsor
- Celltrion
Rheumatoid Arthritis
Joint Ultrasound Evaluation of Asymptomatic Rheumatic Feet
Objectives: The aims of the present study were to compare ultrasound on asymptomatic feet of patients with rheumatoid arthritis (RA) and normal controls, determine the association between ultrasound and global disease activity…
- Trial name
- NCT01677416
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Rheumatoid Arthritis
Gonadotropin-Releasing Hormone (GnRH)-Antagonist Therapy in Rheumatoid Arthritis
The purpose of this study is to compare the safety and efficacy of gonadotropin-releasing hormone (GnRH) antagonist therapy versus placebo in patients with moderate to severe rheumatoid arthritis.
- Trial name
- AGRA (NCT00667758)
- Testing
- Cetrorelix
- Where
- Norway
- Volunteers
- 104 people
- Sponsor
- Betanien Hospital