Clinical trials: Rheumatoid
Rheumatoid Arthritis
Study of KB003 In Biologics-Inadequate Rheumatoid Arthritis
The purpose of this study is to evaluate the safety, pharmacokinetics (PK), and efficacy of various repeat-dose regimens of KB003 in subjects with active Rheumatoid Arthritis (RA) who have had an inadequate prior treatment…
- Trial name
- NCT00995449
- Testing
- KB003
- Where
- 11 sites in United States
- Volunteers
- 9 people
- Sponsor
- Humanigen, Inc.
Arthritis, Juvenile Rheumatoid
A Study to Evaluate the Efficacy and Safety of Celecoxib Suspension Compared to Naproxen Suspension in Patients With JRA
To study Celebrex versus naproxen to see if it decreases symptoms of juvenile arthritis such as pain and swelling.
- Trial name
- NCT00652925
- Testing
- Celecoxib, Naproxen
- Where
- 58 sites in United States, Belgium and 13 more
- Volunteers
- 225 people
- Sponsor
- Pfizer
Rheumatoid Arthritis
Safety, Tolerability, and Pharmacokinetics of GS-5745 in Subjects With Rheumatoid Arthritis
This study is to assess the safety, tolerability, and pharmacokinetics (PK) of multiple infusions of GS-5745 in adults with rheumatoid arthritis (RA).
- Trial name
- NCT02176876
- Testing
- GS-5745
- Where
- 4 sites in Czechia, Hungary
- Volunteers
- 18 people
- Sponsor
- Gilead Sciences
Active Rheumatoid Arthritis
Study Evaluating Multiple Doses Of ATN-103 In Subjects With Active Rheumatoid Arthritis
The purpose of this study is to evaluate the safety and efficacy of ATN-103 when administered to subjects with active rheumatoid arthritis compared with placebo. All subjects must be on a stable dose and route of methotrexate.
- Trial name
- NCT00959036
- Testing
- ATN-103, Methotrexate
- Where
- 67 sites in United States, Belgium and 7 more
- Volunteers
- 252 people
- Sponsor
- Ablynx, a Sanofi company
Rheumatoid Arthritis
A Non-Interventional Study of RoActemra/Actemra (Tocilizumab) Treatment in Patients With Rheumatoid Arthritis
This multicenter, observational study will evaluate the use and efficacy of RoActemra/Actemra (tocilizumab) in routine clinical practice in patients with moderate to severe rheumatoid arthritis.
- Trial name
- NCT01952509
- Where
- 6 sites in Costa Rica, Dominican Republic and 2 more
- Volunteers
- 169 people
- Sponsor
- Hoffmann-La Roche
Osteoarthritis, Rheumatoid Arthritis
Randomized Controlled Clinical Evaluation to Compare Vanguard Cruciate Retaining and AGC Total Condylar Knee Implants
This evaluation is being conducted on the relative new knee system, the Vanguard Cruciate Retaining (CR) to evaluate clinical efficacy of the Vanguard CR components.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis
- Trial name
- Vanguard (NCT01064063)
- Testing
- Vanguard CR, AGC knee
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Zimmer Biomet
Arthritis, Rheumatoid
A Study of the Safety and Effectiveness of Infliximab (Remicade) in Patients With Rheumatoid Arthritis.
The purpose of this study is to evaluate the safety and effectiveness of Infliximab (Remicade) in patients with Rheumatoid Arthritis.
- Trial name
- NCT00036387
- Testing
- Infliximab
- Volunteers
- 347 people
- Sponsor
- Centocor, Inc.
Rheumatoid Arthritis
Study of PTC844 in Participants With Active Rheumatoid Arthritis
This study is designed to assess the safety, pharmacokinetics (PK), and biomarker effects of PTC844 compared to placebo in participants with active rheumatoid arthritis (RA).
- Trial name
- NCT07779616
- Testing
- PTC844
- Volunteers
- 75 people
- Sponsor
- PTC Therapeutics
Arthritis, Rheumatoid
Safety and Efficacy of Meloxicam Compared to Other Nonsteroidal Antiinflammatory Drugs (NSAIDs) in an Observational Cohort Study of Patients With Rheumatoid Arthritis, Osteoarthritis, Lumbago, Scapulohumeral Periarthritis, Neck, Shoulder and Arm Syndrome
Study to assess the safety profile of meloxicam by comparing incidence of gastrointestinal adverse events of meloxicam with that of NSAID in the routine daily therapeutic situation.
- Trial name
- NCT02180516
- Testing
- Meloxicam, Other Non Steroidal Anti-Inflammatory Drugs (NSAIDs) except etodolac
- Volunteers
- 9,984 people
- Sponsor
- Boehringer Ingelheim
Arthritis, Rheumatoid
Study Of The Safety Of CE 224,545 And Methotrexate In Patients With Rheumatoid Arthritis
CE 224,535 is being developed for the treatment of rheumatoid arthritis. The purpose of this study is to evaluate the safety and tolerability of CE 224,535 after 4 weeks of treatment in subjects with rheumatoid arthritis already…
- Trial name
- NCT00446784
- Testing
- CE-224,535, Methotrexate
- Where
- 5 sites in United States
- Volunteers
- 20 people
- Sponsor
- Pfizer
Arthritis, Juvenile Rheumatoid
A One Year Double-blind Trial to Investigate the Efficacy and Safety of Meloxicam Oral Suspension in Juvenile Rheumatoid Arthritis (JRA/JIA)
A one year double-blind trial to investigate the efficacy and safety of meloxicam oral suspension 0.25 mg/kg and 0.125 mg/kg administered once daily in comparison to naproxen oral suspension 5 mg/kg administered twice daily in…
- Trial name
- NCT00279747
- Testing
- meloxicam 0.25 mg/kg, meloxicam 0.125 mg/kg, naproxen 10 mg/kg
- Where
- 34 sites in Austria, Belgium and 5 more
- Volunteers
- 226 people
- Sponsor
- Boehringer Ingelheim
Arthritis, Rheumatoid
A Study to Evaluate the Effectiveness of Infliximab and Changes in Hand and Wrist Magnetic Resonance Imaging (MRI) in Participants With Active Rheumatoid Arthritis (RA) (P08136)
This is a study to compare the effect of infliximab versus placebo on synovial inflammation as measured by dynamic contrast enhanced (DCE)-MRI of one wrist.
- Trial name
- NCT01313520
- Testing
- Infliximab
- Volunteers
- 61 people
- Sponsor
- Merck Sharp & Dohme LLC
Moderate to Severe Active Rheumatoid Arthritis
Phase III Clinical Trial Comparing the Safety, Efficacy, and Immunogenicity of Recombinant Anti-interleukin-6 Receptor Humanized Monoclonal Antibody Injection in Combination With Methotrexate and Jamelor ® in the Treatment of Moderate to Severe Rheumatoid Arthritis
This is a multi-center, randomized, double-blind, parallel-group study to evaluate the efficacy and safety of intravenous HS628 in combination with MTX versus Actemra in combination with MTX, in participants with moderate to…
- Trial name
- NCT06048224
- Testing
- HS628+MTX, Actemra +MTX
- Where
- China
- Volunteers
- 669 people
- Sponsor
- Zhejiang Hisun Pharmaceutical Co. Ltd.
Osteoarthritis, Rheumatoid Arthritis
PS150 Total Knee Arthroplasty Outcomes Registry
This registry is intended to evaluate the clinical outcomes of the DePuy P.F.C. Sigma PS150 RP Total Knee System. 200 participants will be enrolled prospectively or retrospectively and the follow up period will be 5 years.
- Trial name
- NCT02319291
- Testing
- P.F.C. Sigma PS150 RP Total Knee System
- Where
- 4 sites in Australia, South Korea
- Volunteers
- 175 people
- Sponsor
- DePuy Orthopaedics
Arthritis, Rheumatoid
A Study to Assess CH1504 in Patients With Active Rheumatoid Arthritis
The purpose of this trial is to assess the clinical effect of CH-1504 at doses of 0.25, 0.5 and 1.0 mg per day in patients with active rheumatoid arthritis by determining the proportion of patients achieving an American College…
- Trial name
- CH-1504-201 (NCT00658047)
- Testing
- CH-1504, Methotrexate (MTX)
- Where
- Canada
- Volunteers
- 201 people
- Sponsor
- Chelsea Therapeutics
Rheumatoid Arthritis
An Observational Study on Long-Term Efficacy and Safety of RoActemra/Actemra (Tocilizumab) in Patients With Moderate to Severe Rheumatoid Arthritis (FAct)
This observational study will evaluate the long-term efficacy and safety of RoActemra/Actemra (tocilizumab in participants of the ACT SURE clinical trial and further patients with moderate to severe rheumatoid arthritis starting…
- Trial name
- NCT01483326
- Where
- 19 sites in Netherlands
- Volunteers
- 215 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
A Study of Re-Treatment With MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to a Single Anti-TNF Inhibitor.
This single arm study will evaluate the efficacy and safety of repeated courses of MabThera in patients with active rheumatoid arthritis who have participated in ML19070, and have completed the week 24 visit.
- Trial name
- NCT00502840
- Testing
- rituximab [MabThera/Rituxan]
- Where
- 51 sites in Germany
- Volunteers
- 193 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis (RA)
Methotrexate - Inadequate Response Device Sub-Study
The purpose of this study is to determine the safety and acceptability of a device used in place of traditional syringes for abatacept self-injection.
- Trial name
- MTX-IR (NCT01173120)
- Testing
- Abatacept combination product (ACP)
- Volunteers
- 62 people
- Sponsor
- Bristol-Myers Squibb
Rheumatoid Arthritis
A Study for Japanese Participants With Rheumatoid Arthritis (RA)
This study will evaluate the safety and tolerability of multiple doses of LY2127399 (tabalumab) in Japanese participants with RA. The study consists of a 20-week treatment period.
- Trial name
- NCT01253226
- Testing
- LY2127399 (Tabalumab)
- Where
- 10 sites in Japan
- Volunteers
- 32 people
- Sponsor
- Eli Lilly and Company
Rheumatoid Arthritis
A Study of MabThera (Rituximab) in Participants With Rheumatoid Arthritis Who Have Had an Inadequate Response to Disease-Modifying Antirheumatic Drugs (DMARD) and/or Anti-Tumor Necrosis Factor (Anti-TNF) Therapy.
This single arm study will evaluate the safety and efficacy of MabThera in participants with active rheumatoid arthritis who have had an inadequate response to prior treatment with DMARDs and/or anti-TNF alpha agent.
- Trial name
- NCT00503425
- Testing
- Rituximab [MabThera/Rituxan]
- Where
- 16 sites in Israel
- Volunteers
- 215 people
- Sponsor
- Hoffmann-La Roche