Clinical trials: Rheumatoid
Rheumatoid Arthritis
Study of Adalimumab Administered as Subcutaneous Injections in Adult Chinese Rheumatoid Arthritis Subjects Treated With Methotrexate
A Randomized, Double-Blind, Placebo-Controlled, Study of the Adalimumab Administered as Subcutaneous Injections in Adult Chinese Rheumatoid Arthritis Subjects Treated with Methotrexate
- Trial name
- NCT00647920
- Testing
- adalimumab
- Where
- Taiwan
- Volunteers
- 47 people
- Sponsor
- Abbott
Rheumatoid Arthritis
Study of the Human Anti-TNF Monoclonal Antibody in Patients With Active Rheumatoid Arthritis
The primary objective of this study is to assess the safety (by collecting adverse events and serious adverse events) of adalimumab administered every other week to patients with moderately to severly active rheumatoid arthritis…
- Trial name
- CanAct (NCT00649545)
- Testing
- adalimumab
- Sponsor
- Abbott
Rheumatoid Arthritis
Assessment of the Effect of Adalimumab on Response to Influenza Virus and Pneumococcal Vaccines in Subjects With Rheumatoid Arthritis
To evaluate the immunogeneicity of the Influenza virus and standard 23-valent pneumococcal virus in subject with RA receiving adalimumab or placebo
- Trial name
- NCT00649922
- Testing
- adalimumab
- Volunteers
- 226 people
- Sponsor
- Abbott
Rheumatoid Arthritis
Open Label Study to Assess Efficacy and Safety of the Fully Human Anti-TNF-Alpha Monoclonal Antibody Adalimumab
The study was to explore the efficacy of adalimumab in subjects previously treated with infliximab and failed infliximab treatment due to lack of efficacy or intolerance.
- Trial name
- PROWD (NCT00650390)
- Testing
- adalimumab
- Sponsor
- Abbott
Rheumatoid Arthritis
A Study of Adalimumab in Adult Japanese Subjects With Rheumatoid Arthritis
The primary objective of this study is to evaluate the safety, efficacy and pharmacokinetics of three doses of adalimumab in adult Japanese subjects with RA
- Trial name
- NCT00647491
- Testing
- adalimumab
- Where
- 25 sites in Japan
- Volunteers
- 352 people
- Sponsor
- Abbott
Rheumatoid Arthritis
A Phase 2 Study to Evaluate the Efficacy and Safety of 60mg of MM-093 in Patients With Active Rheumatoid Arthritis
The purpose of this study is to determine whether MM-093 is safe and effective in the treatment of RA.
- Trial name
- NCT00458146
- Testing
- MM-093
- Where
- 20 sites in United States
- Volunteers
- 100 people
- Sponsor
- Merrimack Pharmaceuticals
Rheumatoid Arthritis
Ancillary Study to Protocol 20060104
Ancillary study to the Etanercept protocol 20060104. Subjects have been asked to provide additional blood samples for further assessment.
- Trial name
- NCT00439894
- Testing
- Blood draw
- Volunteers
- 50 people
- Sponsor
- Amgen
Rheumatoid Arthritis
Assessment of the Effectiveness of Low-Level Laser Therapy on the Hands of Patients With Rheumatoid Arthritis
The purpose of the present study was to assess the effectiveness of low-level laser therapy on the reduction in pain and improvement in function in the hands of patients with rheumatoid arthritis
- Trial name
- NCT00632710
- Testing
- phototherapy
- Where
- Brazil
- Volunteers
- 82 people
- Sponsor
- Federal University of São Paulo
Rheumatoid Arthritis
Meditation-Based Stress Reduction in Rheumatoid Arthritis
The purpose of this study is to determine whether a mindfulness meditation-based stress reduction program is useful in relieving symptoms associated with rheumatoid arthritis (RA).
- Trial name
- NCT00071292
- Testing
- stress reduction program, meditation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Arthritis, Psoriatic, Autoimmune Diseases
Genetic and Immune Studies of Rheumatoid Arthritis and Related Conditions
This protocol will examine blood, synovial fluid and synovial tissue from patients with rheumatoid arthritis and other chronic inflammatory joint diseases to study genetic and immunologic factors involved in the cause…
- Conditions
- Arthritis, Psoriatic, Autoimmune Diseases, Joint Diseases, Osteoarthritis
- Trial name
- NCT00001291
- Where
- United States
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Arthritis, Arthritis, Reactive
The Pathogenesis of Inflammatory Synovitis: A Study of Early Arthritis
This study will evaluate patients with inflammatory forms of arthritis within the first year of onset. The study will attempt to clarify factors that may predict disease course such as evolution into rheumatoid arthritis (RA) or…
- Conditions
- Arthritis, Arthritis, Reactive, Arthritis, Rheumatoid, Reiter's Disease
- Trial name
- NCT00001375
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Arthritis, Rheumatoid, Healthy
Steroid Hormones, TH1/TH2 Cytokines and Reproductive Status
This study is designed to evaluate blood Th1 and Th2 immunoregulatory cytokine production and hormonal levels associated with the third trimester of pregnancy and the postpartum state.
- Conditions
- Arthritis, Rheumatoid, Healthy, Pregnancy
- Trial name
- NCT00001376
- Where
- United States
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Arthritis, Juvenile Rheumatoid, Uveitis
The Safety and Efficacy of Chicken Type II Collagen on Uveitis Associated With Juvenile Rheumatoid Arthritis
Current treatment modalities for uveitis associated with juvenile rheumatoid arthritis have not been beneficial in the juvenile population.
- Trial name
- NCT00001614
- Testing
- Chicken type II collagen
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- National Eye Institute (NEI)
Arthritis, Rheumatoid, Synovitis
Methotrexate Alone Versus Combination of Methotrexate and Subcutaneous Fludarabine for Severe Rheumatoid Arthritis: Safety, Tolerance and Efficacy
The safety profile and efficacy of combination therapy will be evaluated using methotrexate (MTX) and the nucleoside analog fludarabine in 40 patients with severe refractory rheumatoid arthritis.
- Trial name
- NCT00001677
- Testing
- Methotrexate, Fludarabine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Arthritis, Reactive, Arthritis, Rheumatoid
Prognostic Indicators and Determinants of the 2-5 Year Outcome in a Cohort of Early Synovitis Patients
This study will evaluate the 2-5 year outcome of a cohort of 250 patients with early synovitis, who were recruited into protocol 94-AR-0194 (The Pathogenesis of Inflammatory Synovitis: A Study of Early Arthritis).
- Conditions
- Arthritis, Reactive, Arthritis, Rheumatoid, Synovitis
- Trial name
- NCT00001679
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Juvenile Rheumatoid Arthritis, Uveitis
TNRF:Fc to Treat Eye Inflammation in Juvenile Rheumatoid Arthritis
This study will investigate the safety and effectiveness of the drug TNFR:Fc to treat uveitis (eye inflammation) in patients with juvenile rheumatoid arthritis.
- Trial name
- NCT00001862
- Testing
- Enbrel
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Eye Institute (NEI)
Rheumatoid Arthritis
Infliximab for the Treatment of Early Rheumatoid Arthritis
This study will test whether the drug combination of methotrexate and infliximab (anti-TNF-alpha antibody) is more effective than methotrexate alone for treating rheumatoid arthritis early in the disease.
- Trial name
- NCT00006292
- Testing
- Infliximab
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Rheumatoid Arthritis
Positron Emission Tomography and Magnetic Resonance Imaging to Evaluate Synovial Blood Flow in Rheumatoid Arthritis Patients
This study will test whether positron emission tomography (PET) imaging can be used to measure blood flow to joints in patients with rheumatoid arthritis (RA).
- Trial name
- NCT00014794
- Testing
- 15-O labeled water
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Rheumatoid Arthritis, Healthy
The Role of Cytokines on Growth Hormone Suppression in Premenopausal Women With Rheumatoid Arthritis and the Effect of Treatment With Etanercept
This study has two phases. Phase 1 will examine the role of inflammatory mediators called cytokines on growth hormone levels in women with rheumatoid arthritis (RA).
- Trial name
- NCT00034060
- Testing
- Etanercept
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Rheumatoid Arthritis
Treating Rheumatoid Arthritis With Tripterygium Wilfordi Hook F or Sulfasalazine
Various forms of the plant extract Tripterygium wilfordi Hook F (TwHF) have been used in China as a remedy for inflammatory diseases, including rheumatoid arthritis.
- Trial name
- NCT00062465
- Testing
- TwHF
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)