Clinical trials: Rheumatoid
Rheumatoid Arthritis
Quality of Life Study With Adalimumab in Rheumatoid Arthritis
The purpose of the study is to evaluate the ability of adalimumab combined with methotrexate to improve the quality of life in patients with active RA.
- Trial name
- NCT00234936
- Testing
- Adalimumab, Methotrexate
- Volunteers
- 200 people
- Sponsor
- Abbott
Rheumatoid Arthritis
Remission Induction in Very Early Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a debilitating chronic immune mediated inflammatory disease which affects 1% of the European population. RA is associated with significant joint damage, disability and an enhanced mortality.
- Trial name
- RIVERA (NCT00523692)
- Testing
- Etanercept, methotrexate and depomedrone, depemedrone
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people
- Sponsor
- University Hospital Birmingham
Rheumatoid Arthritis
Adalimumab in Combination With Methotrexate vs Methotrexate Alone in Early Rheumatoid Arthritis
The purpose of the study is to evaluate the effectiveness of adalimumab in combination with methotrexate compared to methotrexate alone on work disability in subjects with early rheumatoid arthritis
- Trial name
- NCT00234845
- Testing
- adalimumab, methotrexate
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Abbott
Rheumatoid Arthritis
Efficacy of HUMIRA in Subjects With Active Rheumatoid Arthritis
The purpose of the study is to assess the efficacy of adalimumab in subjects with rheumatoid arthritis focusing on subject-reported outcomes and early response to treatment
- Trial name
- HERO (NCT00234897)
- Testing
- adalimumab
- Where
- United States
- Volunteers
- 1,938 people
- Sponsor
- Abbott
Rheumatoid Arthritis
Adalimumab Administered in Korean Rheumatoid Arthritis Subjects Treated With Methotrexate
The purpose of the study is to assess the safety and efficacy of adalimumab compared to placebo in subjects with rheumatoid arthritis on methotrexate therapy.
- Trial name
- NCT00235859
- Testing
- adalimumab, methotrexate
- Volunteers
- 128 people
- Sponsor
- Abbott
Rheumatoid Arthritis
Tai Chi for Patients With Rheumatoid Arthritis
The purpose of this study was to study the impact of Tai Chi group exercise on physical function, health and disease activity of patients with RA, and to examine the patients' experience and perception of Tai Chi.
- Trial name
- NCT00522054
- Testing
- Physical exercise
- Where
- Norway
- Volunteers
- 15 people
- Sponsor
- Diakonhjemmet Hospital
Rheumatoid Arthritis
dnaJ Peptide for Relieving Rheumatoid Arthritis
A small protein called dnaJ peptide may help people with rheumatoid arthritis (RA) by preventing their immune system cells from attacking their own tissues.
- Trial name
- NCT00000435
- Testing
- dnaJ peptide
- Where
- 8 sites in United States
- Volunteers
- 160 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Rheumatoid Arthritis
Monoarticular Corticosteroid Injection Versus Systemic Administration in the Treatment of Rheumatoid Arthritis Patients
The purpose of this study is to compare the efficacy and safety of intra-articular glucocorticoid injection to its systemic use for treatment of knee synovitis in patients with Rheumatoid Arthritis
- Trial name
- NCT00506896
- Testing
- intraarticular injection
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of São Paulo
Rheumatoid Arthritis.
The Effectiveness of a Nighttime Positioning Hand Splint in Patients With Rheumatoid Arthritis
The purpose of the present study was to evaluate the effectiveness of a nighttime positioning hand splint in patients with RA in terms of pain, grip and pinch strength, upper limb function, quality of life, and patient…
- Trial name
- NCT00502424
- Testing
- Splint
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Federal University of São Paulo
Rheumatoid Arthritis, Spondylarthritis
Quantiferon-TB Gold in the Assessment of Latent TB in Patients Candidate to Treatment or Treated With TNFα Antagonists
The purpose of this study is to evaluate the value of Quantiferon-TB Gold (QFT-G) assay in the screening for latent tuberculosis infection (LTBI) in rheumatologic patients due to start or on treatment with TNFα antagonists.
- Conditions
- Rheumatoid Arthritis, Spondylarthritis, Tuberculosis
- Trial name
- TNFTB (NCT00491933)
- Testing
- Quantiferon-TB Gold assay, Tuberculin skin test
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- ASST Fatebenefratelli Sacco
Rheumatoid Arthritis
The Clinical Effectiveness of Static Resting Splints in Early Rheumatoid Arthritis
This study tested the hypothesis that there would be a difference in the 12 month progression of structural hand impairment and hand function between a group of patients with early RA who received static resting splints and those…
- Trial name
- NCT00474877
- Testing
- Static resting splints
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Southampton
Rheumatoid Arthritis
The Effect of Rituximab on the Humoral Response to Influenza Vaccine
Rituximab is a genetically engineered chimeric anti-CD20 monoclonal antibody that selectively targets CD20+ B cells and induces a transient depletion of the CD20+ mature B cell subpopulation.The objective of our study was to…
- Trial name
- NCT00466037
- Testing
- Influenza vaccine
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Rheumatoid Arthritis
Open-Label Steroid Reduction Study of Adalimumab With Methotrexate in Patients With Active Rheumatoid Arthritis
The purpose of the study is to evaluate the clinical efficacy of scheduled versus free reduction of steroid treatment in patients with active RA treated with adalimumab + MTX
- Trial name
- NCT00233558
- Testing
- adalimumab (up to 9 months exposure), methotrexate
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Abbott
Rheumatoid Arthritis
The Effect of Low Dose Aspirin on the Pharmacokinetics of Methotrexate
High dose aspirin have been shown to increase the level of Methotrexat in patients with Rheumatoid Arthritis. However, most of RA patients are not currently treated with high dose aspirin.
- Trial name
- NCT00464997
- Volunteers
- 30 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Arthritis, Rheumatoid
Comparison of NeuFlex and Swanson Metacarpophalangeal Implants for Rheumatoid Arthritis
The main hypotheses for this study are as follows: 1. The use of NeuFlex implant results in flexion in the fourth and fifth MP joints that is at least 10 degrees greater than with teh use of the Swanson implant. 2.
- Trial name
- NCT00463424
- Testing
- NeuFlex metacarpophalangeal implant, Swanson metacarpophalangeal implant
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Unity Health Toronto
Rheumatoid Arthritis
Omega-3 and Vitamin E Supplementation in Patients With Rheumatoid Arthritis
The purpose of this study is to determine whether simultaneous supplementation with omega-3 fatty acids and vitamin E is effective in the treatment of patients with rheumatoid arthritis.
- Trial name
- NCT00399282
- Testing
- Omega-3 and Vitamin E supplementation
- Where
- Iran
- Volunteers
- 75 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Rheumatoid Arthritis
Effects of Home-Based Emotional Disclosure in Rheumatoid Arthritis
The purpose of the study is threefold: 1) to develop a home-based emotional disclosure intervention inducing core elements of change (emotional engagement, cognitive restructuring, and positive future directedness); 2) to examine…
- Trial name
- NCT00462150
- Testing
- home-based emotional disclosure, time management control condition
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- UMC Utrecht
Rheumatoid Arthritis
A Multicentre Trial to Determine the Efficacy of AD 452 in RA Subjects.
AD 452 is a new drug which is being developed for use in adult patients with RA. It is believed that AD 452 may modify the underlying disease of RA as well as improving RA symptoms, and in order to establish its efficacy and…
- Trial name
- NCT00141934
- Testing
- AD 452
- Where
- 10 sites in United States
- Volunteers
- 232 people
- Sponsor
- Sosei
Osteoarthritis, Rheumatoid Arthritis
Development and Evaluation of A Mailed Arthritis Self-Management Program
The purpose of this study is twofold, to develop and test the effectiveness of a mailed arthritis self-management education intervention.
- Trial name
- NCT00448474
- Testing
- Mailed Arthritis Self-Management Education
- Where
- United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- University of North Carolina
Rheumatoid Arthritis
Treatment of Rheumatoid Arthritis With Roxithromycin
The purpose of this study is to evaluate the clinical efficacy, safety, and tolerability of roxithromycin in patients with rheumatoid arthritis.
- Trial name
- NCT00439062
- Testing
- Roxithromycin
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Nazilli State Hospital