Clinical trials: Rheumatoid
Rheumatoid Arthritis
Atherosclerosis in Rheumatoid Arthritis and Lupus: Restoring Cholesterol Balance
Hypothesis: SLE and RA increase risk of myocardial infarction (MI, heart attack). Immune reactants in the circulation of SLE patients downregulate cholesterol efflux proteins 27-hydroxylase and ABCA1 and upregulate scavenger…
- Trial name
- NCT01180361
- Where
- United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Osteoarthritis, Arthritis, Rheumatoid
Low Dose Naltrexone for Chronic Pain From Arthritis
Over 100 million Americans report chronic pain. Veterans are disproportionately affected for multiple reasons, including injuries and post-traumatic stress disorder.
- Conditions
- Osteoarthritis, Arthritis, Rheumatoid, Arthritis, Psoriatic
- Trial name
- LDN-VA (NCT03008590)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- VA Office of Research and Development
Active Rheumatoid Arthritis
A Study to Assess the Safety and Efficacy of Different Doses of ELV001 to Treat Active Rheumatoid Arthritis in Patients With an Inadequate Response to Methotrexate and Tumor Necrosis Factor Inhibition (START SYNERGY)
This is a Phase 2 randomized, double-blind, placebo-controlled study with a total duration of 32 weeks from Screening to End-of-Study (EOS) Visit. Approximately 180 participants are planned to be enrolled.
- Trial name
- NCT07409103
- Testing
- ELV001 25 mg, ELV001 75 mg, ELV001 125 mg
- Where
- 34 sites in United States, Serbia and 1 more
- Volunteers
- 180 people
- Sponsor
- Elevara Medicines Limited
Arthritis, Rheumatoid, Colitis, Ulcerative
A Study of Jyseleca Tablet (Filgotinib Maleate) in Korean Participants
The purpose of this study is to collect and evaluate the following information in relation to the safety and the efficacy of Jyseleca tablet (Filgotinib Maleate) 100 milligram (mg) and 200 mg in this post marketing setting: (1)…
- Trial name
- NCT06246123
- Testing
- Non-interventional
- Where
- 59 sites in South Korea
- Volunteers
- 2,040 people
- Sponsor
- Eisai Korea Inc.
Arthritis, Rheumatoid
A Study To Investigate The Effect Of 28 Days Of Dosing With GW856553 On Patients With Rheumatoid Arthritis
This study is designed to look at the safety, tolerability and effectiveness of 28 days of dosing of GW856553 in rheumatoid arthritis patients.
- Trial name
- NCT00393146
- Testing
- GW856553
- Where
- 15 sites in Romania, Russia and 1 more
- Volunteers
- 57 people
- Sponsor
- GlaxoSmithKline
Rheumatoid Arthritis, Osteoarthritis
The Relationship Between Serum Chemokine Ligand 21 (CCL-21) Level and Disease Activity
Rheumatoid arthritis (RA) is a chronic systemic disease characterized by the development of new capillaries involved in the infiltration of inflammatory cells causing synovial hyperplasia and progressive destruction of cartilage…
- Trial name
- NCT06540573
- Testing
- Laboratory tests (examination), Western Ontario and McMaster Universities Osteoarthritis (WOMAC) Index, The Disease Activity Score28 (DAS28)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Rheumatoid Arthritis
Prospective Cohort Study on Refractory Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic erosive arthritis. Without timely and appropriate treatment, it can lead to joint destruction and disability.
- Trial name
- NCT07126431
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
Rheumatic Diseases, Rheumatoid Arthritis (RA)
Pain Neuroscience Education and Vagus Nerve Stimulation on Recovery in Individuals With Rheumatoid Arthritis
In the context of this randomized controlled study, patients who are diagnosed with Rheumatoid arthritis in Cerrahpaşa Faculty of Medicine Hospital, will be taken into a rehabilitation program by a qualified physiotherapist to…
- Trial name
- NCT07274124
- Testing
- Pain Neuroscience Education, Vagal Nerve Stimulation, Structured Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Medipol University
Training Leaflet, Training Workshop
Group Training and Quality of Life and Reduction of Pain in Rheumatoid Arthritis Patients
Abstract Background: It is documented that some patient education interventions, preferably with a behavioral component included, may improve pain, disability and moods Purpose of the study: the purpose of this study was to…
- Trial name
- NCT01998373
- Testing
- training leaflet and oral training
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Tehran University of Medical Sciences
Rheumatoid Arthritis
A Study of RoActemra/Actemra and, if Initially Inadequately Responded to RoActemra/Actemra, Followed by MabThera/Rituxan in Patients With Rheumatoid Arthritis
This open-label, multi-center, two-arm, uncontrolled and non-randomized study will evaluate the efficacy and safety of RoActemra/Actemra (tocilizumab) in patients with rheumatoid arthritis.
- Trial name
- NCT01332994
- Testing
- rituximab [MabThera/Rituxan], tocilizumab [RoActemra/Actemra]
- Where
- 83 sites in Germany
- Volunteers
- 519 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
Tolerogenic Dendritic Cell Therapy for Rheumatoid Arthritis
Rationale: In rheumatoid arthritis, immune cells cause joint inflammation and destruction in response to autoantigens. Immunosuppressive therapies offer relief but fail to induce tolerance to autoantigens.
- Trial name
- TOLERANT (NCT05251870)
- Testing
- autologous mature tolerogenic monocyte-derived Dendritic Cells loaded with the B29 peptide of HSP70
- Where
- 3 sites in Netherlands
- Volunteers
- 18 people
- Sponsor
- UMC Utrecht
Rheumatoid Arthritis
Progressive Resistance Exercise in Rheumatoid Arthritis
A randomized controlled trial with rheumatoid arthritis patients will be realized. Patients will be randomized into two groups. Experimental group will do a 12 weeks training of progressive resistance exercise for global muscles…
- Trial name
- NCT02219022
- Testing
- Control group, Experimental group
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of São Paulo
Healthy Volunteers, Arthritis, Rheumatoid
Characterization of Breg Cells
Recently, it has been shown that B cells could also have regulatory functions through the secretion of interleukin 10 (IL-10). They are called the B regulatory cells (Breg).
- Trial name
- Breg (NCT02615951)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Rheumatoid Arthritis
A Study to Investigate How JNJ-38518168 May Affect the Plasma Levels of Methotrexate in Rheumatoid Arthritis Participants
The purpose of this study is to evaluate the effects of JNJ-38518168 on the pharmacokinetics (how the body handles a drug) of methotrexate in participants with rheumatoid arthritis.
- Trial name
- NCT01450982
- Testing
- JNJ-38518168 / MTX
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Rheumatoid Arthritis
To Evaluate The Safety of SAR153191 (REGN88) and Tocilizumab Added to Other RA Drugs in Patients With RA Who Are Not Responding to or Intolerant of Anti-TNF Therapy (SARIL-RA-ASCERTAIN)
Primary Objective: To assess, in the same study, the safety of sarilumab and tocilizumab in participants with rheumatoid arthritis (RA) who were inadequate responders to or intolerant of tumor necrosis factor (TNF) antagonists.
- Trial name
- NCT01768572
- Testing
- sarilumab SAR153191 (REGN88), tocilizumab, hydroxychloroquine
- Where
- 78 sites in United States, Argentina and 17 more
- Volunteers
- 202 people
- Sponsor
- Sanofi
Rheumatoid Arthritis
Factors Affecting Hand Dysfunction in Patient With Rheumatoid Arthritis and Its Correlation With Quality of Life
The aims of the research are: To predict factors affecting hand dysfunction in patient with rheumatoid arthritis To study the effect of hand dysfunction on quality of life in patient with rheumatoid arthritis
- Trial name
- NCT03274570
- Volunteers
- 100 people
- Sponsor
- Assiut University
Neck Pain
Characteristics of Rheumatoid Arthritis Patients With Atlantoaxial Synovitis Detected by Plain X-ray and MRI
This study detects the presence of atlantoaxial joint affection in symptomatic versus asymptomatic rheumatoid arthritis patients revealed by plain X-ray and magnetic resonance imaging of the cervical spine
- Trial name
- MRI (NCT02774070)
- Testing
- Plain X-ray, Magnetic resonance imaging
- Sponsor
- Assiut University
Amyotrophic Lateral Sclerosis (ALS), Angina, Stable
Quest to Analyze One Thousand Humans Meditating
This study will be focused on assessing the molecular, physiological, and emotional correlates of an intensive meditation experience in the context of a retreat setting in a large 2000 plus-person cohort comprised of healthy and…
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Angina, Stable, Anxiety, Asthma
- Trial name
- QUANTUM (NCT06583395)
- Testing
- Advanced multi-component meditation practice
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Tobias Moeller-Bertram
Rheumatoid Arthritis, Pregnancy Related
The Clinical Features and Pregnancy Outcomes of RA Patients
This study includes RA patients in pregnancy, who are using different treatment regimens，including prednisone, hydroxychloroquine, and/or TNF inhibitors.
- Trial name
- NCT05651373
- Testing
- Prednisone, Hydroxychloroquine, CertolizumabPegol injection
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Qilu Hospital of Shandong University
Rheumatoid Arthritis
A Retrospective Chart Review of MabThera (Rituximab) Treatment in Rheumatoid Arthritis (RA) Participants in Australia
This is a cross-sectional, observational study examining the factors leading to the therapeutic decision to use MabThera (rituximab) in participants with RA.
- Trial name
- NCT02564770
- Where
- Australia
- Volunteers
- 167 people
- Sponsor
- Hoffmann-La Roche