Clinical trials: Rheumatoid Arthritis, completed
Rheumatoid Arthritis (RA), Periodontitis
Effects of Nonsurgical Periodontal Treatment on GCF Calprotectin and IL-10 in Rheumatoid Arthritis
This study evaluates the relationship between rheumatoid arthritis and periodontal health and examines the effects of nonsurgical periodontal treatment on clinical periodontal findings and gingival crevicular fluid biomarkers.
- Conditions
- Rheumatoid Arthritis (RA), Periodontitis, Gingivitis
- Trial name
- NCT07844564
- Testing
- Non-surgical Periodontal Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Rheumatoid Arthritis, Ankylosing Spondylitis
Artificial Intelligence Literacy and E-Health Literacy in Rheumatic Diseases
This study aims to evaluate digital health competencies in individuals with rheumatic and degenerative joint diseases. Specifically, it assesses e-health literacy and artificial intelligence literacy, which refer to individuals'…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis, Knee Osteoarthritis
- Trial name
- NCT07054749
- Where
- Turkey (Türkiye)
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Gulseren Demir Karakilic
Inflammatory Rheumatic Diseases
A Study on Changes in IFN-gamma Levels Following Anti-TNF Treatment in Patients Undergoing Serial QuantiFERON-TB Gold In-Tube
The screening for latent tuberculosis infection (LTBI) prior to the onset of anti-tumor necrosis factor therapy, as well as a watchful monitoring during the treatment, is strongly recommended.
- Trial name
- NCT01475409
- Testing
- QuantiFERON-TB Gold In-Tube (QFT-GIT)
- Volunteers
- 119 people
- Sponsor
- University of Roma La Sapienza
Arthritis, Rheumatoid
Efficacy and Safety of Valdecoxib and Naproxen in Treating the Signs and Symptoms of Rheumatoid Arthritis (RA) in a Severe Rheumatoid Arthritis Patients
The objectives of the study were to evaluate the efficacy, safety, and tolerability of valdecoxib 10 mg once daily (QD) or naproxen 500 mg twice daily (BID) versus placebo, and to assess the efficacy of valdecoxib 10 mg QD versus…
- Trial name
- NCT00650455
- Testing
- valdecoxib, naproxen
- Where
- 55 sites in United States, Canada
- Volunteers
- 489 people
- Sponsor
- Pfizer
Arthritis, Rheumatoid
Biomarkers of Anti-TNF-α Therapy Efficacy in Rheumatoid Arthritis to Define Unresponsive Patients
The primary objective of this study was to validate the ability of an 8-gene biomarker set to differentiate between participants who met or did not meet European League Against Rheumatism (EULAR) Disease Activity Score (DAS)-28…
- Trial name
- BATTER-UP (NCT01211678)
- Where
- 30 sites in United States
- Volunteers
- 301 people
- Sponsor
- Biogen
Rheumatoid Arthritis
Study Evaluating the Clinical Remission in Early Aggressive Rheumatoid Arthritis
This is an observational prospective, multicenter study. The aim of the study is to evaluate how the Italian population of patients are treated with early aggressive RA, defined by the Italian Society of Rheumatology Guidelines…
- Trial name
- ARPA (NCT00267852)
- Testing
- as clinical practice
- Where
- 16 sites in Italy
- Volunteers
- 152 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Rheumatoid Arthritis
Antimalarial and Covid 19 in Rheumatoid Arthritis
The antimalarial agent hydroxychloroquine(HCQ) have been used widely used for the treatment of rheumatoid arthritis and systemic lupus erythematosus.
- Trial name
- NCT04389320
- Testing
- Hydroxychloroquine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Rheumatoid Arthritis (RA
Effect of Siwan Sand Therapy on Pulmonary Functions of Rheumatoid Arthritis Patients
The purpose of this study was to compare between the effects of Siwan sand therapy and physical therapy program on pulmonary function, functional activity, and pain in rheumatoid arthritis patients.
- Trial name
- NCT07287696
- Testing
- sand therapy, physical therapy program
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Ahram Canadian University
Rheumatoid Arthritis, Exercise
Comparison of the Effects of Aerobic and Resistive Exercises in Female Patients With Rheumatoid Arthritis
It is aimed to objectively demonstrate and compare the effectiveness of aerobic and resistant exercises performed on female patients with rheumatoid arthritis with sonographic muscle measurements.
- Conditions
- Rheumatoid Arthritis, Exercise, Exercise Therapy
- Trial name
- NCT04570280
- Testing
- Aerobic Exercises, Resistive Exercises, Range of Motion Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Sjögren's Syndrome, Xerostomia
Effects of Hydroxychloroquine on Oral Complaints of Sjögren Patients
Chronic inflammation that comprises the exocrine glands' function leads to xerophthalmia and xerostomia in Sjögren's syndrome. The oral consequences range widely and they are related to decreased salivary output.
- Trial name
- NCT00873496
- Testing
- Hydroxychloroquine
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ege University
Keratoconjunctivitis Sicca, Sjogren's Syndrome
Six Month Clinical Research Study for Patients With Moderate or Severe Dry Eye Syndrome
A six-month clinical research trial to evaluate the effectiveness of an investigational medication for the treatment of dry eye syndrome in patients that have been diagnosed with moderate to severe dry eye syndrome, an autoimmune…
- Conditions
- Keratoconjunctivitis Sicca, Sjogren's Syndrome, Lupus Erythematosus, Systemic, Arthritis, Rheumatoid
- Trial name
- NCT00025818
- Testing
- Ophthalmic Emulsion
- Where
- 17 sites in United States
- Volunteers
- 290 people
- Sponsor
- Allergan
Arthritis, Juvenile Rheumatoid
Safety, Efficacy and Pharmacokinetics of Subcutaneous ACZ885 in Patients With Systemic Juvenile Idiopathic Arthritis (SJIA)
This study is a multi-center, open label, repeated dose, range finding study to evaluate the safety, tolerability, immunogenicity, pharmacokinetics and efficacy of ACZ885, a fully human anti-interleukin-1B (anti-IL-1B) monoclonal…
- Trial name
- NCT00426218
- Testing
- ACZ885
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Novartis
Rheumatoid Arthritis
Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Tofacitinib vs Abatacept
This study aims to evaluate the comparative risk of dementia/Alzheimer's disease onset between patients treated with medications that target specific metabolic pathways and patients treated with alternative medications for the…
- Trial name
- DREAM (NCT04529876)
- Testing
- Tofacitinib, Abatacept
- Where
- United States
- Volunteers
- 29,464 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Rheumatoid Arthritis, Systemic Lupus Erythematosus
Study During Pregnancy of Expression of miRNAs in RA or SLE
Rheumatoid arthritis (RA) is a systemic disease, which mainly targets joints and results in osteoarticular destruction and serious disability.
- Trial name
- SPIRALE (NCT02350491)
- Testing
- Collection of biological samples
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Rheumatoid Arthritis
A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Non-biologic DMARDs
This multicenter, open-label, single arm study will assess the safety and efficacy of RoActemra/Actemra (tocilizumab) in combination with methotrexate in patients with active rheumatoid arthritis who have an inadequate response…
- Trial name
- NCT01353859
- Testing
- tocilizumab [RoActemra/Actemra], methotrexate
- Where
- 5 sites in Indonesia
- Volunteers
- 39 people
- Sponsor
- Hoffmann-La Roche
Sjögren Syndrome, Sicca Syndrome
N-acetylcysteine for Primary Sjögren's Syndrome
N-acetylcysteine (NAC) allows the elimination of reactive oxygen species (ROSs) and it has an anti-inflammatory effect. For this reason, NAC has been used and researched for treatment of several diseases, such as autoimmune…
- Trial name
- NACSS (NCT04793646)
- Testing
- N-acetylcysteine syrup
- Where
- 2 sites in Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Rheumatoid Arthritis
Comparative, Multicenter Study in Subjects with Rheumatoid Arthritis, ALVOFLEX
This is a study to compare the efficacy, safety and immunogenicity of AVT05 versus EU-Simponi® in combination with methotrexate (MTX) in subjects with moderate to severe rheumatoid arthritis (RA).
- Trial name
- ALVOFLEX (NCT05842213)
- Testing
- AVT05 (proposed biosimilar to golimumab), Simponi (Golimumab)
- Where
- Bulgaria
- Volunteers
- 502 people
- Sponsor
- Alvotech Swiss AG
Arthritis, Rheumatoid
Phase II Study Evaluating the Safety and Efficacy of GSK315234A in Patients With Rheumatoid Arthritis
This is a randomized, double-blinded, placebo-controlled adaptive, dose finding study to investigate the safety, tolerability, PK, PD and efficacy of single and repeat intravenous infusions of GSK315243A in patients with active…
- Trial name
- NCT00674635
- Testing
- GSK3152314A
- Where
- 19 sites in Australia, New Zealand and 3 more
- Volunteers
- 135 people
- Sponsor
- GlaxoSmithKline
Spondyloarthritis (SpA), Psoriatic Arthritis (PsA)
Assessment of Nutritional Status in Rheumatic Diseases and Association to Disease Activity
The aim of the present work is to assess the nutritional status among different rheumatic diseases patients and to study its association with the corresponding diseases activity.
- Conditions
- Spondyloarthritis (SpA), Psoriatic Arthritis (PsA), Systemic Lupus Erythematous (SLE), Systemic Sclerosis (SSc)
- Trial name
- NCT07277491
- Where
- Egypt
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dry Eye Disease, Sjögren Syndrome
Tivanisiran for Dry Eye in Subjects With Sjögren's Syndrome
This study will examine the efficacy and safety of tivanisiran sodium eye drops versus vehicle after a 2-week run-in phase when dosed once daily for 3 months in subjects with signs and symptoms of dry eye disease (DED) due to…
- Trial name
- NCT04819269
- Testing
- Tivanisiran sodium ophthalmic solution, Vehicle ophthalmic solution
- Where
- 46 sites in United States, Spain
- Volunteers
- 203 people
- Sponsor
- Sylentis, S.A.
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