Clinical trials: Rheumatoid Arthritis of Knee
Degenerative Arthritis, Osteoarthritis
Total Knee Replacement With Duracon® and Vanguard™ Prostheses
The purpose of this study is to compare range of motion, Knee Society Scores, and duration of surgery for different total knee prostheses.
- Conditions
- Degenerative Arthritis, Osteoarthritis, Rheumatoid Arthritis, Knee Arthritis
- Trial name
- NCT00588887
- Testing
- Duracon®, Vanguard™
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Biomet Orthopedics, LLC
Abnormality in Synovial Tissue
Examination of Biopsies From Healthy Knee Joints
The purpose of the project is to examine what kind of molecular mechanism which causes inflammatory joint diseases. This examination is carried out by a collection and analysis of synovial tissues for patients without…
- Trial name
- NCT02458170
- Where
- Denmark
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Northern Orthopaedic Division, Denmark
Osteoarthritis, Arthritis, Rheumatoid
Primary TKA Cruciate Retaining vs Cruciate Substituting With Rotating Platform Knee Prostheses
The purpose of the study is to evaluate the clinical performance of the cruciate ligament retaining or cruciate ligament substituting implants by obtaining a series of primary TKAs.
- Conditions
- Osteoarthritis, Arthritis, Rheumatoid, Avascular Necrosis of Bone, Post-traumatic Arthritis
- Trial name
- NCT00289081
- Testing
- Total Knee Replacement
- Where
- 4 sites in United States
- Volunteers
- 399 people
- Sponsor
- DePuy Orthopaedics
Degenerative Joint Disease, Osteoarthritis
Post-Market Study of the 3DKnee™ System
The purpose of this study is to evaluate the use and efficacy of the 3DKnee™ System for total knee replacement surgery.
- Conditions
- Degenerative Joint Disease, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis
- Trial name
- NCT00819481
- Testing
- 3DKnee™ System
- Where
- 8 sites in United States
- Volunteers
- 229 people
- Sponsor
- Encore Medical, L.P.
Osteoarthritis, Knee, Arthritis, Rheumatoid
Gamma Vacuum Foil (GVF) Versus Cross-linked Polyethylene in Total Knee Arthroplasty Study
The purpose of this study is to evaluate long-term clinical and radiographic data between geometrically identical GVF and cross-linked polyethylene-bearing inserts in total knee arthroplasty.
- Trial name
- NCT00289133
- Testing
- total knee arthroplasty
- Where
- 9 sites in United States
- Volunteers
- 938 people
- Sponsor
- DePuy Orthopaedics
Knee Pain Chronic, Osteoarthritis
Persona Ti-Nidium Post-Market Clinical Follow-up
The main objectives of this study are to evaluate overall clinical performance and safety of the Persona Ti-Nidium implant in total knee arthroplasty.
- Conditions
- Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis
- Trial name
- TKA (NCT04817969)
- Testing
- Zimmer Biomet Persona Ti-Nidium Total Knee System
- Where
- 7 sites in United States
- Volunteers
- 240 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Septic Arthritis
Analysis of Human Knee Joint Fluid Using Metabonomic, Genomic and Tribology Techniques
Making the diagnosis underlying a painful, swollen joint currently involves aspiration followed by numerous microbiological and biochemical laboratory tests.
- Conditions
- Osteoarthritis, Septic Arthritis, Rheumatoid Arthritis
- Trial name
- NCT02565160
- Testing
- Intra-articular aspiration of Joint, Joint irrigation washout, Total Joint Arthroplasty
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Imperial College London
Arthroplasty, Replacement, Knee, Recovery of Function
The Influence of Rapid Recovery on Sleep Quality Following Total Knee Replacement Surgery
The purpose of this study is to evaluate the influence of rapid recovery on sleep quality following total knee replacement surgery.
- Conditions
- Arthroplasty, Replacement, Knee, Recovery of Function, Arthritis, Rheumatoid
- Trial name
- NCT02845960
- Testing
- rapid recovery
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Southwest Hospital, China
Degenerative Joint Disease of Knee, Rheumatoid Arthritis
Intra-Articular Adelmidrol 2%/Hyaluronic Acid 1% With or Without m/umPEA, in Knee Pain Due to Joint Degeneration.
Degenerative knee joint diseases are characterized by chronic pain, inflammation, and functional impairment. In these conditions, mast cell density in the synovial membrane is increased, resulting in an excessive release of…
- Trial name
- NCT07680101
- Testing
- Adelmidrol 2% / Hyaluronic Acid 1%, micronized Palmitoylethanolamide (mPEA) 300mg + ultramicronized Palmitoylethanolamide (umPEA) 600mg
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Universita di Verona
Osteoarthritis, Rheumatoid Arthritis
A Prospective, Clinical Investigation of the Vanguard 360 Revision Knee
The purpose of this study is to evaluate performance of the Vanguard 360 revision knee system utilizing offset on either the tibial component, femoral component, or both in terms of the restoration of mechanical alignment…
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Post Traumatic Deformity
- Trial name
- NCT01542580
- Testing
- Vanguard SSK 360 with PS Bearing, Vanguard SSK 360 with PSC bearing, Vanguard DA 360
- Where
- 12 sites in United States, Belgium and 6 more
- Volunteers
- 255 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Knee, Traumatic Arthritis
Physica System Total Knee Replacement Registry Study
The primary objective of this study is to obtain long-term implant survivorship (out to 10 years) and to assess clinical, patient-reported outcome measures, and radiographic data for the commercially available Physica system.
- Conditions
- Osteoarthritis, Knee, Traumatic Arthritis, Avascular Necrosis, Degenerative Joint Disease of Knee
- Trial name
- NCT03048201
- Testing
- Physica Kinematic Retaining Knee System, Physica Cruciate Retaining Knee System, Physica Posterior Stabilized Knee System
- Where
- 5 sites in United States
- Volunteers
- 800 people
- Sponsor
- Limacorporate S.p.a
Patellofemoral Pain, PFP
A Study on the Effectiveness of Ankle Dorsiflexion Range of Motion Training in Patients With Patellofemoral Joint Pain.
Patellofemoral Pain (PFP) is a common knee condition causing pain around the kneecap during activities like running or squatting.
- Trial name
- NCT06958757
- Testing
- Standard Exercise Therapy + Ankle Dorsiflexion Training, Standard Exercise Therapy Only
- Volunteers
- 64 people
- Sponsor
- Tianjin University of Sport
Knee Osteoarthritis
Post Market Clinical Follow-Up Study- EVOLUTION® Revision CCK
Sponsor is conducting this post market clinical follow-up (PMCF) study to evaluate the safety and efficacy of its EVOLUTION® Revision CCK Tibia and EVOLUTION® Revision CCK Femur with EVOLUTION® CCK Tibial inserts.
- Trial name
- NCT04145401
- Testing
- Revision Knee implants
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- MicroPort Orthopedics Inc.
Metabolic Syndrome, Osteoarthritis, Hip
Effects of a Clinical Dietary Intervention During Inpatient Treatment
The purpose of the study is a scientific and prospective documentation of the clinical effects of an inpatient treatment at the Immanuel Hospital of Berlin, in the department for complementary and integrative medicine, with the…
- Conditions
- Metabolic Syndrome, Osteoarthritis, Hip, Osteoarthritis, Knee, Rheumatoid Arthritis
- Trial name
- FASTA (NCT03785197)
- Testing
- Prolonged modified fasting
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Charite University, Berlin, Germany
Rheumatoid Arthritis, Knee Pain Chronic
The Cartilage and Muscle Thickness on Knee Pain in Patients With Rheumatoid Arthritis
The knee pain status of the patients who are followed in the rheumatology special branch of the Physical Medicine and Rehabilitation Outpatient Clinic and who meet the inclusion criteria will be questioned.
- Conditions
- Rheumatoid Arthritis, Knee Pain Chronic, Muscle Loss, Cartilage Degeneration
- Trial name
- NCT05999266
- Testing
- Ultrasonographic Measurements
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Knee Pain Chronic, Rheumatoid Arthritis
Cemented vs Cementless Persona Keel RCT
The main objective of this study is to evaluate the safety, performance, and clinical benefits of the Persona Keel cementless and cemented knee.
- Conditions
- Knee Pain Chronic, Rheumatoid Arthritis, Osteoarthritis, Traumatic Arthritis
- Trial name
- NCT05630053
- Testing
- Cementless Persona Knee System, Cemented Persona Knee System
- Where
- 7 sites in United States
- Volunteers
- 300 people
- Sponsor
- Zimmer Biomet
Rheumatoid Arthritis of Knee, Osteoarthritis of the Knee
Exploratory Study on Safety of PEEK Knee Prosthesis
In this study, 10 subjects will be underwent total knee arthroplasty with PEEK knee prosthesis and be followed up 3, 6, and 12 months after surgery.
- Trial name
- NCT04927104
- Testing
- PEEK Knee Prosthesis
- Where
- China
- Volunteers
- 10 people
- Sponsor
- RenJi Hospital
Rheumatoid Arthritis, Traumatic Arthritis
3DKnee™ System vs. the MJS Knee System
The purpose of this study is to compare the survivorship and efficacy of the Encore 3DKnee™ system with that of the Encore MJS™ Knee System in a group of 600 patients for whom data collection is already under way.
- Conditions
- Rheumatoid Arthritis, Traumatic Arthritis, Joint Disease Secondary to Osteoarthritis
- Trial name
- NCT00764803
- Testing
- Encore 3DKnee™ system, Encore MJS™ Knee System
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Encore Medical, L.P.
Rheumatoid Arthritis
Draining PLN and Synovial Inflammation in RA Knee Joints Pre and Post Anti-TNF or B Cell Depletion Therapy
The purpose of this study is to examine the effect of anti-TNF therapy on rheumatoid arthritis using magnetic resonance imaging (MRI) and ultrasound imaging.
- Trial name
- NCT01083563
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Rochester
Osteoarthritis, Inflammatory Arthritis
Gender Solutions Natural Knee Post-Market Study
This is a prospective multicenter study of the Gender Solutions Natural Knee Flex System when used in primary total knee arthroplasty.
- Conditions
- Osteoarthritis, Inflammatory Arthritis, Post-traumatic Arthritis, Rheumatoid Arthritis
- Trial name
- NCT01463566
- Testing
- Zimmer Gender(R) Solutions(TM) Natural-Knee(R) Flex System
- Sponsor
- Zimmer Biomet