Clinical trials: Rheumatology, open to volunteers
Knee Osteoarthritis, Knee Osteoarthritis (OA)
Knee Osteoarthritis and Spa Therapy
The aim of this clinical trial is to assess the efficacy of the 18-day balneotherapy program (therapeutic indication: Rheumatology) in terms of functional incapacity and the disorders (pain, joint stiffness) induced by…
- Trial name
- SANTIAGO (NCT06617975)
- Testing
- Balneotherapy program in rheumatology indication
- Where
- France
- Volunteers
- 80 people
- Sponsor
- CEN Biotech
Arthritis
Transarterial Embolization Versus Sham Procedure in Adults With Treatment-Resistant Inflammatory Arthritis of a Single Large Joint
The goal of this clinical trial is to learn whether transarterial embolization (TAE) can relieve pain and improve well-being in adults with inflammatory arthritis that remains active in only one large joint (wrist, elbow…
- Trial name
- ADVENTURE (NCT07873892)
- Testing
- Transarterial embolization with resorbable gelatin microspheres
- Volunteers
- 30 people
- Sponsor
- Istituto Ortopedico Rizzoli
Chronic Pain, Chronic Pain Syndrome
Shiatsu for Chronic Non-Inflammatory Pain in Children and Adolescents
The goal of this clinical trial is to learn if adding Shiatsu therapy to standard treatment can improve quality of life in children and adolescents with chronic pain that is not caused by inflammation.
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Chronic Pain and Comorbid Emotional Problems, Chronic Pain, Psychogenic
- Trial name
- ShiQoL (NCT06929598)
- Testing
- Shiatsu Therapy
- Where
- 2 sites in Israel
- Volunteers
- 40 people
- Sponsor
- Tel Aviv University
Radiculopathy
Interest of the Virtual Reality as an Analgesic Support and in the Management the Pre-procedural Anxiety in Rheumatology
As a part of the current rheumatological practice skills, epidural injections through the sacrococcygeal hiatus take part in the strategy for managing radicular diseases.
- Trial name
- REAVIR (NCT05289999)
- Testing
- Virtual reality headset for first injection, Virtual reality headset for second injection
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Centre Hospitalier le Mans
Inflammatory Bowel Diseases, Ulcerative Colitis
Evolution and Treatments of Chronic Inflammatory Systemic Diseases
Patients with chronic inflammatory diseases (CID) followed in gastroenterology, dermatology and rheumatology have physiopathological, epidemiological and therapeutic focal points.
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease, Arthritis, Rheumatoid
- Trial name
- MISTIC (NCT04191395)
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Rheumatoid Arthritis, Ankylosing Spondylitis
Korean College of Rheumatology Biologics and Targeted Therapy Registry
We established a nationwide biologics and targeted synthetic DMARDs registry (in the form of an inception cohort) to study the safety profiles in rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis patients…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis
- Trial name
- KOBIO (NCT01965132)
- Testing
- Biologic or targeted synthetic DMARD
- Where
- South Korea
- Volunteers
- 10,000 people
- Sponsor
- Seoul National University Hospital
Rheumatic Conditions
Health Economic Impact of Steroids
Three focus groups will be conducted with patients who have an inflammatory rheumatic condition and have been treated with steroids in the last three years to discuss the impact of steroids on their quality of life, the financial…
- Trial name
- HEIST (NCT07863245)
- Testing
- This is a qualitative focus group study therefore no interventions planned
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University of the West of England
Tuberculosis (TB)
ESAT6/CFP10 Skin Testing for TB Infection in Rheumatologic Patients
The aim of the study is to pilot the application of a novel ESAT6/CFP10 (C-TST) skin test in rheumatologic disease patients prior to initiation of treatment with biologic and/or targeted synthetic disease-modifying antirheumatic…
- Trial name
- NCT06796647
- Testing
- ESAT6/CFP10 skin test
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Arthritis, Ultrasonication
The Efficacy of Ultrasonication in Combination With Corticosteroid Intraarticular Injection for Arthritis
This study investigates whether ultrasound therapy applied prior to intra-articular corticosteroid injection can enhance the treatment efficacy for patients with joint arthritis and assess its safety.
- Conditions
- Arthritis, Ultrasonication, Intra-articular Injections, Rheumatology
- Trial name
- NCT07363876
- Testing
- Therapeutic Ultrasound, Intra-articular corticosteroid injection
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taichung Veterans General Hospital
Systemic Juvenile Idiopathic Arthritis (sJIA), Systemic Juvenile Idiopathic Arthritis
Clinical Features and Treatment of Systemic JIA in Children
This study aims to describe the clinical features, disease patterns, and different treatment modalities used in children with systemic juvenile idiopathic arthritis (sJIA).
- Trial name
- CST-SJIA (NCT07814963)
- Testing
- Tocilizumab (Actemra®)
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Juvenile Idiopathic Arthritis, Tenosynovitis
Tenosynovitis in Polyarticular and Oligoarticular Juvenile Idiopathic Arthritis
Juvenile Idiopathic Arthritis (JIA) is a chronic condition that causes joint inflammation in children. In some cases, the inflammation also affects the protective sheath surrounding the tendons, a condition known as…
- Conditions
- Juvenile Idiopathic Arthritis, Tenosynovitis, Polyarticular Juvenile Idiopathic Arthritis, Oligoarticular Juvenile Idiopathic Arthritis
- Trial name
- NCT07553910
- Volunteers
- 106 people
- Sponsor
- Assiut University
SLE
Argentinian Prospective Registry of Patients With Lupus
In Latin America, information about patients with systemic lupus erythematosus (SLE) is limited. Multicenter studies are needed to obtain "real world data '' and to carry out longer follow-ups.
- Trial name
- NCT05470569
- Where
- Argentina
- Volunteers
- 1,500 people
- Sponsor
- Sociedad Argentina de Reumatologia
Lupus, Dermatomyositis, Juvenile
Teams Engaged in Accessible Mental Health Interventions for Lupus Erythematosus and Dermatomyositis Stress
The objectives of this study are to determine if the 'Teams Engaged in Accessible Mental Health Interventions for Lupus Erythematosus and Dermatomyositis Stress' (TEAM-LEADS) intervention is feasible and acceptable to adolescents…
- Conditions
- Lupus, Dermatomyositis, Juvenile, Dermatomyositis, Lupus Erythematosus
- Trial name
- TEAM-LEADS (NCT06999109)
- Testing
- TEAM-LEADS
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Scoliosis
Scoliosis and Functional Outcomes in Children With Juvenile Idiopathic Arthritis
Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disease that may affect musculoskeletal development and posture in children.
- Trial name
- NCT07433894
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Polyarticular Course Juvenile Idiopathic Arthritis (JIA)
Trial of Sequential Medications AfteR TNFi Failure in Juvenile Idiopathic Arthritis
This study is an open-label, randomized, multicenter trial that incorporates a multi-arm design comparing each of 3 non-TNFi (Tumor Necrosis Factor inhibitor) medications to a second TNFi (active control) within a sequential…
- Trial name
- SMART-JIA (NCT06654882)
- Testing
- TNFi (Tumor Necrosis Factor inhibitor) medication, Abatacept, Tocilizumab
- Where
- 7 sites in United States, Germany and 2 more
- Volunteers
- 400 people
- Sponsor
- Duke University
Still´s Disease
A Phase II Trial to Evaluate the Clinical Efficacy, Safety and Tolerability of MAS825 in Pediatric and Adult Participants With Still's Disease
The study is a phase II trial designed to evaluate the clinical efficacy, safety, and tolerability of MAS825 (arumakimig) in pediatric and adult participants with Still's disease
- Trial name
- NCT07203001
- Testing
- MAS825
- Where
- 23 sites in United States, Canada and 6 more
- Volunteers
- 30 people
- Sponsor
- Novartis Pharmaceuticals
Autoimmune Rheumatic Diseases
Influence of Methotrexate Discontinuation on Immunogenicity After PCV-20 Vaccine in Patients ARDs
This clinical trial aims to evaluate the effect of temporary methotrexate (MTX) discontinuation on the humoral immunogenicity of the 20-valent pneumococcal conjugate vaccine (PCV20) in adult patients with autoimmune rheumatic…
- Trial name
- MTX-PCV20-ARD (NCT07242092)
- Testing
- Pneumococcal Vaccine
- Where
- Brazil
- Volunteers
- 192 people
- Sponsor
- University of Sao Paulo General Hospital
Autoimmune Rheumatologic Disease
Immunogenicity and Safety of MenB Vaccine in Pediatric Patients With Autoimmune Rheumatic Diseases
The goal of this clinical trial is to evaluate the humoral immunogenicity of the meningococcal B vaccine (MenB-4C) in pediatric patients with autoimmune rheumatic diseases (ARDs), compared to age- and sex-matched…
- Trial name
- MENB-PARD (NCT07252804)
- Testing
- Meningococcal B (Bexsero)
- Where
- 2 sites in Brazil
- Volunteers
- 263 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Systemic Lupus Erythematosus of Childhood (Disorder)
Transforming Care for Individuals With Childhood-onset Systemic Lupus Erythematosus
This study aims to investigate the feasibility and effectiveness of a cognitive behavioral coping skills program, Treatment and Education Approach for Childhood-onset Lupus (TEACH), for youth with cSLE when integrated into…
- Trial name
- cSLE (NCT06232304)
- Testing
- TEACH
- Where
- 7 sites in United States, Canada
- Volunteers
- 175 people
- Sponsor
- Michigan State University
Acute Rheumatic Pain
Pharmacokinetic Study of the Use of Nefopam 30 mg Tablets in Patients Suffering From Acute Pain in Rheumatology
Nefopam is a non-opioid analgesic approved for the symptomatic treatment of acute pain, particularly postoperative pain. The HAS has authorized nefopam tablet, while emphasizing the lack of bibliographic data on both the…
- Trial name
- NEFOPAIN kinet (NCT07491393)
- Testing
- Nefopam administration and prelevment
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Rouen