Clinical trials: Rhinosinusitis Chronic
Chronic Rhinosinusitis With Nasal Polyps
A Study of GR1802 in Participants With Chronic Sinusitis With Nasal Polyps
The goal of this clinical trial is to learn if GR1802 works to treat severe chronic rhinosinusitis with nasal polyps (CRSwNP) in adults. It will also learn about the safety of GR1802. The main questions it aims to answer are: 1.
- Trial name
- NCT06516302
- Testing
- GR1802
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Genrix (Shanghai) Biopharmaceutical Co., Ltd.
Chronic Sinusitis
Efficacy of Seprapack Sinus Dressing Versus No Dressing in the Prevention of Intranasal Adhesions Following Sinus Surgery
The purpose of this study is to investigate if the space occupying effect of Seprapack will lead to a reduction in post operative adhesions and more healing of the sinus cavity when compared to the use of no packing material.
- Trial name
- NCT00140608
- Testing
- Seprapack Sinus Dressing
- Where
- 3 sites in United States
- Sponsor
- Genzyme, a Sanofi Company
Chronic Rhinosinusitis (Diagnosis)
The Effect of Intra-sinus Application of Betamethasone Dipropionate Nasal Cream on Patients with Chronic Rhinosinusitis Post Functional Endoscopic Sinus Surgery (FESS)
To assess the safety and efficacy of one (single) application of Betamethasone Dipropionate Nasal Cream (BMDP CREAM) onto the sinus mucosa.
- Trial name
- NCT05882903
- Testing
- Betamethasone Dipropionate Nasal Cream 0.0644%, Pre-filled syringe and applicator device
- Where
- 4 sites in Australia
- Volunteers
- 24 people
- Sponsor
- Oticara Australia PTY LTD
Chronic Rhinosinusitis (Diagnosis)
Treatment of Eosinophilic Chronic Rhinosinusitis Utilizing Betamethasone Dipropionate Nasal Cream
This is an open-label, single dose, pilot study, to assess the efficacy and safety of Betamethasone Dipropionate Nasal Cream 0.0644% (equivalent to 0.05% Betamethasone) for the treatment of eosinophilic Chronic Rhinosinusitis…
- Trial name
- OT-007 (NCT05220293)
- Testing
- Betamethasone Dipropionate Nasal Cream 0.0644%, Pre-filled syringe and applicator device
- Where
- Australia
- Volunteers
- 2 people
- Sponsor
- Oticara Australia PTY LTD
Rhinosinusitis, Rhinitis
Safety and Efficacy of DSM 32444 Postbiotic in the Treatment of Acute Rhinosinusitis
Rhinitis is a type of upper respiratory infection with a common nasal pathology especially in Southeast Asia, which is characterized by the presence of one or more of the following symptoms: itchy nose, sneezing, runny nose, and…
- Trial name
- NCT05999955
- Testing
- Neomycin/ Dexameythasone/Xylometazoline, Bacillus subtilis DSM32444
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Huro Biotech Joint Stock Company
Chronic Rhinosinusitis (Diagnosis)
A Clinical Evaluation of PROPEL® Contour Sinus Implant
The objective of this study is to evaluate the efficacy of PROPEL Contour placement following an in-office frontal sinus balloon dilation (SBD) in patients with chronic rhinosinusitis (CRS)
- Trial name
- EXPAND (NCT04858802)
- Testing
- PROPEL Contour Sinus Implant, Balloon Sinus Dilation Alone
- Where
- 14 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Intersect ENT
Asthma
Retrospective Analysis of Systemic Glucocorticoid Mediated Long-term Effects, Patient Pathways and Economic Burden Across Multiple Indications
Glucocorticoids are important in the treatment of many inflammatory, allergic, immunologic, and malignant disorders. However, the adverse effects of systemic corticosteroids are one of the most common causes of iatrogenic…
- Trial name
- NCT06488703
- Where
- Germany
- Volunteers
- 107,032 people
- Sponsor
- GlaxoSmithKline
Chronic Sinusitis
Balloon Sinus Dilation In Office or OR
Endoscopic sinus surgery will be performed either in the physician's office or in the operating room (OR). Patients treated in the physician's office will have endoscopic sinus surgery performed with balloon sinuplasty devices.
- Trial name
- ORIOS (NCT00939393)
- Testing
- FESS instruments with or without balloon treatment, Balloon Sinuplasty
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Integra LifeSciences Corporation
Sinusitis
A Study To Measure The Level Of Drug In Nasal Tissue And Blood After Taking A Single 2g Dose Or 500mg Tablets For Up To
To measure the level of drug in nasal tissue and blood after taking a single 2g dose or 500mg tablets for up to 3 days.
- Trial name
- NCT00232154
- Testing
- Zithromax™ (azithromycin) 500mg tablets, Endoscopic Sinus Surgery, Blood sampling for hematology
- Where
- 18 sites in United States
- Volunteers
- 72 people
- Sponsor
- Pfizer
Nasal Polyps, Chronic Rhinosinusitis
A Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitis With Nasal Polyps
The purpose of this study is to determine the efficacy and safety of omalizumab compared with placebo in adult participants with chronic rhinosinusitis with nasal polyps (CRSwNP) who have had an inadequate response to…
- Trial name
- POLYP 1 (NCT03280550)
- Testing
- Omalizumab
- Where
- 37 sites in United States, Canada and 8 more
- Volunteers
- 138 people
- Sponsor
- Hoffmann-La Roche
Rhinosinusitis Chronic, Microbiome
Impact of Symbiofilm On Nasal Microbiota
Healsea® chronic is CE marked medical device indicated in adults for the treatment of nasal symptoms of chronic rhinosinusitis. This is an hypertonic seawater-based nasal spray supplemented with natural Symbiofilm® extract (0.2%)…
- Trial name
- ISONAM (NCT05015530)
- Testing
- Healsea® Chronic, hypertonic seawater-based nasal spray supplemented with natural Symbiofilm® extract
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Lallemand Pharma AG
Rhinosinusitis, Chronic Polyposis
Buparid/PARI SINUS Versus Budes® Nasal Spray in the Therapy of Chronic Rhinosinusitis With Polyposis Nasi
The study should create data for the selection of a clinically relevant primary endpoint to assess the efficacy and safety of Buparid/PARI SINUS as compared to Budes Nasal Spray in the therapy of chronic rhinosinusitis (CRS) with…
- Trial name
- NCT01946711
- Testing
- Budesonide
- Where
- 4 sites in Germany
- Volunteers
- 14 people
- Sponsor
- Pari Pharma GmbH
Chronic Rhinosinusitis (Diagnosis)
Real-Life Chronic Rhinosinusitis Outcome Registry
An international consortium of leading medical experts in the field of chronic respiratory disease, the research team of Galenus Health and the non-profit organization EUFOREA (European Forum for Research and Education in Allergy…
- Trial name
- NCT04670172
- Where
- 13 sites in Austria, Belgium and 8 more
- Volunteers
- 4,550 people
- Sponsor
- Change Accelerator in Respiratory Care
Rhinosinusitis, Sinusitis
Clinical Outcomes and Patient Satisfaction With Velnez Versus Nasopore in Nasal Surgery
This clinical trial evaluated two absorbable nasal packing materials - VELNEZ and NASOPORE - in adult patients (18-70 years) who underwent nasal surgery, including septoplasty, FESS, or turbinoplasty.
- Conditions
- Rhinosinusitis, Sinusitis, Chronic Rhino-sinusitis
- Trial name
- NCT07560254
- Testing
- VELNEZ Nasal Pack, NASOPORE Nasal Pack
- Where
- Malaysia
- Volunteers
- 20 people
- Sponsor
- Ayu, Inc.
Chronic Sinusitis
A Clinical Evaluation of the Sinexus Intranasal Splint Following Functional Endoscopic Sinus Surgery in Patients With Chronic Rhinosinusitis
The purpose of this study is to assess the safety and performance of the Sinexus Intranasal Splint when used following Functional Endoscopic Sinus Surgery (FESS) in patients with Chronic Rhinosinusitis.
- Trial name
- CONSENSUS II (NCT00840970)
- Testing
- non-coated Intranasal Splint, Sinexus Intranasal Splint
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Intersect ENT
Chronic Sinusitis
Clinical Evaluation of Propel Nova Sinus Implant in Peripheral Sinus Ostia
This is a feasibility study is to assess the performance, safety and initial signals of efficacy of the drug-eluting Propel Nova Sinus Implant when used in chronic sinusitis patients undergoing sinus surgery of peripheral sinus…
- Trial name
- EXCEED (NCT02228720)
- Testing
- Propel Nova Sinus Implant
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Intersect ENT
Chronic Sinusitis
Photodynamic Therapy for the Treatment of Chronic Rhinosinusitis
The purpose of this study is to determine whether the use of light and a topically applied photosensitizer can relieve symptoms and clinically improve patients with chronic rhinosinusitis.
- Trial name
- NCT01854619
- Testing
- Photodisinfection (antimicrobial photodynamic therapy, aPDT), Saline irrigation
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Ondine Biomedical Inc.
Chronic Rhinosinusitis With Nasal Polyps
A Proof-of-concept Study of Lunsekimig Compared With Placebo in Adults With Chronic Rhinosinusitis With Nasal Polyps
This is a parallel, Phase 2, 2-arm, multicenter, randomized, double-blind, placebo-controlled, proof-of-concept study for treatment of CRSwNP.
- Trial name
- NCT06454240
- Testing
- lunsekimig
- Where
- 29 sites in United States, Argentina and 4 more
- Volunteers
- 79 people
- Sponsor
- Sanofi
Chronic Rhinosinusitis
Study Evaluating the Efficacy and Safety of Intranasal Administration of OPN-375 in Subjects With Chronic Rhinosinusitis Without the Presence of Nasal Polyps
This is a 24-week randomized, double-blind, placebo-controlled, parallel-group, multicenter study to evaluate the efficacy and safety of intranasal administration of 186 and 372 μg twice daily (BID) of OPN-375 in subjects with…
- Trial name
- NCT03960580
- Testing
- OPN-375
- Where
- 87 sites in United States, Australia and 8 more
- Volunteers
- 223 people
- Sponsor
- Optinose US Inc.
Chronic Rhinosinusitis With Nasal Polyps
A Study in Male and Female Adult Participants With Chronic Rhinosinusitis With Nasal Polyps In the Greater Gulf Region
Primary Objective: To describe the clinical characteristics of participants with chronic rhinosinusitis with nasal polyps (CRSwNP) in terms of disease severity, Type 2 inflammation-related comorbidities (such as asthma and…
- Trial name
- NCT05649813
- Where
- Kuwait
- Volunteers
- 148 people
- Sponsor
- Sanofi