Clinical trials: Rhythm; Sleep
Breast Cancer, Fatigue
The Role of Circadian Rhythms in Cancer-Related Symptoms
Emerging evidence indicates that circadian rhythms may be disrupted following cancer and its treatment, and that circadian rhythm disruption may be an underlying pathophysiological mechanism of cancer- and cancer…
- Conditions
- Breast Cancer, Fatigue, Cognitive Impairment, Sleep
- Trial name
- CHRONO (NCT04401189)
- Where
- Denmark
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Circadian Rhythm Sleep-Wake Disorders, Shift Work Type, Sleep Initiation and Maintenance Disorders
Optimizing Sleep Health in Nurses
The aim of the proposed study is to pilot test two behavioral sleep intervention strategies for improving insomnia among night shift working nurses.
- Trial name
- OSHIN (NCT05965609)
- Testing
- CBTI, MRTI
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Oregon State University
Borderline Personality Disorder, Sleep Disturbances
Circadian Sleep-wake Cycles and Light Therapy in Borderline Personality Disorder
Individuals with borderline personality disorder (BPD) frequently suffer from emotional instability, daytime fatigue and sleep disturbances.
- Conditions
- Borderline Personality Disorder, Sleep Disturbances, Depression
- Trial name
- NCT01311193
- Testing
- light therapy
- Where
- Switzerland
- Sponsor
- University Hospital, Basel, Switzerland
Alzheimer Disease
The CIRCADIAN Study: Evaluation of Modulating Effect of Galantamine on Circadian Rhythm in Patients With Mild to Moderate Alzheimer's Disease
The purpose of this study is to assess the modulating effect of galantamine on circadian rhythm in patients with moderate Alzheimer's disease.
- Trial name
- NCT01181921
- Testing
- Galantamine
- Where
- Spain
- Volunteers
- 1 people
- Sponsor
- Janssen-Cilag, S.A.
Sleep Disorders, Circadian Rhythm
Circadian Phase Adjustment and Improvement of Metabolic Control in Night Shift Workers
EuRhythDia II is a multicenter, randomized, double-blind controlled study. The rationale of EuRhythdia is to explore the effects of 12 weeks of timed melatonin treatment on circadian rhythm, metabolic control and cardiovascular…
- Trial name
- NCT02108353
- Testing
- Melatonin 2mg
- Where
- 3 sites in Germany, Italy
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Shift Work Type Circadian Rhythm Sleep Disorder, Insomnia, Psychophysiological
Shift Worker Intervention for Sleep Health
The aim of this study is to pilot test a comprehensive, personalized, media-augmented telehealth intervention ("SWISH") designed to improve sleep health among shift workers.
- Trial name
- SWISH (NCT06384742)
- Testing
- Shift Worker Intervention for Sleep Health
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Oregon State University
Chromosome Disorders
Melatonin Levels in Smith Magenis Syndrome (SMS)
The goal of this pilot project is to determine whether melatonin levels are disordered in patients with Smith-Magenis Syndrome (SMS) and whether melatonin treatment can correct abnormal circadian rhythms in SMS patients.
- Trial name
- NCT00691574
- Testing
- Melatonin, Enviro-light artificial light box
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Seasonal Affective Disorder
Ramelteon in the Treatment of Sleep and Mood in Patients With Seasonal Affective Disorder
The purpose of this study is to determine whether treating sleep difficulties in patients with seasonal affective disorder also improves their depressive symptoms.
- Trial name
- SAM-SAD (NCT00502320)
- Testing
- Ramelteon
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Lehigh Valley Hospital
Bipolar Disorder, Circadian Rhythm
Effects of Sex Hormones on Circadian Rhythm in Men and Women
For many years researchers have been trying to better understand the regulation of sleep and activity by studying circadian (daily) rhythms of human beings.
- Conditions
- Bipolar Disorder, Circadian Rhythm, Depressive Disorder
- Trial name
- NCT00001285
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Chronic Insomnia, Cognitive Behavioral Therapy
Cognitive Behavioral Therapy for Insomnia Among Different Types of Shift Workers
The aim of the study is to compare the implementation and effectiveness of group and self-help based cognitive behavioral treatment for insomnia (CBT-I) delivered by occupational health services (OHS) in a randomized and…
- Conditions
- Chronic Insomnia, Cognitive Behavioral Therapy, Sleep Disorders, Circadian Rhythm, Sleep Disorders, Shift-Work
- Trial name
- CBT-INSOMNIA (NCT02523079)
- Testing
- Cognitive Behavioral Group Therapy for Insomnia, Cognitive Behavioral Self-help Therapy for Insomnia, Sleep Hygiene Guidance
- Where
- 5 sites in Finland
- Volunteers
- 83 people
- Sponsor
- Finnish Institute of Occupational Health
Blindness
Blind Elderly Melatonin Treatment Study
The primary focus of this five-year study will be to optimize the melatonin dosing regimen for synchronizing the body clocks of elderly blind individuals to the 24-hour day.
- Trial name
- NCT00692094
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Oregon Health and Science University
Depression, Sleep Disorders, Circadian Rhythm
Longitudinal Ecological Study on Sleep-Wake Patterns in MDD Using Actigraphy
The proposed study will include a longitudinal ecological study (Study 1) and a randomised controlled trial (Study 2). The aims will be to (1) identify the sleep-wake profiles in individuals with Major Depressive Disorder (MDD)…
- Trial name
- NCT06233422
- Testing
- No intervention involved
- Where
- Hong Kong
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Shift Work Sleep Disorder
A Pilot of a Personalized Circadian mHealth to Improve Sleep in Night Shift Workers
The goal of this project is to establish the evidence base for equitable accessibility and implementation of the precision sleep medicine mobile application, SHIFT.
- Trial name
- SAIL (NCT06809335)
- Testing
- Personalized circadian mHealth
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Henry Ford Health System
Nocturnal Enuresis
The Effect of Melatonin on Nocturnal Enuresis
Aim: To investigate the effect of melatonin in bedwetting.
- Trial name
- NCT01575678
- Testing
- Melatonin, Lactose
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- University of Aarhus
Essential Arterial Hypertension, Circadian Disruption
Circadian Disruption And Cardiovascular Risk In Young Adults With Hypertension
This prospective observational study will investigate whether circadian disruption is associated with higher blood pressure and a less favorable cardiovascular profile in young adults aged 18 to 45 years with essential arterial…
- Trial name
- CIRCA-HT (NCT07770958)
- Where
- Bulgaria
- Volunteers
- 200 people
- Sponsor
- Medical University of Sofia
Stroke, Ischemic, Sleep Disorder
The Role of Circadian Factors in Regulation of Neuroplasticity in Ischemic Stroke (Observational)
The study is aimed at the investigation of the association of biomarkers of circadian rhythms with sleep characteristics and stroke outcome in acute stroke patients.
- Trial name
- NCT05242393
- Testing
- No intervention is planned
- Where
- Russia
- Volunteers
- 250 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Shift-Work Sleep Disorder
Assessments in Stress and Quality of Sleep/Life in Night-shift Nurses and Doctors
This study aims to evaluate the effects of aroma massage to sleep quality of the nurses and staff during night shift.
- Trial name
- NCT02541747
- Testing
- massage
- Where
- Taiwan
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Taichung Veterans General Hospital
Parkinson Disease, Restless Leg Syndrome
Circadian Character of Food Compulsions and Impulses Control Disorders in Parkinsonian Patients With and Without Resting Leg Syndrome
Investigator have recently shown that Parkinson disease patients' with restless leg Syndrome have more frequent impulse control behavior in particular compulsive feeding that patients without Restless Leg Syndrome (RLS).
- Trial name
- RLS nighfood (NCT03818243)
- Testing
- Diary (for reporting all impulse control disorders especially compulsive eating disorders)
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Clermont-Ferrand
Colorectal Neoplasm, Circadian Rhythm Sleep Disorder
Sleep and Survival in Colorectal Cancer
Objective The objective of the current trial is to investigate the effect of perioperative sleep and circadian rhythm on the natural course of survival among patient diagnosed with colorectal cancer.
- Conditions
- Colorectal Neoplasm, Circadian Rhythm Sleep Disorder, Depression, Quality of Life
- Trial name
- NCT03254836
- Testing
- Standard of care
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Zealand University Hospital
Sleep Apnea, Cardiovascular Diseases
Platelet Activation and Circadian Rhythms of Clotting-Fibrinolysis Factors in Patients With Sleep Apnea Syndrome
The objective of the study is to define and compare clotting- fibrinolysis patterns, platelet function markers and endothelial dysfunction in patients with SAHS before and after treatment and normal controls age and weight…
- Trial name
- NCT00456287
- Testing
- CPAP (Continuous Positive Airway Pressure)
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica